Angewandte Chemie International Edition

Cover image for Vol. 48 Issue 19

April 27, 2009

Volume 48, Issue 19

Pages 3371–3539

  1. Cover Picture

    1. Top of page
    2. Cover Picture
    3. Inside Cover
    4. Graphical Abstract
    5. Corrigendum
    6. News
    7. Author Profile
    8. Book Reviews
    9. Highlights
    10. Essay
    11. Review
    12. Communications
    13. Preview
    1. Cover Picture: Total Synthesis and Absolute Configuration of the Bisanthraquinone Antibiotic BE-43472B (Angew. Chem. Int. Ed. 19/2009) (page 3371)

      K. C. Nicolaou, Yee Hwee Lim and Jochen Becker

      Article first published online: 23 APR 2009 | DOI: 10.1002/anie.200990095

      Thumbnail image of graphical abstract

      A cascade sequence featuring a Diels–Alder reaction, a lactolization, and an SN(Ar)-type substitution forms the core of the bisanthraquinone antibiotic BE-43472B in its first total synthesis, which K. C. Nicolaou et al. describe in their Communication on page 3444 ff. The background of the cover picture is a photograph of Ecteinascidia turbinata (courtesy of John Easley Photography), the marine source of the streptomyces strain producing this antibiotic.

  2. Inside Cover

    1. Top of page
    2. Cover Picture
    3. Inside Cover
    4. Graphical Abstract
    5. Corrigendum
    6. News
    7. Author Profile
    8. Book Reviews
    9. Highlights
    10. Essay
    11. Review
    12. Communications
    13. Preview
    1. Inside Cover: hallium(I) as a Coordination Site Protection Agent: Preparation of an Isolable Zero-Valent Nickel Tris-Isocyanide (Angew. Chem. Int. Ed. 19/2009) (page 3372)

      Brian J. Fox, Matthew D. Millard, Antonio G. DiPasquale, Arnold L. Rheingold and Joshua S. Figueroa

      Article first published online: 23 APR 2009 | DOI: 10.1002/anie.200990096

      Thumbnail image of graphical abstract

      Binding of thallium(I) by low-valent nickel establishes the use of main-group ions as coordination site protection agents for transition-metal centers. As described by J. S. Figueroa and co-workers in their Communication on page 3473 ff., Tl(I) coordination provides a route to the preparation of a coordinatively unsaturated nickel tris-isocyanide complex. Thallium functions as a protecting group towards Lewis bases and is readily removed upon addition of halide ions.

  3. Graphical Abstract

    1. Top of page
    2. Cover Picture
    3. Inside Cover
    4. Graphical Abstract
    5. Corrigendum
    6. News
    7. Author Profile
    8. Book Reviews
    9. Highlights
    10. Essay
    11. Review
    12. Communications
    13. Preview
    1. Graphical Abstract: Angew. Chem. Int. Ed. 19/2009 (pages 3375–3384)

      Article first published online: 23 APR 2009 | DOI: 10.1002/anie.200990097

  4. Corrigendum

    1. Top of page
    2. Cover Picture
    3. Inside Cover
    4. Graphical Abstract
    5. Corrigendum
    6. News
    7. Author Profile
    8. Book Reviews
    9. Highlights
    10. Essay
    11. Review
    12. Communications
    13. Preview
    1. You have free access to this content
      A Stable Tetraalkyl Complex of Nickel(IV) (page 3384)

      Matthew Carnes, Daniela Buccella, Judy Y.-C. Chen, Arthur P. Ramirez, Nicholas J. Turro, Colin Nuckolls and Michael Steigerwald

      Article first published online: 23 APR 2009 | DOI: 10.1002/anie.200990098

      This article corrects:

      A Stable Tetraalkyl Complex of Nickel(IV)

      Vol. 48, Issue 2, 290–294, Article first published online: 19 NOV 2008

  5. News

    1. Top of page
    2. Cover Picture
    3. Inside Cover
    4. Graphical Abstract
    5. Corrigendum
    6. News
    7. Author Profile
    8. Book Reviews
    9. Highlights
    10. Essay
    11. Review
    12. Communications
    13. Preview
  6. Author Profile

