Angewandte Chemie International Edition

Cover image for Angewandte Chemie International Edition

October 6, 2008

Volume 47, Issue 42

Pages 7967–8131

  1. Cover Picture

    1. Top of page
    2. Cover Picture
    3. Inside Cover
    4. Graphical Abstract
    5. News
    6. Book Review
    7. Highlights
    8. Essay
    9. Review
    10. Communications
    11. Preview
    1. Cover Picture: Single-Crystalline Molecular Flasks: Chemical Transformation with Bulky Reagents in the Pores of Porous Coordination Networks (Angew. Chem. Int. Ed. 42/2008) (page 7967)

      Takehide Kawamichi, Tomoki Kodama, Masaki Kawano and Makoto Fujita

      Article first published online: 29 SEP 2008 | DOI: 10.1002/anie.200890207

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      Porous coordination networks can act as crystalline molecular flasks. As shown in the cover picture, chemical reactions may proceed in these flasks as in solution. M. Kawano, M. Fujita et al. report in their Communication on page 8030 ff. that organic transformations with bulky reagents proceed smoothly within the pores with the reagents diffusing through the network. Unlike solution-state reactions, those within the crystalline flask can be easily analyzed by crystallography.

  2. Inside Cover

    1. Top of page
    2. Cover Picture
    3. Inside Cover
    4. Graphical Abstract
    5. News
    6. Book Review
    7. Highlights
    8. Essay
    9. Review
    10. Communications
    11. Preview
    1. Inside Cover: Unmasking Representative Structures of TMP-Active Hauser and Turbo-Hauser Bases (Angew. Chem. Int. Ed. 42/2008) (page 7968)

      Pablo García-Álvarez, David V. Graham, Eva Hevia, Alan R. Kennedy, Jan Klett, Robert E. Mulvey, Charles T. O'Hara and Susan Weatherstone

      Article first published online: 29 SEP 2008 | DOI: 10.1002/anie.200890208

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      The molecular engines that drive enhanced magnesium–hydrogen exchange reactions are revealed by R. E. Mulvey and co-workers in their Communication on page 8079 ff. with the structure elucidation of a 2,2,6,6-tetramethylpiperidide Hauser base and its recently reported updated turbo model. These bases have become key reagents for the regioselective functionalization of a wide variety of aryl, heteroaryl, and metallocenyl compounds.

  3. Graphical Abstract

    1. Top of page
    2. Cover Picture
    3. Inside Cover
    4. Graphical Abstract
    5. News
    6. Book Review
    7. Highlights
    8. Essay
    9. Review
    10. Communications
    11. Preview
  4. News

    1. Top of page
    2. Cover Picture
    3. Inside Cover
    4. Graphical Abstract
    5. News
    6. Book Review
    7. Highlights
    8. Essay
    9. Review
    10. Communications
    11. Preview
  5. Book Review

    1. Top of page
    2. Cover Picture
    3. Inside Cover
    4. Graphical Abstract
    5. News
    6. Book Review
    7. Highlights
    8. Essay
    9. Review
    10. Communications
    11. Preview
  6. Highlights

    1. Top of page
    2. Cover Picture
    3. Inside Cover
    4. Graphical Abstract
    5. News
    6. Book Review
    7. Highlights
    8. Essay
    9. Review
    10. Communications
    11. Preview
    1. Mass Spectrometry

      The Wave Property of Heavy Molecules—Its Use in Mass Spectrometry (pages 7990–7991)

      Karl-Otto Greulich

      Article first published online: 11 SEP 2008 | DOI: 10.1002/anie.200803290

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      The perfect wave: The wave properties of large molecules have been used for mass spectrometry. A perfluoroalkylated palladium complex has been investigated by this method and its mass and polarizability determined from the visibility of the molecules interferogram. This method allows the differentiation of molecule fragments in the source from those generated in the detector. Applications based on matter waves are now conceivable.

