Angewandte Chemie International Edition

Cover image for Vol. 47 Issue 19

April 28, 2008

Volume 47, Issue 19

Pages 3469–3649

  1. Cover Picture

    1. Top of page
    2. Cover Picture
    3. Inside Cover
    4. Graphical Abstract
    5. News
    6. Book Review
    7. Highlights
    8. Essay
    9. Reviews
    10. Communications
    11. Preview
    1. Cover Picture: In Situ Synchrotron-Based IR Microspectroscopy To Study Catalytic Reactions in Zeolite Crystals (Angew. Chem. Int. Ed. 19/2008) (page 3469)

      Eli Stavitski, Marianne H. F. Kox, Ingmar Swart, Frank M. F. de Groot and Bert M. Weckhuysen

      Article first published online: 21 APR 2008 | DOI: 10.1002/anie.200890084

      Thumbnail image of graphical abstract

      Heterogeneous catalysis through infrared goggles: In their Communication on page 3543 ff., B. M. Weckhuysen and co-workers use synchrotron-based IR microspectroscopy with diffraction-limited spatial resolution to map the catalytic activity of ZSM-5 zeolite crystals in styrene oligomerization and identify the carbocationic reaction products entrapped in zeolite pores. They propose a combined three-pronged microspectroscopic approach for in-depth spatially- and time-resolved characterization of catalytic processes taking place within catalyst grains.

  2. Inside Cover

    1. Top of page
    2. Cover Picture
    3. Inside Cover
    4. Graphical Abstract
    5. News
    6. Book Review
    7. Highlights
    8. Essay
    9. Reviews
    10. Communications
    11. Preview
    1. Inside Cover: Total Synthesis of (±)-Axinellamines A and B (Angew. Chem. Int. Ed. 19/2008) (page 3470)

      Daniel P. O'Malley, Junichiro Yamaguchi, Ian S. Young, Ian B. Seiple and Phil S. Baran

      Article first published online: 21 APR 2008 | DOI: 10.1002/anie.200890085

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      Chemoselective by design is the total synthesis of marine pyrrole–imidazole alkaloids of the axinellamine/palau'amine/massadine class described by P. S. Baran and co-workers in their Communication on page 3581 ff. Their approach features unconventional transformations on completely unprotected polyamino and hydroxylated substrates and a new method for chemoselective oxidations in such settings.

  3. Graphical Abstract

    1. Top of page
    2. Cover Picture
    3. Inside Cover
    4. Graphical Abstract
    5. News
    6. Book Review
    7. Highlights
    8. Essay
    9. Reviews
    10. Communications
    11. Preview
  4. News

    1. Top of page
    2. Cover Picture
    3. Inside Cover
    4. Graphical Abstract
    5. News
    6. Book Review
    7. Highlights
    8. Essay
    9. Reviews
    10. Communications
    11. Preview
  5. Book Review

    1. Top of page
    2. Cover Picture
    3. Inside Cover
    4. Graphical Abstract
    5. News
    6. Book Review
    7. Highlights
    8. Essay
    9. Reviews
    10. Communications
    11. Preview
  6. Highlights

    1. Top of page
    2. Cover Picture
    3. Inside Cover
    4. Graphical Abstract
    5. News
    6. Book Review
    7. Highlights
    8. Essay
    9. Reviews
    10. Communications
    11. Preview
    1. Oxazaborolidines as Catalysts for Enantioselective Cycloadditions: Now [2+2]! (pages 3492–3495)

      Holger Butenschön

      Article first published online: 28 MAR 2008 | DOI: 10.1002/anie.200800574

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      More and more applicable: The adduct of an oxazaborolidine and aluminum tribromide (see picture) turns out to be an efficient catalyst not only for enantioselective Diels–Alder reactions but now also for enantioselective [2+2] cycloadditions. The products are important enantiomerically pure building blocks for the synthesis of complex organic compounds.

    2. Ionically Cross-Linked Gold Clusters and Gold Nanoparticles (pages 3496–3498)

      Günter Schmid

      Article first published online: 27 MAR 2008 | DOI: 10.1002/anie.200800506

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      Nuggets and buckyballs: Cationic small molecular gold clusters linked together by anions form ionic crystals. The cutting edge of such intercluster compounds involves combinations of Au7 and Au8 clusters and fullerides obtained by the reaction of KC60 with [Au8(PPh3)8](NO3)2 in MeCN/THF. The picture shows a simplified view of the crystal structure of [Au7(PPh3)7]C60⋅THF in the direction of [010] (C gray, Au yellow).