    1. Top of page
    2. Cover Picture
    3. Inside Cover
    4. Graphical Abstract
    5. Corrigendum
    6. News
    7. Author Profile
    8. Book Reviews
    9. Highlights
    10. Essay
    11. Review
    12. Communications
    13. Preview
    1. P. Melchiorre (page 3389)

      Article first published online: 23 APR 2009 | DOI: 10.1002/anie.200900763

      Thumbnail image of graphical abstract

      „My most exciting discovery to date has been always the last one (or better still, the next one). The biggest challenge facing scientists is the responsible use of knowledge and scientific power for the betterment of humanity. …“ This and more about P. Melchiorre can be found on page 3389.

  7. Book Reviews

    1. Top of page
    2. Cover Picture
    3. Inside Cover
    4. Graphical Abstract
    5. Corrigendum
    6. News
    7. Author Profile
    8. Book Reviews
    9. Highlights
    10. Essay
    11. Review
    12. Communications
    13. Preview
    1. Handbook Of Heterogeneous Catalysis. 2., completely revised and enlarged Edition. Vol. 1–8. Edited by G. Ertl, H. Knözinger, F. Schüth, and J. Weitkamp. (pages 3390–3391)

      John Meurig Thomas

      Article first published online: 23 APR 2009 | DOI: 10.1002/anie.200901598

      Thumbnail image of graphical abstract

      Wiley-VCH, Weinheim 2008. 3966 pp., hardcover € 1999.00.—ISBN 978-3527312412

    2. The Periodic Table.Its Story and Its Significance. By Eric R. Scerri. (pages 3391–3392)

      W. H. Eugen Schwarz

      Article first published online: 23 APR 2009 | DOI: 10.1002/anie.200785599

      Thumbnail image of graphical abstract

      Oxford University Press, Oxford 2006. 346 pp., hardcover € 29.00.—ISBN 978-0-19-530573-6

  8. Highlights

    1. Top of page
    2. Cover Picture
    3. Inside Cover
    4. Graphical Abstract
    5. Corrigendum
    6. News
    7. Author Profile
    8. Book Reviews
    9. Highlights
    10. Essay
    11. Review
    12. Communications
    13. Preview
    1. Supramolecular Chemistry

      Molecular Recognition in Self-Assembled Integrated Circuits: Getting Smaller while under Control (pages 3394–3396)

      Yong-beom Lim and Myongsoo Lee

      Article first published online: 12 MAR 2009 | DOI: 10.1002/anie.200805687

      Thumbnail image of graphical abstract

      Available in small print: Block copolymer lithography has great potential for reducing the size and fabrication time of integrated circuits. Hydrogen-bonding-mediated molecular recognition in self-assembly processes can be used to produce highly ordered square arrays of block copolymers on the surface of a silicon substrate (see picture).

    2. Natural Antibiotics

      Lost in Transcription—Inhibition of RNA Polymerase (pages 3397–3400)

      Dieter Haebich and Franz von Nussbaum

      Article first published online: 17 MAR 2009 | DOI: 10.1002/anie.200900338

      Thumbnail image of graphical abstract

      Form and function: The natural product myxopyronin A provides the key to understanding the inhibition of bacterial RNA polymerase and should spark new ideas for the design of new antibiotics against tuberculosis and other infectious diseases.

    3. NMR Spectroscopy

      Spin-Polarized Structures and Solid-State NMR Spectroscopy of Paramagnetic Compounds (pages 3401–3403)

      Jörn Schmedt auf der Günne

      Article first published online: 23 MAR 2009 | DOI: 10.1002/anie.200900360

      Thumbnail image of graphical abstract

      On an atomic scale and with high sensitivity, solid-state NMR spectroscopy can provide information about the electronic spin density and coupling mechanisms in paramagnetic compounds. The picture shows how the hyperfine splitting collapses through relaxation. Insights into which compounds are suitable and which approximations have to be made are given.

