Angewandte Chemie International Edition

Cover image for Vol. 49 Issue 11

March 8, 2010

Volume 49, Issue 11

Pages 1895–2067

  1. Cover Picture

    1. Top of page
    2. Cover Picture
    3. Inside Cover
    4. Graphical Abstract
    5. Corrigendum
    6. News
    7. Author Profile
    8. News
    9. Book Review
    10. Highlights
    11. Review
    12. Communications
    13. Preview
    1. Cover Picture: Dynamers at the Solid–Liquid Interface: Controlling the Reversible Assembly/Reassembly Process between Two Highly Ordered Supramolecular Guanine Motifs (Angew. Chem. Int. Ed. 11/2010) (page 1895)

      Artur Ciesielski, Stefano Lena, Stefano Masiero, Gian Piero Spada and Paolo Samorì

      Article first published online: 22 FEB 2010 | DOI: 10.1002/anie.201000346

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      Dynamers in action can be observed with responsive supramolecular architectures on surfaces. In their Communication on page 1963 ff., G. P. Spada, P. Samorì, and co-workers report how scanning tunneling microscopy was used to achieve submolecular-scale visualization of the metal-templated reversible assembly/reassembly process of N9-alkylguanine monolayers. Changes in pH switch the resulting structures from highly ordered quartets to ribbons.

  2. Inside Cover

    1. Top of page
    2. Cover Picture
    3. Inside Cover
    4. Graphical Abstract
    5. Corrigendum
    6. News
    7. Author Profile
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    9. Book Review
    10. Highlights
    11. Review
    12. Communications
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    1. Inside Cover: Stereospecific Isotopic Labeling of Methyl Groups for NMR Spectroscopic Studies of High-Molecular-Weight Proteins (Angew. Chem. Int. Ed. 11/2010) (page 1896)

      Pierre Gans, Olivier Hamelin, Remy Sounier, Isabel Ayala, M. Asunción Durá, Carlos D. Amero, Marjolaine Noirclerc-Savoye, Bruno Franzetti, Michael J. Plevin and Jérôme Boisbouvier

      Article first published online: 22 FEB 2010 | DOI: 10.1002/anie.201000347

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      NMR spectroscopy of large protein assemblies necessitates targeted protonation of specific sites within a perdeuterated background. In their Communication on page 1958 ff., J. Boisbouvier et al. outline the use of an acetolactate precursor for the specific biosynthetic incorporation of 13C1H3 into the pro-S methyl groups of leucine and valine. This labeling strategy enhances spectral quality and provides an efficient basis for the application of solution-state NMR techniques to complex biomolecules.

  3. Graphical Abstract

    1. Top of page
    2. Cover Picture
    3. Inside Cover
    4. Graphical Abstract
    5. Corrigendum
    6. News
    7. Author Profile
    8. News
    9. Book Review
    10. Highlights
    11. Review
    12. Communications
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  4. Corrigendum

    1. Top of page
    2. Cover Picture
    3. Inside Cover
    4. Graphical Abstract
    5. Corrigendum
    6. News
    7. Author Profile
    8. News
    9. Book Review
    10. Highlights
    11. Review
    12. Communications
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    1. You have free access to this content
      Electromeric Rhodium Radical Complexes (page 1909)

      Florian Frank Puschmann, Jeffrey Harmer, Daniel Stein, Heinz Rüegger, Bas de Bruin and Hansjörg Grützmacher

      Article first published online: 3 MAR 2010 | DOI: 10.1002/anie.201090028

      This article corrects:

      Electromeric Rhodium Radical Complexes1

      Vol. 49, Issue 2, 385–389, Article first published online: 2 DEC 2009

  5. News

    1. Top of page
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    4. Graphical Abstract
    5. Corrigendum
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    9. Book Review
    10. Highlights
    11. Review
    12. Communications
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  6. Author Profile

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    1. Alexandre Alexakis (page 1914)

      Article first published online: 18 FEB 2010 | DOI: 10.1002/anie.201000195

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      “My biggest motivation is curiosity. The most significant advance in chemistry in the last hundred years has been catalysis, any catalysis …” This and more about Alexandre Alexakis can be found on page 1914.

