Structure-Based Discovery of Natural-Product-like TNF-α Inhibitors (pages 2860–2864)
Daniel Shiu-Hin Chan, Ho-Man Lee, Fang Yang, Chi-Ming Che, Catherine C. L. Wong, Ruben Abagyan, Chung-Hang Leung and Dik-Lung Ma
Version of Record online: 16 MAR 2010 | DOI: 10.1002/anie.200907360
Small but effective: Two natural-product-like inhibitors of tumor necrosis factor α (TNF-α; represented in green in the picture) have been identified using structure-based virtual screening. These compounds represent only the third and fourth examples of direct targeting of TNF-α by a small molecule, and display potency comparable to that of the strongest TNF-α inhibitor reported to date.