  9. Essay

    1. Top of page
    2. Cover Picture
    3. Inside Cover
    4. Graphical Abstract
    5. Corrigendum
    6. News
    7. Author Profile
    8. Book Reviews
    9. Highlights
    10. Essay
    11. Review
    12. Communications
    13. Preview
    1. Periodic System

      Icon of Chemistry: The Periodic System of Chemical Elements in the New Century (pages 3404–3415)

      Shu-Guang Wang and W. H. Eugen Schwarz

      Article first published online: 10 FEB 2009 | DOI: 10.1002/anie.200800827

      Thumbnail image of graphical abstract

      A closer look: A deeper theoretical understanding of the multifaceted periodic system of elements (PSE) has been achieved in recent years. The large energy gaps above the noble gas shells 1s2 and np6 (n=2–6) impress periodicity onto the whole PSE, which is complete with Period 7. The electron configurations of unbound atoms are chemically misleading. The common n+l rule is an example of the “invention of facts” even in the hard sciences.

  10. Review

    1. Top of page
    2. Cover Picture
    3. Inside Cover
    4. Graphical Abstract
    5. Corrigendum
    6. News
    7. Author Profile
    8. Book Reviews
    9. Highlights
    10. Essay
    11. Review
    12. Communications
    13. Preview
    1. Molecular Flasks

      Functional Molecular Flasks: New Properties and Reactions within Discrete, Self-Assembled Hosts (pages 3418–3438)

      Michito Yoshizawa, Jeremy K. Klosterman and Makoto Fujita

      Article first published online: 23 APR 2009 | DOI: 10.1002/anie.200805340

      Thumbnail image of graphical abstract

      Insider dealing: Self-assembled hosts applied as “molecular flasks” can alter and control the reactivity and properties of molecules encapsulated within their well-defined, confined spaces. A variety of functional hosts of differing sizes, shapes, and utility have been prepared by using the facile and modular concepts of self-assembly.

  11. Communications

    1. Top of page
    2. Cover Picture
    3. Inside Cover
    4. Graphical Abstract
    5. Corrigendum
    6. News
    7. Author Profile
    8. Book Reviews
    9. Highlights
    10. Essay
    11. Review
    12. Communications
    13. Preview
    1. Natural Product Synthesis

      Total Synthesis of Hopeahainol A and Hopeanol (pages 3440–3443)

      K. C. Nicolaou, T. Robert Wu, Qiang Kang and David Y.-K. Chen

      Article first published online: 11 MAR 2009 | DOI: 10.1002/anie.200900438

      Thumbnail image of graphical abstract

      Similar, but different: Possessing almost the same but not identical structures, the recently discovered natural products hopeahainol A (1) and hopeanol (2) exhibit important but differing biological properties (see structures). Their first total synthesis has now been achieved through a series of novel cascade reactions and skeletal rearrangements.

    2. Total Synthesis and Absolute Configuration of the Bisanthraquinone Antibiotic BE-43472B (pages 3444–3448)

      K. C. Nicolaou, Yee Hwee Lim and Jochen Becker

      Article first published online: 23 FEB 2009 | DOI: 10.1002/anie.200900058

      Thumbnail image of graphical abstract

      An-T-biotic: The first total synthesis of the T-shaped bisanthraquinone natural product BE-43472B was accomplished and its absolute configuration assigned. Key transformations in the pivotal cascade sequence include a Diels–Alder reaction, a hemiketal formation, and a nucleophilic aromatic ipso substitution.

    3. Total Synthesis of Sporolide B (pages 3449–3453)

      K. C. Nicolaou, Yefeng Tang and Jianhua Wang

      Article first published online: 24 FEB 2009 | DOI: 10.1002/anie.200900264

      Thumbnail image of graphical abstract

      An ocean of discovery: The first total synthesis of the highly oxygenated, marine-derived, natural product sporolide B has been achieved through a convergent strategy. The key steps involve a ruthenium-catalyzed [2+2+2] cycloaddition to assemble the indene structural motif and a thermally induced Diels–Alder-type reaction to forge the macrocycle (see scheme).

