Angewandte Chemie International Edition

Cover image for Vol. 48 Issue 33

August 3, 2009

Volume 48, Issue 33

Pages 5971–6173

  1. Cover Picture

    1. Top of page
    2. Cover Picture
    3. Inside Cover
    4. Graphical Abstract
    5. News
    6. Author Profile
    7. Book Review
    8. Highlights
    9. Review
    10. Communications
    11. Preview
    1. Cover Picture: Oxygen Atom Transfer in the Photocatalytic Oxidation of Alcohols by TiO2: Oxygen Isotope Studies (Angew. Chem. Int. Ed. 33/2009) (page 5971)

      Miao Zhang, Qi Wang, Chuncheng Chen, Ling Zang, Wanhong Ma and Jincai Zhao

      Article first published online: 29 JUL 2009 | DOI: 10.1002/anie.200990170

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      An Oxygen-Atom Transfer … in the photocatalytic aerobic oxidation of alcohols by TiO2 is identified through the oxygen isotopic labeling studies shown in the cover picture and described by J. Zhao and co-workers in their Communication on page 6081 ff. They found that the oxygen atom in the substrate alcohol is completely replaced by an oxygen atom from dioxygen during the photocatalytic transformation. The reaction occurs over pure anatase TiO2 in organic solvents such as benzotrifluoride.

  2. Inside Cover

    1. Top of page
    2. Cover Picture
    3. Inside Cover
    4. Graphical Abstract
    5. News
    6. Author Profile
    7. Book Review
    8. Highlights
    9. Review
    10. Communications
    11. Preview
    1. Inside Cover: Direct Observation of Contact Ion-Pair Formation in Aqueous Solution (Angew. Chem. Int. Ed. 33/2009) (page 5972)

      Mark R. Antonio, May Nyman and Travis M. Anderson

      Article first published online: 29 JUL 2009 | DOI: 10.1002/anie.200990171

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      Contact between anions and cations in aqueous solution is rarely observed, especially by direct spectroscopic methods. The Cs8[Nb6O19] polyoxometalate salt with its high negative charge, spherical symmetry, excellent X-ray scattering power, and very good aqueous solubility provides the ideal scenario. In their Communication on page 6136 ff., M. R. Antonio, M. Nyman, and T. M. Anderson present a small-angle X-ray scattering study that reveals how contact ion pairing in solution matches the solid-state structure.

  3. Graphical Abstract

    1. Top of page
    2. Cover Picture
    3. Inside Cover
    4. Graphical Abstract
    5. News
    6. Author Profile
    7. Book Review
    8. Highlights
    9. Review
    10. Communications
    11. Preview
  4. News

    1. Top of page
    2. Cover Picture
    3. Inside Cover
    4. Graphical Abstract
    5. News
    6. Author Profile
    7. Book Review
    8. Highlights
    9. Review
    10. Communications
    11. Preview
  5. Author Profile

    1. Top of page
    2. Cover Picture
    3. Inside Cover
    4. Graphical Abstract
    5. News
    6. Author Profile
    7. Book Review
    8. Highlights
    9. Review
    10. Communications
    11. Preview
    1. Lukas J. Gooßen (page 5992)

      Article first published online: 14 JUL 2009 | DOI: 10.1002/anie.200903077

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      “My biggest motivation is when I see one of my students achieving something that I could not have done myself. My favorite subject at school was ancient greek. …” This and more about Lukas J. Gooßen can be found on page 5992.

  6. Book Review

    1. Top of page
    2. Cover Picture
    3. Inside Cover
    4. Graphical Abstract
    5. News
    6. Author Profile
    7. Book Review
    8. Highlights
    9. Review
    10. Communications
    11. Preview
    1. Iridium Complexes in Organic Synthesis.Edited by Luis A. Oro and Carmen Claver. (page 5993)

      Anthony Haynes

      Article first published online: 29 JUL 2009 | DOI: 10.1002/anie.200903039

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      Wiley-VCH, Weinheim 2008. 396 pp., hardcover € 139.00.—ISBN 978-3527319961