    2. Quantum Computing

      Quantum Information Processing Using Molecular Nanomagnets As Qubits (pages 7992–7994)

      Richard E. P. Winpenny

      Article first published online: 9 SEP 2008 | DOI: 10.1002/anie.200802742

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      Quantum leap: Recent observations using pulsed EPR spectroscopy suggest that it is possible magnetic molecules such as the {V15} polyoxometalate cage (see picture; V red, As blue, O white) could be used in quantum information processing (QIP). Controlled interactions of cage complexes with an S=1/2 ground state, acting as qubits, could allow QIP.

  7. Essay

    1. Top of page
    2. Cover Picture
    3. Inside Cover
    4. Graphical Abstract
    5. News
    6. Book Review
    7. Highlights
    8. Essay
    9. Review
    10. Communications
    11. Preview
    1. Chemical Geometry

      A Short History of an Elusive Yet Ubiquitous Structure in Chemistry, Materials, and Mathematics (pages 7996–8000)

      Stephen T. Hyde, Michael O'Keeffe and Davide M. Proserpio

      Article first published online: 2 SEP 2008 | DOI: 10.1002/anie.200801519

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      Beauty in the sciences: The extraordinary history of a three-periodic net and its associated surface, the gyroid, is recounted (see picture). These structures appear in diverse contexts in mathematics, as the topology for crystal structures in materials, which is the basis for liquid crystal phases and derived mesoporous materials, and in insect pigments.

  8. Review

    1. Top of page
    2. Cover Picture
    3. Inside Cover
    4. Graphical Abstract
    5. News
    6. Book Review
    7. Highlights
    8. Essay
    9. Review
    10. Communications
    11. Preview
    1. Gel Materials

      High-Tech Applications of Self-Assembling Supramolecular Nanostructured Gel-Phase Materials: From Regenerative Medicine to Electronic Devices (pages 8002–8018)

      Andrew R. Hirst, Beatriu Escuder, Juan F. Miravet and David K. Smith

      Article first published online: 29 SEP 2008 | DOI: 10.1002/anie.200800022

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      Starting to gel: Recent developments in self-assembling low-molecular-weight gelators has led to rationally designed materials with increasingly advanced and specialized applications. Recent demonstrations of molecular gels in diverse technological fields are reviewed, including tissue engineering, regenerative medicine, and nanoelectronics.

  9. Communications

    1. Top of page
    2. Cover Picture
    3. Inside Cover
    4. Graphical Abstract
    5. News
    6. Book Review
    7. Highlights
    8. Essay
    9. Review
    10. Communications
    11. Preview
    1. Plasma Chemistry

      Nanoscale Corona Discharge in Liquids, Enabling Nanosecond Optical Emission Spectroscopy (pages 8020–8024)

      David Staack, Alexander Fridman, Alexander Gutsol, Yury Gogotsi and Gary Friedman

      Article first published online: 29 AUG 2008 | DOI: 10.1002/anie.200802891

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      My corona! A nonthermal corona discharge inside a liquid medium around electrodes with ultrasharp tips or elongated nanoparticles allows simultaneous chemical analysis of multiple dissolved elements within nanoseconds. The proposed optical emission spectroscopy method can be applied for ultrafast time-resolved multielemental analysis of femtoliter volumes of liquid with a one-micrometer spatial resolution.

    2. Fluorescent Probes

      A Ratiometric Fluorescent Probe Based on FRET for Imaging Hg2+ Ions in Living Cells (pages 8025–8029)

      Xiaolin Zhang, Yi Xiao and Xuhong Qian

      Article first published online: 15 SEP 2008 | DOI: 10.1002/anie.200803246

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      Mercury rising: A FRET-based ratiometric probe (see picture; FRET=fluorescence resonance energy transfer) can selectively detect Hg2+ ions on the parts-per-billion scale under physiological conditions. The probe undergoes a clear Hg2+-induced change in the intensity ratio of the two well-separated and equally intense emission bands of dipyrrometheneboron difluoride and rhodamine. Experiments show that the probe can be used in living cells.

