Angewandte Chemie International Edition

Cover image for Vol. 50 Issue 13

March 21, 2011

Volume 50, Issue 13

Pages 2857–3090

  1. Cover Picture

    1. Top of page
    2. Cover Picture
    3. Inside Cover
    4. Graphical Abstract
    5. News
    6. Author Profile
    7. News
    8. Obituary
    9. Book Reviews
    10. Highlight
    11. Correspondence
    12. Minireview
    13. Review
    14. Communications
    15. Preview
    16. Back Cover
    1. Cover Picture: Highly Efficient Capture of Circulating Tumor Cells by Using Nanostructured Silicon Substrates with Integrated Chaotic Micromixers (Angew. Chem. Int. Ed. 13/2011) (page 2857)

      Dr. Shutao Wang, Dr. Kan Liu, Dr. Jian Liu, Dr. Zeta T.-F. Yu, Xiaowen Xu, Libo Zhao, Tom Lee, Dr. Eun Kyung Lee, Jean Reiss, Prof. Yi-Kuen Lee, Prof. Leland W. K. Chung, Prof. Jiaoti Huang, Prof. Matthew Rettig, Prof. David Seligson, Dr. Kumaran N. Duraiswamy, Prof. Clifton K.-F. Shen and Prof. Hsian-Rong Tseng

      Version of Record online: 4 MAR 2011 | DOI: 10.1002/anie.201100624

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      A capture-agent-coated nanostructured substrate is combined with a microfluidic chaotic mixer to give a new-generation technology for cancer diagnosis. In their Communication on page 3084 ff. H.-R. Tseng and co-workers show that with this system it is possible to isolate circulating tumor cells from whole blood with great efficiency, thus opening up opportunities for the early detection of cancer metastasis not possible with existing technologies.

  2. Inside Cover

    1. Top of page
    2. Cover Picture
    3. Inside Cover
    4. Graphical Abstract
    5. News
    6. Author Profile
    7. News
    8. Obituary
    9. Book Reviews
    10. Highlight
    11. Correspondence
    12. Minireview
    13. Review
    14. Communications
    15. Preview
    16. Back Cover
    1. Inside Cover: Empty Helical Nanochannels with Adjustable Order from Low-Symmetry Macrocycles (Angew. Chem. Int. Ed. 13/2011) (page 2858)

      Dr. Martin Fritzsche, Dr. Anne Bohle, Dr. Dmytro Dudenko, Dr. Ute Baumeister, Dr. Daniel Sebastiani, Dr. Gabriele Richardt, Prof. Dr. Hans Wolfgang Spiess, Dr. Michael Ryan Hansen and Prof. Dr. Sigurd Höger

      Version of Record online: 1 MAR 2011 | DOI: 10.1002/anie.201101115

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      Supramolecular organization of appropriate building blocks is a well-established tool for creating tubular molecular structures. In their Communication on page 3030 ff., M. R. Hansen, S. Höger, and co-workers describe how dissipative forces can be utilized in the self-assembly of a molecular channel-forming system based on shape-persistent macrocycles that have an inner diameter greater than one nanometer in the liquid-crystalline phase.

  3. Graphical Abstract

    1. Top of page
    2. Cover Picture
    3. Inside Cover
    4. Graphical Abstract
    5. News
    6. Author Profile
    7. News
    8. Obituary
    9. Book Reviews
    10. Highlight
    11. Correspondence
    12. Minireview
    13. Review
    14. Communications
    15. Preview
    16. Back Cover
  4. News

    1. Top of page
    2. Cover Picture
    3. Inside Cover
    4. Graphical Abstract
    5. News
    6. Author Profile
    7. News
    8. Obituary
    9. Book Reviews
    10. Highlight
    11. Correspondence
    12. Minireview
    13. Review
    14. Communications
    15. Preview
    16. Back Cover
  5. Author Profile

    1. Top of page
    2. Cover Picture
    3. Inside Cover
    4. Graphical Abstract
    5. News
    6. Author Profile
    7. News
    8. Obituary
    9. Book Reviews
    10. Highlight
    11. Correspondence
    12. Minireview
    13. Review
    14. Communications
    15. Preview
    16. Back Cover
    1. Alois Fürstner (pages 2880–2882)

      Version of Record online: 7 MAR 2011 | DOI: 10.1002/anie.201007191

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      “My favorite subject at school was certainly not sports. The three qualities that make a good scientist are curiosity, creativity, and dedication …” This and more about Alois Fürstner can be found on page 2880.