  7. Highlights

    1. Top of page
    2. Cover Picture
    3. Inside Cover
    4. Graphical Abstract
    5. News
    6. Author Profile
    7. Book Review
    8. Highlights
    9. Review
    10. Communications
    11. Preview
    1. DNA Dendrimers

      Dendritic DNA Building Blocks for Amplified Detection Assays and Biomaterials (pages 5996–6000)

      Udo Feldkamp, Barbara Saccà and Christof M. Niemeyer

      Article first published online: 27 JUN 2009 | DOI: 10.1002/anie.200902285

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      DNA branches out: Recent advances in the assembly of dendritic DNA structures enable applications in biosensing of pathogens and the generation of novel pads of DNA hydrogel biomaterials (see scheme, left). These pads are immersed in a cell extract containing RNA polymerase (red), ribosomes (yellow), and other components for in vitro protein biosynthesis, where they can be used as templates for cell-free protein production.

    2. Radiochemistry

      Methods for the Incorporation of Carbon-11 To Generate Radiopharmaceuticals for PET Imaging (pages 6001–6004)

      Peter J. H. Scott

      Article first published online: 24 JUN 2009 | DOI: 10.1002/anie.200901481

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      Diversification to meet demand: The growing demand for novel radiopharmaceuticals can only be met through the development of new approaches to isotopic labeling. Effective strategies for 11C labeling are highlighted with emphasis on reactions with [11C]carbon dioxide and [11C]methyl iodide (see scheme). DBU=1,8-diazabicyclo[5.4.0]undec-7-ene, TMAO=trimethylamine N-oxide.

    3. Total Synthesis

      Chirality Relay To Access Oxygenated Angular Aromatic Polyketides (pages 6005–6007)

      Aleksandra Baranczak and Gary A. Sulikowski

      Article first published online: 25 JUN 2009 | DOI: 10.1002/anie.200901712

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      Solution to a difficult problem: The selective glycosylation of one hydroxy group of the pseudo-C2-symmetric trans diol of benanomicin–pradimicin antibiotics presents a significant synthetic challenge. Sequential asymmetric cleavage of a biaryl lactone and pinacol cyclization (see scheme) provide access to these compounds as well as the naphthoxanthene antibiotic FD-594. The product diol emerges differentially protected from the pinacol coupling.

  8. Review

    1. Top of page
    2. Cover Picture
    3. Inside Cover
    4. Graphical Abstract
    5. News
    6. Author Profile
    7. Book Review
    8. Highlights
    9. Review
    10. Communications
    11. Preview
    1. Ultracold Chemistry

      Cold Molecules: Preparation, Applications, and Challenges (pages 6010–6031)

      Melanie Schnell and Gerard Meijer

      Article first published online: 27 JUL 2009 | DOI: 10.1002/anie.200805503

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      Catching them cold: Research with cold molecules has developed rapidly in recent years. A current area of emphasis is the development of new ways to bring the temperature of molecules even closer to absolute zero. Samples of cold molecules open the way not only to applications in high-resolution spectroscopy; they also promise entry into exotic realms of chemical reactivity, in which phenomena such as quantum tunneling and quantum resonances dominate.

  9. Communications

    1. Top of page
    2. Cover Picture
    3. Inside Cover
    4. Graphical Abstract
    5. News
    6. Author Profile
    7. Book Review
    8. Highlights
    9. Review
    10. Communications
    11. Preview
    1. Natural Product Synthesis

      Total Synthesis of the Antibiotic Kendomycin by Macrocyclization using Photo-Fries Rearrangement and Ring-Closing Metathesis (pages 6032–6036)

      Thomas Magauer, Harry J. Martin and Johann Mulzer

      Article first published online: 6 APR 2009 | DOI: 10.1002/anie.200900522

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      Crossing swords: Two novel approaches to the antibiotic kendomycin are described. Salient features are complex Claisen–Ireland rearrangements and macrocyclizations by ring-closing metathesis (RCM) and a photo-Fries rearrangement (see retrosynthesis scheme).