    4. Ambiphilic Ligands

      Gold(I) Complexes of Phosphanyl Gallanes: From Interconverting to Separable Coordination Isomers (pages 3454–3457)

      Marie Sircoglou, Maxime Mercy, Nathalie Saffon, Yannick Coppel, Ghenwa Bouhadir, Laurent Maron and Didier Bourissou

      Article first published online: 9 APR 2009 | DOI: 10.1002/anie.200900737

      Thumbnail image of graphical abstract

      Gallant exchange: Upon coordination of phosphanyl gallane ligands to AuCl, both neutral and zwitterionic complexes coexist. NMR spectroscopy provides direct evidence for the transfer of the chloride between gold and gallium in diphosphanyl gallane. The introduction of a third phosphanyl buttress allows the separation and structural characterization of the two coordination isomers (see picture; Au yellow, P red, Cl green, Ga blue).

    5. Synthetic Methods

      A Multicomponent Reaction of Arynes, Isocyanides, and Terminal Alkynes: Highly Chemo- and Regioselective Synthesis of Polysubstituted Pyridines and Isoquinolines (pages 3458–3461)

      Feng Sha and Xian Huang

      Article first published online: 6 APR 2009 | DOI: 10.1002/anie.200900212

      Thumbnail image of graphical abstract

      Many components make light work: A novel synthetic strategy for the preparation of pyridines and isoquinolines in high chemo- and regioselectivity has been developed. By manipulating the reaction conditions, either product can be generated smoothly in a highly efficient and atom-economic manner (see scheme).

    6. Natural Product Synthesis

      First Stereoselective Total Synthesis of FD-594 Aglycon (pages 3462–3465)

      Ritsuki Masuo, Ken Ohmori, Lukas Hintermann, Saki Yoshida and Keisuke Suzuki

      Article first published online: 3 APR 2009 | DOI: 10.1002/anie.200806338

      Thumbnail image of graphical abstract

      Stereocontrolled access to the hexacyclic core of FD-594 has been achieved. The key steps include the intramolecular SNAr reaction for construction of the densely functionalized xanthone skeleton, the stereoselective lactone cleavage using a chiral nucleophile to induce the axial stereochemistry, and the SmI2-mediated pinacol cyclization for the stereocontrolled conversion of axially chiral biaryl dialdehyde into the corresponding trans diol.

    7. Chiral Polyoxometalates

      Chiral Recognition of Hybrid Metal Oxide by Peptides (pages 3466–3468)

      Kévin Micoine, Bernold Hasenknopf, Serge Thorimbert, Emmanuel Lacôte and Max Malacria

      Article first published online: 7 APR 2009 | DOI: 10.1002/anie.200806247

      Thumbnail image of graphical abstract

      Resolution of gram quantities of a subtly chiral polyoxometalate (POM; the chirality originates from substitution of one metal in the nanosized framework) is possible by reaction with small peptides. Functionalizable acyl polyoxotungstate (TBA)61-P2W17O61{SnCH2CH2C([DOUBLE BOND]O)}] (see picture) can be resolved by kinetic resolution. This approach paves the way for applications of chiral POMs ranging from asymmetric catalysis to their bioactivity.

    8. Molecular Logic

      Fluorescent Logic Gates Chemically Attached to Silicon Nanowires (pages 3469–3472)

      Lixuan Mu, Wensheng Shi, Guangwei She, Jack C. Chang and Shuit-Tong Lee

      Article first published online: 2 APR 2009 | DOI: 10.1002/anie.200805015

      Thumbnail image of graphical abstract

      I′m in the mood for dansyl: A chemically controlled fluorescent logic gate was formed by grafting a dansyl unit onto silicon nanowires (SiNWs; see picture). The logic gate was operated by utilizing pH changes, HgII, and Cl or Br ions as inputs and the fluorescence of the modified SiNWs as output. The modified SiNWs could perform as a three-input logic gate that combines the YES and INH operations.

    9. Protecting Groups

      Thallium(I) as a Coordination Site Protection Agent: Preparation of an Isolable Zero-Valent Nickel Tris-Isocyanide (pages 3473–3477)

      Brian J. Fox, Matthew D. Millard, Antonio G. DiPasquale, Arnold L. Rheingold and Joshua S. Figueroa

      Article first published online: 27 JAN 2009 | DOI: 10.1002/anie.200806007

      Thumbnail image of graphical abstract

      Blocking the pass: Low-valent Ni centers readily bind TlI ions in a synthetically reversible fashion. The Tl units, in turn, serve as coordination site protection agents for Ni with respect to incoming Lewis basic ligands. This synthetic sequence allows for the isolation of a reactive zero-valent Ni tris-isocyanide complex.

    10. Enzyme Catalysis

      Efforts Toward the Direct Experimental Characterization of Enzyme Microenvironments: Tyrosine100 in Dihydrofolate Reductase (pages 3478–3481)

      Dan Groff, Megan C. Thielges, Susan Cellitti, Peter G. Schultz and Floyd E. Romesberg

      Article first published online: 3 APR 2009 | DOI: 10.1002/anie.200806239

      Thumbnail image of graphical abstract

      State secrets: Site-specific deuteration and FTIR studies reveal that Tyr100 in dihydrofolate reductase plays an important role in catalysis, with a strong electrostatic coupling occuring between Tyr100 and the charge that develops in the hydride-transfer transition state (see picture, NADP+ purple, Tyr100 green). However, relaying correlated motions that facilitate catalysis from distal sites of the protein to the hydride donor may also be involved.

    11. Radiotracer Synthesis

      One-Pot, Direct Incorporation of [11C]CO2 into Carbamates (pages 3482–3485)

      Jacob M. Hooker, Achim T. Reibel, Sidney M. Hill, Michael J. Schueller and Joanna S. Fowler

      Article first published online: 6 APR 2009 | DOI: 10.1002/anie.200900112

      Thumbnail image of graphical abstract

      Why beat about the bush? An operationally simple and mild reaction based on the direct fixation of 11CO2 with 1,8-diazabicyclo[5.4.0]undec-7-ene (DBU) has been developed for the synthesis of 11C-labeled carbamates at 75 °C within 10 minutes in radiochemical yields above 70 % (see scheme). This strategy should be immediately useful for the construction of new radiotracers for positron emission tomography and other applications.

    12. Deep-Eutectic Solvents

      Versatile Structure-Directing Roles of Deep-Eutectic Solvents and Their Implication in the Generation of Porosity and Open Metal Sites for Gas Storage (pages 3486–3490)

      Jian Zhang, Tao Wu, Shumei Chen, Pingyun Feng and Xianhui Bu

      Article first published online: 2 APR 2009 | DOI: 10.1002/anie.200900134

      Thumbnail image of graphical abstract

      Trap it in and burn it out: A deep-eutectic solvent provides a versatile medium for the creation of highly stable porous frameworks encapsulating neutral coordinating ligand molecules, which can escape intact from the pores upon heating to form crystals directly, leaving behind permanent porosity and coordinatively unsaturated metal sites with potential applications in gas storage and catalysis.

    13. Diprotic Superacids

      Superacidity of Boron Acids H2(B12X12) (X=Cl, Br) (pages 3491–3493)

      Amy Avelar, Fook S. Tham and Christopher A. Reed

      Article first published online: 2 APR 2009 | DOI: 10.1002/anie.200900214

      Thumbnail image of graphical abstract

      Acid remarks: The anhydrous diprotic boron acids H2(B12X12) (X=Cl, Br; see picture, B orange, X green) are the first examples of diprotic superacids and may be the strongest acids yet isolated. Both protons protonate benzene to give benzenium ion salts that are stable at room temperature. These acids owe their existence to the stability of the icosahedral B12 cluster with its dinegative charge buried beneath a layer of halide substituents.

    14. Photoresponsive Polymers

      Reversible Switching of the Shear Modulus of Photoresponsive Liquid-Crystalline Polymers (pages 3494–3498)

      Eric Verploegen, Johannes Soulages, Mariel Kozberg, Tejia Zhang, Gareth McKinley and Paula Hammond

      Article first published online: 6 APR 2009 | DOI: 10.1002/anie.200900583

      Thumbnail image of graphical abstract

      Manipulation makes light work: The morphology and rheological properties of a liquid-crystalline system can be dynamically manipulated with UV light by attaching photoresponsive liquid-crystalline moieties to a siloxane-based polymer. Stimulation with UV light induces a conformational change in the molecule, which disrupts the liquid-crystalline mesophase (see picture), and results in a dramatic change in its rheological properties.

