Angewandte Chemie International Edition

Cover image for Vol. 48 Issue 28

June 29, 2009

Volume 48, Issue 28

Pages 5055–5217

  1. Cover Picture

    1. Top of page
    2. Cover Picture
    3. Inside Cover
    4. Graphical Abstract
    5. News
    6. Author Profile
    7. Book Review
    8. Highlights
    9. Minireview
    10. Review
    11. Communications
    12. Preview
    1. Cover Picture: Spectroscopic Tracking of Molecular Transport Junctions Generated by Using Click Chemistry (Angew. Chem. Int. Ed. 28/2009) (page 5055)

      Xiaodong Chen, Adam B. Braunschweig, Michael J. Wiester, Sina Yeganeh, Mark A. Ratner and Chad A. Mirkin

      Article first published online: 25 JUN 2009 | DOI: 10.1002/anie.200990144

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      The in situ generation of molecules that bridge nanogaps generated by on-wire lithography is achieved by using click chemistry. C. A. Mirkin, M. A. Ratner, and co-workers show in their Communication on page 5178 ff. that these molecular junctions give high yields, and they describe how this strategy can be generalized to incorporate diverse molecular architectures within the nanogaps. Tracking of the molecular assembly process within the nanogaps is allowed by their strong electromagnetic field.

  2. Inside Cover

    1. Top of page
    2. Cover Picture
    3. Inside Cover
    4. Graphical Abstract
    5. News
    6. Author Profile
    7. Book Review
    8. Highlights
    9. Minireview
    10. Review
    11. Communications
    12. Preview
    1. Inside Cover: Adsorption, Diffusion, and Self-Assembly of an Engineered Gold-Binding Peptide on Au(111) Investigated by Atomic Force Microscopy (Angew. Chem. Int. Ed. 28/2009) (page 5056)

      Christopher R. So, Candan Tamerler and Mehmet Sarikaya

      Article first published online: 25 JUN 2009 | DOI: 10.1002/anie.200990145

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      The binding, diffusion, and aggregation mechanism of an engineered binding peptide on Au(111), showing non-equilibrium surface structures that lead to the formation of a confluent monolayer, is described by M. Sarikaya et al. in their Communication on page 5174 ff. The observed dynamic structural evolution involving the surface diffusion of peptides and multiple stages of molecular thin film topology are explained. Ersin Emre Oren is thanked for the design of the graphic.

  3. Graphical Abstract

    1. Top of page
    2. Cover Picture
    3. Inside Cover
    4. Graphical Abstract
    5. News
    6. Author Profile
    7. Book Review
    8. Highlights
    9. Minireview
    10. Review
    11. Communications
    12. Preview
  4. News

    1. Top of page
    2. Cover Picture
    3. Inside Cover
    4. Graphical Abstract
    5. News
    6. Author Profile
    7. Book Review
    8. Highlights
    9. Minireview
    10. Review
    11. Communications
    12. Preview
  5. Author Profile

    1. Top of page
    2. Cover Picture
    3. Inside Cover
    4. Graphical Abstract
    5. News
    6. Author Profile
    7. Book Review
    8. Highlights
    9. Minireview
    10. Review
    11. Communications
    12. Preview
    1. Joost N. H. Reek (page 5074)

      Article first published online: 27 MAY 2009 | DOI: 10.1002/anie.200901804

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      “The biggest challenge facing scientists is finding technology for green energy. If I could have dinner with three famous scientists from history, they would be Bohr, Einstein, and Heisenberg. …” This and more about Joost N. H. Reek can be found on page 5074.

  6. Book Review

    1. Top of page
    2. Cover Picture
    3. Inside Cover
    4. Graphical Abstract
    5. News
    6. Author Profile
    7. Book Review
    8. Highlights
    9. Minireview
    10. Review
    11. Communications
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    1. Mechanisms of Atmospheric Oxidation of the Alkanes.By Jack G. Calvert et al.. (page 5075)

      Jean-Claude Rayez and Robert Lesclaux

      Article first published online: 25 JUN 2009 | DOI: 10.1002/anie.200901202

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      Oxford University Press, Oxford 2008. 992 pp., hardcover $ 295.00.—ISBN 978–0195365818

  7. Highlights

    1. Top of page
    2. Cover Picture
    3. Inside Cover
    4. Graphical Abstract
    5. News
    6. Author Profile
    7. Book Review
    8. Highlights
    9. Minireview
    10. Review
    11. Communications
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    1. Metal–Metal Interactions

      An Iron Complex with an Unsupported Fe–Fe Bond (pages 5076–5077)

      Carlos A. Murillo

      Article first published online: 18 MAY 2009 | DOI: 10.1002/anie.200901802

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      Full metal bonding: The reduction of a six-coordinate, mononuclear Werner-type iron(II) complex (see scheme) resulted in the isolation of a compound with an extraordinarily rare, unsupported Fe–Fe bond having an experimental Fe–Fe distance of 2.6869(6) Å and a calculated bond order of 0.5.

