Silicon-Based Building Blocks for One-Step 18F-Radiolabeling of Peptides for PET Imaging (pages 4922–4925)
Linjing Mu, Aileen Höhne, P. August Schubiger, Simon M. Ametamey, Keith Graham, John E. Cyr, Ludger Dinkelborg, Timo Stellfeld, Ananth Srinivasan, Ulrike Voigtmann and Ulrich Klar
Article first published online: 21 MAY 2008 | DOI: 10.1002/anie.200705854
Radio-controlled landing of F: The facile 18F labeling of biomolecules has been achieved under mild conditions by using a unique silicon-based one-step approach (see scheme). A di-tert-butylsilyl derivative with an aryl linker was attached to a tetrapeptide. The assembly shows a hydrolytic stability that appears to be within the range required for in vivo positron emission tomography (PET) imaging applications.