Angewandte Chemie International Edition

Cover image for Vol. 48 Issue 4

January 12, 2009

Volume 48, Issue 4

Pages 619–827

  1. Cover Picture

    1. Top of page
    2. Cover Picture
    3. Inside Cover
    4. Graphical Abstract
    5. Corrigendum
    6. Author Profile
    7. News
    8. Book Reviews
    9. Highlights
    10. Minireview
    11. Review
    12. Communications
    13. Preview
    1. Cover Picture: Isotopic Polymorphism in Pyridine (Angew. Chem. Int. Ed. 4/2009) (page 619)

      Stephen Crawford, Michael T. Kirchner, Dieter Bläser, Roland Boese, William I. F. David, Alice Dawson, Annette Gehrke, Richard M. Ibberson, William G. Marshall, Simon Parsons and Osamu Yamamuro

      Article first published online: 7 JAN 2009 | DOI: 10.1002/anie.200990000

      Thumbnail image of graphical abstract

      A low-temperature polymorph is found to exist for [D5]pyridine that does not exist for [H5]pyridine. In their Communication on page 755 ff., R. Boese, S. Parsons, and co-workers report the unusual complexity of the solid-state structures of one of the simplest heteroaromatic molecules. Pyridine shows the unusual property of isotopic polymorphism, which is rare for organic or molecular compounds as isotopic substitution rarely has an effect on the stabilities of crystal structures.

  2. Inside Cover

    1. Top of page
    2. Cover Picture
    3. Inside Cover
    4. Graphical Abstract
    5. Corrigendum
    6. Author Profile
    7. News
    8. Book Reviews
    9. Highlights
    10. Minireview
    11. Review
    12. Communications
    13. Preview
    1. Inside Cover: Site-Directed Asymmetric Quaternization of a Peptide Backbone at a C-Terminal Azlactone (Angew. Chem. Int. Ed. 4/2009) (page 620)

      Daisuke Uraguchi, Yoshihiro Asai and Takashi Ooi

      Article first published online: 7 JAN 2009 | DOI: 10.1002/anie.200990001

      Thumbnail image of graphical abstract

      A D2-symmetric chiral tetraaminophosphonium salt functions as an effective phase-transfer catalyst to achieve highly stereoselective alkylation of C-terminal azlactones of growing peptides, as described by T. Ooi and co-workers in their Communication on page 733 ff. The judicious combination of this method with a direct ligation process is a practical strategy for incorporating various chiral, non-racemic α,α-dialkyl-α-amino acids into a specific site of the peptide strand.

  3. Graphical Abstract

    1. Top of page
    2. Cover Picture
    3. Inside Cover
    4. Graphical Abstract
    5. Corrigendum
    6. Author Profile
    7. News
    8. Book Reviews
    9. Highlights
    10. Minireview
    11. Review
    12. Communications
    13. Preview
    1. Graphical Abstract: Angew. Chem. Int. Ed. 4/2009 (pages 623–632)

      Article first published online: 7 JAN 2009 | DOI: 10.1002/anie.200990002

  4. Corrigendum

    1. Top of page
    2. Cover Picture
    3. Inside Cover
    4. Graphical Abstract
    5. Corrigendum
    6. Author Profile
    7. News
    8. Book Reviews
    9. Highlights
    10. Minireview
    11. Review
    12. Communications
    13. Preview
    1. You have free access to this content
      High Internal Phase Emulsions Stabilized Solely by Functionalized Silica Particles (page 632)

      Vivian O. Ikem, Angelika Menner and Alexander Bismarck

      Article first published online: 7 JAN 2009 | DOI: 10.1002/anie.200990003

      This article corrects:

      High Internal Phase Emulsions Stabilized Solely by Functionalized Silica Particles1

      Vol. 47, Issue 43, 8277–8279, Article first published online: 22 SEP 2008

  5. Author Profile

    1. Top of page
    2. Cover Picture
    3. Inside Cover
    4. Graphical Abstract
    5. Corrigendum
    6. Author Profile
    7. News
    8. Book Reviews
    9. Highlights
    10. Minireview
    11. Review
    12. Communications
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    1. Rustem F. Ismagilov (page 637)

