Highly Efficient Capture of Circulating Tumor Cells by Using Nanostructured Silicon Substrates with Integrated Chaotic Micromixers (pages 3084–3088)
Dr. Shutao Wang, Dr. Kan Liu, Dr. Jian Liu, Dr. Zeta T.-F. Yu, Xiaowen Xu, Libo Zhao, Tom Lee, Dr. Eun Kyung Lee, Jean Reiss, Prof. Yi-Kuen Lee, Prof. Leland W. K. Chung, Prof. Jiaoti Huang, Prof. Matthew Rettig, Prof. David Seligson, Dr. Kumaran N. Duraiswamy, Prof. Clifton K.-F. Shen and Prof. Hsian-Rong Tseng
Version of Record online: 4 MAR 2011 | DOI: 10.1002/anie.201005853
Finding a needle in a haystack: A new technology is demonstrated to enrich circulating tumor cells (CTCs) with high efficiency by integrating an antibody-coated silicon nanopillar (SiNP, see picture; gray) substrate with an overlaid polydimethylsiloxane (PDMS) microfluidic chaotic mixer (turquoise). It shows significantly improved sensitivity in detecting rare CTCs from whole blood, thus providing an alternative for monitoring cancer progression.