Angewandte Chemie International Edition

Cover image for Vol. 48 Issue 39

September 14, 2009

Volume 48, Issue 39

Pages 7103–7265

  1. Cover Picture

    1. Top of page
    2. Cover Picture
    3. Inside Cover
    4. Graphical Abstract
    5. News
    6. Author Profile
    7. Book Reviews
    8. Highlights
    9. Minireview
    10. Review
    11. Communications
    12. Preview
    1. Cover Picture: Microscale Control of Stiffness in a Cell-Adhesive Substrate Using Microfluidics-Based Lithography (Angew. Chem. Int. Ed. 39/2009) (page 7103)

      Yuk Kee Cheung, Evren U. Azeloglu, David A. Shiovitz, Kevin D. Costa, Dror Seliktar and Samuel K. Sia

      Version of Record online: 9 SEP 2009 | DOI: 10.1002/anie.200990204

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      Microfluidics-based lithography is used to pattern a cell-adhesive hydrogel substrate with microscale variations in stiffness that can mimic those of native tissues. As shown by S. K. Sia and co-workers in their Communication on page 7188 ff., the micropatterns are fabricated by delivering PEG-fibrinogen and various amounts of poly(ethylene glycol) diacrylate (PEGDA) into a microfluidic chamber. Cells are then placed on top of the micropatterns to study their interactions with the extracellular matrix.

  2. Inside Cover

    1. Top of page
    2. Cover Picture
    3. Inside Cover
    4. Graphical Abstract
    5. News
    6. Author Profile
    7. Book Reviews
    8. Highlights
    9. Minireview
    10. Review
    11. Communications
    12. Preview
    1. Inside Cover: Poly(polyoxotungstate)s with 20 Nickel Centers: From Nanoclusters to One-Dimensional Chains (Angew. Chem. Int. Ed. 39/2009) (page 7104)

      Shou-Tian Zheng, Jie Zhang, Juan Modesto Clemente-Juan, Da-Qiang Yuan and Guo-Yu Yang

      Version of Record online: 9 SEP 2009 | DOI: 10.1002/anie.200990205

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      The greatest number of nickel ions incorporated into polyoxometalates to date are reported by G.-Y. Yang et al. in their Communication on page 7176 ff. The two largest nickel-substituted poly(polyoxotungstate)s are prepared by degradation reactions and structural directing effects of trilacunary Keggin {B-α-PW9O34} fragments under hydrothermal conditions in the presence of nickel ions.

  3. Graphical Abstract

    1. Top of page
    2. Cover Picture
    3. Inside Cover
    4. Graphical Abstract
    5. News
    6. Author Profile
    7. Book Reviews
    8. Highlights
    9. Minireview
    10. Review
    11. Communications
    12. Preview
  4. News

    1. Top of page
    2. Cover Picture
    3. Inside Cover
    4. Graphical Abstract
    5. News
    6. Author Profile
    7. Book Reviews
    8. Highlights
    9. Minireview
    10. Review
    11. Communications
    12. Preview
  5. Author Profile

    1. Top of page
    2. Cover Picture
    3. Inside Cover
    4. Graphical Abstract
    5. News
    6. Author Profile
    7. Book Reviews
    8. Highlights
    9. Minireview
    10. Review
    11. Communications
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    1. Timothy J. Donohoe (page 7119)

      Version of Record online: 8 SEP 2009 | DOI: 10.1002/anie.200903879

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      “If I could be anyone for a day, I would be Barack Obama. The secret of being a successful scientist is dedication, integrity and hard work. …” This and more about Timothy J. Donohoe can be found on page 7121.

  6. Book Reviews

    1. Top of page
    2. Cover Picture
    3. Inside Cover
    4. Graphical Abstract
    5. News
    6. Author Profile
    7. Book Reviews
    8. Highlights
    9. Minireview
    10. Review
    11. Communications
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    1. Green Catalysis.1–3. Edited by Robert H. Crabtree. (pages 7120–7121)

      Julia J. Neumann and Frank Glorius

      Version of Record online: 9 SEP 2009 | DOI: 10.1002/anie.200903584

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      Wiley-VCH, Weinheim 2009. 1082 pp., hardcover € 499.00.—ISBN 978-3527315772

    2. Calixarenes and Resorcinarenes.Synthesis, Properties and Applications. By Wanda Sliwa and Cezary Kozlowski. (pages 7121–7122)