      Article first published online: 7 JAN 2009 | DOI: 10.1002/anie.200805885

      Thumbnail image of graphical abstract
  6. News

    1. Top of page
    2. Cover Picture
    3. Inside Cover
    4. Graphical Abstract
    5. Corrigendum
    6. Author Profile
    7. News
    8. Book Reviews
    9. Highlights
    10. Minireview
    11. Review
    12. Communications
    13. Preview
  7. Book Reviews

    1. Top of page
    2. Cover Picture
    3. Inside Cover
    4. Graphical Abstract
    5. Corrigendum
    6. Author Profile
    7. News
    8. Book Reviews
    9. Highlights
    10. Minireview
    11. Review
    12. Communications
    13. Preview
  8. Highlights

    1. Top of page
    2. Cover Picture
    3. Inside Cover
    4. Graphical Abstract
    5. Corrigendum
    6. Author Profile
    7. News
    8. Book Reviews
    9. Highlights
    10. Minireview
    11. Review
    12. Communications
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    1. Catalytic Propargylation

      Transition-Metal-Catalyzed Propargylic Substitution (pages 642–644)

      Natalie Ljungdahl and Nina Kann

      Article first published online: 19 DEC 2008 | DOI: 10.1002/anie.200804114

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      Keen for a share in the glory: Until recently, the title reaction stood in the shadows, its famous sister, catalytic allylic substitution, in the limelight. Catalytic propargylic substitution has now emerged as an efficient transformation that can be catalyzed by a variety of transition metals (see picture). Among the recent developments are copper-catalyzed asymmetric propargylic amination reactions. Nu = nucleophile

    2. Conjugate Addition

      Copper-Catalyzed Asymmetric Michael Addition of Magnesium, Zinc, and Aluminum Organometallic Reagents: Efficient Synthesis of Chiral Molecules (pages 645–648)

      Tobias Thaler and Paul Knochel

      Article first published online: 29 DEC 2008 | DOI: 10.1002/anie.200804446

      Thumbnail image of graphical abstract

      Choosing the right metal for the job: A broad range of asymmetric conjugate addition reactions are catalyzed efficiently by copper complexes, provided the appropriate organometallic reagent is used. With aluminum reagents, for example, quaternary stereogenic centers with functionalized aryl substituents can be generated with high enantioselectivity (see scheme).

  9. Minireview

    1. Top of page
    2. Cover Picture
    3. Inside Cover
    4. Graphical Abstract
    5. Corrigendum
    6. Author Profile
    7. News
    8. Book Reviews
    9. Highlights
    10. Minireview
    11. Review
    12. Communications
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    1. Coordination Polymers

      Modular Synthesis of Functional Nanoscale Coordination Polymers (pages 650–658)

      Wenbin Lin, William J. Rieter and Kathryn M. L. Taylor

      Article first published online: 9 DEC 2008 | DOI: 10.1002/anie.200803387

      Thumbnail image of graphical abstract

      Next-generation nanomaterials: The coordination-directed assembly of metal ions and organic bridging ligands has afforded bulk-scale functional hybrid materials. Their scaling-down to the nano-regime has led to nanoscale coordination polymers and metal–organic frameworks which have been used in a broad range of applications including catalysis, spin-crossover, templating, biosensing, biomedical imaging, and anticancer drug delivery.

  10. Review

    1. Top of page
    2. Cover Picture
    3. Inside Cover
    4. Graphical Abstract
    5. Corrigendum
    6. Author Profile
    7. News
    8. Book Reviews
    9. Highlights
    10. Minireview
    11. Review
    12. Communications
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    1. Natural Products

      Recent Advances in the Chemistry and Biology of Naturally Occurring Antibiotics (pages 660–719)

      K. C. Nicolaou, Jason S. Chen, David J. Edmonds and Anthony A. Estrada

      Article first published online: 7 JAN 2009 | DOI: 10.1002/anie.200801695

      Thumbnail image of graphical abstract

      Exciting developments in the area of antibiotics are discussed in this stimulating review article as the authors present highlights of research carried out since the year 2000, emphasizing the pivotal role that total synthesis plays in moving the field forward and into new possibilities of drug design. The three compounds are shown as an illustration of the structural diversity of antibiotics.