    2. Natural Products

      Cycloadditions in the Total Synthesis of Sporolide B (pages 5078–5080)

      Pengfei Li and Dirk Menche

      Article first published online: 9 JUN 2009 | DOI: 10.1002/anie.200901894

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      Closing rings: A recent total synthesis of sporolide B by the Nicolaou group is highlighted by two advantageous cycloadditions. Firstly, a regioselective [2+2+2] cycloaddition of highly elaborate substrates assembles the halogenated aromatic ring and subsequently an ortho-quinone [4+2] cyclization closes stereoselectively the dioxane-containing macrocycle. These approaches should be considered in complex target syntheses.

  8. Minireview

    1. Top of page
    2. Cover Picture
    3. Inside Cover
    4. Graphical Abstract
    5. News
    6. Author Profile
    7. Book Review
    8. Highlights
    9. Minireview
    10. Review
    11. Communications
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    1. Boron Radicals

      Boron Atoms as Spin Carriers in Two- and Three-Dimensional Systems (pages 5082–5091)

      Wolfgang Kaim, Narayan S. Hosmane, Stanislav Záliš, John A. Maguire and William N. Lipscomb

      Article first published online: 31 MAR 2009 | DOI: 10.1002/anie.200803493

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      To “B” or not to “B”: The unusual bonding of boron in organoboranes or oligoboron clusters is not only apparent in diamagnetic molecules but also in paramagnetic systems, including mixed-valent species and oligoborane/carborane cluster radicals. The picture shows the singly occupied molecular orbital of the radical ion [C4B8R4H8].−, determined by DFT calculations.

  9. Review

    1. Top of page
    2. Cover Picture
    3. Inside Cover
    4. Graphical Abstract
    5. News
    6. Author Profile
    7. Book Review
    8. Highlights
    9. Minireview
    10. Review
    11. Communications
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    1. Synthetic Methods

      Palladium(II)-Catalyzed C[BOND]H Activation/C[BOND]C Cross-Coupling Reactions: Versatility and Practicality (pages 5094–5115)

      Xiao Chen, Keary M. Engle, Dong-Hui Wang and Jin-Quan Yu

      Article first published online: 25 JUN 2009 | DOI: 10.1002/anie.200806273

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      Pick your Pd partners: A number of catalytic systems have been developed for palladium-catalyzed C[BOND]H activation/C[BOND]C bond formation. Recent studies concerning the palladium(II)-catalyzed coupling of C[BOND]H bonds with organometallic reagents through a PdII/Pd0 catalytic cycle are discussed (see scheme), and the versatility and practicality of this new mode of catalysis are presented. Unaddressed questions and the potential for development in the field are also addressed.

  10. Communications

    1. Top of page
    2. Cover Picture
    3. Inside Cover
    4. Graphical Abstract
    5. News
    6. Author Profile
    7. Book Review
    8. Highlights
    9. Minireview
    10. Review
    11. Communications
    12. Preview
    1. Nanofiber Networks

      Tough Supersoft Sponge Fibers with Tunable Stiffness from a DNA Self-Assembly Technique (pages 5116–5120)

      Chang Kee Lee, Su Ryon Shin, Ji Young Mun, Sung-Sik Han, Insuk So, Ju-Hong Jeon, Tong Mook Kang, Sun I. Kim, Philip G Whitten, Gordon G. Wallace, Geoffrey M. Spinks and Seon Jeong Kim

      Article first published online: 4 MAR 2009 | DOI: 10.1002/anie.200804788

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      Tough and soft: Highly porous, spongelike materials self-assemble by calcium ion condensation of DNA-wrapped carbon nanotubes (SWNTs–DNA; see picture, IL=ionic liquid). The toughness, modulus, and swellability of the electrically conductive sponges can be tuned by controlling the density and strength of interfiber junctions. The sponges have compliances similar to the softest natural tissue, while robust interfiber junctions give high toughness.