  7. Essay

    1. Top of page
    2. Cover Picture
    3. Inside Cover
    4. Graphical Abstract
    5. News
    6. Book Review
    7. Highlights
    8. Essay
    9. Reviews
    10. Communications
    11. Preview
    1. From Basic Science to Blockbuster Drug: The Discovery of Lyrica (pages 3500–3504)

      Richard B. Silverman

      Article first published online: 28 FEB 2008 | DOI: 10.1002/anie.200704280

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      The anticonvulsant drug (S)-(+)-3-isobutyl-γ-aminobutyric acid ((S)-(+)-3-isobutyl-GABA, Lyrica; see structure) was developed from a study of fundamental science, which took an unexpected course. The activity of Lyrica was found to be unrelated to the originally anticipated activation of L-glutamic acid decarboxylase and the increase in the inhibitory neurotransmitter GABA; instead, it antagonizes a calcium ion channel, which inhibits the release of the excitatory neurotransmitter L-glutamate. The ultimate effect, however, is the same.

  8. Reviews

    1. Top of page
    2. Cover Picture
    3. Inside Cover
    4. Graphical Abstract
    5. News
    6. Book Review
    7. Highlights
    8. Essay
    9. Reviews
    10. Communications
    11. Preview
    1. Catalytic Oxidation of Organic Substrates by Molecular Oxygen and Hydrogen Peroxide by Multistep Electron Transfer—A Biomimetic Approach (pages 3506–3523)

      Julio Piera and Jan-E. Bäckvall

      Article first published online: 28 MAR 2008 | DOI: 10.1002/anie.200700604

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      Going green: The use of environmentally friendly oxidation materials such as O2 or H2O2 is a very important goal in organic chemistry, particularly for oxidations in industrial chemistry. The use of electron-transfer mediators (ETMs) to facilitate the use of these oxidants for the oxidation of organic substrates is described.

    2. Reactions at Surfaces: From Atoms to Complexity (Nobel Lecture) (pages 3524–3535)

      Gerhard Ertl

      Article first published online: 20 MAR 2008 | DOI: 10.1002/anie.200800480

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      The spatio–temporal formation of patterns on the surface during a chemical reaction is one phenomenon that can now be understood and modeled thanks to the Nobel Prize winning research on the course of heterogeneous catalysis. The picture shows a pattern formed by a feedback mechanism during the oxidation of CO. Reactions that have been illuminated by this work include the synthesis of ammonia and the purification of waste gases.

  9. Communications

    1. Top of page
    2. Cover Picture
    3. Inside Cover
    4. Graphical Abstract
    5. News
    6. Book Review
    7. Highlights
    8. Essay
    9. Reviews
    10. Communications
    11. Preview
    1. Unravelling the Shuttling Mechanism in a Photoswitchable Multicomponent Bistable Rotaxane (pages 3536–3539)

      Paolo Raiteri, Giovanni Bussi, Clotilde S. Cucinotta, Alberto Credi, J. Fraser Stoddart and Michele Parrinello

      Article first published online: 20 MAR 2008 | DOI: 10.1002/anie.200705207

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      On the move: A computational investigation of the photo-triggered shuttling of a multicomponent bistable rotaxane in solution has shown that decomplexation of the counterions from the positively charged stations may be the efficiency-limiting step of the nanomachine. The picture shows the free-energy profile as a function of the ring position for the oxidized (ground) state (blue) and the reduced state (red) generated by photoexcitation.

    2. Coreduction Colloidal Synthesis of III–V Nanocrystals: The Case of InP (pages 3540–3542)

      Zhaoping Liu, Amar Kumbhar, Dan Xu, Jun Zhang, Zhaoyong Sun and Jiye Fang

      Article first published online: 31 MAR 2008 | DOI: 10.1002/anie.200800281

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      Finding the little InP particles: A coreduction method allows high-quality colloidal InP nanocrystals to be synthesized by using PCl3 as the phosphorus source and superhydride as the reducing agent. Etching the as-grown nanocrystals with HF leads to high-efficiency photoluminescence. The synthetic strategy can be extended to the preparation of other III–V nanocrystals with the corresponding pnicogen halides.

    3. In Situ Synchrotron-Based IR Microspectroscopy To Study Catalytic Reactions in Zeolite Crystals (pages 3543–3547)

      Eli Stavitski, Marianne H. F. Kox, Ingmar Swart, Frank M. F. de Groot and Bert M. Weckhuysen

      Article first published online: 28 MAR 2008 | DOI: 10.1002/anie.200705562

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      CSI: Carbocation species identification: The nonhomogeneous distribution of the reaction products of styrene oligomerization on large ZSM-5 crystals was mapped with in situ IR microspectroscopy. Diffraction-limited spatial resolution was achieved with synchrotron light. IR spectra for possible reaction products were calculated with DFT/B3LYP; by comparison with experimental results carbocationic reaction species formed in zeolite channels could be singled out.

    4. Dynamics in the p38α MAP Kinase–SB203580 Complex Observed by Liquid-State NMR Spectroscopy (pages 3548–3551)

      Valerie S. Honndorf, Nicolas Coudevylle, Stefan Laufer, Stefan Becker and Christian Griesinger

      Article first published online: 3 APR 2008 | DOI: 10.1002/anie.200705614

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      Added flexibility: NMR data for p38α MAP kinase in a complex with the SB203580 inhibitor show intermediate exchange of residues in the binding pocket (affected residues marked in blue and red on the structure), which indicates increased flexibility compared to that of the unbound protein. Based on residual dipolar couplings, the overall solution structure of p38α is very similar to the crystal structure. Thus, the increased mobility in solution is an effect of the inhibitor that is not reflected in the crystal structure.

    5. Highly Diastereoselective Synthesis of Orthoquinone Monoketals through λ3-Iodane-Mediated Oxidative Dearomatization of Phenols (pages 3552–3555)

      Laurent Pouységu, Stefan Chassaing, Delphine Dejugnac, Anne-Marie Lamidey, Karinne Miqueu, Jean-Marc Sotiropoulos and Stéphane Quideau

      Article first published online: 28 MAR 2008 | DOI: 10.1002/anie.200705816

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      Versatile chiral substrates for asymmetric synthesis are formed through the spiroketalization of phenols with a chiral substituted ethanol unit O-tethered to the ortho position upon treatment with PhI(OAc)2 (see example; TFE=2,2,2-trifluoroethanol). Intermediates with a six-membered iodine(III)-containing ring (the natural localized molecular orbitals associated with the I[BOND]C6 bond are shown) undergo ligand coupling to give the spiroketals.

    6. Glycodynamers: Fluorescent Dynamic Analogues of Polysaccharides (pages 3556–3559)

      Yves Ruff and Jean-Marie Lehn

      Article first published online: 26 MAR 2008 | DOI: 10.1002/anie.200703490

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      A change in the constitution: Dynamic glycopolymers based on a poly(acylhydrazone) main chain bearing lateral oligosaccharide groups have been obtained and their structure has been characterized as a bottlebrush type (see picture) by cryo-TEM and small-angle neutron scattering studies. They have remarkable fluorescence with emission wavelengths which are tunable by exchange/incorporation of components which modify the polymer constitution.

    7. Yeast Cells with an Artificial Mineral Shell: Protection and Modification of Living Cells by Biomimetic Mineralization (pages 3560–3564)

      Ben Wang, Peng Liu, Wenge Jiang, Haihua Pan, Xurong Xu and Ruikang Tang

      Article first published online: 3 APR 2008 | DOI: 10.1002/anie.200704718

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      Inspired by eggshells in nature, living yeast cells were conferred with an artificial mineral coat by using a combination of the layer-by-layer (LBL) treatment with functional polymers and in situ biomimetic mineralization. The resulting hard inorganic shells have a tremendous effect on the storage, protection, delivery, and modification of the cells.

    8. Photochromism of a 3D CdII Complex with Two Captured Ligand Isomers Generated In Situ from the Same Precursor (pages 3565–3567)

      Ming-Sheng Wang, Guo-Cong Guo, Wen-Qiang Zou, Wei-Wei Zhou, Zhang-Jing Zhang, Gang Xu and Jin-Shun Huang

      Article first published online: 4 APR 2008 | DOI: 10.1002/anie.200705545

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      Color on command: A hydrothermally synthesized 3D CdII complex with an unusual 426682 topology consisting of cadmium centers as five-connected nodes and two in situ generated isomers from the same precursor as linkers was found to exhibit reversible redox photochromic behavior.

    9. Total Synthesis and Structural Revision of Callipeltoside C (pages 3568–3572)

      Joseph Carpenter, Alan B. Northrup, deMichael Chung, John J. M. Wiener, Sung-Gon Kim and David W. C. MacMillan

      Article first published online: 1 APR 2008 | DOI: 10.1002/anie.200800086

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      Look again: Highlights of the 20-step synthesis of callipeltoside C include the proline-catalyzed direct aldol reaction, enantioselective α-oxyamination reaction, and rapid access to the carbohydrate framework using a de novo synthesis protocol. Based on this work the previously assigned absolute configuration of the pendent 2-O-methylevalose unit has been revised.

