dsRNA-Functionalized Multifunctional γ-Fe2O3 Nanocrystals: A Tool for Targeting Cell Surface Receptors (pages 4748–4752)
Mohammed Ibrahim Shukoor, Filipe Natalio, Nadine Metz, Natalie Glube, Muhammad Nawaz Tahir, Helen Annal Therese, Vadim Ksenofontov, Patrick Theato, Peter Langguth, Jean-Paul Boissel, Heinz C. Schröder, Werner E. G. Müller and Wolfgang Tremel
Article first published online: 15 MAY 2008 | DOI: 10.1002/anie.200704735
Specific cell recognition: Magnetic γ-Fe2O3 nanoparticles (MNPs) functionalized with a fluorescently labeled polymer and polyinosinic-polycytidylic acid [poly(I:C)] allow the specific visualizion of the TLR3 receptors on the the surface of Caki-1 cells. The expression of TLR3 on the Caki-1 cells was demonstrated independently by RT-PCR and immunostaining techniques.