Angewandte Chemie International Edition

Cover image for Vol. 48 Issue 38

September 7, 2009

Volume 48, Issue 38

Pages 6923–7101

  1. Cover Picture

    1. Top of page
    2. Cover Picture
    3. Inside Cover
    4. Graphical Abstract
    5. Corrigenda
    6. News
    7. Author Profile
    8. Book Review
    9. Highlights
    10. Minireview
    11. Review
    12. Communications
    13. Preview
    1. Cover Picture: Kinetics of Thiol/Disulfide Exchange Correlate Weakly with the Restoring Force in the Disulfide Moiety (Angew. Chem. Int. Ed. 38/2009) (page 6923)

      Timothy J. Kucharski, Zhen Huang, Qing-Zheng Yang, Yancong Tian, Nicholas C. Rubin, Carlos D. Concepcion and Roman Boulatov

      Article first published online: 1 SEP 2009 | DOI: 10.1002/anie.200990196

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      Increasing the strain in a series of macrocyclic disulfides was used to show that the kinetics of thiol/disulfide exchange is independent of force. The seemingly counterintuitive finding that pulling on a molecule does not accelerate its fragmentation is presented by R. Boulatov and co-workers on page 7040 ff. These results are consistent with the SN2 mechanism of thiol/disulfide exchange and the simplest model of chemomechanical kinetics.

  2. Inside Cover

    1. Top of page
    2. Cover Picture
    3. Inside Cover
    4. Graphical Abstract
    5. Corrigenda
    6. News
    7. Author Profile
    8. Book Review
    9. Highlights
    10. Minireview
    11. Review
    12. Communications
    13. Preview
    1. Inside Cover: Writing Self-Erasing Images using Metastable Nanoparticle “Inks” (Angew. Chem. Int. Ed. 38/2009) (page 6924)

      Rafal Klajn, Paul J. Wesson, Kyle J. M. Bishop and Bartosz A. Grzybowski

      Article first published online: 1 SEP 2009 | DOI: 10.1002/anie.200990197

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      Light-sensitive inks for self-erasing images are formed from metal nanoparticles (NPs) covered with photoswitchable ligands dispersed in a polymer film, as described by B. A. Grzybowski and co-workers on page 7035 ff. Upon exposure to UV light, the NPs form metastable aggregates; the apparent color corresponds to the degree of aggregation. In the absence of light, the aggregates fall apart and the images gradually self-erase. Multicolor images can be also be created with a single NP ink.

  3. Graphical Abstract

    1. Top of page
    2. Cover Picture
    3. Inside Cover
    4. Graphical Abstract
    5. Corrigenda
    6. News
    7. Author Profile
    8. Book Review
    9. Highlights
    10. Minireview
    11. Review
    12. Communications
    13. Preview
    1. Graphical Abstract: Angew. Chem. Int. Ed. 38/2009 (pages 6927–6938)

      Article first published online: 1 SEP 2009 | DOI: 10.1002/anie.200990198

  4. Corrigenda

    1. Top of page
    2. Cover Picture
    3. Inside Cover
    4. Graphical Abstract
    5. Corrigenda
    6. News
    7. Author Profile
    8. Book Review
    9. Highlights
    10. Minireview
    11. Review
    12. Communications
    13. Preview
    1. You have free access to this content
      Chiral Neutral Zirconium Amidate Complexes for the Asymmetric Hydroamination of Alkenes (page 6937)

      Mark C. Wood, David C. Leitch, Charles S. Yeung, Jennifer A. Kozak and Laurel L. Schafer

      Article first published online: 1 SEP 2009 | DOI: 10.1002/anie.200990199

      This article corrects:

      Chiral Neutral Zirconium Amidate Complexes for the Asymmetric Hydroamination of Alkenes1

      Vol. 46, Issue 3, 354–358, Article first published online: 9 OCT 2006

    2. You have free access to this content
      Highly Regio- and Enantioselective Copper-Catalyzed Hydroboration of Styrenes (page 6938)