    10. Isolation, Structure Elucidation, and Biomimetic Total Synthesis of Versicolamide B, and the Isolation of Antipodal (−)-Stephacidin A and (+)-Notoamide B from Aspergillus versicolor NRRL 35600 (pages 3573–3577)

      Thomas J. Greshock, Alan W. Grubbs, Ping Jiao, Donald T. Wicklow, James B. Gloer and Robert M. Williams

      Article first published online: 3 APR 2008 | DOI: 10.1002/anie.200800106

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      Stereochemically unique: A new prenylated indole alkaloid, (+)-versicolamide B, has been isolated from cultures of Aspergillus versicolor NRRL 35600. The structure has been assigned by 2D NMR experiments, and confirmed by a biomimetic total synthesis. Versicolamide B is the first member of the paraherquamide/stephacidin family of alkaloids found to possess the anti relative stereochemistry at C19. ent-Stephacidin A and ent-notoamide B were also isolated for the first time.

    11. Synthesis of 1,9-Dideoxy-pre-axinellamine (pages 3578–3580)

      Junichiro Yamaguchi, Ian B. Seiple, Ian S. Young, Daniel P. O'Malley, Michael Maue and Phil S. Baran

      Article first published online: 20 MAR 2008 | DOI: 10.1002/anie.200705913

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      Within reach: A 19-step route to 1,9-dideoxy-pre-axinellamine has been designed and executed. This key compound represents a hypothetical precursor to an entire family of alkaloid natural products.

    12. Total Synthesis of (±)-Axinellamines A and B (pages 3581–3583)

      Daniel P. O'Malley, Junichiro Yamaguchi, Ian S. Young, Ian B. Seiple and Phil S. Baran

      Article first published online: 20 MAR 2008 | DOI: 10.1002/anie.200801138

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      Chemoselective by design: The first total synthesis of members of the axinellamine/palau'amine/massadine class of pyrrole–imidazole alkaloids features unconventional transformations on completely unprotected polyamino and hydroxylated substrates and a new method for chemoselective oxidations in such settings.

    13. Near-Infrared Dichromic Fluorescent Carbocyanine Molecules (pages 3584–3587)

      Zongren Zhang, Mikhail Y. Berezin, Jeff L. F. Kao, André d'Avignon, Mingfeng Bai and Samuel Achilefu

      Article first published online: 2 APR 2008 | DOI: 10.1002/anie.200800475

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      Bilingual fluorescent molecules: An array of asymmetric carbocyanines capable of dual fluorescence emissions in the near-infrared region is described (see image). The fluorescent molecules are robust in different pH and solvents. Additionally, each fluorescence peak possesses a distinct fluorescence lifetime. These properties are retained after conjugation of the dyes with small bioactive peptides.

    14. A General Approach to the Size- and Shape-Controlled Synthesis of Platinum Nanoparticles and Their Catalytic Reduction of Oxygen (pages 3588–3591)

      Chao Wang, Hideo Daimon, Taigo Onodera, Tetsunori Koda and Shouheng Sun

      Article first published online: 9 APR 2008 | DOI: 10.1002/anie.200800073

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      Catalytic cobblestones: Monodisperse platinum nanoparticles were prepared with controlled sizes (3–7 nm) and shapes (polyhedron, truncated cube, or cube). The cubic nanoparticles are a much more active cathode catalyst for the oxygen reduction reaction: the current density J from 7 nm cubes is four times that of the other shapes (see picture), indicating great potential for fuel cell applications.

    15. Non-Aqueous Routes to Metal Oxide Thin Films by Atomic Layer Deposition (pages 3592–3595)

      Erwan Rauwel, Guylhaine Clavel, Marc-Georg Willinger, Protima Rauwel and Nicola Pinna

      Article first published online: 31 MAR 2008 | DOI: 10.1002/anie.200705550

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      Controlled growth: A non-aqueous approach inspired from sol–gel chemistry and adapted to the formation of metal oxide thin films by means of atomic layer deposition is presented. The process is based on the reaction of a carboxylic acid with an alkoxide. Growth of metal oxides is achieved at temperatures as low as 50 °C on various supports including carbon nanotubes (see TEM picture). The as-grown films show excellent uniformity and possess good dielectric properties.