    3. Molecular Flasks

      Single-Crystalline Molecular Flasks: Chemical Transformation with Bulky Reagents in the Pores of Porous Coordination Networks (pages 8030–8032)

      Takehide Kawamichi, Tomoki Kodama, Masaki Kawano and Makoto Fujita

      Article first published online: 11 AUG 2008 | DOI: 10.1002/anie.200802545

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      In a crystal, yet as in solution: Bulky reagents are sufficiently mobile in the pores of a porous network complex to react with imbedded substrates in a single-crystal-to-single-crystal fashion. Acylation and ureidation of amines and Schiff-base formation from aldehydes occur efficiently. The pore of the complex thus serves as a crystalline molecular flask, where reaction products are simply determined by X-ray crystallographic analysis.

    4. Hydrogen Bonds

      Finite Size Effects on Hydrogen Bonds in Confined Water (pages 8033–8035)

      Raluca Musat, Jean Philippe Renault, Marco Candelaresi, D. Jason Palmer, Sophie Le Caër, Roberto Righini and Stanislas Pommeret

      Article first published online: 12 SEP 2008 | DOI: 10.1002/anie.200802630

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      Femtosecond IR spectroscopy was used to study water confined in 1–50 nm pores. The results show that even large pores induce significant changes (for example excited-state lifetimes, see diagram) to the hydrogen-bond network, which are independent of pore diameter between 1 and 50 nm. Thus, the changes are not surface-induced but rather finite size effects, and suggest a confinement-induced enhancement of the acidic character of water.

    5. Rotaxanes

      An Ion-Pair Template for Rotaxane Formation and its Exploitation in an Orthogonal Interaction Anion-Switchable Molecular Shuttle (pages 8036–8039)

      Michael J. Barrell, David A. Leigh, Paul J. Lusby and Alexandra M. Z. Slawin

      Article first published online: 15 SEP 2008 | DOI: 10.1002/anie.200802745

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      Chloride control: The serendipitous discovery of a molecular recognition motif that is triggered by the formation of an anion-palladium coordination bond is exploited as an efficient rotaxane-forming template and as the basis of a molecular shuttle. The macrocycle of this rotaxane moves between the two stations when the counterion is changed from chloride to hexafluorophosphate (see picture).

    6. Dinitrogen Cleavage

      Energetics and Mechanism of Dinitrogen Cleavage at a Mononuclear Surface Tantalum Center: A New Way of Dinitrogen Reduction (pages 8040–8043)

      Jun Li and Shuhua Li

      Article first published online: 16 SEP 2008 | DOI: 10.1002/anie.200801668

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      A rare side-on mode of N2coordination to the TaIII center of [([TRIPLE BOND]SiO)2TaH], which was found to be the active species for N2 reduction at a mononuclear surface Ta center, is critical for the subsequent hydride-transfer steps in the cleavage of N2 according to B3LYP calculations. The rate-determining steps are the first (potential energy surface shown in the scheme) and third hydride transfers from the metal to the N2 ligand.

    7. Frustrated Phases

      Frustrated Phases of Block Copolymers in Nanoparticles (pages 8044–8046)

      Takeshi Higuchi, Atsunori Tajima, Kiwamu Motoyoshi, Hiroshi Yabu and Masatsugu Shimomura

      Article first published online: 12 SEP 2008 | DOI: 10.1002/anie.200803003

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      3D confinement effect: Block copolymers form novel phase separation structures in the nanoparticles owing to frustration of the nanosized confinement effect. Whereas films of the block copolymers form lamellar structures, the nanoparticles formed unique structures (Janus-type, tennis-ball-, mushroom-, wheel-, and screwlike structures) depending on the ratio between particle diameter and molecular weight.

