Maradolipids: Diacyltrehalose Glycolipids Specific to Dauer Larva in Caenorhabditis elegans (pages 9430–9435)
Sider Penkov, Fanny Mende, Vyacheslav Zagoriy, Cihan Erkut, Dr. René Martin, Ulrike Pässler, Kai Schuhmann, Dr. Dominik Schwudke, Dr. Margit Gruner, Jana Mäntler, Dr. Thomas Reichert-Müller, Dr. Andrej Shevchenko, Prof. Dr. Hans-Joachim Knölker and Prof. Dr. Teymuras V. Kurzchalia
Article first published online: 4 NOV 2010 | DOI: 10.1002/anie.201004466
Don't stress: Maradolipids (see picture; red O, grey C, white H) are the first diacyltrehaloses found to be produced in animal organisms. The nematode Caenorhabditis elegans synthesizes maradolipids for the highly stress-resistant dauer larvae. Genetic knockout studies result in the improper morphology of the gut lumen of dauer larvae. Maradolipids might be important for understanding the chemical basis for the resistance of dauer larvae to extreme environmental stress.