      Jack Harrowfield

      Version of Record online: 9 SEP 2009 | DOI: 10.1002/anie.200903182

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      Wiley-VCH, Weinheim 2009. 316 pp., hardcover € 129.00.—ISBN 978-3527322633

  7. Highlights

    1. Top of page
    2. Cover Picture
    3. Inside Cover
    4. Graphical Abstract
    5. News
    6. Author Profile
    7. Book Reviews
    8. Highlights
    9. Minireview
    10. Review
    11. Communications
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    1. Asymmetric Catalysis

      Asymmetric Reductive Amination by Combined Brønsted Acid and Transition-Metal Catalysis (pages 7124–7125)

      Martin Klussmann

      Version of Record online: 28 AUG 2009 | DOI: 10.1002/anie.200903765

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      The best of both worlds: A combination of organocatalysis and transition-metal catalysis serve in the highly stereoselective and atom-economical reductive amination of a broad range of ketones. A chiral Brønsted acid catalyst facilitates the formation of protonated imines in situ and serves as chiral counteranion, while a chiral iridium complex catalyzes the reduction with elemental hydrogen.

    2. C[BOND]H Activation

      Meta-Selective Transition-Metal Catalyzed Arene C[BOND]H Bond Functionalization (pages 7126–7128)

      Yang Zhou, Jing Zhao and Lei Liu

      Version of Record online: 4 AUG 2009 | DOI: 10.1002/anie.200902762

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      The selectivity is meta! Recent developments on transition-metal catalyzed meta-selective C[BOND]H functionalization are highlighted (see scheme; EDG=electron-donating group, EWG=electron-withdrawing group). The method is complementary to traditional methodologies and might provide numerous opportunities to access previously difficult organic products. Possible mechanisms are discussed.

  8. Minireview

    1. Top of page
    2. Cover Picture
    3. Inside Cover
    4. Graphical Abstract
    5. News
    6. Author Profile
    7. Book Reviews
    8. Highlights
    9. Minireview
    10. Review
    11. Communications
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    1. Mass Spectrometry

      Ultraviolet Photodissociation: Developments towards Applications for Mass-Spectrometry-Based Proteomics (pages 7130–7137)

      Tony Ly and Ryan R. Julian

      Version of Record online: 16 JUL 2009 | DOI: 10.1002/anie.200900613

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      Shedding light on proteomics: The chemical diversity found in proteins presents a tremendous challenge for proteome analysis. Recent developments in ultraviolet photodissociation mass spectrometry (see illustration of selective fragmentation in a protein) have provided promising analytical tools for proteomics, particularly with respect to selective fragmentation, de novo sequencing, and the identification of posttranslational modifications.

  9. Review

    1. Top of page
    2. Cover Picture
    3. Inside Cover
    4. Graphical Abstract
    5. News
    6. Author Profile
    7. Book Reviews
    8. Highlights
    9. Minireview
    10. Review
    11. Communications
    12. Preview
    1. Samarium Diiodide

      Samarium Diiodide Mediated Reactions in Total Synthesis (pages 7140–7165)

      K. C. Nicolaou, Shelby P. Ellery and Jason S. Chen

      Version of Record online: 27 AUG 2009 | DOI: 10.1002/anie.200902151

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      A powerful and versatile single-electron reductant that has found extensive use in the synthesis of complex molecules such as those shown in the scheme (Bz=benzoyl, PGG2=prostaglandin G2) is samarium diiodide (SmI2). Representative examples illustrate its scope and versatility, with special emphasis on cascade sequences.

  10. Communications

    1. Top of page
    2. Cover Picture
    3. Inside Cover
    4. Graphical Abstract
    5. News
    6. Author Profile
    7. Book Reviews
    8. Highlights
    9. Minireview
    10. Review
    11. Communications
    12. Preview
    1. Nanoarchitectures

      A General Synthetic Approach to Interconnected Nanowire/Nanotube and Nanotube/Nanowire/Nanotube Heterojunctions with Branched Topology (pages 7166–7170)

      Guowen Meng, Fangming Han, Xianglong Zhao, Bensong Chen, Dachi Yang, Jianxiong Liu, Qiaoling Xu, Mingguang Kong, Xiaoguang Zhu, Yung Joon Jung, Yajun Yang, Zhaoqin Chu, Min Ye, Swastik Kar, Robert Vajtai and Pulickel M. Ajayan

      Version of Record online: 18 JUN 2009 | DOI: 10.1002/anie.200901999

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      A large variety of interconnected nanowire/nanotube (NW/NT) and nanotube/nanowire/nanotube (NT/NW/NT, see picture) hybrid architectures with branched topology have been prepared using a combinatorial process of electrodepositing nanowires in the branched channels of anodic aluminum oxide templates, selectively etching part of the deposited nanowires, and growing nanotubes in the remaining empty channels on the ends of the nanowires.