    8. Cellulose Conversion

      Depolymerization of Cellulose Using Solid Catalysts in Ionic Liquids (pages 8047–8050)

      Roberto Rinaldi, Regina Palkovits and Ferdi Schüth

      Article first published online: 22 SEP 2008 | DOI: 10.1002/anie.200802879

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      Wood you believe it! Solid acids act as powerful catalysts for the hydrolysis of cellulose dissolved in an ionic liquid. Cellulose undergoes selective depolymerization, yielding cellulose oligomers (cellooligomers) without any substantial formation of side products. Even wood, a lignocellulosic material, is hydrolyzed using this methodology.

    9. Synthetic Methods

      Catalytic Enantioselective Michael Addition of 1-Fluorobis(phenylsulfonyl)methane to α,β-Unsaturated Ketones Catalyzed by Cinchona Alkaloids (pages 8051–8054)

      Tatsuya Furukawa, Norio Shibata, Satoshi Mizuta, Shuichi Nakamura, Takeshi Toru and Motoo Shiro

      Article first published online: 22 SEP 2008 | DOI: 10.1002/anie.200802904

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      A catalyst worth its salt: The ammonium salts of cinchona alkaloids possessing sterically demanding substituents effectively catalyzed the enantioselective 1,4-conjugate addition of 1-fluorobis(phenylsulfonyl)methane to α,β-unsaturated ketones to furnish the Michael adducts in high yield with excellent enantioselectivity (see scheme). The adducts are useful for the synthesis of chiral monofluoromethylated molecules.

    10. Natural Product Synthesis

      Harnessing Glycal-Epoxide Rearrangements: The Generation of the AB, EF, and IJ Rings of Adriatoxin (pages 8055–8058)

      Clement Osei Akoto and Jon D. Rainier

      Article first published online: 10 SEP 2008 | DOI: 10.1002/anie.200803791

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      Climbing the ladder: The generation of three bicyclic subunits of adriatoxin (see structure) was accomplished by using glycal-epoxide rearrangements, glycal-Claisen rearrangements, and C-glycoside-forming reactions.

    11. Homogeneous Catalysis

      A General Palladium-Catalyzed Suzuki–Miyaura Coupling of Aryl Mesylates (pages 8059–8063)

      Chau Ming So, Chak Po Lau and Fuk Yee Kwong

      Article first published online: 11 SEP 2008 | DOI: 10.1002/anie.200803193

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      Catalyze this! The first palladium-catalyzed Suzuki–Miyaura coupling of unactivated aryl mesylates is reported, with not only arylboronic acids, but also other organoboron nucleophiles (see picture; Z=B(OH)2, BF3K, BPin). The reaction conditions are compatible with various common functional groups (R1=alkyl, OMe, CHO, CO, CN, CO2R′, heteroaryl).

    12. Low Coordinate Phosphorus

      Chiral Ligand Design: A Bidentate Ligand Incorporating an Acyclic Phosphaalkene (pages 8064–8067)

      Julien Dugal-Tessier, Gregory R. Dake and Derek P. Gates

      Article first published online: 15 SEP 2008 | DOI: 10.1002/anie.200802949

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      Simply made and stable: An asymmetric phosphaalkene has been synthesized from L-valine, a readily available chiral precursor. This air-stable ligand forms a P(sp2),N(sp2) complex to iridium(I) (see scheme) and is the first example of a new class of chiral phosphorus-based ligands which are expected to possess excellent π-acceptor properties.

    13. Iron Oxo Complexes

      An Inverted and More Oxidizing Isomer of [FeIV(O)(tmc)(NCCH3)]2+ (pages 8068–8071)

      Kallol Ray, Jason England, Adam T. Fiedler, Marlène Martinho, Eckard Münck and Lawrence Que Jr.

      Article first published online: 16 SEP 2008 | DOI: 10.1002/anie.200802219

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      Oxoferryl gymnastics: The oxo and CH3CN ligands in 1-NCCH3 can swap positions in the presence of iodosobenzene and tetrafluoroborate anion leading to the generation of a more reactive isomer 2. This conversion is proposed to take place via an activated FeIV unit (1 a) or a transient dioxoiron(VI) species (1 b).

    14. Tuneable Degradation

      Substituted 1,3,5-Triazaadamantanes: Biocompatible and Degradable Building Blocks (pages 8072–8074)

      Amy M. Balija, Richie E. Kohman and Steven C. Zimmerman

      Article first published online: 18 SEP 2008 | DOI: 10.1002/anie.200802222

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      Basic groups from acid hydrolysis: 1,3,5-Triazaadamantanes (TAAs) are shown to degrade in acidic conditions to produce basic byproducts (see scheme). The rate of hydrolysis can be tuned by changing the substituents present on the aromatic rings. TAA-containing dendrimers can be synthesized readily as a result of the branched architecture of the TAA building blocks.

    15. Amyloids

      A Fiberlike Peptide Material Stabilized by Single Intermolecular Hydrogen Bonds (pages 8075–8078)

      Gaetano Angelici, Giuseppe Falini, Hans-Jörg Hofmann, Daniel Huster, Magda Monari and Claudia Tomasini

      Article first published online: 15 SEP 2008 | DOI: 10.1002/anie.200802587

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      One is enough: The dipeptide Boc-L-Phe-D-Oxd-OBn (Boc=tert-butoxycarbonyl, Phe=phenylalanine, Oxd=4-methyl-5-carboxy oxazolidin-2-one, Bn=benzyl; see picture; gray C, white H, red O, blue N) spontaneously forms uniform fibers consisting of parallel infinite linear chains arising from single intermolecular N[BOND]H⋅⋅⋅O[DOUBLE BOND]C hydrogen bonds. This is the absolute borderline case of a parallel β-sheet structure.

    16. Hauser Bases

      You have full text access to this OnlineOpen article
      Unmasking Representative Structures of TMP-Active Hauser and Turbo-Hauser Bases (pages 8079–8081)

      Pablo García-Álvarez, David V. Graham, Eva Hevia, Alan R. Kennedy, Jan Klett, Robert E. Mulvey, Charles T. O'Hara and Susan Weatherstone

      Article first published online: 1 AUG 2008 | DOI: 10.1002/anie.200802618

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      The molecular engines that drive enhanced magnesiations are unveiled through structural elucidation of a 2,2,6,6-tetramethylpiperidide (TMP) Hauser base and its turbo model (see structure; Mg green, Li violet, C purple, O red, N blue, Cl yellow).

    17. Asymmetric Synthesis

      Carbohydrate-Templated Asymmetric Diels–Alder Reactions of Masked ortho-Benzoquinones for the Synthesis of Chiral Bicyclo[2.2.2]oct-5-en-2-ones (pages 8082–8085)

      Shun-Yuan Luo, Yeong-Jiunn Jang, Jing-Yuan Liu, Chrong-Shyua Chu, Chun-Chen Liao and Shang-Cheng Hung

      Article first published online: 16 SEP 2008 | DOI: 10.1002/anie.200802693

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      A sweet addition: Asymmetric [4+2] cycloaddition of masked ortho-benzoquinones with various alkenols by using sugars as chiral auxiliaries (see scheme; Bn: benzyl) affords the optically pure bicyclo[2.2.2]oct-5-en-2-ones with excellent diastereoselectivity and in good yields.

    18. Natural Product Synthesis

      (+)-Zwittermicin A: Assignment of its Complete Configuration by Total Synthesis of the Enantiomer and Implication of D-Serine in its Biosynthesis (pages 8086–8089)

      Evan W. Rogers, Doralyn S. Dalisay and Tadeusz F. Molinski

      Article first published online: 16 SEP 2008 | DOI: 10.1002/anie.200801561

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      D-Serine is the prime suspect: The total synthesis of (−)-zwittermicin A has been achieved from a suitably protected C2-symmetric diamino tetraol unit and has allowed the complete stereochemical assignment of natural (+)-zwittermicin A. The unexpected 14R configuration implies the involvement of a “D-serine” motif in the biosynthesis of (+)-zwittermicin A (see scheme).

