Modulation of the Biological Properties of Aspirin by Formation of a Bioorganometallic Derivative (pages 1160–1163)
Ingo Ott, Brigitte Kircher, Christoph P. Bagowski, Danielle H. W. Vlecken, Elisabeth B. Ott, Joanna Will, Kerstin Bensdorf, William S. Sheldrick and Ronald Gust
Article first published online: 29 DEC 2008 | DOI: 10.1002/anie.200803347
Beyond treating headaches: The derivatization of biologically active compounds by organometallic units modulates their pharmacological properties. In studies of antitumor-related biochemical properties, the Co2(CO)6 derivative of aspirin 1 shows significantly modified influence on several relevant pathways, which might be based on an altered interaction with the target enzyme COX-2.