    15. Heptameric Lanthanum Clusters

      Olive-Shaped Chiral Supramolecules: Simultaneous Self-Assembly of Heptameric Lanthanum Clusters and Carbon Dioxide Fixation (pages 3499–3502)

      Xiao-Liang Tang, Wen-Hua Wang, Wei Dou, Jie Jiang, Wei-Sheng Liu, Wen-Wu Qin, Guo-Lin Zhang, Hong-Rui Zhang, Kai-Bei Yu and Li-Min Zheng

      Article first published online: 7 APR 2009 | DOI: 10.1002/anie.200900838

      Thumbnail image of graphical abstract

      Cluster's last stand: Six chiral reduced Schiff base ligands containing amino acids and seven LaIII ions self-assemble to form a novel heptameric lanthanum supramolecule with the aid of the CO32− ion (see picture). The cluster exists as a single chiral triple helix. The CO32− ion, which is derived from atmospheric CO2 , adopts a rare μ3-tridentate bridging mode that links three LaIII ions, thus allowing the cluster to efficiently fix CO2.

    16. Hydrogenases

      Influence of the [2Fe]H Subcluster Environment on the Properties of Key Intermediates in the Catalytic Cycle of [FeFe] Hydrogenases: Hints for the Rational Design of Synthetic Catalysts (pages 3503–3506)

      Maurizio Bruschi, Claudio Greco, Markus Kaukonen, Piercarlo Fantucci, Ulf Ryde and Luca De Gioia

      Article first published online: 6 APR 2009 | DOI: 10.1002/anie.200900494

      Thumbnail image of graphical abstract

      Nature's recipe: A theoretical study analyzes how the environment of the [FeFe] hydrogenase's catalytic cofactor affects its chemical properties, particularly the relative stability of complexes with bridging and terminal hydride ligands (see picture; Fe teal, S yellow, C green, N blue, O red, H gray). The results help to elucidate key rules for the design of bioinspired synthetic catalysts for H2 production.

    17. Cell Patterning

      Mass Spectrometry Assisted Lithography for the Patterning of Cell Adhesion Ligands on Self-Assembled Monolayers (pages 3507–3511)

      Young-Kwan Kim, Soo-Ryoon Ryoo, Sul-Jin Kwack and Dal-Hee Min

      Article first published online: 3 APR 2009 | DOI: 10.1002/anie.200806098

      Thumbnail image of graphical abstract

      Pattern of events: A simple and flexible method has been developed for patterning cell adhesion ligands. Locally erasing self-assembled monolayers with tri(ethyleneglycol) groups on a gold substrate by using a MALDI-TOF MS nitrogen laser and filling the exposed gold surface with an alkanethiol presenting carboxylic acid groups enables subsequent immobilization of maleimide and a cell adhesion peptide, which can then recognize cells (see scheme).

    18. Biosensing

      Colorimetric Sensing by Using Allosteric-DNAzyme-Coupled Rolling Circle Amplification and a Peptide Nucleic Acid–Organic Dye Probe (pages 3512–3515)

      M. Monsur Ali and Yingfu Li

      Article first published online: 9 APR 2009 | DOI: 10.1002/anie.200805966

      Thumbnail image of graphical abstract

      Target detection by the naked eye: The action of an RNA-cleaving allosteric DNAzyme in response to ligand binding was coupled to a rolling circle amplification process to generate long single-stranded DNA molecules for colorimetric sensing (see scheme). Upon hybridization of the resulting DNA with a complementary PNA sequence in the presence of a duplex-binding dye, the color of the dye changed from blue to purple.