  11. Communications

    1. Top of page
    2. Cover Picture
    3. Inside Cover
    4. Graphical Abstract
    5. Corrigendum
    6. Author Profile
    7. News
    8. Book Reviews
    9. Highlights
    10. Minireview
    11. Review
    12. Communications
    13. Preview
    1. Host–Guest Systems

      Filling the Cavity of Conjugated Carbazole Macrocycles with Graphene Molecules: Monolayers Formed by Physisorption Serve as a Surface for Pulsed Laser Deposition (pages 720–724)

      Bruno Schmaltz, Ali Rouhanipour, Hans Joachim Räder, Wojciech Pisula and Klaus Müllen

      Article first published online: 13 NOV 2008 | DOI: 10.1002/anie.200803156

      Thumbnail image of graphical abstract

      Finding the middle ground: A 1:1 host–guest complex consisting of a hexa-peri-hexabenzocoronene molecule sitting in the middle of the free cavity of a giant π-conjugated carbazole macrocycle has been obtained (see STM image). The complex has been prepared by physisorption of a monolayer of macrocycles followed by gas-phase deposition of graphene molecules by pulsed laser deposition.

    2. Ammosamides, Biological Chemistry

      The Ammosamides: Structures of Cell Cycle Modulators from a Marine-Derived Streptomyces Species (pages 725–727)

      Chambers C. Hughes, John B. MacMillan, Susana P. Gaudêncio, Paul R. Jensen and William Fenical

      Article first published online: 17 DEC 2008 | DOI: 10.1002/anie.200804890

      Thumbnail image of graphical abstract

      From the ocean: Ammosamides A (1) and B (2) were isolated from a marine-derived Streptomyces species collected in the Bahamas. The structures of these chlorinated tricyclic pyrroloquinoline alkaloids were solved using X-ray crystallographic techniques. Ammosamide A (1) was shown to contain an unusual thio-γ-lactam ring. Both metabolites show specific nanomolar cytotoxicity against selected cancer cell lines.

    3. Ammosamides, Chemical Biology

      Ammosamides A and B Target Myosin (pages 728–732)

      Chambers C. Hughes, John B. MacMillan, Susana P. Gaudêncio, William Fenical and James J. La Clair

      Article first published online: 18 DEC 2008 | DOI: 10.1002/anie.200804107

      Thumbnail image of graphical abstract

      The protein target of the ammosamides, cytotoxic natural products from a marine-derived actinomycete, has been elucidated. An immunoaffinity fluorescent tag was used to construct a fluorescent molecular probe (see structure). First, uptake and localization of the probe in cells was visualized with fluorescence microscopy. The probe was then used to co-immunoprecipitate proteins that bound to the ammosamide core. Myosin was thus identified as a target.

    4. Peptide Modification

      Site-Directed Asymmetric Quaternization of a Peptide Backbone at a C-Terminal Azlactone (pages 733–737)

      Daisuke Uraguchi, Yoshihiro Asai and Takashi Ooi

      Article first published online: 25 NOV 2008 | DOI: 10.1002/anie.200803661

      Thumbnail image of graphical abstract

      Dual-purpose activation: Peptide C-terminal azlactones I undergo stereoselective alkylation with high efficiency by the use of a newly devised chiral tetraaminophosphonium salt as a phase-transfer catalyst, and the alkylated azlactone products II can be employed directly for peptide ligation (see scheme, LG=leaving group). In this way, a wide range of chiral quaternary α-amino acid residues can be incorporated at specific sites of a peptide strand.

    5. Isomerization

      Synthesis and Redox-Induced Structural Isomerization of the Pentagonal Bipyramidal Complexes [W(CN)5(CO)2]3− and [W(CN)5(CO)2]2− (pages 738–741)

      Hemamala I. Karunadasa and Jeffrey R. Long

      Article first published online: 15 DEC 2008 | DOI: 10.1002/anie.200804199

      Thumbnail image of graphical abstract

      Mixed company: The use of a mixed carbonyl/cyanide ligand set enables stabilization of two new heptacoordinate complexes: [W(CN)5(CO)2]3− and [W(CN)5(CO)2]2−. In the trianionic complex the two carbonyl ligands occupy the axial positions. Remarkably, one-electron oxidation causes loss of this axial symmetry, as shown by X-ray crystallography (see picture, orange W, gray C, blue N, red O), IR, and EPR spectroscopy.