    16. Fast CisTrans Isomerization of an Azobenzene Derivative in Liquids and Liquid Crystals under a Low Electric Field (pages 3596–3599)

      Xia Tong, Maxime Pelletier, Andrzej Lasia and Yue Zhao

      Article first published online: 31 MAR 2008 | DOI: 10.1002/anie.200705699

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      A dramatically increased rate of cistrans isomerization of an azobenzene derivative dissolved in liquids (e.g. benzonitrile) and liquid crystals relative to the corresponding thermally activated process can be achieved by applying a low static electric field (see picture) without adding any supporting electrolyte. This electric-field-induced isomerization can affect the electrooptical behavior of azobenzene-doped liquid crystals.

    17. Observation of Direct Bonds between Carbon and Nitrogen in Si-B-N-C Ceramic after Pyrolysis at 1400 °C (pages 3600–3602)

      Yee Hwa Sehlleier, Aswin Verhoeven and Martin Jansen

      Article first published online: 1 APR 2008 | DOI: 10.1002/anie.200705786

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      An unlikely couple: Carbon and nitrogen usually go separate ways above 600 °C, but in a precursor-derived high-performance SiBNC ceramic pyrolyzed at 1400 °C the presence of carbon–nitrogen bonds was demonstrated by using various double-resonance solid-state NMR techniques in combination with a novel isotope labeling scheme.

    18. A Pincer-Type Anionic Platinum(0) Complex (pages 3603–3606)

      Leonid Schwartsburd, Revital Cohen, Leonid Konstantinovski and David Milstein

      Article first published online: 27 MAR 2008 | DOI: 10.1002/anie.200705927

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      Holding a Pt0anion in a pincer: Reduction of the pincer-type PtII complex 1 results in the formation of the thermally stable anionic Pt0 complex 2. This complex adopts a T-shaped structure and exhibits diverse reactivity, including efficient electron-transfer processes in which 2 is re-oxidized quantitatively to PtII. Protonation of 2 with water gives a PtII hydride complex, and C[BOND]F activation under mild conditions leads to 3 (see scheme).

    19. RhI-Catalyzed Hydration of Organonitriles under Ambient Conditions (pages 3607–3609)

      Akihiro Goto, Kohei Endo and Susumu Saito

      Article first published online: 31 MAR 2008 | DOI: 10.1002/anie.200800366

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      New scoop on scope and selectivity: The hydration of organonitriles catalyzed by a RhI(OMe) species under nearly pH-neutral and ambient conditions (25 °C, 1 atm) is chemoselective and high-yielding (93 to 99 %), has a broad substrate scope, and may thus be complementary to enzymatic hydration methods for the introduction of a terminal amido group (CONH2) onto a carbon chain.

    20. Carbon Nanotube–Polymer Composite for Light-Driven Microthermal Control (pages 3610–3613)

      Eijiro Miyako, Hideya Nagata, Ken Hirano and Takahiro Hirotsu

      Article first published online: 2 APR 2008 | DOI: 10.1002/anie.200800296

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      Rapid temperature control: A phospholipid–bovine serum albumin functionalized single-walled carbon nanotube complex (PL–BSA–SWNT) was found to be readily dispersible in poly(dimethylsiloxane) (PDMS). A photoinduced PDMS microchip encapsulating this complex is capable of achieving ultrarapid control of the temperature of a solution contained in one of its microchannels (see image).

    21. Total Synthesis of Salinamide A: A Potent Anti-Inflammatory Bicyclic Depsipeptide (pages 3614–3617)

      Li Tan and Dawei Ma

      Article first published online: 28 MAR 2008 | DOI: 10.1002/anie.200800397

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      It's swell! The first total synthesis of potent anti-inflammatory agent salinamide A was achieved. This synthesis features a concise elaboration of the phenylglycine-derived epoxide fragment and the identification of two possible macrolactamization sites (see scheme).

    22. Efficient Assembly of an Indole Alkaloid Skeleton by Cyclopropanation: Concise Total Synthesis of (±)-Minfiensine (pages 3618–3621)

      Liqun Shen, Min Zhang, Yi Wu and Yong Qin

      Article first published online: 28 MAR 2008 | DOI: 10.1002/anie.200800566

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      Cascading into (±)-minfiensine: An efficient method was developed for the assembly of tetracyclic skeleton 1 by a three-step, one-pot cascade reaction including cyclopropanation, ring opening, and ring closure (see scheme; Ts=p-toluenesulfonyl). The concise total synthesis of the (±)-minfiensine was completed in about a 4 % overall yield.