    2. Organocatalysis

      Enantioselective Linchpin Catalysis by SOMO Catalysis: An Approach to the Asymmetric α-Chlorination of Aldehydes and Terminal Epoxide Formation (pages 5121–5124)

      Muriel Amatore, Teresa D. Beeson, Sean P. Brown and David W. C. MacMillan

      Article first published online: 12 JUN 2009 | DOI: 10.1002/anie.200901855

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      Time for SOme MOre: For the first time SOMO (singly occupied molecular orbital) activation has been exploited to allow a new approach to the α-chlorination of aldehydes. This transformation can be readily implemented as part of a linchpin catalysis approach to the enantioselective production of terminal epoxides.

    3. Polymer Nanostructures

      Suprapolymer Structures from Nanostructured Polymer Particles (pages 5125–5128)

      Takeshi Higuchi, Atsunori Tajima, Kiwamu Motoyoshi, Hiroshi Yabu and Masatsugu Shimomura

      Article first published online: 3 JUN 2009 | DOI: 10.1002/anie.200900002

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      Divide and conquer: Polymer nanoparticles with phase-separation structures prepared with block copolymers and homopolymer blends were used to fabricate unique suprapolymer structures by cross-linking one polymer moiety and dissolving the other (see scheme; PI=polyisoprene, PSt=polystyrene).

    4. Nanoparticle Crystallinity

      Quantitative Assessment of Nanoparticle Single Crystallinity: Palladium-Catalyzed Splitting of Polycrystalline Metal Oxide Nanoparticles (pages 5129–5133)

      Hyunjin Kim, Myounghoon Lee, Youngki Kim, Jiyoung Huh, Heonjo Kim, Minsik Kim, Taekhoon Kim, Vu Ngoc Phan, Young-Boo Lee, Gi-Ra Yi, Seungjoo Haam and Kwangyeol Lee

      Article first published online: 9 JUN 2009 | DOI: 10.1002/anie.200900083

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      Crystal gazing: A simple Pd-catalyzed site-specific nanoetching method was developed to visualize the polycrystalline nature of Fe3O4 (see picture), Fe2O3, MnFe2O4, CoFe2O4, and MnO nanoparticle systems. The technique relies on the very fast etching speed of the grain interface within bi- or polycrystalline nanocrystals.

    5. DNA Nanofibers

      White Luminescence from Multiple-Dye-Doped Electrospun DNA Nanofibers by Fluorescence Resonance Energy Transfer (pages 5134–5138)

      Yogesh Ner, James G. Grote, Jeffrey A. Stuart and Gregory A. Sotzing

      Article first published online: 5 JUN 2009 | DOI: 10.1002/anie.200900885

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      A DNA spin-off: Electrospinning of DNA complexes gives nanofibers with a highly ordered morphology that allows homogeneous distribution of encapsulated multiple chromophores. The emission color can be controlled by suitable choice of the donor–acceptor pair and the doping ratio. Pure white-light emission from nanofibers is demonstrated (see picture).

    6. Hydrogen Evolution

      Hydrogen Evolution at Liquid–Liquid Interfaces (pages 5139–5142)

      Imren Hatay, Bin Su, Fei Li, Raheleh Partovi-Nia, Heron Vrubel, Xile Hu, Mustafa Ersoz and Hubert H. Girault

      Article first published online: 3 JUN 2009 | DOI: 10.1002/anie.200901757

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      Blowing bubbles: Hydrogen evolution by proton reduction with [(C5Me5)2Fe] occurs at a soft interface between water and 1,2-dichloroethane (DCE). The reaction proceeds by proton transfer assisted by [(C5Me5)2Fe] across the water–DCE interface with subsequent proton reduction in DCE. The interface essentially acts as a proton pump, allowing hydrogen evolution by directly using the aqueous proton.

    7. Asymmetric Catalysis

      Iridium-Catalyzed Asymmetric Isomerization of Primary Allylic Alcohols (pages 5143–5147)

      Luca Mantilli, David Gérard, Sonya Torche, Céline Besnard and Clément Mazet

      Article first published online: 12 JUN 2009 | DOI: 10.1002/anie.200901863

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      Nothing to sm(Ir)k at: Under appropriate reaction conditions, iridium hydride catalysts promote the isomerization of primary allylic alcohols. The best catalysts, like (R)-1 (P green, O red, N blue, Ir yellow), deliver the desired chiral aldehydes with excellent enantioselectivity and good yields. Mechanistic hypotheses have been developed on the basis of preliminary investigations.

    8. Ionic Liquids

      Double Layer of Au(100)/Ionic Liquid Interface and Its Stability in Imidazolium-Based Ionic Liquids (pages 5148–5151)

      Yu-Zhuan Su, Yong-Chun Fu, Jia-Wei Yan, Zhao-Bin Chen and Bing-Wei Mao

      Article first published online: 12 JUN 2009 | DOI: 10.1002/anie.200900300

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      Ring any bells? The differential capacitance curve of Au(100) in neat [BMI]BF4 (BMI=1-butyl-3-methylimidazolium) ionic liquid has a bell-shaped feature (see picture). The adsorption of BMI+ shows a disorder–order transition and depends on the structure of the surface. Ordered adsorption in a micelle-like structure stabilizes the underlying Au surface.

    9. Germanium Cations

      Germanium(II) Dications Stabilized by Azamacrocycles and Crown Ethers (pages 5152–5154)

      Fei Cheng, Andrew L. Hector, William Levason, Gillian Reid, Michael Webster and Wenjian Zhang

      Article first published online: 5 JUN 2009 | DOI: 10.1002/anie.200901247

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      A crown for germanium: Neutral aza- and oxamacrocycles enable stabilization of halide-free germanium(II) dications (see structure, Ge teal, N blue, C gray). The resulting structures show a marked dependence upon the denticity, donor type, and ring size of the macrocycle.

    10. Cationic Crown Ether Complexes of Germanium(II) (pages 5155–5158)

      Paul A. Rupar, Rajoshree Bandyopadhyay, Benjamin F. T. Cooper, Michael R. Stinchcombe, Paul J. Ragogna, Charles L. B. Macdonald and Kim M. Baines

      Article first published online: 28 MAY 2009 | DOI: 10.1002/anie.200901351

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      Fit for a king: Cationic complexes of GeII can be prepared by using crown ethers to stabilize and protect the germanium center. Three different crown ethers were employed: [12]crown-4 (see structure, Ge teal, O red, C gray), [15]crown-5, and [18]crown-6. The structures of the cationic complexes depend on the cavity size of the crown ether and on the substituent on germanium.

    11. Enzyme Design

      Enantioselective Artificial Metalloenzymes Based on a Bovine Pancreatic Polypeptide Scaffold (pages 5159–5162)

      David Coquière, Jeffrey Bos, Joris Beld and Gerard Roelfes

      Article first published online: 25 JUN 2009 | DOI: 10.1002/anie.200901134

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      Site creation: Enantioselective artificial metalloenzymes have been created by grafting a new active site onto bovine pancreatic polypeptide through the introduction of an amino acid capable of coordinating a copper(II) ion. This hybrid catalyst gave good enantioselectivities in the Diels–Alder and Michael addition reactions in water (see scheme) and displayed a very high substrate selectivity.

    12. Metal–Organic Frameworks

      [Al4(OH)2(OCH3)4(H2N-bdc)3]⋅x H2O: A 12-Connected Porous Metal–Organic Framework with an Unprecedented Aluminum-Containing Brick (pages 5163–5166)

      Tim Ahnfeldt, Nathalie Guillou, Daniel Gunzelmann, Irene Margiolaki, Thierry Loiseau, Gérard Férey, Jürgen Senker and Norbert Stock

      Article first published online: 5 JUN 2009 | DOI: 10.1002/anie.200901409

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      Al together now! A new stable aluminum aminoterephthalate system contains octameric building blocks that are connected by organic linkers to form a 12-connected net (see picture). The structure adopts a cubic centered packing motive in which octameric units replace individual atoms, thus forming distorted octahedral (red sphere) and tetrahedral cages (green spheres) with effective accessible diameters of 1 and 0.45 nm, respectively.

    13. Nanomaterials

      Liquid-Crystalline Phases Made of Gold Nanoparticles (pages 5167–5169)

      Michal Wojcik, Wiktor Lewandowski, Joanna Matraszek, Jozef Mieczkowski, Jolanta Borysiuk, Damian Pociecha and Ewa Gorecka

      Article first published online: 3 JUN 2009 | DOI: 10.1002/anie.200901206

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      Spontaneous formation of smectic and columnar structures was observed when spherical gold nanoparticles were functionalized with mesogenic thiols (see layered structure and X-ray pattern of a sample in smectic phase). The particle ordering is stimulated by softening of the interparticle potential and flexibility for deformation of the grafting layer.