    6. Luminescent Metal Phosphites

      A Fully Integrated Nanotubular Yellow-Green Phosphor from an Environmentally Friendly Eutectic Solvent (pages 742–745)

      Pei-Ci Jhang, Ya-Ching Yang, Yi-Chun Lai, Wei-Ren Liu and Sue-Lein Wang

      Article first published online: 12 DEC 2008 | DOI: 10.1002/anie.200804744

      Thumbnail image of graphical abstract

      Glowing with pride: An activator-free gallium oxalatophosphite is a new class of color conversion phosphors for NUV and blue light-emitting diodes. It is synthesized by using an organic template and an environmentally friendly eutectic solvent in a reaction that shows efficient atom economy. The resulting material has a tubular structure (see picture) and intriguing luminescence properties.

    7. Single-Molecule Studies

      Single-Molecule-Magnet Carbon-Nanotube Hybrids (pages 746–750)

      Lapo Bogani, Chiara Danieli, Elisa Biavardi, Nedjma Bendiab, Anne-Laure Barra, Enrico Dalcanale, Wolfgang Wernsdorfer and Andrea Cornia

      Article first published online: 15 DEC 2008 | DOI: 10.1002/anie.200804967

      Thumbnail image of graphical abstract

      Devices and desires: The self-assembly of single-molecule-magnet (SMM) carbon-nanotube (CNT) hybrids (see picture) in conditions compatible to the creation of electronic devices is described. The process is controlled at the single-molecule level, and the resulting CNT–field-effect transistors display single-SMM sensitivity at room temperature.

    8. Lipopeptides

      Coiled-Coil Lipopeptides Mimicking the Prehairpin Intermediate of Glycoprotein gp41 (pages 751–754)

      Steffen Schuy, Edith Schäfer, Nicholas C. Yoder, Stephan Hobe, Krishna Kumar, Reiner Vogel and Andreas Janshoff

      Article first published online: 17 DEC 2008 | DOI: 10.1002/anie.200803080

      Thumbnail image of graphical abstract

      A sheep in wolf's clothes? Mimicking the crucial conformational step in viral fusion promises to be an efficient method to detect potential antagonists of retroviral infection (see scheme). Reconstituted lipopeptides derived from the N peptides of the class I virus fusion protein of SIV serve as receptors for potential inhibitors that function like the C peptides of the virus protein.

    9. Low-Temperature Polymorphs

      Isotopic Polymorphism in Pyridine (pages 755–757)

      Stephen Crawford, Michael T. Kirchner, Dieter Bläser, Roland Boese, William I. F. David, Alice Dawson, Annette Gehrke, Richard M. Ibberson, William G. Marshall, Simon Parsons and Osamu Yamamuro

      Article first published online: 26 NOV 2008 | DOI: 10.1002/anie.200803589

      Thumbnail image of graphical abstract

      Not so simple: It is normally assumed that deuteration has only a minor effect on the stabilities of crystal structures. This assumption is wrong for pyridine. A low-temperature polymorph exists for [D5]pyridine, but not for [H5]pyridine, which adds a further twist to the already unusual structural chemistry of one of the simplest and most familiar laboratory chemicals.

    10. Pyrrole Synthesis

      Unusual Domino Michael/Aldol Condensation Reactions Employing Oximes as N-Selective Nucleophiles: Synthesis of N-Hydroxypyrroles (pages 758–761)

      Bin Tan, Zugui Shi, Pei Juan Chua, Yongxin Li and Guofu Zhong

      Article first published online: 7 JAN 2009 | DOI: 10.1002/anie.200805205

      Thumbnail image of graphical abstract

      A facile synthesis of N-hydroxypyrroles has been developed using readily available α-carbonyl oximes and α,β-unsaturated aldehydes. The domino reaction proceeds through iminium activation of α,β-unsaturated aldehydes, Michael addition using oximes as N-selective nucleophiles, and aldol condensation.

    11. Enantioselective Catalysis

      Enantioselective Synthesis of P-Stereogenic Phosphinates and Phosphine Oxides by Molybdenum-Catalyzed Asymmetric Ring-Closing Metathesis (pages 762–766)

      James Stephen Harvey, Steven J. Malcolmson, Katherine S. Dunne, Simon J. Meek, Amber L. Thompson, Richard R. Schrock, Amir H. Hoveyda and Véronique Gouverneur

      Article first published online: 19 DEC 2008 | DOI: 10.1002/anie.200805066

      Thumbnail image of graphical abstract

      The first catalytic route toward the title compounds by asymmetric ring-closing metathesis is described. A remarkable reversal of enantioselectivity is observed when the achiral imido ligand of the chiral molybdenum-catalyst is changed (see scheme), thus highlighting the importance of the achiral and the chiral ligands in catalyst design.

    12. Natural Product Synthesis

      Formation of the Pyridazine Natural Product Azamerone by Biosynthetic Rearrangement of an Aryl Diazoketone (pages 767–770)

      Jaclyn M. Winter, Ariane L. Jansma, Tracy M. Handel and Bradley S. Moore

      Article first published online: 15 DEC 2008 | DOI: 10.1002/anie.200805140

      Thumbnail image of graphical abstract

      All in the family: Knowledge of the biosynthesis of N[BOND]N containing natural products is limited. Feeding experiments with 13C and 15N-labeled molecules establish that the phthalazinone core of azamerone is derived from the diazo chlorinated meroterpenoid SF2415A3. A biosynthetic mechanism involving an oxidative rearrangement of the aryl diazoketone followed by rearomatization with the dinitrogen group is proposed.

    13. Helical Porphyrinoids

      Enantioselective Induction of Helical Chirality in Cyclooctapyrroles by Metal-Complex Formation (pages 771–775)

      Jun-ichiro Setsune, Aki Tsukajima, Naho Okazaki, Juha M. Lintuluoto and Masami Lintuluoto

      Article first published online: 17 DEC 2008 | DOI: 10.1002/anie.200803538

      Thumbnail image of graphical abstract

      Fixed chirality: The treatment of cyclooctapyrroles (see picture) with a metal source with optically active carboxylate or amine ligands leads to enantioselective metalation to give stereochemically stable helical mononuclear and dinuclear complexes without a chiral auxiliary. The helicity of the dicopper complex was determined by the simulation of the CD spectrum on the basis of X-ray crystallographic data.

    14. Asymmetric Catalysis

      Diastereoselective and Enantioselective Synthesis of Tertiary α-Hydroxy Phosphonates through Hydrogen-Bond Catalysis (pages 776–779)

      Vijaya Bhasker Gondi, Koji Hagihara and Viresh H. Rawal

      Article first published online: 18 DEC 2008 | DOI: 10.1002/anie.200804244

      Thumbnail image of graphical abstract

      Hydrogen-bond activation by a diol promotes enantioselective Mukaiyama aldol reactions of acyl phosphonates. This mild and general method gives α-hydroxy phosphonate products having two chiral centers, one tertiary and one quaternary, formed with high diastereo- and enantioselectivity.

    15. Nanostructures

      Formation of Hierarchical InAs Nanoring / GaAs Nanowire Heterostructures (pages 780–783)

      Mohanchand Paladugu, Jin Zou, Ya-Nan Guo, Xin Zhang, Hannah J. Joyce, Qiang Gao, H. Hoe Tan, Chennupati Jagadish and Yong Kim

      Article first published online: 12 DEC 2008 | DOI: 10.1002/anie.200804630

      Thumbnail image of graphical abstract

      Rings around the wire: Novel hierarchical heterostructures, assembled by radial deposition of InAs on GaAs nanowires with nonplanar side walls, result in the formation of InAs nanorings. The mechanism of formation of such structures, determined by transmission electron microscopy, involves the preferential nucleation of InAs at concave regions of the GaAs surface by capillarity effects.

    16. C[BOND]H Functionalization

      Benzofurans Prepared by C[BOND]H Bond Functionalization with Acylsilanes (pages 784–786)

      Zengming Shen and Vy M. Dong

      Article first published online: 12 DEC 2008 | DOI: 10.1002/anie.200804854

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      Instant carbenes—that's hot: The thermal 1,2-Brook rearrangement of acylsilanes generates siloxycarbene intermediates that can undergo intramolecular C[BOND]H bond insertion to provide benzofuran derivatives. This metal-free tandem reaction occurs in less than 10 minutes in the microwave.

    17. Asymmetric Catalysis

      Asymmetric Alkaloid Synthesis: A One-Pot Organocatalytic Reaction to Quinolizidine Derivatives (pages 787–791)

      Johan Franzén and Andreas Fisher

      Article first published online: 17 DEC 2008 | DOI: 10.1002/anie.200805130

      Thumbnail image of graphical abstract

      One pot+two steps=three stereocenters: A short enantioselective synthesis to access the indolo[2,3a]quinolizidine and the benzo[a]quinolizidine skeleton has been developed (see scheme; TMS=trimethylsilyl, R1=aromatic, R2=3-indoyl or 3,4-dimethoxyphenyl). The sequence involves an organocatalytic conjugate addition and subsequent acid-catalyzed cyclization of the acyliminium ion.

      Corrected by:

      Corrigendum: Asymmetric Alkaloid Synthesis: A One-Pot Organocatalytic Reaction to Quinolizidine Derivatives

      Vol. 48, Issue 8, 1351, Article first published online: 2 FEB 2009

    18. C[BOND]C Coupling

      The Copper-Catalyzed Decarboxylative Coupling of the sp3-Hybridized Carbon Atoms of α-Amino Acids (pages 792–795)

      Hai-Peng Bi, Liang Zhao, Yong-Min Liang and Chao-Jun Li

      Article first published online: 7 JAN 2009 | DOI: 10.1002/anie.200805122

      Thumbnail image of graphical abstract

      Joined at the Cs: A novel intermolecular decarboxylative Cmath image[BOND]Cmath image, Cmath image[BOND]Cmath image, and Cmath image[BOND]Csp coupling catalyzed by CuBr and using α-amino acids as starting materials has been developed (see scheme). Various functionalized nitrogen-containing compounds were obtained by this method.

    19. Structure Elucidation

      Belizeanolide, a Cytotoxic Macrolide from the Dinoflagellate Prorocentrum belizeanum (pages 796–799)

      José G. Napolitano, Manuel Norte, José M. Padrón, José J. Fernández and Antonio Hernández Daranas

      Article first published online: 19 DEC 2008 | DOI: 10.1002/anie.200804023

      Thumbnail image of graphical abstract

      An exclusive club: The first member of an unprecedented class of polyunsaturated and polyhydroxylated macrocycle, belizeanolide (see structure), has been isolated from a marine dinoflagellate. The corresponding open form, belizeanolic acid, was also found. Their structures were determined primarily by analysis of NMR spectroscopic data. Both compounds showed significant antiproliferative activities.

    20. Asymmetric Catalysis

      Efficient Synthesis of Chiral β-Arylisopropylamines by Using Catalytic Asymmetric Hydrogenation (pages 800–802)

      Jian Chen, Weicheng Zhang, Huiling Geng, Wei Li, Guohua Hou, Aiwen Lei and Xumu Zhang

      Article first published online: 19 DEC 2008 | DOI: 10.1002/anie.200805058

      Thumbnail image of graphical abstract

      Direct condensation of β-arylketones with acetamide afforded both Z and E enamides. The Z-configured substrates underwent hydrogenation with excellent enantioselectivity by using the Rh/tangphos catalytic system (see scheme; tangphos=1,1′-di-tert-butyl-[2,2′]-diphospholanyl). The product β-arylisopropylamines are important precursors to several drugs.