  7. News

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    11. Review
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  8. Book Review

    1. Top of page
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    1. Handbook of Thiophene-Based Materials. Applications in Organic Electronics and Photonics. 2 volumes. Edited by Igor F. Perepichka and Dmitrii F. Perepichka. (pages 1916–1917)

      Seth C. Rasmussen

      Article first published online: 3 MAR 2010 | DOI: 10.1002/anie.200907335

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      John Wiley & Sons, Hoboken 2009. 910 pp., hardcover € 339.00.—ISBN 978-0470057322

  9. Highlights

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    4. Graphical Abstract
    5. Corrigendum
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    1. Supramolecular Catalysis

      Charged-Assisted Supramolecular Catalysis (pages 1918–1920)

      Diane Rix and Jérôme Lacour

      Article first published online: 12 FEB 2010 | DOI: 10.1002/anie.200906392

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      Charged up: An aminophosphonium cation, two phenols, and a phenoxide anion self-assemble in a cyclic network of intermolecular hydrogen-bonds. This charged-assisted reactive combination efficiently catalyzes the conjugate addition of azlactones to α,β-unsaturated acylbenzotriazoles.

    2. Multiferroic MOFs

      Multiferroic Materials: The Attractive Approach of Metal–Organic Frameworks (MOFs) (pages 1921–1923)

      Guillaume Rogez, Nathalie Viart and Marc Drillon

      Article first published online: 5 FEB 2010 | DOI: 10.1002/anie.200906660

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      Peaceful coexistence: Metal–organic frameworks (MOFs) offer new openings in the stabilization of multiferroic materials. A series of compounds with a hydrogen-bond-triggered order–disorder transition combines both electric and magnetic order. These compounds constitute a new approach that significantly differs from other reported routes to multiferroic oxide materials.

  10. Review

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    4. Graphical Abstract
    5. Corrigendum
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    12. Communications
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    1. Inorganic Nanostructures

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      Peptide-Based Methods for the Preparation of Nanostructured Inorganic Materials (pages 1924–1942)

      Chun-Long Chen and Nathaniel L. Rosi

      Article first published online: 22 FEB 2010 | DOI: 10.1002/anie.200903572

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      Versatile agents: The sequence-specific recognition properties of peptides can be used to control the nucleation of inorganic nanoparticles, and their unique self-assembly properties can be used to direct the assembly of the particles. Complex peptides with both substrate recognition and self-assembly properties can be designed to simultaneously direct both nanoparticle synthesis and assembly.

  11. Communications

    1. Top of page
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    5. Corrigendum
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    1. Surface Chemistry

      “Hot” Surface Activation of Molecular Complexes: Insight from Modeling Studies (pages 1944–1948)

      Ettore Fois, Gloria Tabacchi, Davide Barreca, Alberto Gasparotto and Eugenio Tondello

      Article first published online: 9 FEB 2010 | DOI: 10.1002/anie.200907312

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      Rock-and-roll over hot floors: Theoretical modeling of the first activation stages of a Cu complex (see picture) on top of a heated surface (750 K) revealed two mobility regimes, a slow “bump-and-rock” diffusion over the surface and a fast “roll-and-go” motion accompanied by significant temperature-induced bond oscillations. This study enables a deeper insight into “hot” surface molecular activation processes.

    2. Asymmetric Catalysis

      Enantioselective Gold Catalysis: Opportunities Provided by Monodentate Phosphoramidite Ligands with an Acyclic TADDOL Backbone (pages 1949–1953)

      Henrik Teller, Susanne Flügge, Richard Goddard and Alois Fürstner

      Article first published online: 19 FEB 2010 | DOI: 10.1002/anie.200906550

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      The tail makes the difference: Removing the isopropylidene acetal unit from well-known TADDOL ligands improved the performance of the derived phosphoramidite ligands in asymmetric gold catalysis (see scheme; Ts=4-toluenesulfonyl). X-ray crystallography showed that the binding pocket has an effective threefold symmetry, with through-space interactions between the arene rings of the ligand and the gold center.

    3. Valence Tautomerism

      Soft-X-ray-Induced Redox Isomerism in a Cobalt Dioxolene Complex (pages 1954–1957)

      Giordano Poneti, Matteo Mannini, Lorenzo Sorace, Philippe Sainctavit, Marie-Anne Arrio, Edwige Otero, Julio Criginski Cezar and Andrea Dei

      Article first published online: 16 FEB 2010 | DOI: 10.1002/anie.200906895

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      A soft touch: Interconversion of two redox isomers of a cobalt dioxolene complex (see picture; Cat: catecholato, SQ: semiquinonato) is stimulated by soft X-rays. Analysis of X-ray absorption spectroscopy (XAS) spectra shows that the soft-X-ray-induced redox isomer is the same as that obtained by optical irradiation of the sample in the near-IR region or by warming the sample.