    14. Organocatalysis

      Hydrogen-Bonding Catalysts Based on Fluorinated Alcohol Derivatives for Living Polymerization (pages 5170–5173)

      Olivier Coulembier, Daniel P. Sanders, Alshakim Nelson, Andrew N. Hollenbeck, Hans W. Horn, Julia E. Rice, Masaki Fujiwara, Philippe Dubois and James L. Hedrick

      Article first published online: 12 JUN 2009 | DOI: 10.1002/anie.200901006

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      Recognize this! A hydrogen-bonding motif based on hexafluorinated alcohol derivatives (see picture; O red, F yellow) activates electrophilic substrates. The catalytic activity of the hydrogen-bonded systems was demonstrated for the ring-opening polymerization of a variety of strained heterocycles. Narrowly dispersed polymers with predictable molecular weights were obtained with end-group fidelity.

    15. Peptide Adsorption and Assembly

      Adsorption, Diffusion, and Self-Assembly of an Engineered Gold-Binding Peptide on Au(111) Investigated by Atomic Force Microscopy (pages 5174–5177)

      Christopher R. So, Candan Tamerler and Mehmet Sarikaya

      Article first published online: 6 APR 2009 | DOI: 10.1002/anie.200805259

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      Go for the gold! The structural evolution of peptide binding and assembly on a Au(111) surface is dynamic and involves surface diffusion and multiple stages of molecular thin-film topology development (see schematic depiction and corresponding AFM images). The new fundamental observations may form the basis of peptide-based novel hybrid molecular technologies of the future.

    16. Molecular Electronics

      Spectroscopic Tracking of Molecular Transport Junctions Generated by Using Click Chemistry (pages 5178–5181)

      Xiaodong Chen, Adam B. Braunschweig, Michael J. Wiester, Sina Yeganeh, Mark A. Ratner and Chad A. Mirkin

      Article first published online: 19 FEB 2009 | DOI: 10.1002/anie.200806028

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      Click to fill the gap: The in situ modular fabrication of molecular transport junctions in nanogaps generated by on-wire lithography is achieved by using click chemistry (see picture). The formation of molecular junctions proceeds in high yields and can be used to test different molecules; the triazole group also maintains conjugation in the molecular wires. Raman spectroscopy is used to characterize the molecular assembly processes.

    17. Homogeneous Catalysis

      Activation of Hydrogen by Palladium(0): Formation of the Mononuclear Dihydride Complex trans-[Pd(H)2(IPr)(PCy3)] (pages 5182–5186)

      Serena Fantasia, Jonathan D. Egbert, Václav Jurčík, Catherine S. J. Cazin, Heiko Jacobsen, Luigi Cavallo, D. Michael Heinekey and Steven P. Nolan

      Article first published online: 12 JUN 2009 | DOI: 10.1002/anie.200900463

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      An even split: In sharp contrast with the general behavior of Pd0 complexes, [Pd(IPr)(PCy3)] is able to activate the H[BOND]H bond. The resulting trans-[Pd(H)2(IPr)(PCy3)] is the first isolated mononuclear dihydride palladium compound. Its formation is supported by multinuclear NMR spectroscopy, density functional calculations, and X-ray diffraction studies. The stability and reactivity of this new species are examined.

    18. Polymers

      Adapting N-Heterocyclic Carbene/Azide Coupling Chemistry for Polymer Synthesis: Enabling Access to Aromatic Polytriazenes (pages 5187–5190)

      Daniel J. Coady, Dimitri M. Khramov, Brent C. Norris, Andrew G. Tennyson and Christopher W. Bielawski

      Article first published online: 3 JUN 2009 | DOI: 10.1002/anie.200901046

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      A click by any other name: Coupling bis(N-heterocyclic carbene)s with bis(azide)s afforded a novel class of conjugated polytriazenes. These polymers were rendered electrically conductive upon doping, and fluorene-containing variants exhibited luminescence. This adaptation of N-heterocyclic carbene (NHC)/azide coupling chemistry to polymer synthesis reveals the potential of NHCs as building blocks for accessing polymers having useful electronic properties.

    19. Homogeneous Catalysis

      An [(NHC)(NHCEWG)RuCl2(CHPh)] Complex for the Efficient Formation of Sterically Hindered Olefins by Ring-Closing Metathesis (pages 5191–5194)

      Tim Vorfalt, Steffen Leuthäußer and Herbert Plenio

      Article first published online: 3 JUN 2009 | DOI: 10.1002/anie.200900935

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      NHC with EWGs for RCM: Ruthenium complexes with two N-heterocyclic carbenes (NHCs), one of them substituted with electron-withdrawing groups (EWGs), are highly efficient (pre)catalysts for the synthesis of tetrasubstituted olefins and trisubstituted olefins by ring-closing metathesis reactions (RCM, see scheme).