    19. Nanoparticles

      Reconstruction of Silver Nanoplates by UV Irradiation: Tailored Optical Properties and Enhanced Stability (pages 3516–3519)

      Qiao Zhang, Jianping Ge, Tri Pham, James Goebl, Yongxing Hu, Zhenda Lu and Yadong Yin

      Article first published online: 3 APR 2009 | DOI: 10.1002/anie.200900545

      Thumbnail image of graphical abstract

      The size and shape of it: The optical properties of Ag nanoplates can be precisely tuned in a wide range through a UV-light-induced reconstruction process in which the morphology of the nanoparticles is changed from thin triangular plates to thick round plates (see picture). This unconventional “backward tuning” strategy is a practical route to stable silver nanoplates that display a wide range of plasmon wavelengths.

    20. Solid-State Chemistry

      How Much Water Does Calcined Gypsum Contain? (pages 3520–3524)

      Horst Weiss and Michael F. Bräu

      Article first published online: 6 APR 2009 | DOI: 10.1002/anie.200900726

      Thumbnail image of graphical abstract

      Ordered water: Gypsum has been used for construction for millennia. The structure and water content of calcined gypsum, CaSO4⋅0.5 H2O, has been under discussion until now: single-crystal structure analysis (see picture: S yellow, Ca gray, O blue, H red) provides an ordered model that is confirmed by DFT calculations.

    21. Surface Permeabilities

      Assessing Surface Permeabilities from Transient Guest Profiles in Nanoporous Host Materials (pages 3525–3528)

      Despina Tzoulaki, Lars Heinke, Hyuna Lim, Jing Li, David Olson, Jürgen Caro, Rajamani Krishna, Christian Chmelik and Jörg Kärger

      Article first published online: 3 APR 2009 | DOI: 10.1002/anie.200804785

      Thumbnail image of graphical abstract

      Easy come, easy go? Transport resistances on particle surfaces are important for mass transfer in nanoporous materials and bulk diffusion in crystals. Interference microscopy and IR micro-imaging are shown to be excellent tools for determining such transport resistances. By studying short-chain-length alkane guest molecules in crystals of the metal–organic framework compound Zn(tbip) a data collection of surface permeabilities is established.

    22. Core–Shell Catalyst

      Adsorbate-Induced Surface Segregation for Core–Shell Nanocatalysts (pages 3529–3531)

      Karl J. J. Mayrhofer, Viktorija Juhart, Katrin Hartl, Marianne Hanzlik and Matthias Arenz

      Article first published online: 6 APR 2009 | DOI: 10.1002/anie.200806209

      Thumbnail image of graphical abstract

      Coming to the surface: The surface composition of carbon-supported Pt3Co catalyst particles changes upon a CO-annealing treatment. Platinum atoms segregate to the particle surface so that nanoparticles with a platinum shell surrounding an alloy core are formed. This modified catalyst has a superior activity in the oxygen reduction reaction compared to both a plain platinum catalyst and the untreated alloy particles.

    23. Divergent Evolution

      Converting an Esterase into an Epoxide Hydrolase (pages 3532–3535)

      Helge Jochens, Konstanze Stiba, Christopher Savile, Ryota Fujii, Juin-Guo Yu, Tatsiana Gerassenkov, Romas J. Kazlauskas and Uwe T. Bornscheuer

      Article first published online: 6 APR 2009 | DOI: 10.1002/anie.200806276

      Thumbnail image of graphical abstract

      Entering the fold: A common structural motif in hydrolytic enzymes is the α,β-hydrolase fold. The interconversion of one enzyme into another by introduction of mechanistically important residues is not enough; only substitution of a loop allows epoxide hydrolase activity in the esterase scaffold to be formed (see picture; structure comparison of epoxide hydrolases (green) with the esterase (orange)). The result is an enantioselective chimeric enzyme.

  12. Preview

    1. Top of page
    2. Cover Picture
    3. Inside Cover
    4. Graphical Abstract
    5. Corrigendum
    6. News
    7. Author Profile
    8. Book Reviews
    9. Highlights
    10. Essay
    11. Review
    12. Communications
    13. Preview
    1. You have free access to this content
      Preview: Angew. Chem. Int. Ed. 20/2009 (page 3539)

      Article first published online: 23 APR 2009 | DOI: 10.1002/anie.200990100

SEARCH

SEARCH BY CITATION