    21. Hydroxylation

      A Dynamic Kinetic Asymmetric Transformation in the α-Hydroxylation of Racemic Malonates and Its Application to Biologically Active Molecules (pages 803–806)

      Dhande Sudhakar Reddy, Norio Shibata, Jun Nagai, Shuichi Nakamura and Takeshi Toru

      Article first published online: 19 DEC 2008 | DOI: 10.1002/anie.200804476

      Thumbnail image of graphical abstract

      Sly like a “DBFOX”: The chiral α-hydroxy malonate 2 can be prepared in high yield and with up to 98 % ee from racemic malonate 1 through α-hydroxylation using oxaziridine 3 and is catalyzed by the (R,R)-DBFOX-Ph/NiII complex (see scheme). Biologically useful molecules have been prepared by using this method and illustrate its efficiency.

    22. Low-Valent Lewis Acids

      The Reaction of Dizincocene with Preservation of the Zn[BOND]Zn Bond (pages 807–810)

      Daniella Schuchmann, Ulrich Westphal, Stephan Schulz, Ulrich Flörke, Dieter Bläser and Roland Boese

      Article first published online: 15 DEC 2008 | DOI: 10.1002/anie.200803736

      Thumbnail image of graphical abstract

      Reaction without Zn[BOND]Zn rupture: [equation imageZn2] reacts with a fourfold excess of the strong Lewis base 4-dimethylaminopyridine (dmap) to unexpectedly form the Lewis acid–base adduct 1, in which both dmap molecules coordinate in a geminal binding mode to only one zinc atom. Cp*=C5Me5.

    23. Enzyme Inhibitors

      Cation–π Interactions at the Active Site of Factor Xa: Dramatic Enhancement upon Stepwise N-Alkylation of Ammonium Ions (pages 811–814)

      Laura M. Salonen, Christoph Bucher, David W. Banner, Wolfgang Haap, Jean-Luc Mary, Jörg Benz, Olivier Kuster, Paul Seiler, W. Bernd Schweizer and François Diederich

      Article first published online: 19 DEC 2008 | DOI: 10.1002/anie.200804695

      Thumbnail image of graphical abstract

      In pocket: A new class of potent inhibitors of factor Xa features a quaternary ammonium ion to fill the aromatic box in the S4 pocket and a 2-chlorothiophenyl group to occupy the S1 pocket (see picture; red O, blue N, yellow S, green Cl). Changing from a primary to a quaternary ammonium ion increases the binding affinity by a factor of 1000. The poor affinity in the former case suggests negligible cation–π interactions between Lys and Trp.

    24. Electron Transfer

      Discrete Supramolecular Donor–Acceptor Complexes (pages 815–819)

      S. Shankara Gayathri, Mateusz Wielopolski, Emilio M. Pérez, Gustavo Fernández, Luis Sánchez, Rafael Viruela, Enrique Ortí, Dirk M. Guldi and Nazario Martín

      Article first published online: 7 JAN 2009 | DOI: 10.1002/anie.200803984

      Thumbnail image of graphical abstract

      On the ball: Charge transfer occurs readily in tightly interacting complexes formed from π-extended tetrathiafulvalenes, which act as pincerlike receptors, and C60 in a variety of solvents upon photoexcitation (see picture; PET=photoelectron transfer). It should be feasible to construct simple photovoltaic devices from systems based on similar recognition motifs.

    25. Protein Folding

      Surprising Simplicity in the Single-Molecule Folding Mechanics of Proteins (pages 820–822)

      Michael Schlierf and Matthias Rief

      Article first published online: 19 DEC 2008 | DOI: 10.1002/anie.200804723

      Thumbnail image of graphical abstract

      The anisotropy of the folding-energy landscape of proteins under force can be tested with cysteine engineering. The shorter the actively contracting polypeptide (see scheme, from blue to green), the higher the force at which the protein folds. The anisotropy of the folding mechanics can be described surprisingly simply with the help of a minimal model, mainly considering the entropic elasticity of the polypeptide.

  12. Preview

    1. Top of page
    2. Cover Picture
    3. Inside Cover
    4. Graphical Abstract
    5. Corrigendum
    6. Author Profile
    7. News
    8. Book Reviews
    9. Highlights
    10. Minireview
    11. Review
    12. Communications
    13. Preview
    1. You have free access to this content
      Preview: Angew. Chem. Int. Ed. 5/2009 (page 827)

      Article first published online: 7 JAN 2009 | DOI: 10.1002/anie.200990005

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