    20. Organocatalysis

      Bifunctional Guanidine via an Amino Amide Skeleton for Asymmetric Michael Reactions of β-Ketoesters with Nitroolefins: A Concise Synthesis of Bicyclic β-Amino Acids (pages 5195–5198)

      Zhipeng Yu, Xiaohua Liu, Lin Zhou, Lili Lin and Xiaoming Feng

      Article first published online: 5 JUN 2009 | DOI: 10.1002/anie.200901337

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      Two activations are better than one: The chiral bifunctional guanidine 1, which features an amino amide backbone, catalyzes the asymmetric Michael addition of a range of substrates and gives products with excellent stereoselectivities. The method also allows the efficient synthesis of optically pure β-amino acid esters. Both the guanidine group and the NH proton of the amide were important for the dual activation.

    21. Rearrangement

      The Benzyne Aza-Claisen Reaction (pages 5199–5202)

      Alastair A. Cant, Guillaume H. V. Bertrand, Jaclyn L. Henderson, Lee Roberts and Michael F. Greaney

      Article first published online: 12 JUN 2009 | DOI: 10.1002/anie.200901410

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      Adding an aryne to a tertiary allylamine affords o-allylaniline products of an aza-Claisen rearrangement. The aryne simultaneously provides the π component for the rearrangement and the quaternization event that lowers the activation energy for the sigmatropic shift. The reaction was applied to the synthesis of medium-ring benzannulated amines (see scheme).

      Corrected by:

      Corrigendum: Corrigendum: The Benzyne Aza-Claisen Reaction

      Vol. 51, Issue 41, 10214, Article first published online: 1 OCT 2012

    22. Metallacumulenes

      Self-Coupling of a 4-H-Butatrienylidene Tungsten Complex (pages 5203–5206)

      Sergey N. Semenov, Olivier Blacque, Thomas Fox, Koushik Venkatesan and Heinz Berke

      Article first published online: 12 JUN 2009 | DOI: 10.1002/anie.200901914

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      Tungsten tryst: A 4-H-butatrienylidene complex of tungsten was successfully isolated and structurally characterized. It undergoes a unique self-coupling, which leads to a dimer (see picture; P pink, O red) with a cross-conjugated π system and with electrochemically and magnetically active metal centers.

    23. Structural Biology

      The Thermodynamic Influence of Trapped Water Molecules on a Protein–Ligand Interaction (pages 5207–5210)

      Christian M. Stegmann, Daniel Seeliger, George M. Sheldrick, Bert L. de Groot and Markus C. Wahl

      Article first published online: 4 JUN 2009 | DOI: 10.1002/anie.200900481

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      Water molecules doing time: Atomic-resolution crystal structures of the PPIase domain of cyclophilin G, alone and in complex with cyclosporin A, and together with MD simulations and calorimetry, reveal how trapped water molecules influence the thermodynamic profile of a protein–ligand interaction.

    24. Indole Alkaloids

      Structural Basis and Enzymatic Mechanism of the Biosynthesis of C9- from C10-Monoterpenoid Indole Alkaloids (pages 5211–5213)

      Liuqing Yang, Marco Hill, Meitian Wang, Santosh Panjikar and Joachim Stöckigt

      Article first published online: 3 JUN 2009 | DOI: 10.1002/anie.200900150

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      Cutting carbons: The three-dimensional structure of polyneuridine aldehyde esterase (PNAE) gives insight into the enzymatic mechanism of the biosynthesis of C9- from C10-monoterpenoid indole alkaloids (see scheme). PNAE is a very substrate-specific serine esterase. It harbors the catalytic triad S87-D216-H244, and is a new member of the α/β-fold hydrolase superfamily. Its novel function leads to the diversification of alkaloid structures.

  11. Preview

    1. Top of page
    2. Cover Picture
    3. Inside Cover
    4. Graphical Abstract
    5. News
    6. Author Profile
    7. Book Review
    8. Highlights
    9. Minireview
    10. Review
    11. Communications
    12. Preview
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      Preview: Angew. Chem. Int. Ed. 29/2009 (page 5217)

      Article first published online: 25 JUN 2009 | DOI: 10.1002/anie.200990148

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