    19. Marine Metabolites

      Marine Metabolites and Metal Ion Chelation: Intact Recovery and Identification of an Iron(II) Complex in the Extract of the Ascidian Eudistoma gilboviride (pages 8090–8092)

      Stephen H. Wright, Andrea Raab, Jioji N. Tabudravu, Jörg Feldmann, Paul F. Long, Christopher N. Battershill, Walter C. Dunlap, Bruce F. Milne and Marcel Jaspars

      Article first published online: 15 SEP 2008 | DOI: 10.1002/anie.200802060

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      Sequestering sea squirts: Liquid chromatography with parallel inductively coupled plasma mass spectrometry/electrospray mass spectrometry was used to discover and identify novel lipophilic metal complexes in the solvent extract of the ascidian Eudistoma gilboviride. Using these tools it is now possible to examine whether such complexes play an integral part in an organism's physiology.

    20. Nanoclusters

      Aerobic Oxidation of Hydroquinone Derivatives Catalyzed by Polymer-Incarcerated Platinum Catalyst (pages 8093–8095)

      Hiroyuki Miyamura, Mika Shiramizu, Ryosuke Matsubara and Shū Kobayashi

      Article first published online: 18 SEP 2008 | DOI: 10.1002/anie.200802192

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      It's a lock-in! A remarkably wide substrate scope of hydroquinones are oxidized to quinones in high yields in a platinum-catalyzed process with as low as 0.05 mol % catalyst. The aerobic oxidation is catalyzed by platinum nanoclusters trapped in a styrene-based polymer network (see scheme, PI Pt=polymer-incarcerated nanoclusters). The catalyst could be reused at least 13 times without any loss of catalytic activity.

    21. Cross-Coupling

      Palladium-Catalyzed Annulation of vic-Bis(pinacolatoboryl)alkenes and -phenanthrenes with 2,2′-Dibromobiaryls: Facile Synthesis of Functionalized Phenanthrenes and Dibenzo[g,p]chrysenes (pages 8096–8099)

      Masaki Shimizu, Ikuhiro Nagao, Yosuke Tomioka and Tamejiro Hiyama

      Article first published online: 15 SEP 2008 | DOI: 10.1002/anie.200803213

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      Double-cross: An annulation approach to functionalized polycyclic aromatic hydrocarbons involving a palladium-catalyzed double cross-coupling reaction of vic-diborylalkenes and -phenanthrenes with 2,2′-dibromobiaryls led to a variety of phenanthrenes and dibenzo[g,p]chrysenes, as well as [5]helicenes, dithienobenzenes, and triphenyleno[1,2-b:4,3-b′]dithiophenes (see scheme; Bpin=pinacolatoboryl).

    22. Electrocyclization Reaction

      Catalysis of 6π Electrocyclizations (pages 8100–8103)

      Lee M. Bishop, Jennifer E. Barbarow, Robert G. Bergman and Dirk Trauner

      Article first published online: 10 SEP 2008 | DOI: 10.1002/anie.200803336

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      Filling the gap: Lewis acid catalysis of a 6π electrocyclization has been achieved for the first time (see scheme). DFT calculations were performed on the coordination of a Lewis acid to a Lewis basic group in the 2-position of a triene, and experimentally, the rates of the electrocyclization increase in the presence of Me2AlCl.

    23. Electrophosphorescence

      A Simple Carbazole/Oxadiazole Hybrid Molecule: An Excellent Bipolar Host for Green and Red Phosphorescent OLEDs (pages 8104–8107)

      Youtian Tao, Qiang Wang, Chuluo Yang, Qi Wang, Zhiqiang Zhang, Taotao Zou, Jingui Qin and Dongge Ma

      Article first published online: 16 SEP 2008 | DOI: 10.1002/anie.200803396

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      An enhanced performance: Electroluminescent devices incorporating a simple carbazole/oxadiazole hybrid as a host for dopants show maximum external quantum efficiencies (ηEQE) as high as 20.2 % for green and 18.5 % for deep red electrophosphorescence (see picture, J=current density). The host can be conveniently prepared and has good thermal and morphological stabilities and a high triplet energy level.

