Externally Triggered Glass Transition Switch for Localized On-Demand Drug Delivery (pages 9867–9870)
Jos T. F. Keurentjes, Maartje F. Kemmere, Henny Bruinewoud, Micky A. M. E. Vertommen, Stefan A. Rovers, Richard Hoogenboom, Léon F. S. Stemkens, Fabiènne L. A. M. A. Péters, Naomi J. C. Tielen, Dirk T. A. van Asseldonk, Anne F. Gabriel, Elbert A. Joosten and Marco A. E. Marcus
Article first published online: 26 NOV 2009 | DOI: 10.1002/anie.200904172
I want a new drug dose: External on-demand laser triggering is used in a drug-delivery concept, with on/off ratios in excess of 1000/1. The switching mechanism involves the glass transition of hydrophobic polymers with a large change in diffusivity. Formation of a glassy surface layer of the implant in the off state plays a key role, resulting in negligible off-release. (Picture: data points indicate ibuprofen concentration).