    2. Synthetic Methods

      Oxidation of Catecholboron Enolates with TEMPO (pages 6037–6040)

      Martin Pouliot, Philippe Renaud, Kurt Schenk, Armido Studer and Thomas Vogler

      Article first published online: 7 JUL 2009 | DOI: 10.1002/anie.200902242

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      Persistent radical meets enolates: Catecholboron ketone enolates are oxidized efficiently under mild conditions by treatment with the persistent TEMPO radical. Catecholboron enolates are readily prepared by 1,4-reduction of α,β-unsaturated ketones or by transmetalation of silyl enol ethers and zinc enolates with chlorocatecholboranes. Enolate formation and oxidation can be performed as a one-pot process with high regio- and stereoselectivity.

    3. Homogeneous Catalysis

      Iron-Catalyzed Carbonylation: Selective and Efficient Synthesis of Succinimides (pages 6041–6044)

      Katrin Marie Driller, Holger Klein, Ralf Jackstell and Matthias Beller

      Article first published online: 9 JUL 2009 | DOI: 10.1002/anie.200902078

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      A convenient one-pot method for the synthesis of various substituted succinimides has been developed. By starting from commercially available amines (or ammonia) and alkynes, a range of interesting succinimides have been obtained selectively in the presence of either [Fe(CO)5] or [Fe3(CO)12] (see scheme; R′=H, alkyl, aryl; R′′, R′′′=alkyl, aryl).

    4. C[BOND]H Bond Functionalization

      Ruthenium-Catalyzed Regioselective Direct Alkylation of Arenes with Unactivated Alkyl Halides through C[BOND]H Bond Cleavage (pages 6045–6048)

      Lutz Ackermann, Petr Novák, Rubén Vicente and Nora Hofmann

      Article first published online: 11 JUL 2009 | DOI: 10.1002/anie.200902458

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      Cut to the chase: A ruthenium complex derived from 1-adamantyl carboxylate (1-AdCO2) enabled highly regioselective intermolecular direct alkylation of arenes with unactivated primary and secondary alkyl halides bearing β-hydrogen atoms (see scheme; NMP=N-methylpyrrolidinone).

    5. Asymmetric Crystallization

      Nucleotide-Catalyzed Conversion of Racemic Zeolite-Type Zincophosphate into Enantioenriched Crystals (pages 6049–6051)

      Jian Zhang, Shumei Chen and Xianhui Bu

      Article first published online: 13 JUL 2009 | DOI: 10.1002/anie.200903001

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      A perfect match: The asymmetric crystallization of an inorganic zeolite-type material has been achieved by using a nucleotide as the chirality-induction agent, and is based on a strategy that matches the functional groups of this agent with the bonding features in the chiral crystals (see picture). The mechanism involves the binding of the phosphate unit to the crystal nuclei and absolute chirality control from the sugar unit.

    6. Asymmetric Catalysis

      Rhodium-Catalyzed Enantioselective and Diastereoselective Hydrogenation of β-Ketoenamides: Efficient Access to anti 1,3-Amino Alcohols (pages 6052–6054)

      Huiling Geng, Weicheng Zhang, Jian Chen, Guohua Hou, Le Zhou, Yaping Zou, Wenjun Wu and Xumu Zhang

      Article first published online: 13 JUL 2009 | DOI: 10.1002/anie.200902339

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      Valuable chiral building blocks were synthesized with excellent enantioselectivity and diastereoselectivity through tandem hydrogenation of (Z)-β-ketoenamides, which were in turn prepared by the direct condensation of 1,3-diketones with acetamide (see scheme). The chiral amino alcohol products can be converted into useful γ-aryl isobutylamines through hydrogenolysis with Pd/C. R1=aryl, heteroaryl, methyl; R2=alkyl.

    7. Encapsulated Cluster

      A Ferromagnetic [Cu3(OH)2]4+ Cluster Formed inside a Tritopic Nonaazapyridinophane: Crystal Structure and Solution Studies (pages 6055–6058)

      Almudena González-Alvarez, Ignacio Alfonso, Juan Cano, Pilar Díaz, Vicente Gotor, Vicente Gotor-Fernández, Enrique García-España, Santiago García-Granda, Hermas R. Jiménez and Francesc Lloret

      Article first published online: 13 JUL 2009 | DOI: 10.1002/anie.200901888

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      An encapsulated Cu3(OH)2ensemble is formed within a macrocyclic ligand consisting of three (R,R)-1,2-cyclohexanediamine residues linked through 2,6-dimethylpyridine spacers (see picture; Cu orange, O red, N blue). Its crystal structure, magnetic behavior, and characterization in solution by potentiometric measurements and paramagnetic 1H NMR spectroscopy are reported.

