Drug Design for G-Protein-Coupled Receptors by a Ligand-Based NMR Method (pages 1426–1429)
Stefan Bartoschek, Thomas Klabunde, Elisabeth Defossa, Viktoria Dietrich, Siegfried Stengelin, Christian Griesinger, Teresa Carlomagno, Ingo Focken and K. Ulrich Wendt
Version of Record online: 18 JAN 2010 | DOI: 10.1002/anie.200905102
A nonradioactive binding assay relying on NMR methods has been devised for a G-protein-coupled receptor; in addition the INPHARMA methods give access to the relative orientation of multiple ligands and supports ligand-based drug design (see picture of superimposed ligands). The method is fast and does not require any structural information from protein crystal structures.