    23. Catalytic Three-Component Ugi Reaction (pages 3622–3625)

      Subhas Chandra Pan and Benjamin List

      Article first published online: 28 MAR 2008 | DOI: 10.1002/anie.200800494

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      Perfect atom economy characterizes a novel catalytic three-component Ugi reaction (see example). Different α-amino amides are formed in good yields from aldehydes, primary amines, and isocyanides in the presence of phenyl phosphinic acid as the catalyst. The products will be useful for the synthesis of α-amino acid derivatives and in diversity-oriented synthesis.

      Corrected by:

      Corrigendum: Catalytic Three-Component Ugi Reaction

      Vol. 47, Issue 30, 5490, Article first published online: 9 JUL 2008

    24. Self-Assembly of a DNA Dodecahedron from 20 Trisoligonucleotides with C3h Linkers (pages 3626–3630)

      Jan Zimmermann, Martin P. J. Cebulla, Sven Mönninghoff and Günter von Kiedrowski

      Article first published online: 28 MAR 2008 | DOI: 10.1002/anie.200702682

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      Can 20 trisoligonucleotides with 20×3 individual sequences be programmed to self-assemble into a DNA dodecahedron? The answer is yes if one starts from a new generation of trisoligonucleotides based on C3h-symmetric linkers with proper flexibility. The resulting dodecahedron has C1 symmetry and may facilitate the construction of multimodular scaffolds in the future.

    25. The Enantioselective, Brønsted Acid Catalyzed, Vinylogous Mannich Reaction (pages 3631–3634)

      Marcel Sickert and Christoph Schneider

      Article first published online: 2 APR 2008 | DOI: 10.1002/anie.200800103

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      Chiral phosphoric acid 4 catalyzes enantioselectively the highly γ-regioselective addition of a silyl dienolate 2 to imines 1 in good yields and furnishes α,β-unsaturated δ-amino carboxylic esters 3 in one step. The reaction may also be carried out as a direct three-component coupling (PMP=para-methoxyphenyl; TBS=tert-butyldimethylsilyl).

    26. Control of Planar Chirality: The Construction of a Copper-Ion-Controlled Chiral Molecular Hinge (pages 3635–3638)

      Gebhard Haberhauer

      Article first published online: 21 APR 2008 | DOI: 10.1002/anie.200800062

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      An open-and-closed case: When a chiral clamp is attached to a molecular hinge the open–close motion induced by coordination to a metal ion becomes unidirectional (see scheme). The large change in amplitude caused by the unidirectional rotation and the relatively simple preparation of the hinge open up the possibility of using this concept for even more-complex molecular machines.

    27. Intermolecular Forces in an Ionic Liquid ([Mmim][Cl]) versus Those in a Typical Salt (NaCl) (pages 3639–3641)

      Stefan Zahn, Frank Uhlig, Jens Thar, Christian Spickermann and Barbara Kirchner

      Article first published online: 31 MAR 2008 | DOI: 10.1002/anie.200705526

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      A subtle difference: In ionic liquids the “weak” dispersion forces have a significant impact on the shape of the potential energy surface, which results in a shallow profile when all of the contributions are considered. Such findings are commonly accepted to determine the liquid state.

    28. Synthesis of Protein Mimics with Nonlinear Backbone Topology by a Combined Recombinant, Enzymatic, and Chemical Synthesis Strategy (pages 3642–3645)

      Stephan Pritz, Oliver Kraetke, Annerose Klose, Jana Klose, Sven Rothemund, Klaus Fechner, Michael Bienert and Michael Beyermann

      Article first published online: 28 MAR 2008 | DOI: 10.1002/anie.200705718

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      The synthesis of a 23-kDa protein that mimics the ligand-binding extracellular part of a G-protein-coupled receptor shows the potential of a combined recombinant, enzymatic, and chemical synthesis (CRECS) strategy. The mimic of the corticotropin-releasing factor receptor, synthesized from single domains by chemical ligation and sortase A-mediated coupling, has a high affinity for natural ligands.

  10. Preview

    1. Top of page
    2. Cover Picture
    3. Inside Cover
    4. Graphical Abstract
    5. News
    6. Book Review
    7. Highlights
    8. Essay
    9. Reviews
    10. Communications
    11. Preview
    1. Preview: Angew. Chem. Int. Ed. 20/2008 (page 3649)

      Article first published online: 21 APR 2008 | DOI: 10.1002/anie.200890088

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