    24. Asymmetric Catalysis

      Asymmetric Palladium-Catalyzed Intramolecular α-Arylation of Aldehydes (pages 8108–8111)

      Jorge García-Fortanet and Stephen L. Buchwald

      Article first published online: 15 SEP 2008 | DOI: 10.1002/anie.200803809

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      Phoxy ligand: The first catalytic method for the asymmetric palladium-catalyzed intramolecular α-arylation of α-branched aldehydes was developed (see scheme). This process is distinguished by the high yields and enantioselectivities that can be obtained, making this protocol a useful synthetic tool for further applications.

    25. Asymmetric Epoxidation

      Catalytic Asymmetric Hydroperoxidation of α,β-Unsaturated Ketones: An Approach to Enantiopure Peroxyhemiketals, Epoxides, and Aldols (pages 8112–8115)

      Corinna M. Reisinger, Xingwang Wang and Benjamin List

      Article first published online: 22 SEP 2008 | DOI: 10.1002/anie.200803238

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      Efficient, selective: The primary amine salt 1 derived from quinine efficiently catalyzes the highly enantioselective hydroperoxidation of α,β-unsaturated ketones furnishing stable and isolable cyclic peroxyhemiketals in enantiopure form. The versatility of the peroxyhemiketals was demonstrated with the syntheses of aldols and epoxides from α,β-unsaturated ketones and hydrogen peroxide (see scheme).

    26. Triazinyl Phosphorus Compounds

      The Influence of Electron-Withdrawing Groups on the Chemistry of Phosphorus: Tautomerization of Bis(s-triazinyl)phosphanes (pages 8116–8119)

      Berthold Hoge and Waldemar Wiebe

      Article first published online: 16 SEP 2008 | DOI: 10.1002/anie.200802943

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      A one-sided deal: The bis(s-triazin-2-yl)phosphane derivative 1 exhibits a solvent- and temperature-dependent equilibrium with its zwitterionic tautomer 2. The significantly different P[BOND]C bond lengths in the methoxy derivative 4 (174.5/ 179.4 pm; red O, blue N, green P) can be described by the formulation of a mesomeric phosphaalkene derivative 3. R=OCH3, iPr.

    27. Synthetic Methods

      Fluorinating Cleavage of Solid Phase Linkers for Combinatorial Synthesis (pages 8120–8122)

      Matthias S. Wiehn, Stephen D. Lindell and Stefan Bräse

      Article first published online: 15 SEP 2008 | DOI: 10.1002/anie.200802126

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      Multitasking: A new preparative route to fluorine-containing compounds combines the advantages of solid-phase synthesis with the incorporation of fluorine at the end of the synthetic route. A sulfur linker enables simultaneous fluorination of the target structures in the cleavage step. As it is stable under different reaction conditions, the linker has potential in the combinatorial synthesis of fluorinated drug structures.

    28. Template Synthesis

      PO43−-Mediated Polyoxometalate Supercluster Assembly (pages 8123–8126)

      Xikui Fang and Paul Kögerler

      Article first published online: 18 SEP 2008 | DOI: 10.1002/anie.200802491

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      Small anion, big task: The assembly of a ten-component, heterochiral polyoxometalate aggregate, driven by the templating effect of a single phosphate anion, proceeds through a coordination-number-controlled formation route from three dimeric Dawson anion based magnetic building blocks.

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    2. Cover Picture
    3. Inside Cover
    4. Graphical Abstract
    5. News
    6. Book Review
    7. Highlights
    8. Essay
    9. Review
    10. Communications
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      Preview: Angew. Chem. Int. Ed. 43/2008 (page 8131)

      Article first published online: 29 SEP 2008 | DOI: 10.1002/anie.200890211

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