      Dongwan Noh, Heesung Chea, Junghwan Ju and Jaesook Yun

      Article first published online: 1 SEP 2009 | DOI: 10.1002/anie.200990200

      This article corrects:

      Highly Regio- and Enantioselective Copper-Catalyzed Hydroboration of Styrenes1

      Vol. 48, Issue 33, 6062–6064, Article first published online: 9 JUL 2009

    3. You have free access to this content
      Iron-Catalyzed Dehydrogenative Coupling of Tertiary Silanes (page 6938)

      Masumi Itazaki, Kensuke Ueda and Hiroshi Nakazawa

      Article first published online: 1 SEP 2009 | DOI: 10.1002/anie.200990203

      This article corrects:

      Iron-Catalyzed Dehydrogenative Coupling of Tertiary Silanes1

      Vol. 48, Issue 18, 3313–3316, Article first published online: 31 MAR 2009

  5. News

    1. Top of page
    2. Cover Picture
    3. Inside Cover
    4. Graphical Abstract
    5. Corrigenda
    6. News
    7. Author Profile
    8. Book Review
    9. Highlights
    10. Minireview
    11. Review
    12. Communications
    13. Preview
  6. Author Profile

    1. Top of page
    2. Cover Picture
    3. Inside Cover
    4. Graphical Abstract
    5. Corrigenda
    6. News
    7. Author Profile
    8. Book Review
    9. Highlights
    10. Minireview
    11. Review
    12. Communications
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    1. Masakatsu Shibasaki (pages 6944–6946)

      Article first published online: 31 AUG 2009 | DOI: 10.1002/anie.200904210

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      “The most significant scientific advances of the last 100 years have been the discovery of penicillin and the development of vaccines for various infections. If I could be anyone for a day, I would be a novelist. …” This and more about Masakatsu Shibasaki can be found on page 6944.

  7. Book Review

    1. Top of page
    2. Cover Picture
    3. Inside Cover
    4. Graphical Abstract
    5. Corrigenda
    6. News
    7. Author Profile
    8. Book Review
    9. Highlights
    10. Minireview
    11. Review
    12. Communications
    13. Preview
    1. The Mizoroki–Heck Reaction. Edited by Martin Oestreich. (page 6947)

      Christian Frech

      Article first published online: 1 SEP 2009 | DOI: 10.1002/anie.200903122

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      John Wiley & Sons, Hoboken 2009. 608 pp., hardcover € 119.00.—ISBN 978-0470033944

  8. Highlights

    1. Top of page
    2. Cover Picture
    3. Inside Cover
    4. Graphical Abstract
    5. Corrigenda
    6. News
    7. Author Profile
    8. Book Review
    9. Highlights
    10. Minireview
    11. Review
    12. Communications
    13. Preview
    1. Rotaxanes

      The Marriage of Inorganic and Organic Building Blocks for the Assembly of Rotaxanes (pages 6948–6949)

      Euan K. Brechin and Leroy Cronin

      Article first published online: 15 AUG 2009 | DOI: 10.1002/anie.200902228

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      Take this ring … Hybrid organic–inorganic rotaxanes can be prepared using a thread incorporating an alkyl ammonium functionality to template the self-assembly of an inorganic wheel cluster. This approach was used to assemble a range of examples, including a system combining two rings and two threads (see picture; C gray, H white, O red, Cu orange, Cr blue-gray, N blue, F light blue).

    2. Bicyclic Cyclopentenes

      A Palladium-Catalyzed Formal (4+1) Annulation: A New Approach to Cyclopentene Construction (pages 6950–6952)

      Ross A. Widenhoefer

      Article first published online: 7 AUG 2009 | DOI: 10.1002/anie.200902404

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      Juggling rings: A novel two-step procedure achieves the formal (4+1) annulation of a conjugated diene with a β-keto ester to form a functionalized cyclopentene in good yield under mild conditions. The transformation involves a palladium-catalyzed intramolecular oxidative cyclopropanation of an ε-dienyl β-keto ester followed by magnesium iodide mediated rearrangement of the resulting vinyl cyclopropane.