    8. Hybrid Materials

      Titanosilsesquioxanes Embedded in Synthetic Clay as a Hybrid Material for Polymer Science (pages 6059–6061)

      Fabio Carniato, Chiara Bisio, Giorgio Gatti, Enrico Boccaleri, Luca Bertinetti, Salvatore Coluccia, Orietta Monticelli and Leonardo Marchese

      Article first published online: 7 JUL 2009 | DOI: 10.1002/anie.200901927

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      Between the sheets: A novel hybrid material (see graphical representation) was prepared by the intercalation of a bifunctional titanosilsesquioxane in synthetic sodium saponite. The hybrid was used as a filler of polystyrene to create a polymer nanocomposite with enhanced thermooxidative properties.

    9. Asymmetric Hydroboration

      Highly Regio- and Enantioselective Copper-Catalyzed Hydroboration of Styrenes (pages 6062–6064)

      Dongwan Noh, Heesung Chea, Junghwan Ju and Jaesook Yun

      Article first published online: 9 JUL 2009 | DOI: 10.1002/anie.200902015

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      An existing challenge is the development of efficient regioselective catalytic systems that are compatible with stable hydroboration reagents and can be rendered enantioselective by the use of nonracemic ligands. Copper(I) complexes with chelating phosphines catalyzed the regio- and enantioselective hydroboration of styrenes with pinacolborane (PinBH) at room temperature to afford the corresponding branched boronate esters (see example).

      Corrected by:

      Corrigendum: Highly Regio- and Enantioselective Copper-Catalyzed Hydroboration of Styrenes

      Vol. 48, Issue 38, 6938, Article first published online: 1 SEP 2009

    10. Electrochemistry

      Regulating Copper-Binding Affinity with Photoisomerizable Azobenzene Ligand by Construction of a Self-Assembled Monolayer (pages 6065–6068)

      Isao Takahashi, Yuichiro Honda and Shun Hirota

      Article first published online: 11 JUL 2009 | DOI: 10.1002/anie.200902048

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      Catch and release! Self-assembled monolayers (SAMs) of both trans- and cis-azobenzene ligands can bind CuII ions. Ions bound to the trans ligand are released by cyclic voltammetry (CV) redox scans whereas those bound to the cis ligand are not (see picture). Irradiation of the cis-SAM with visible light leads to removal of the bound Cu ions by cis-to-trans photoisomerization.

    11. Conducting Polymers

      Size-Controlled Synthesis of Conducting-Polymer Microspheres by Pulsed Sonoelectrochemical Polymerization (pages 6069–6072)

      Mahito Atobe, Kengo Ishikawa, Ryosuke Asami and Toshio Fuchigami

      Article first published online: 9 JUL 2009 | DOI: 10.1002/anie.200902062

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      Pulse rate: The size of conducting-polymer microspheres is controlled by adjusting the width of the electric pulses in a pulsed sonoelectrochemical polymerization process (see picture). A solution-cast film of the microspheres on an electrode shows a sharp redox response versus potential.

    12. Atropisomerism

      Axial Chirality Control of Gold(biphep) Complexes by Chiral Anions: Application to Asymmetric Catalysis (pages 6073–6077)

      Kohsuke Aikawa, Masafumi Kojima and Koichi Mikami

      Article first published online: 7 JUL 2009 | DOI: 10.1002/anie.200902084

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      The axial chirality of tropos gold–biphep (biphep=bis(phosphanyl)biphenyl) complexes, which is controlled by a chiral anion such as (S)-2 (=X*−), is imprinted and memorized even after the dissociation of chiral anion. An enantiopure complex thus obtained efficiently function as an atropos asymmetric catalyst in an intramolecular hydroamination.

    13. Synthetic Methods

      Highly Chemoselective Nickel-Catalyzed Three-Component Cross-Trimerization of Three Distinct Alkynes Leading to 1,3-Dien-5-ynes (pages 6078–6080)

      Kenichi Ogata, Jun Sugasawa and Shin-ichi Fukuzawa

      Article first published online: 7 JUL 2009 | DOI: 10.1002/anie.200902099

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      Cross-yned: The first highly chemoselective three-component cross-trimerization between a triisopropylsilylacetylene, an ether-functionalized unsymmetrical internal alkyne, and a symmetrical internal alkyne leading to a 1,3-dien-5-yne was achieved using a [Ni(cod)2]/PPh3 catalyst. This reaction is applicable for various internal alkynes with high regio- and stereoselectivities.

    14. Surface Chemistry

      Oxygen Atom Transfer in the Photocatalytic Oxidation of Alcohols by TiO2: Oxygen Isotope Studies (pages 6081–6084)

      Miao Zhang, Qi Wang, Chuncheng Chen, Ling Zang, Wanhong Ma and Jincai Zhao

      Article first published online: 2 APR 2009 | DOI: 10.1002/anie.200900322

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      An uninvited guest: In the photocatalytic oxidation of alcohols to their corresponding aldehydes or ketones using TiO2 in organic solvents, such as benzotrifluoride (BTF), an oxygen atom transfer from the dioxygen to the α-carbon atom of the alcohol dominates the reaction process.

    15. Water Splitting

      SiC: A Photocathode for Water Splitting and Hydrogen Storage (pages 6085–6088)

      Dennis H. van Dorp, Niek Hijnen, Marcel Di Vece and John J. Kelly

      Article first published online: 7 JUL 2009 | DOI: 10.1002/anie.200900796

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      A SiC way to split water: Illuminated p-type 4H-SiC, as a photocathode short-circuited to Pt, was found to split water (see picture). The hydrogen generated is stored to a considerable extent in the solid.

    16. Heterocycles

      Highly Stereoselective One-Pot Synthesis of Bicyclic Isoxazolidines with Five Stereogenic Centers by an Organocatalytic Process (pages 6089–6092)

      Di Zhu, Min Lu, Lu Dai and Guofu Zhong

      Article first published online: 13 JUL 2009 | DOI: 10.1002/anie.200901249

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      High five! A novel, facile, and highly stereoselective synthesis of the title compounds has been developed with the control of five stereogenic centers through an organocatalytic asymmetric one-pot tandem process involving a diastereoselective intramolecular nitrone [3+2] cycloaddition (see scheme).

    17. Domino Reactions

      Selectivity Control in Lewis Acid Catalyzed Regiodivergent Tandem Cationic Cyclization/Ring Expansion Terminated by Pinacol Rearrangement (pages 6093–6096)

      Lu Liu and Junliang Zhang

      Article first published online: 11 JUL 2009 | DOI: 10.1002/anie.200901628

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      Catalyst is key: The title reaction sequence has been carried out on 1 in the presence of AgSbF6 (5 mol %) in DCE or In(OTf)3 (5 mol %) with MeOH (4 equiv) to afford 2 or 3, respectively, in up to >20:1 ratio (see scheme; DCE=1,2-dichloroethane, Tf=trifluoromethanesulfonyl).

    18. C–H Activation

      Palladium(II)-Catalyzed ortho Alkylation of Benzoic Acids with Alkyl Halides (pages 6097–6100)

      Yang-Hui Zhang, Bing-Feng Shi and Jin-Quan Yu

      Article first published online: 9 JUL 2009 | DOI: 10.1002/anie.200902262

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      Outsmarting the competition: In the PdII-catalyzed reaction of benzoates with alkyl halides, an aryl C[BOND]H bond is activated before the competitive alkylation of the carboxylate anion can takes place. The alkylation reaction was followed by an intramolecular lactonization to give broadly useful γ- and δ-benzolactones (see scheme).

    19. C[BOND]Cl Activation

      Heck Reactions with Palladium Nanoparticles in Ionic Liquids: Coupling of Aryl Chlorides with Deactivated Olefins (pages 6101–6103)

      Vincenzo Calò, Angelo Nacci, Antonio Monopoli and Pietro Cotugno

      Article first published online: 14 JUL 2009 | DOI: 10.1002/anie.200902337

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      Smooth operators: Heck reactions of aryl chlorides were catalyzed by ligand-free palladium acetate in a molten mixture of tetraalkylammonium ionic liquids under aerobic and relatively mild conditions (see example). Deactivated electron-rich aryl chlorides reacted with a wide array of substituted alkenes under these conditions, which thus enabled the coupling of combinations of substrates that are commonly unreactive with traditional catalysts.

    20. Natural Product Synthesis

      Total Synthesis of Celogentin C (pages 6104–6107)

      Bing Ma, Dmitry N. Litvinov, Liwen He, Biplab Banerjee and Steven L. Castle

      Article first published online: 24 JUN 2009 | DOI: 10.1002/anie.200902425

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      Crazy cross-links: The first total synthesis of a member of the celogentin/moroidin family of antimitotic bicyclic peptides features a Knoevenagel condensation–radical conjugate addition sequence to install the Leu[BOND]Trp cross-link and an indole–imidazole oxidative coupling to fashion the Trp[BOND]His cross-link (see structure).

    21. Boron Heterocycles

      Benzo- and Naphthoborepins: Blue-Emitting Boron Analogues of Higher Acenes (pages 6108–6111)

      Lauren G. Mercier, Warren E. Piers and Masood Parvez

      Article first published online: 13 JUL 2009 | DOI: 10.1002/anie.200902803

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      Feelin' Blue: Extended aromatic systems with a borepin core (see picture) can be synthesized by tin–boron exchange. The properties of these air- and moisture-tolerant materials include strong blue fluorescence.

    22. Aromatic Rings

      Selective Synthesis of [12]Cycloparaphenylene (pages 6112–6116)

      Hiroko Takaba, Haruka Omachi, Yosuke Yamamoto, Jean Bouffard and Kenichiro Itami

      Article first published online: 8 JUL 2009 | DOI: 10.1002/anie.200902617

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      Tighten your belt: [12]Cycloparaphenylene, the sidewall segment of a carbon nanotube (see picture), has been synthesized in a selective manner through stepwise palladium-catalyzed coupling reactions. The synthesis capitalizes on the ability of the cis-1,4-dihydroxycyclohexane-1,4-diyl unit to attenuate the build-up of strain energy during macrocyclization.

    23. Perovskites

      Indium-Based Perovskites: A New Class of Near-Room-Temperature Multiferroics (pages 6117–6120)

      Alexei A. Belik, Takao Furubayashi, Yoshitaka Matsushita, Masahiko Tanaka, Shunichi Hishita and Eiji Takayama-Muromachi

      Article first published online: 13 JUL 2009 | DOI: 10.1002/anie.200902827

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      The temperature's rising: New multiferroic perovskites In1−xMxMO3 with x=0.112–0.176 and M=Fe0.5Mn0.5 (see picture) were prepared using high-pressure techniques. They have the same structure as BiFeO3 and high Curie temperatures; in addition, they are canted antiferromagnets with Néel temperatures close to room temperature.

    24. Homogeneous Catalysis

      Chemoselectivity in Catalytic C[BOND]C and C[BOND]H Bond Activation: Controlling Intermolecular Carboacylation and Hydroarylation of Alkenes (pages 6121–6123)

      Michael T. Wentzel, Venkata Jaganmohan Reddy, Todd K. Hyster and Christopher J. Douglas

      Article first published online: 9 JUL 2009 | DOI: 10.1002/anie.200902215

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      It's all under control: The selection between C[BOND]C and C[BOND]H activation pathways in 8-acylquinolines can be influenced by the choice of catalyst and solvent (see scheme; cod=cycloocta-1,5-diene). In this approach, an unstrained C[BOND]C σ bond is activated and subsequent intermolecular carboacylation of an olefin results in the formation of two new C[BOND]C σ bonds.

    25. Nanoporous Materials

      Network Topology of a Hybrid Organic Zinc Phosphate with Bimodal Porosity and Hydrogen Adsorption (pages 6124–6127)

      Shu-Hao Huang, Chia-Her Lin, Wei-Chang Wu and Sue-Lein Wang

      Article first published online: 11 JUL 2009 | DOI: 10.1002/anie.200901744

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      Fill 'er up! A nanoporous hybrid organic zinc phosphate (see picture; [Zn2PO4] columns dark blue) with amine (gray) and aryl carboxylate ligands (cyan) incorporated into the structure has an unusual bimodal porosity and hydrogen gas storage ability.

    26. Protein Labeling

      Segmental Isotopic Labeling of a Central Domain in a Multidomain Protein by Protein Trans-Splicing Using Only One Robust DnaE Intein (pages 6128–6131)

      Alena E. L. Busche, A. Sesilja Aranko, Mehdi Talebzadeh-Farooji, Frank Bernhard, Volker Dötsch and Hideo Iwaï

      Article first published online: 9 JUL 2009 | DOI: 10.1002/anie.200901488

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      A split intein saves nine: A naturally split intein is used to create an efficient three-way ligation method that does not require any refolding steps. This method enables the selective labeling of a central domain within a three-domain protein, with NMR active isotopes (see picture) allowing domain–domain interactions in multidomain proteins to be investigated.

    27. Fluorophores

      A Color-Tunable Europium Complex Emitting Three Primary Colors and White Light (pages 6132–6135)

      Guangjie He, Dong Guo, Cheng He, Xiaolin Zhang, Xiuwen Zhao and Chunying Duan

      Article first published online: 7 JUL 2009 | DOI: 10.1002/anie.200901266

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      Tunable emission colors are shown by a single-component emitter incorporating an EuIII moiety as the origin of red light and an organic ligand comprising coumarin (blue emission) and Rhodamine 6G (green emission) fluorophores. This dye can emit three individual primary colors (blue, green, and red) as well as nearly pure white light (see picture).

    28. Polyoxometalates

      Direct Observation of Contact Ion-Pair Formation in Aqueous Solution (pages 6136–6140)

      Mark R. Antonio, May Nyman and Travis M. Anderson

      Article first published online: 24 APR 2009 | DOI: 10.1002/anie.200805323

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      Nude or neutralized? Small-angle X-ray Scattering (SAXS) measurements provide direct observation of contact ion pairing between the [Nb6O19]8− polyoxometalate and its eight charge-balancing cesium cations in aqueous solution. The radius of gyration (Rg) for Cs8[Nb6O19] and [Nb6O19]8− is shown.

    29. Tautomerism

      Rotational Spectral Signatures of Four Tautomers of Guanine (pages 6141–6143)

      José L. Alonso, Isabel Peña, Juan C. López and Vanesa Vaquero

      Article first published online: 29 JUN 2009 | DOI: 10.1002/anie.200901462

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      By supersonic jet: The rotational spectrum of guanine was investigated by laser ablation molecular beam Fourier transform microwave (LA MB FTMW) spectroscopy. The N7H keto, N9H keto, N9H enol trans, and N9H enol cis forms (see structures) were identified conclusively in the supersonic expansion from the experimental values of the rotational constants.

    30. Helical Structures

      Self-Assembled ABC Triblock Copolymer Double and Triple Helices (pages 6144–6147)

      John Dupont, Guojun Liu, Ken-ichi Niihara, Ryuhei Kimoto and Hiroshi Jinnai

      Article first published online: 7 JUL 2009 | DOI: 10.1002/anie.200901517

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      A new twist on the block: The self-assembly of an achiral linear ABC triblock copolymer in solvents that were poor for the middle B block, good for the C block, and marginal for the A block yielded biomimetic double helices (see image), together with some triple helices. This result was reproduced in three different solvent pairs, thus suggesting that the multiple helices are thermodynamic products.