  6. News

    1. Top of page
    2. Cover Picture
    3. Inside Cover
    4. Graphical Abstract
    5. News
    6. Author Profile
    7. News
    8. Obituary
    9. Book Reviews
    10. Highlight
    11. Correspondence
    12. Minireview
    13. Review
    14. Communications
    15. Preview
    16. Back Cover
  7. Obituary

    1. Top of page
    2. Cover Picture
    3. Inside Cover
    4. Graphical Abstract
    5. News
    6. Author Profile
    7. News
    8. Obituary
    9. Book Reviews
    10. Highlight
    11. Correspondence
    12. Minireview
    13. Review
    14. Communications
    15. Preview
    16. Back Cover
    1. William von Eggers Doering (1917–2011) (pages 2885–2886)

      Frank-Gerrit Klärner

      Version of Record online: 24 FEB 2011 | DOI: 10.1002/anie.201100453

  8. Book Reviews

    1. Top of page
    2. Cover Picture
    3. Inside Cover
    4. Graphical Abstract
    5. News
    6. Author Profile
    7. News
    8. Obituary
    9. Book Reviews
    10. Highlight
    11. Correspondence
    12. Minireview
    13. Review
    14. Communications
    15. Preview
    16. Back Cover
    1. Enantioselective Chemical Synthesis. Methods, Logic and Practice. By Elias J. Corey and László Kürti. (pages 2887–2888)

      Hans-Günther Schmalz

      Version of Record online: 25 FEB 2011 | DOI: 10.1002/anie.201100655

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      Direct Book Publishing, 2010. 334 pp., hardcover, $ 75.00.—ISBN 978-0615395159

    2. 4D Electron Microscopy. Imaging in Space and Time. By Ahmed H. Zewail and John M. Thomas. (page 2888)

      Gustaaf Van Tendeloo

      Version of Record online: 2 MAR 2011 | DOI: 10.1002/anie.201101049

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      Imperial College Press, 2010. 360 pp., softcover, £ 36.00.—ISBN 978-1848164000

  9. Highlight

    1. Top of page
    2. Cover Picture
    3. Inside Cover
    4. Graphical Abstract
    5. News
    6. Author Profile
    7. News
    8. Obituary
    9. Book Reviews
    10. Highlight
    11. Correspondence
    12. Minireview
    13. Review
    14. Communications
    15. Preview
    16. Back Cover
    1. Brønsted Acid Catalysis

      A Chiral N-Phosphinyl Phosphoramide: Another Offspring for the Sage Phosphoric Acid Progenitor (pages 2890–2891)

      Prof. Dr. Jeffrey N. Johnston

      Version of Record online: 15 FEB 2011 | DOI: 10.1002/anie.201006951

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      Nitrogen enriched: The continuing quest for Brønsted acid catalysts that address unmet selectivity needs in organic synthesis has resulted in a new chiral phosphoric acid derivative. At the heart of this catalyst is a hydrogen-bond donor (N[BOND]H) that promotes an enantioselective intramolecular addition of oxygen (OH) to an azomethine (C[DOUBLE BOND]N). Diversity within a privileged chiral architecture invariably leads to new catalytic enantioselective chemical reactions.