  9. Minireview

    1. Top of page
    2. Cover Picture
    3. Inside Cover
    4. Graphical Abstract
    5. Corrigenda
    6. News
    7. Author Profile
    8. Book Review
    9. Highlights
    10. Minireview
    11. Review
    12. Communications
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    1. Coupling Reactions

      Catalytic C[BOND]C, C[BOND]N, and C[BOND]O Ullmann-Type Coupling Reactions (pages 6954–6971)

      Florian Monnier and Marc Taillefer

      Article first published online: 13 AUG 2009 | DOI: 10.1002/anie.200804497

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      Back to the future: Major achievements have been made in copper-catalyzed Ullmann reactions since its renaissance in the early 2000s. This Minireview highlights developments since 2004 in the corresponding intermolecular arylations and vinylations of N, O, and C nucleophiles by aromatic and vinyl halides under homogeneous and heterogeneous conditions (see scheme; EWG=electron-withdrawing group, EDG=electron-donating group).

  10. Review

    1. Top of page
    2. Cover Picture
    3. Inside Cover
    4. Graphical Abstract
    5. Corrigenda
    6. News
    7. Author Profile
    8. Book Review
    9. Highlights
    10. Minireview
    11. Review
    12. Communications
    13. Preview
    1. Bioorthogonal Chemistry

      Bioorthogonal Chemistry: Fishing for Selectivity in a Sea of Functionality (pages 6974–6998)

      Ellen M. Sletten and Carolyn R. Bertozzi

      Article first published online: 27 AUG 2009 | DOI: 10.1002/anie.200900942

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      Being specific: A combination of selective chemical transformations and methods to modify biological species has yielded new insights into cellular processes. Key to these new techniques are bioorthogonal chemical reactions, whose components must react rapidly and selectively with each other under physiological conditions in the presence of the plethora of functionality found within living systems.

  11. Communications

    1. Top of page
    2. Cover Picture
    3. Inside Cover
    4. Graphical Abstract
    5. Corrigenda
    6. News
    7. Author Profile
    8. Book Review
    9. Highlights
    10. Minireview
    11. Review
    12. Communications
    13. Preview
    1. Holographic Lithography

      Holographic Fabrication of Microstructures with Internal Nanopatterns Using Microprism Arrays (pages 7000–7005)

      Seung-Kon Lee, Hyo Sung Park, Gi-Ra Yi, Jun Hyuk Moon and Seung-Man Yang

      Article first published online: 27 MAY 2009 | DOI: 10.1002/anie.200901166

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      Through the looking glass: Holographic lithography through a microprism array enables the production of microstructured arrays with 3D internal nanoscale features (see picture). In a single-step exposure of 0.1 s, thousands of features are generated in a spot size of about 1 cm2. They exhibit 14-times enhanced fluorescence compared with conventional microarrays.

    2. Molecular Capsules

      Induced-Fit Formation of a Tetrameric Organic Capsule Consisting of Hexagram-Shaped Amphiphile Molecules (pages 7006–7009)

      Shuichi Hiraoka, Koji Harano, Takashi Nakamura, Motoo Shiro and Mitsuhiko Shionoya

      Article first published online: 22 AUG 2009 | DOI: 10.1002/anie.200902652

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      Fitting in: Hexagram-shaped amphiphiles self-assemble in the presence of a spherical, hydrophobic guest molecule to form a tetrahedron-shaped tetrameric organic capsule in an aqueous methanol solution (see picture). In the presence of adamantane, an aqueous solution of a box-shaped hexameric capsule composed of hexagram-shaped amphiphiles was converted into a novel 1.7 nm sized tetrameric capsule that has an encapsulated adamantane template molecule.

    3. Anion Recognition

      Inclusion of Anionic Guests inside a Molecular Cage with Palladium(II) Centers as Electrostatic Anchors (pages 7010–7012)

      Guido H. Clever, Shohei Tashiro and Mitsuhiko Shionoya

      Article first published online: 13 AUG 2009 | DOI: 10.1002/anie.200902717

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      Anchors away! Four banana-shaped ligands and two PdII ions assemble quantitatively to form a ball-shaped object with four large portals (see picture). The two PdII ions form stable, square-planar complexes with the pyridyl donors of the ligands, but can undergo further interactions with anions. Their positioning in a confined distance by the rigid ligands make them act as electrostatic anchors for dianionic guests of a certain size.