    2. RNA Catalysis

      Structure and Function Converge To Identify a Hydrogen Bond in a Group I Ribozyme Active Site (pages 7171–7175)

      Marcello Forconi, Raghuvir N. Sengupta, Mao-Chin Liu, Alan C. Sartorelli, Joseph A. Piccirilli and Daniel Herschlag

      Version of Record online: 25 AUG 2009 | DOI: 10.1002/anie.200903006

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      Enzymes establish intricate networks of interactions to catalyze reactions, and X-ray crystallography is a powerful tool for the visualization of such networks. But what happens when different structural models (see picture) suggest different interactions for the same residue? Functional data based on double-mutant cycles can provide an answer, as shown for the Tetrahymena group I ribozyme.

    3. Poly(polyoxometalate)s

      Poly(polyoxotungstate)s with 20 Nickel Centers: From Nanoclusters to One-Dimensional Chains (pages 7176–7179)

      Shou-Tian Zheng, Jie Zhang, Juan Modesto Clemente-Juan, Da-Qiang Yuan and Guo-Yu Yang

      Version of Record online: 15 AUG 2009 | DOI: 10.1002/anie.200901653

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      Line them up: Under hydrothermal conditions, trilacunary Keggin {B-α-PW9O34} fragments and nickel ions form the two largest Ni-substituted poly(polyoxotungstate)s with the greatest number of Ni ions in a known polyoxometalate. Bridging amine ligands connect the fragments to form the 1D structure of the polyoxometalates (see structure; red octahedra WO6, yellow tetrahedra PO4, green Ni, red O, blue N, gray C).

    4. Microreactor Networks

      Multistep Continuous-Flow Microsynthesis of Magnetic and Fluorescent γ-Fe2O3@SiO2 Core/Shell Nanoparticles (pages 7180–7183)

      Ali Abou-Hassan, Rana Bazzi and Valérie Cabuil

      Version of Record online: 25 AUG 2009 | DOI: 10.1002/anie.200902181

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      Coupled microreactors allow fast, continuous, multistep synthesis of the title compound. Thus, grafting with APTES is carried out in microreactor I, mixing with sol–gel TEOS and APTES labeled with Rhodamine B isothiocyanate (RITC) in II, and coating in III. This technique opens the way to developing a lab-on-a-chip platform for nanoparticle synthesis.

    5. Vibrational Dynamics

      Vibrational Coherences and Relaxation in the High-Spin State of Aqueous [FeII(bpy)3]2+ (pages 7184–7187)

      Cristina Consani, Mirabelle Prémont-Schwarz, Amal ElNahhas, Christian Bressler, Frank van Mourik, Andrea Cannizzo and Majed Chergui

      Version of Record online: 28 AUG 2009 | DOI: 10.1002/anie.200902728

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      Dizzy cooling: Femtosecond excitation of the singlet states of aqueous [FeII(bpy)3]2+ (bpy=2,2′-bipyridine) leads to the formation of a vibrationally hot quintet state that exhibits wave-packet dynamics arising from a chelate-ring and bending mode. The vibrational relaxation involves at least two modes: the Fe[BOND]N stretching mode (see picture) and the coherently excited chelate-ring and bending mode, which relax on different time scales.

    6. Micropatterning

      Microscale Control of Stiffness in a Cell-Adhesive Substrate Using Microfluidics-Based Lithography (pages 7188–7192)

      Yuk Kee Cheung, Evren U. Azeloglu, David A. Shiovitz, Kevin D. Costa, Dror Seliktar and Samuel K. Sia

      Version of Record online: 28 MAY 2009 | DOI: 10.1002/anie.200900807

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      Microfluidics-based lithography based on microfluidics is used to pattern cell-adhesive hydrogel substrates with micro-variations in stiffness. The micropatterns are generated by feeding PEG-fibrinogen and various amounts of polyethylene glycol diacrylate (PEGDA) into the micofluidic channel (see picture).

