Targeted Optimization of a Protein Nanomachine for Operation in Biohybrid Devices (pages 312–316)
Mamta Amrute-Nayak, Ralph P. Diensthuber, Walter Steffen, Daniela Kathmann, Falk K. Hartmann, Roman Fedorov, Claus Urbanke, Dietmar J. Manstein, Bernhard Brenner and Georgios Tsiavaliaris
Version of Record online: 17 NOV 2009 | DOI: 10.1002/anie.200905200
A long life with controlled movement: Engineered protein nanomachines with defined and adjustable functional features offer opportunities for controlling movement on nano- to microscale biohybrid devices. Myosin motors (the picture shows a dimeric motor) have now been constructed with optimized properties with regard to stability and regulation, including switchable processivity and tight control of the velocity of movement.