    4. Live-Cell Imaging

      Fast and Sensitive Pretargeted Labeling of Cancer Cells through a Tetrazine/trans-Cyclooctene Cycloaddition (pages 7013–7016)

      Neal K. Devaraj, Rabi Upadhyay, Jered B. Haun, Scott A. Hilderbrand and Ralph Weissleder

      Article first published online: 20 AUG 2009 | DOI: 10.1002/anie.200903233

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      A label for six, please! A fluorescent tetrazine derivative was used to image trans-cyclooctene-modified affinity ligands on live cancer cells through a bioorthogonal cycloaddition with a reaction rate of approximately 6000±200 M−1 s−1 in serum at 37 °C (see scheme). To maximize the fluorescence signal, up to six trans-cyclooctene moieties were attached to the antibody used to pretarget cells for labeling.

    5. Oxygenation Reactions

      Transformation of Ethylzinc Species to Zinc Acetate Mediated by O2 Activation: Reactive Oxygen-Centered Radicals Under Control (pages 7017–7020)

      Janusz Lewiński, Marek Kościelski, Karolina Suwała and Iwona Justyniak

      Article first published online: 18 AUG 2009 | DOI: 10.1002/anie.200902716

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      The controlled oxygenation of ethylzinc complexed with a tridentate pyrroloimine leads to an unprecedented transformation of the resulting ethylperoxide into an acetate. The zinc acetate appears to form without involvement of redox-active metal centers by a combination of O[BOND]O bond activation and multiple rearrangements of ZnO. and .OEt radical species.

    6. Activator Mapping

      A High-Resolution Interaction Map of Three Transcriptional Activation Domains with a Key Coactivator from Photo-Cross-Linking and Multiplexed Mass Spectrometry (pages 7021–7024)

      Chinmay Y. Majmudar, Bo Wang, Jenifer K. Lum, Kristina Håkansson and Anna K. Mapp

      Article first published online: 13 AUG 2009 | DOI: 10.1002/anie.200902669

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      Binding with distinction: Photo-cross-linking followed by the complementary use of ESI and MALDI mass spectrometric techniques yielded the interaction sites of three prototypical amphipathic transcriptional activators (represented by different-colored helices in the picture) with the coactivator Med15. Investigation of the functional relevance of these sites in yeast revealed overlapping yet distinct binding patterns for the activators investigated.

    7. Synthetic Methods

      Direct, Chemoselective N-tert-Prenylation of Indoles by C[BOND]H Functionalization (pages 7025–7029)

      Michael R. Luzung, Chad A. Lewis and Phil S. Baran

      Article first published online: 22 AUG 2009 | DOI: 10.1002/anie.200902761

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      Four steps in one: The direct prenylation of indoles at N-1 can be achieved by C[BOND]H functionalization in the presence of a PdII source. This reaction proceeds by direct intermolecular olefin amination, tolerates a broad range of functional groups, and can be carried out on a gram scale, as demonstrated by the formal syntheses of a number of natural products and the synthesis of an antifungal natural product (see scheme).

    8. Fluorescent Organogels

      Dual-Mode Switching in Highly Fluorescent Organogels: Binary Logic Gates with Optical/Thermal Inputs (pages 7030–7034)

      Jong Won Chung, Seong-Jun Yoon, Seon-Jeong Lim, Byeong-Kwan An and Soo Young Park

      Article first published online: 18 AUG 2009 | DOI: 10.1002/anie.200902777

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      An on/off relationship: A supramolecular binary “OR” logic gate that generates highly enhanced fluorescence emission as the output signal is demonstrated (see picture). The system comprises a mixture of organogelator and photochromic compound and is able to process dual inputs of UV irradiation and thermal heating.

