Water-Soluble Monofunctional Perylene and Terrylene Dyes: Powerful Labels for Single-Enzyme Tracking (pages 3372–3375)
Kalina Peneva, Gueorgui Mihov, Fabian Nolde, Susana Rocha, Jun-ichi Hotta, Kevin Braeckmans, Johan Hofkens, Hiroshi Uji-i, Andreas Herrmann and Klaus Müllen
Version of Record online: 26 MAR 2008 | DOI: 10.1002/anie.200705409
All in one: Exceptionally photostable, highly fluorescent, water-soluble, and monofunctional perylene and terrylene dyes bearing reactive groups for covalent attachment to biomolecules have been synthesized (see picture). Single-molecule enzyme tracking revealed that single enzymes could be visualized even on a substrate with fluorescent background.