    4. Protein Labeling

      Stereospecific Isotopic Labeling of Methyl Groups for NMR Spectroscopic Studies of High-Molecular-Weight Proteins (pages 1958–1962)

      Pierre Gans, Olivier Hamelin, Remy Sounier, Isabel Ayala, M. Asunción Durá, Carlos D. Amero, Marjolaine Noirclerc-Savoye, Bruno Franzetti, Michael J. Plevin and Jérôme Boisbouvier

      Article first published online: 15 FEB 2010 | DOI: 10.1002/anie.200905660

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      Sometimes less is more: [13C1H3]methyl isotopomers can be biosynthetically incorporated specifically into the pro-S methyl groups of leucine and valine residues in large protein assemblies within a perdeuterated background by using an acetolactate precursor. This stereospecific labeling strategy considerably enhances NMR spectra for large protein assemblies.

    5. Self-Assembly

      Dynamers at the Solid–Liquid Interface: Controlling the Reversible Assembly/Reassembly Process between Two Highly Ordered Supramolecular Guanine Motifs (pages 1963–1966)

      Artur Ciesielski, Stefano Lena, Stefano Masiero, Gian Piero Spada and Paolo Samorì

      Article first published online: 4 FEB 2010 | DOI: 10.1002/anie.200905827

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      String quartet: A dynamic assembly/reassembly process in octadecyl guanine (G) monolayers was triggered by addition of [2.2.2]cryptand, potassium picrate (K+(pic)), and trifluoromethanesulfonic acid. The resulting structures, which alternate between a hydrogen-bonded G ribbon and a G quartet, were monitored by STM at the solid–liquid interface on graphite (see picture).

    6. Structural Biology

      An Efficient Protocol for NMR-Spectroscopy-Based Structure Determination of Protein Complexes in Solution (pages 1967–1970)

      Bernd Simon, Tobias Madl, Cameron D. Mackereth, Michael Nilges and Michael Sattler

      Article first published online: 10 FEB 2010 | DOI: 10.1002/anie.200906147

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      Putting the pieces together: An efficient, generally applicable approach for structural analysis of protein complexes and multidomain proteins in solution based on NMR spectroscopy is presented. Starting from available high-resolution structures of individual domains or subunits, the overall domain arrangement is calculated from NMR spectroscopy data that can be obtained for high-molecular-weight complexes.

    7. Bioorganic Chemistry

      Strongly Binding Cell-Adhesive Polypeptides of Programmable Valencies (pages 1971–1975)

      Benjamin W. Lee, Rajib Schubert, Yuk Kee Cheung, Federico Zannier, Qian Wei, Daniele Sacchi and Samuel K. Sia

      Article first published online: 10 FEB 2010 | DOI: 10.1002/anie.200906482

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      Longer and stronger: Engineered multivalent polypeptides were used to increase and tune the adhesion strength of cells to surfaces. Monodisperse polypeptides containing programmable valencies of a cell-adhesion sequence were synthesized (with up to 80 repeats of the RGD sequence; see schematic illustration). The multivalent cell-adhesion polypeptides provided strong resistance to cellular delamination under shear.

    8. Nanoparticles

      A Simple Spectroscopic Method for Differentiating Cellular Uptakes of Gold Nanospheres and Nanorods from Their Mixtures (pages 1976–1980)

      Eun Chul Cho, Yang Liu and Younan Xia

      Article first published online: 9 FEB 2010 | DOI: 10.1002/anie.200906584

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      See the difference: UV/Vis spectroscopy allows differentiation of the cellular uptakes of gold nanospheres and nanorods from their mixtures by taking advantage of their distinctive optical signatures (see picture).