    9. Self-Erasing Paper

      Writing Self-Erasing Images using Metastable Nanoparticle “Inks” (pages 7035–7039)

      Rafal Klajn, Paul J. Wesson, Kyle J. M. Bishop and Bartosz A. Grzybowski

      Article first published online: 16 JUN 2009 | DOI: 10.1002/anie.200901119

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      Mission Impossible: Metal nanoparticles (NPs) coated with photoresponsive ligands are used as “inks” for self-erasing “paper” whereby light-induced self-assembly of the NPs is transduced into local color changes (see picture). Depending on the degree of self-assembly, multicolor images can be written using only one type of NP ink. Duration of image erasure is regulated by the surface concentration of photoactive groups and can range from seconds to days.

    10. Force-Dependent Kinetics

      Kinetics of Thiol/Disulfide Exchange Correlate Weakly with the Restoring Force in the Disulfide Moiety (pages 7040–7043)

      Timothy J. Kucharski, Zhen Huang, Qing-Zheng Yang, Yancong Tian, Nicholas C. Rubin, Carlos D. Concepcion and Roman Boulatov

      Article first published online: 16 JUN 2009 | DOI: 10.1002/anie.200901511

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      S-S-Stretch! A series of increasingly strained macrocyclic disulfides investigated experimentally and by high-level DFT calculations reveals that the kinetics of thiol/disulfide exchange are independent of the restoring force in the disulfide moiety. This finding is consistent with the SN2 mechanism of thiol/disulfide exchange and lends insight into the acceleration of disulfide reduction upon stretching of certain proteins.

    11. Fluorescent Probes

      In-Stem Molecular Beacon Containing a Pseudo Base Pair of Threoninol Nucleotides for the Removal of Background Emission (pages 7044–7047)

      Hiromu Kashida, Tomohiko Takatsu, Taiga Fujii, Koji Sekiguchi, Xingguo Liang, Kosuke Niwa, Tomokazu Takase, Yasuko Yoshida and Hiroyuki Asanuma

      Article first published online: 24 AUG 2009 | DOI: 10.1002/anie.200902367

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      Off means off: An in-stem molecular beacon in which D-threoninol units tether perylene and anthraquinone in the stem region effectively detected target sequences and was able to discriminate a one-base-deletion mutant from the wild-type (full-match) sequence without background emission (see picture).

    12. Porous Hollow Structures

      A General Single-Source Route for the Preparation of Hollow Nanoporous Metal Oxide Structures (pages 7048–7051)

      Lianzhou Wang, Fengqiu Tang, Kiyoshi Ozawa, Zhi-Gang Chen, Aniruddh Mukherj, Yingchun Zhu, Jin Zou, Hui-Ming Cheng and G. Q. (Max) Lu

      Article first published online: 24 AUG 2009 | DOI: 10.1002/anie.200900539

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      A hole in one: Hollow nanoporous structures are prepared by controlled decomposition–dissolution. The partial thermal decomposition of transition-metal salts forms a metal oxide shell on the surface of the metal salt particles. Acid washing removes the metal salt cores, resulting in hollow nanoporous metal oxide shells (see picture). This new strategy provides a template-free single-source route to hollow structures.

    13. Disiloxanes

      The Photochemical Irradiation of R3SiH in the Presence of [(η5-C5H5)Fe(CO)2CH3] in DMF Leads to Disiloxanes not Disilanes (pages 7052–7054)

      Hemant K. Sharma and Keith H. Pannell

      Article first published online: 22 AUG 2009 | DOI: 10.1002/anie.200903021

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      Not Si[BOND]Si, rather Si[BOND]O[BOND]Si: Dimethylformamide (DMF) acts as an oxygen source in the efficient transformation of tertiary silanes (R3SiH; R3=Ph2Me, PhMe2, Et3) into disiloxanes R3Si[BOND]O[BOND]SiR3 in the presence of the catalyst [(η5-C5H5)Fe(CO)2CH3] (1; see scheme). This result contradicts a recently published related study, in which the formation of disilanes is reported.

    14. Polyoxometalates

      Inorganic Cryptand: Size-Selective Strong Metallic Cation Encapsulation by a Disilicoicosatungstate (Si2W20) Polyoxometalate (pages 7055–7058)

      Akihiro Yoshida, Yoshinao Nakagawa, Kazuhiro Uehara, Shiro Hikichi and Noritaka Mizuno

      Article first published online: 24 AUG 2009 | DOI: 10.1002/anie.200903275

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      A select club: The polyoxometalate [(γ-SiW10O32)2(μ-O)4]8− (18−) has a cavity that can size-selectively encapsulate the ions Pb2+, Sr2+, Na+, Ag+, K+, and Rb+ (see picture, light blue; Si hidden, W gray, O red). Larger Ba2+ and Cs+ ions (pink) are not encapsulated by 1. The molecular structures of [Mn+1](8−n)− (Mn+=Pb2+, Sr2+, Ag+, Ba2+) were characterized by X-ray crystallography.

    15. Metallostructures

      Predesigned Hexanuclear CuII and CuII/NiII Metallacycles Featuring Six-Node Metallacoronand Structural Motifs (pages 7059–7063)

      Feng Li, Jack K. Clegg, Paul Jensen, Keith Fisher, Leonard F. Lindoy, George V. Meehan, Boujemaa Moubaraki and Keith S. Murray

      Article first published online: 17 AUG 2009 | DOI: 10.1002/anie.200903185

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      Crowning glory: The assembly of CuII or CuII and NiII and a new 1,4-aryl-linked bis(triketonato) ligand designed to adopt a ‘bent’ configuration leads to unusual Cu6−nNinL3 (n=0, 3) metallacycles that feature unique hexanuclear metallacoronand structural motifs. In the case of the hexanuclear CuII species, strong antiferromagnetic interactions exist between proximate pairs of metal ions in each structure.

    16. Tandem Catalysis

      Efficient Synthesis of Benzothiophenes by an Unusual Palladium-Catalyzed Vinylic C[BOND]S Coupling (pages 7064–7068)

      Christopher S. Bryan, Julia A. Braunger and Mark Lautens

      Article first published online: 18 AUG 2009 | DOI: 10.1002/anie.200902843

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      The simultaneous construction of a C[BOND]S and a C[BOND]C bond under catalytic conditions forms the basis of an efficient route to diversely functionalized benzothiophenes from gem-dihalovinyl thiophenols. The C[BOND]C bond can be formed in this tandem catalytic process with an organoboron reagent as shown in the scheme (R1=H, Me, F, Cl, Br, [BOND]OCH2O[BOND]; R2=H, Me; R3=aryl, heteroaryl, alkenyl, alkyl), or by Heck or Sonogashira coupling with an alkene or alkyne.

    17. Chirality

      Trityl Ethers: Molecular Bevel Gears Reporting Chirality through Circular Dichroism Spectra (pages 7069–7072)

      Jacek Ściebura, Paweł Skowronek and Jacek Gawronski

      Article first published online: 17 AUG 2009 | DOI: 10.1002/anie.200902167

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      More than a protecting group: The trityl group senses the chirality of an alkyl substituent in chiral trityl ethers. The CD spectra of trityl-protected alcohols are highly sensitive to the chirality of the alcohol. The use of a trityl CD sensor provides new insight into the structure and mode of action of chiral molecular bevel gears and shows the relation between the absolute configurations of molecules and their Cotton effect patterns.

    18. Layer-By-Layer Films

      Diffusional Self-Organization in Exponential Layer-By-Layer Films with Micro- and Nanoscale Periodicity (pages 7073–7077)

      Paul Podsiadlo, Marc Michel, Kevin Critchley, Sudhanshu Srivastava, Ming Qin, Jung Woo Lee, Eric Verploegen, A. John Hart, Ying Qi and Nicholas A. Kotov

      Article first published online: 20 AUG 2009 | DOI: 10.1002/anie.200901720

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      The layer-by-layer deposition of poly(diallyldimethylammonium chloride) and poly(acrylic acid) incorporating inorganic sheets of sodium montmorillonite clay leads to a stratified structure throughout the film interior, with micrometer-thick polymer complex layers and thin clay strata (see picture; right: cross-section).

