Isotopic Polymorphism in Pyridine (pages 755–757)
Stephen Crawford, Michael T. Kirchner, Dieter Bläser, Roland Boese, William I. F. David, Alice Dawson, Annette Gehrke, Richard M. Ibberson, William G. Marshall, Simon Parsons and Osamu Yamamuro
Article first published online: 26 NOV 2008 | DOI: 10.1002/anie.200803589
Not so simple: It is normally assumed that deuteration has only a minor effect on the stabilities of crystal structures. This assumption is wrong for pyridine. A low-temperature polymorph exists for [D5]pyridine, but not for [H5]pyridine, which adds a further twist to the already unusual structural chemistry of one of the simplest and most familiar laboratory chemicals.