    7. Cytochrome P450

      Calculated and Experimental Spin State of Seleno Cytochrome P450 (pages 7193–7195)

      Yongying Jiang, Santhosh Sivaramakrishnan, Takahiro Hayashi, Shimrit Cohen, Pierre Moënne-Loccoz, Sason Shaik and Paul R. Ortiz de Montellano

      Version of Record online: 28 AUG 2009 | DOI: 10.1002/anie.200901485

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      A change for the better: The proximal cysteine thiolate in a cytochrome P450 enzyme is replaced by a selenocysteine. The resulting selenolate-ligated CYP119 protein has UV/Vis (see spectrum, ••••), EPR, and resonance Raman spectra that are similar to those of the native protein (—). These results are the first to fully describe a hemoprotein with a selenolate proximal ligand.

    8. Asymmetric Organocatalysis

      Organocascade Reactions of Enones Catalyzed by a Chiral Primary Amine (pages 7196–7199)

      Li-Yuan Wu, Giorgio Bencivenni, Michele Mancinelli, Andrea Mazzanti, Giuseppe Bartoli and Paolo Melchiorre

      Version of Record online: 28 AUG 2009 | DOI: 10.1002/anie.200903280

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      Primary amines do it differently: Acyclic α,β-unsaturated ketones are activated toward a characteristic stepwise double-Michael addition sequence by chiral primary amine catalysis, which offers a powerful alternative in the design of synthetically useful organocascade reactions (see scheme, EWG=electron-withdrawing group). This method complements the Diels–Alder reaction for the one-step synthesis of complex cyclohexane scaffolds with excellent optical purity.

    9. Synthetic Methods

      Targeting Structural and Stereochemical Complexity by Organocascade Catalysis: Construction of Spirocyclic Oxindoles Having Multiple Stereocenters (pages 7200–7203)

      Giorgio Bencivenni, Li-Yuan Wu, Andrea Mazzanti, Berardino Giannichi, Fabio Pesciaioli, Mao-Ping Song, Giuseppe Bartoli and Paolo Melchiorre

      Version of Record online: 7 AUG 2009 | DOI: 10.1002/anie.200903192

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      Not so complex: The asymmetric one-step construction of multiple stereocenters in complex spirocyclic oxindoles was achieved with very high fidelity by using distinct organocascade reactions utilizing two organocatalysts, each activating different carbonyl compounds (see scheme; TMS=trimethylsilyl). The complementary approaches demonstrate the potential of organocascade catalysis to face challenging synthetic problems.

    10. Solid-State Structures

      Synthetic Control of Selenide Supertetrahedral Clusters and Three-Dimensional Co-assembly by Charge-Complementary Metal Cations (pages 7204–7207)

      Tao Wu, Xiqing Wang, Xianhui Bu, Xiang Zhao, Le Wang and Pingyun Feng

      Version of Record online: 28 AUG 2009 | DOI: 10.1002/anie.200903758

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      Controlling the charge: 3D open-framework selenide superlattices based on T2 and T4 supertetrahedral clusters were synthesized using charge-complementary and geometry-matching metal cations such as Zn2+/Ga3+/Ge4+. The clusters are joined into the covalent superlattices with an unequal ratio of 1:4, leading to a framework topology that can be simplified into a previously unknown tetrahedral net.

    11. Multiple Emulsions

      Microfluidic Mass-Transfer Control for the Simple Formation of Complex Multiple Emulsions (pages 7208–7211)

      Chun-Xia Zhao and Anton P. J. Middelberg

      Version of Record online: 24 AUG 2009 | DOI: 10.1002/anie.200902485

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      Transforming emulsions: A straightforward method for turning a single emulsion into multiple emulsions in a common T-junction microfluidic device has been achieved. Water is introduced into oil using a cosolvent; a single emulsion then forms at a T junction, which is followed by the autocatalytic formation of a multiple emulsion by cosolvent shifting into the continuous phase.