    31. Domino Reactions

      Electrophilic Activation of Benzaldehydes through ortho Palladation: One-Pot Synthesis of 3-Methylene-indan-1-ols through a Domino Allylstannylation/Heck Reaction under Neutral Conditions (pages 6148–6151)

      Ján Cvengroš, Jutta Schütte, Nils Schlörer, Jörg Neudörfl and Hans-Günther Schmalz

      Article first published online: 9 JUL 2009 | DOI: 10.1002/anie.200901837

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      Active neighbors: The Pd-catalyzed reaction of ortho-iodo- and ortho-trifluoromethanesulfonyloxy(OTf)benzaldehydes with allyltributylstannane gives 3-alkylidene-1-indanols (see scheme). The allylation/Heck reaction involves a new catalytic activation mode: the electrophilic activation of an aldehyde group by a Lewis acidic PdII center generated at the ortho position by oxidative addition. Alkoxystannanes serve as a base equivalent, allowing Heck-type transformations under neutral conditions.

    32. Gold Catalysis

      Evolution of Propargyl Ethers into Allylgold Cations in the Cyclization of Enynes (pages 6152–6155)

      Eloísa Jiménez-Núñez, Mihai Raducan, Thorsten Lauterbach, Kian Molawi, César R. Solorio and Antonio M. Echavarren

      Article first published online: 11 JUL 2009 | DOI: 10.1002/anie.200902248

      Thumbnail image of graphical abstract

      Shifty moves: 1,n-Enynes with propargyl alcohol, ether, or silyl ether units undergo gold(I)-catalyzed intramolecular 1,(n−1)-migration via allylgold cations (see scheme). These intermediates have been trapped by olefins, indole, and by a formal intramolecular C[BOND]H insertion. In the case of aryl-substituted 1,7-enynes, a cascade process involving a Nazarov-type cyclization leads to 6,7-dihydro-5H-benzo[c]fluorenes.

    33. Host–Guest Systems

      Copper(I) Cuboctahedral Coordination Cages: Host–Guest Dependent Redox Activity (pages 6156–6159)

      Qi-Ting He, Xiang-Ping Li, Yu Liu, Zhi-Quan Yu, Wei Wang and Cheng-Yong Su

      Article first published online: 8 JUL 2009 | DOI: 10.1002/anie.200902276

      Thumbnail image of graphical abstract

      Redox-active cage: Cu+ coordination cages were assembled from a triangular benzimidazole-based ligand. The cages have cuboctahedral shaped cavities and their redox activity can be tuned by the guest anions.

    34. Organic–Inorganic Hybrids

      Size-Selective Sorption of Small Organic Molecules in One-Dimensional Channels of an Ionic Crystalline Organic–Inorganic Hybrid Compound Stabilized by π–π Interactions (pages 6160–6164)

      Hanae Tagami, Sayaka Uchida and Noritaka Mizuno

      Article first published online: 11 JUL 2009 | DOI: 10.1002/anie.200902681

      Thumbnail image of graphical abstract

      Very selective: The cross-sectional area of the narrowest channel opening in an organic–inorganic porous ionic crystal that possesses one-dimensional channels is around 30 Å2. The compound sorbs molecules such as propane, 1-propanol, and 1,2-dichloroethane, which have cross-sectional areas smaller than the channel opening, while n-butane, 1-butanol, and 1,2-dichloropropane are excluded (see picture).

    35. Self-Assembly

      Trimeric Cyclic Assemblies of Calix[4]arene-Tethered Bismerocyanines (pages 6165–6168)

      Andreas Lohr, Shinobu Uemura and Frank Würthner

      Article first published online: 7 JUL 2009 | DOI: 10.1002/anie.200902299

      Thumbnail image of graphical abstract

      One ring to bind them: A cyclic complex containing three calixarene–bismerocyanine conjugates self-assembles by the pairing of chromophores (see picture). A simple mathematical model is introduced for the trimolecular association, and the potential of dipolar aggregation of merocyanine dyes as a directional and specific supramolecular binding motif is demonstrated. (Calixarenes: green; merocyanines: C pale blue, N dark blue, O red).

  10. Preview

    1. Top of page
    2. Cover Picture
    3. Inside Cover
    4. Graphical Abstract
    5. News
    6. Author Profile
    7. Book Review
    8. Highlights
    9. Review
    10. Communications
    11. Preview
    1. Preview: Angew. Chem. Int. Ed. 34/2009 (page 6173)

      Article first published online: 29 JUL 2009 | DOI: 10.1002/anie.200990174

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