O2 Activation and Selective Phenolate ortho Hydroxylation by an Unsymmetric Dicopper μ-η1:η1-Peroxido Complex (pages 2406–2409)
Isaac Garcia-Bosch, Anna Company, Jonathan R. Frisch, Miquel Torrent-Sucarrat, Mar Cardellach, Ilaria Gamba, Mireia Güell, Luigi Casella, Lawrence Que Jr., Xavi Ribas, Josep M. Luis and Miquel Costas
Version of Record online: 28 FEB 2010 | DOI: 10.1002/anie.200906749
Unusual reactivity: A novel unsymmetric dicopper complex gives rise to the unsymmetric species 1-O2 having a μ-η1:η1-O2 binding mode and reactivity patterns not previously observed for symmetric analogues. It is unreactive in oxygen atom transfer reactions, but it can selectively bind phenolate and mediate its ortho hydroxylation, thereby demonstrating a conceptually different tyrosinase model with exquisite selectivity.