    12. Catalytic Cycloisomerization

      Platinum-Catalyzed Intramolecular Cyclizations of Alkynes: Efficient Synthesis of Pyrroloazepinone Derivatives (pages 7212–7216)

      Marina Gruit, Dirk Michalik, Annegret Tillack and Matthias Beller

      Version of Record online: 28 AUG 2009 | DOI: 10.1002/anie.200902937

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      Achieving closure: A platinum-catalyzed cycloisomerization reaction (see scheme; [Pd/Cu]=[PdCl2(PPh3)2]/CuI, Ar=aryl, X=Br,I) is used for the efficient straightforward synthesis of biologically relevant pyrrolo-[3,2-c]azepin-4-one derivatives.

    13. Cross-Coupling

      Rhodium-Catalyzed Cross-Coupling of Organoboron Compounds with Vinyl Acetate (pages 7217–7220)

      Jung-Yi Yu and Ryoichi Kuwano

      Version of Record online: 27 AUG 2009 | DOI: 10.1002/anie.200903146

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      A new coupling partner: Vinyl acetate couples with organoboron compounds in the presence of a rhodium catalyst; carbon–carbon bond formation occurs on the vinylic carbon attached to the acetoxy group. Conventional nickel and palladium catalysts were found to be ineffective for the reaction.

    14. Rearrangement Reactions

      Enantioselective Synthesis of (−)-β-Santalol by a Copper-Catalyzed Enynol Cyclization–Fragmentation Reaction (pages 7221–7223)

      Charles Fehr, Iris Magpantay, Jeremy Arpagaus, Xavier Marquet and Magali Vuagnoux

      Version of Record online: 24 AUG 2009 | DOI: 10.1002/anie.200903449

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      The right cat for the desired odor: The key step in an enantioselective synthesis of the prized fragrance (−)-β-santalol was a highly selective copper-catalyzed cyclization–fragmentation reaction of an enynol (see scheme). When a platinum catalyst was used for the cyclization step, the desired fragmentation did not take place; instead, a product containing a cyclopropane ring was formed with 100 % selectivity.

    15. Synthetic Methods

      Synthesis of Aziridines by Palladium-Catalyzed Reactions of Allylamines with Aryl and Alkenyl Halides: Evidence of a syn-Carboamination Pathway (pages 7224–7226)

      Sayuri Hayashi, Hideki Yorimitsu and Koichiro Oshima

      Version of Record online: 28 AUG 2009 | DOI: 10.1002/anie.200903178

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      Crazy rings: Treatment of N-arylallylamine with an aryl or alkenyl halide under palladium catalysis (see scheme; dba=dibenzylideneacetone, SPhos=2-dicyclohexylphosphanyl-2′,6′-dimethoxybiphenyl) resulted in intramolecular cyclization to form the arylmethyl-substituted aziridine with concomitant C[BOND]C bond formation. The experiments for the elucidation of the reaction mechanism are also described.

    16. Reaction Mechanisms

      Zirconium- and Silicon-Containing Intermediates with Three Fused Rings in a Zirconocene-Mediated Intermolecular Coupling Reaction (pages 7227–7231)

      Wen-Xiong Zhang, Shaoguang Zhang, Xiaohua Sun, Masayoshi Nishiura, Zhaomin Hou and Zhenfeng Xi

      Version of Record online: 27 AUG 2009 | DOI: 10.1002/anie.200903329

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      Veritable Jack-in-the-box: The isolation and characterization of key Zr/Si-containing intermediates was achieved for a zirconocene-mediated intermolecular coupling reaction (see scheme). The fate of the various functional groups was determined, and the reactivity of intermediate 1 with a variety of unsaturated substrates was also investigated.

    17. Fused-Ring Systems

      Acid-Catalyzed Intramolecular [2+2] Cycloaddition of Ene-allenones: Facile Access to Bicyclo[n.2.0] Frameworks (pages 7232–7235)

      Jun-Feng Zhao and Teck-Peng Loh

      Version of Record online: 28 AUG 2009 | DOI: 10.1002/anie.200902471

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      Two plus two equals a bicycle: A highly efficient acid-catalyzed intramolecular [2+2] cycloaddition of ene-allenones affords strained bicyclo[n.2.0] frameworks, which contain vicinal all-carbon quaternary and tertiary centers (see scheme; Tf: trifluoromethanesulfonyl), under mild conditions with excellent yields and chemo-, regio-, and diastereoselectivities.