  10. Correspondence

    1. Top of page
    2. Cover Picture
    3. Inside Cover
    4. Graphical Abstract
    5. News
    6. Author Profile
    7. News
    8. Obituary
    9. Book Reviews
    10. Highlight
    11. Correspondence
    12. Minireview
    13. Review
    14. Communications
    15. Preview
    16. Back Cover
    1. Structure Elucidation

      Pseudosymmetry in Trinitropyrazole: The Cost of Error in Space-Group Determination (pages 2892–2894)

      Dr. Yulia V. Nelyubina, Dr. Igor L. Dalinger and Prof. Konstantin A. Lyssenko

      Version of Record online: 23 FEB 2011 | DOI: 10.1002/anie.201006000

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      Trial and error: Topological analysis of the experimental electron density distribution of trinitropyrazole has allowed the energetic consequences of an overlooked pseudosymmetry to be quantified for the first time. This has allowed measurement of how much a small error in the assignment of a space group may cost a crystal structure; in the case of trinitropyrazole this was 8.9 kcal mol−1.

  11. Minireview

    1. Top of page
    2. Cover Picture
    3. Inside Cover
    4. Graphical Abstract
    5. News
    6. Author Profile
    7. News
    8. Obituary
    9. Book Reviews
    10. Highlight
    11. Correspondence
    12. Minireview
    13. Review
    14. Communications
    15. Preview
    16. Back Cover
    1. Expansion of the Genetic Code

      In Vivo Incorporation of Multiple Noncanonical Amino Acids into Proteins (pages 2896–2902)

      Michael G. Hoesl and Prof. Dr. Nediljko Budisa

      Version of Record online: 25 FEB 2011 | DOI: 10.1002/anie.201005680

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      Integration of new AA members: A pyrrolysyl-tRNA synthetase:tRNA pair can be combined with an orthogonal pair from Methanocaldococcus jannaschii to incorporate two chemically distinct noncanonical amino acids into a single recombinant protein. This modification was enabled by the tandem read-through of a three-base termination codon and a four-base frameshift codon at natural and orthogonal ribosomes.

  12. Review

    1. Top of page
    2. Cover Picture
    3. Inside Cover
    4. Graphical Abstract
    5. News
    6. Author Profile
    7. News
    8. Obituary
    9. Book Reviews
    10. Highlight
    11. Correspondence
    12. Minireview
    13. Review
    14. Communications
    15. Preview
    16. Back Cover
    1. Nanoscience

      TiO2 Nanotubes: Synthesis and Applications (pages 2904–2939)

      Poulomi Roy, Steffen Berger and Patrik Schmuki

      Version of Record online: 10 MAR 2011 | DOI: 10.1002/anie.201001374

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      A new escapade for titania: Titanium dioxide is one of the most studied materials and has many applications, for example in photocatalysis, dye-sensitized solar cells, and biomedical devices. TiO2 nanotubes, which have outstanding properties and have resulted in much research interest, play a particularly important part.

  13. Communications

    1. Top of page
    2. Cover Picture
    3. Inside Cover
    4. Graphical Abstract
    5. News
    6. Author Profile
    7. News
    8. Obituary
    9. Book Reviews
    10. Highlight
    11. Correspondence
    12. Minireview
    13. Review
    14. Communications
    15. Preview
    16. Back Cover
    1. Single-Molecule Spectroscopy

      Far-Field Nanoscopy with Reversible Chemical Reactions (pages 2940–2945)

      Michael Schwering, Dr. Alexander Kiel, Anton Kurz, Dr. Konstantinos Lymperopoulos, Dr. Arnd Sprödefeld, Prof. Dr. Roland Krämer and Priv.-Doz. Dr. Dirk-Peter Herten

      Version of Record online: 15 FEB 2011 | DOI: 10.1002/anie.201006013

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      Revolution in resolution: Abbe's resolution limit has been overcome in fluorescence microscopy by using light-driven processes to switch the emission of fluorophores on and off. Alternatively, chemical reactions can be used, for example the coordination of Cu2+ ions to a fluorescent probe for the stochastic switching between spectroscopic states.

    2. Enzyme Catalysis

      Revealing the Position of the Substrate in Nickel Superoxide Dismutase: A Model Study (pages 2946–2950)

      Dr. Daniel Tietze, Dipl.-Ing. Stephan Voigt, Dipl.-Chem. Doreen Mollenhauer, Dipl.-Chem. Marco Tischler, Dr. Diana Imhof, Dr. