Molecular Engineering of DNA: Molecular Beacons (pages 856–870)
Kemin Wang, Zhiwen Tang, Chaoyong James Yang, Youngmi Kim, Xiaohong Fang, Wei Li, Yanrong Wu, Colin D. Medley, Zehui Cao, Jun Li, Patrick Colon, Hui Lin and Weihong Tan
Article first published online: 9 DEC 2008 | DOI: 10.1002/anie.200800370
A spotlight on light signaling: Molecular beacons are specifically designed DNA hairpin structures (see picture) used as fluorescent probes for numerous bioanalytical applications, including gene detection, the monitoring of messenger RNA (mRNA), and biosensing. Recent studies have led to versatile strategies for the targeted optimization of molecular beacons. ssDNA=single-stranded DNA.