    18. Conductive TiO2

      Semimetallic TiO2 Nanotubes (pages 7236–7239)

      Robert Hahn, Felix Schmidt-Stein, Jarno Salonen, Stefan Thiemann, YanYan Song, Julia Kunze, Vesa-Pekka Lehto and Patrik Schmuki

      Version of Record online: 1 SEP 2009 | DOI: 10.1002/anie.200902207

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      Orchestrating conductors: A carbo-thermal reduction treatment of a TiO2 nanotube layer in acetylene converts the tube walls into highly conductive and stable oxy carbide compounds. The resulting semimetallic TiO2 nanotube layers (TiOxCy) are electrode materials with properties that differ from other TiO2 nanotubes (see picture). They have a high oxygen overpotential and can be used as a catalyst support, for example, for methanol oxidation.

    19. Biological Signaling

      The Ras Pathway Modulator Melophlin A Targets Dynamins (pages 7240–7245)

      Tanja Knoth, Karin Warburg, Catherine Katzka, Amrita Rai, Alexander Wolf, Andreas Brockmeyer, Petra Janning, Thomas F. Reubold, Susanne Eschenburg, Dietmar J. Manstein, Katja Hübel, Markus Kaiser and Herbert Waldmann

      Version of Record online: 31 AUG 2009 | DOI: 10.1002/anie.200902023

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      Natural causes: A combination of organic synthesis, chemical proteomics, biophysics, and cell and molecular biology investigations reveals that the natural product melophlin A (purple) influences signal propagation through the Ras network by interfering with the function of dynamins (green) in endocytosis.

    20. Molecular Spacewalk

      Dynamic Motion in Crown Ether Dendrimer Complexes: A “Spacewalk” on the Molecular Scale (pages 7246–7250)

      Henrik D. F. Winkler, Dominik P. Weimann, Andreas Springer and Christoph A. Schalley

      Version of Record online: 24 AUG 2009 | DOI: 10.1002/anie.200902437

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      Walking on the edge: Mass spectrometry aided by H/D exchange experiments provides evidence for a surprisingly quick movement of [18]crown-6 units across the periphery of POMAM dendrimers (see picture). In the diluted gas phase, dissociation/reassociation equilibria do not play any role. The movement of the crown ether units resembles that of astronauts on the outside of a space station.

      Corrected by:

      Apology: Dynamic Motion in Crown Ether Dendrimer Complexes: A “Spacewalk” on the Molecular Scale

      Vol. 48, Issue 44, 8167, Version of Record online: 13 OCT 2009

    21. Allylic Substitutions

      Preformed π-Allyl Iron Complexes as Potent, Well-Defined Catalysts for the Allylic Substitution (pages 7251–7255)

      Michael Holzwarth, André Dieskau, Misbah Tabassam and Bernd Plietker

      Version of Record online: 22 AUG 2009 | DOI: 10.1002/anie.200901930

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      Reanimation: Catalytically inactive π-allyl iron complexes are “reanimated” upon addition of N-heterocyclic carbene ligands such as 1,3-dimesitylimidazolin-2-ylidene (SIMES). A comparison of stoichiometric and catalytic allylic alkylation reactions shows the π-allyl mechanism to be active in this catalytic system.

    22. Directed Manganation

      Directed Manganation of Functionalized Arenes and Heterocycles Using tmp2Mn⋅2 MgCl2⋅4 LiCl (pages 7256–7260)

      Stefan H. Wunderlich, Marcel Kienle and Paul Knochel

      Version of Record online: 28 AUG 2009 | DOI: 10.1002/anie.200903505

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      Convenient metalation procedures: Directed manganation using tmp2Mn⋅2 MgCl2⋅4 LiCl leads to the corresponding diorganomanganese reagents in high yields at 0–25 °C. Remarkably, a number of functionalities as well as sensitive heterocycles are tolerated in this metalation procedure (see scheme). The organomanganese species react with a great variety of electrophiles and undergo efficient oxidative amination reactions.

      Corrected by:

      Corrigendum: Corrigendum: Directed Manganation of Functionalized Arenes and Heterocycles Using tmp2Mn⋅2 MgCl2⋅4 LiCl

      Vol. 49, Issue 25, 4157, Version of Record online: 1 JUN 2010

  11. Preview

    1. Top of page
    2. Cover Picture
    3. Inside Cover
    4. Graphical Abstract
    5. News
    6. Author Profile
    7. Book Reviews
    8. Highlights
    9. Minireview
    10. Review
    11. Communications
    12. Preview

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