    19. Nanoparticle Assembly

      One-Dimensional Gold Nanoparticle Arrays by Electrostatically Directed Organization Using Polypeptide Self-Assembly (pages 7078–7082)

      Nikhil Sharma, Ayben Top, Kristi L. Kiick and Darrin J. Pochan

      Article first published online: 18 AUG 2009 | DOI: 10.1002/anie.200901621

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      Evenly spaced arrays: The unique molecular architecture of a self-assembled polypeptide template allows the electrostatic deposition of nanoparticles with uniform interparticle spacing. The hierarchical self-assembly mode of the polypeptide results in the display of charged patches at periodic distances along the length of the fibril architecture (see picture).

    20. Fluorination

      Electrophilic Fluorocyclization of Allyl Silanes (pages 7083–7086)

      Susan C. Wilkinson, Oscar Lozano, Marie Schuler, Maria C. Pacheco, Roger Salmon and Véronique Gouverneur

      Article first published online: 20 AUG 2009 | DOI: 10.1002/anie.200901795

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      A refreshing cascade: General fluorocyclization reactions will breathe new life into the use of fluorinated hetero- and carbocycles as pharmaceuticals and agrochemicals. Allyl silanes have now been shown to undergo fluorination–cyclization with N[BOND]F reagents to give cis- and trans-substituted fluorinated heterocycles selectively (see scheme). The correct choice of silyl group was critical to prevent competitive fluorodesilylation.

    21. Metal–Organic Frameworks

      The Effect of Pressure on ZIF-8: Increasing Pore Size with Pressure and the Formation of a High-Pressure Phase at 1.47 GPa (pages 7087–7089)

      Stephen A. Moggach, Thomas D. Bennett and Anthony K. Cheetham

      Article first published online: 13 AUG 2009 | DOI: 10.1002/anie.200902643

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      The big squeeze: On applying pressure to ZIF-8 (0.18 GPa), solvent can be squeezed into the porous cavities, initially increasing the pore size and unit-cell volume. On increasing pressure further to 1.47 GPa, a phase transition takes place (see picture). This transition allows more solvent to enter the original nanopores and enlarges the narrow channels connecting these pores, resulting in higher porous volume and solvent content.

    22. Synthetic Methods

      Molybdenum(0)-Promoted Carbonylative Cyclization of o-Haloaryl- and β-Haloalkenylimine Derivatives by Oxidative Addition of a Carbon(sp2)[BOND]Halogen Bond: Preparation of Two Types of γ-Lactams (pages 7090–7093)

      Jun Takaya, Kenichiro Sangu and Nobuharu Iwasawa

      Article first published online: 24 AUG 2009 | DOI: 10.1002/anie.200902884

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      Lovely lactams: Synthetically useful γ-lactam derivatives have been prepared through the unique title transformation. By utilizing the characteristic property of the molybdenum complex, two kinds of products (both of which have rarely been obtained by reactions catalyzed by late transition metals) were obtained selectively by adjusting the reaction conditions (see scheme).

    23. Aryl Nitriles

      Direct Transformation of Methyl Arenes to Aryl Nitriles at Room Temperature (pages 7094–7097)

      Wang Zhou, Liangren Zhang and Ning Jiao

      Article first published online: 24 AUG 2009 | DOI: 10.1002/anie.200903838

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      Three C[BOND]H bonds are cleaved in the direct transformation of methyl arenes to aryl nitriles under mild and neutral conditions (see scheme). This new synthetic tool may not only be used to construct synthetically and medicinally important aryl nitriles, it also achieves C[BOND]H functionalization under mild conditions. PIDA=phenyliodonium diacetate.

  12. Preview

    1. Top of page
    2. Cover Picture
    3. Inside Cover
    4. Graphical Abstract
    5. Corrigenda
    6. News
    7. Author Profile
    8. Book Review
    9. Highlights
    10. Minireview
    11. Review
    12. Communications
    13. Preview
    1. Preview: Angew. Chem. Int. Ed. 39/2009 (page 7101)

      Article first published online: 1 SEP 2009 | DOI: 10.1002/anie.200990202

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