Labyrinthopeptins: A New Class of Carbacyclic Lantibiotics (pages 1151–1154)
Kathrin Meindl, Timo Schmiederer, Kathrin Schneider, Andreas Reicke, Diane Butz, Simone Keller, Hans Gühring, László Vértesy, Joachim Wink, Holger Hoffmann, Mark Brönstrup, George M. Sheldrick and Roderich D. Süssmuth
Article first published online: 15 JAN 2010 | DOI: 10.1002/anie.200905773
A-maze-ing peptides: The structure of the novel lantibiotic labyrinthopeptin A2 (see picture) contains labionin—an unprecedented carbacyclic, posttranslationally modified amino acid. The identification of the biosynthetic gene cluster of labyrinthopeptins was also successful. Labyrinthopeptin A2 revealed a pronounced in vivo efficacy (attenuation of tactile allodynia) in a mouse model of neuropathic pain.