    9. Surface Chemistry

      Bridging the Gap between CO Adsorption Studies on Gold Model Surfaces and Supported Nanoparticles (pages 1981–1985)

      Miguel López-Haro, Juan J. Delgado, José M. Cies, Eloy del Rio, Serafin Bernal, Robbie Burch, Miguel A. Cauqui, Susana Trasobares, José A. Pérez-Omil, Pascale Bayle-Guillemaud and José J. Calvino

      Article first published online: 23 FEB 2010 | DOI: 10.1002/anie.200903403

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      A happy medium: Volumetric adsorption of carbon monoxide at 308 K and UHR-HAADF-STEM, HREM, and computer modeling techniques were compared. Experimental CO/Au ratios at saturation coverage for two supported gold catalysts were shown to fit very well the predictions of a nanostructural model that considers CO adsorption on gold sites with coordination numbers of less than eight.

    10. Multinuclear Complexes

      A Unique Pd4 Platform with CH3 and μ-CH2 Groups and Its C[BOND]C Coupling Reaction with Simple Olefins (pages 1986–1989)

      Anna Sachse, Michael John and Franc Meyer

      Article first published online: 12 FEB 2010 | DOI: 10.1002/anie.200904745

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      Ménage à quatre: The Pd4 complex 1 features both terminal CH3 and bridging CH2 groups, and it reacts with ethylene at room temperature to give mainly propene. NMR spectroscopic studies reveal several intermediates in the formation of 1 from Pd2 building blocks.

    11. Supramolecular Chemistry

      Philic and Phobic Segregation in Liquid-Crystal Ionic Dendrimers: An Enthalpy–Entropy Competition (pages 1990–1994)

      Silvia Hernández-Ainsa, Mercedes Marcos, Joaquín Barberá and José L. Serrano

      Article first published online: 9 FEB 2010 | DOI: 10.1002/anie.200905654

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      A molecular tug of war between non- and semifluorinated alkyl chains (see picture) occurs when they are forced together by ionic attachment to a poly(propylene imine) dendrimer. Unexpected mesomorphic properties appear as a consequence of the competition of both substituents to control the supramolecular organization of the molecules.

    12. Sol–Gel Processes

      Two-Component Gel Formation by Pseudoenantiomeric Ethynylhelicene Oligomers (pages 1995–1999)

      Ryo Amemiya, Marie Mizutani and Masahiko Yamaguchi

      Article first published online: 16 FEB 2010 | DOI: 10.1002/anie.200906693

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      Long and winding gel: Mixtures of (M)- and (P)-ethynylhelicene oligomers (see structure) differing in the numbers of helicene units formed organogels in toluene, which exhibited better thermoreversibility in the sol–gel process than those formed from enantiomers. Various two-component gels were obtained by changing the combination of the component pseudoenantiomeric oligomers, provided that they were larger than a trimer.

    13. Total Synthesis

      Total Synthesis of the Polycyclic Fungal Metabolite (±)-Communesin F (pages 2000–2003)

      Peng Liu, Jae Hong Seo and Steven M. Weinreb

      Article first published online: 19 FEB 2010 | DOI: 10.1002/anie.200906818

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      What the Heck: The heptacyclic fungal alkaloid communesin F was the target of a total synthesis featuring a rare example of an intramolecular Heck cyclization of a tetrasubstituted alkene, a reductive cyclization of an N-Boc aniline, a stereoselective C allylation of a lactam, and an azide reduction/N-Boc-δ-lactam ring opening sequence (see scheme, BOM=benzyloxymethyl).

    14. C[BOND]H Activation

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      Iron-Catalyzed Direct Arylation of Unactivated Arenes with Aryl Halides (pages 2004–2008)

      Wei Liu, Hao Cao and Aiwen Lei

      Article first published online: 16 FEB 2010 | DOI: 10.1002/anie.200906870

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      Iron tough: Various aryl halides were treated with unactivated arenes to form biaryl compounds in moderate to good yields. The reactions were carried out at relatively low temperature in the presence of a catalytic amount of FeCl3, with DMEDA as the ligand and LiHMDS as the base (see scheme; DMEDA=N,N'-dimethylethane-1,2-diamine, HDMS=hexamethyldisilazanide).

    15. Structure Elucidation

      Octamethylbicyclo[3.2.1]octadienes from the Rhizobacterium Serratia odorifera (pages 2009–2010)

      Stephan H. von Reuß, Marco Kai, Birgit Piechulla and Wittko Francke

      Article first published online: 12 FEB 2010 | DOI: 10.1002/anie.200905680

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      Volatile matters: A hydrocarbon containing 16 carbon atoms with an unprecedented framework, sodorifen (see structure), is the major volatile component released by the rhizobacterium Serratia odorifera. Its structure was elucidated by NMR and EIMS experiments and confirmed by synthesis.

    16. Natural Products

      Closthioamide: An Unprecedented Polythioamide Antibiotic from the Strictly Anaerobic Bacterium Clostridium cellulolyticum (pages 2011–2013)

      Thorger Lincke, Swantje Behnken, Keishi Ishida, Martin Roth and Christian Hertweck

      Article first published online: 15 FEB 2010 | DOI: 10.1002/anie.200906114

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      Choose sulfur in an oxygen-free world: Closthioamide (1) was isolated from the anaerobe Clostridium cellulolyticum (see SEM image) after the induction of its biosynthesis with an aqueous soil extract. An unprecedented type of symmetrical natural product in which all building blocks are connected through thioamide linkages, 1 is active against multiresistant staphylococci. It is the only known secondary metabolite from a strictly anaerobic bacterium.

    17. Synthetic Methods

      Pd-PEPPSI-IPent: Low-Temperature Negishi Cross-Coupling for the Preparation of Highly Functionalized, Tetra-ortho-Substituted Biaryls (pages 2014–2017)

      Selçuk Çalimsiz, Mahmoud Sayah, Debasis Mallik and Michael G. Organ

      Article first published online: 16 FEB 2010 | DOI: 10.1002/anie.200906811

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      Cool couplings: Complex, hindered biaryls have been prepared at temperatures ranging from 0°C to room temperature, or with gentle heating. The Pd-PEPPSI-IPent catalyst (see scheme) nicely couples starting materials containing acidic moieties and routinely prepares biaryl derivatives where one or both rings comprising the biaryl are heterocyclic. Ar1=hindered aryl or heteroaryl, Ar2=unactivated aryl or heteroaryl.

    18. Total Synthesis

      Total Synthesis of Complestatin (Chloropeptin II) (pages 2018–2022)

      Zhihui Wang, Michèle Bois-Choussy, Yanxing Jia and Jieping Zhu

      Article first published online: 10 FEB 2010 | DOI: 10.1002/anie.200906797

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      Substrate-dependent atropostereoselectivity: Cyclization of a linear DEFG tripeptide by an intramolecular Suzuki–Miyaura reaction afforded the 16-membered DEFG ring with complete atroposelectivity. Intramolecular SNAr reaction of a hexapeptide that contained a prebuilt DEFG ring afforded the bismacrocycle ABCDEFG that was converted to complestatin.

    19. Cleavable Linkers

      Bisaryl Hydrazones as Exchangeable Biocompatible Linkers (pages 2023–2027)

      Anouk Dirksen, Subramanian Yegneswaran and Philip E. Dawson

      Article first published online: 22 FEB 2010 | DOI: 10.1002/anie.200906756

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      Catch and release: Stable bisaryl hydrazones undergo rapid exchange under mild conditions in the presence of a catalyst (see schematic illustration; b=biotin). This highly efficient hydrazone exchange is useful for the affinity purification of biotinylated proteins on (strept)avidin beads. The method enables the mild elution of label-exchanged or chemically functionalized proteins.

    20. Gold Catalysis

      Gold-Catalyzed Halogenation of Aromatics by N-Halosuccinimides (pages 2028–2032)

      Fanyang Mo, Jerry Mingtao Yan, Di Qiu, Fei Li, Yan Zhang and Jianbo Wang

      Article first published online: 12 FEB 2010 | DOI: 10.1002/anie.200906699

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      Golden bromination: A highly efficient and mild AuCl3-catalyzed bromination of aromatic rings with N-bromosuccinimide (NBS) has been developed. This method works with a low catalyst loading (down to 0.01 mol %) and can be combined with transition metal catalyzed transformations to deliver various aryl products.

    21. Pheromones (1)

      The Sex Pheromone of the Wasp Spider Argiope bruennichi (pages 2033–2036)

      Satya P. Chinta, Stephan Goller, Julia Lux, Sebastian Funke, Gabriele Uhl and Stefan Schulz

      Article first published online: 12 FEB 2010 | DOI: 10.1002/anie.200906311

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      Wasp spider looking for a mate: Female wasp spiders (see picture) use trimethyl methylcitrate as a volatile cue to attract males. The experiments were performed on a sunny meadow, showing for the first time that spider traps can be used to trap spiders in the field (photo: Helen Sandford).

    22. Pheromones (2)

      Acylated Serine Derivatives: A Unique Class of Arthropod Pheromones of the Australian Redback Spider, Latrodectus hasselti (pages 2037–2040)

      Elena Jerhot, Jeffrey A. Stoltz, Maydianne C. B. Andrade and Stefan Schulz

      Article first published online: 9 FEB 2010 | DOI: 10.1002/anie.200906312

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      Irresistible: Amino acid derivatives are very rarely used as pheromones by arthropods. The widow spider Latrodectus hasselti (see picture) uses a unique compound (see formula) to lure its males. The molecular configuration plays an important role in this unique chemical communication system.

    23. Boron Heterocycles

      Synthesis and Structure of a Carbene-Stabilized π-Boryl Anion (pages 2041–2044)

      Holger Braunschweig, Ching-Wen Chiu, Krzysztof Radacki and Thomas Kupfer

      Article first published online: 15 FEB 2010 | DOI: 10.1002/anie.200906884

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      Attack with π electrons: Reduction of a chloroborole coordinated by an N-heterocyclic carbene results in the formation of a carbene-stabilized borole monoanion (see scheme; Mes=mesityl), the molecular structure of which has been determined by X-ray analysis. Computational and reactivity studies of this boracycle confirm the presence of a π-nucleophilic boron atom, which represents a rare example in the chemistry of boryl anions.

    24. Natural Product Synthesis

      Total Synthesis of Myrtucommulone A (pages 2045–2049)

      Hans Müller, Michael Paul, David Hartmann, Volker Huch, Dagmar Blaesius, Andreas Koeberle, Oliver Werz and Johann Jauch

      Article first published online: 12 FEB 2010 | DOI: 10.1002/anie.200903906

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      In a one-step conversion, commercially available or known compounds are connected to form myrtucommulone A, an anti-inflammatory and apoptosis-inducing substance from the common myrtle Myrtus communis (see scheme). This strategy can be used, as well to prepare myrtucommulone libraries.

    25. Total Synthesis of the Antibiotic Branimycin (pages 2050–2053)

      Stefan Marchart, Alexey Gromov and Johann Mulzer

      Article first published online: 9 FEB 2010 | DOI: 10.1002/anie.200906453

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      Catch 22: The first total synthesis of branimycin (1) has been achieved by a highly convergent approach in which the vinyl lithium derivative 3 was added to a cis-decalin ketone 2. The route has 22 steps in the longest linear sequence and an overall yield of 2 %. It is highly stereocontrolled, scaleable, and flexible. MOM=methoxymethyl, TBS=tert-butyldimethylsilyl.

    26. Microreactors

      Synthesis of Carbohydrate-Functionalized Quantum Dots in Microreactors (pages 2054–2057)

      Raghavendra Kikkeri, Paola Laurino, Arjan Odedra and Peter H. Seeberger

      Article first published online: 15 FEB 2010 | DOI: 10.1002/anie.200905053

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      Continuous sugar coating: A process has been developed for the mild, continuous-flow microreactor synthesis of carbohydrate-coated CdSe/ZnS and CdTe/ZnS quantum dots of narrow size distribution (see scheme; NP: nanoparticle, QD: quantum dot, Prec.: precursor). The products can be prepared efficiently and reproducibly in larger amounts. The surface of the QDs can be modified with biologically relevant molecules.

    27. Hydrogen Transfer

      Transfer Hydrogenation of Imines with Ammonia–Borane: A Concerted Double-Hydrogen-Transfer Reaction (pages 2058–2062)

      Xianghua Yang, Lili Zhao, Thomas Fox, Zhi-Xiang Wang and Heinz Berke

      Article first published online: 19 FEB 2010 | DOI: 10.1002/anie.200906302

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      Direct transfer hydrogenation of imines was observed with ammonia–borane, which proceeded under mild conditions without the help of a catalyst. The results of deuterium kinetic isotope effects, Hammett correlations, and DFT calculations all support a concerted double-hydrogen-transfer mechanism (see scheme).

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    3. Inside Cover
    4. Graphical Abstract
    5. Corrigendum
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    7. Author Profile
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    9. Book Review
    10. Highlights
    11. Review
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    1. You have free access to this content
      Preview: Angew. Chem. Int. Ed. 12/2010 (page 2067)

      Article first published online: 3 MAR 2010 | DOI: 10.1002/anie.201090030

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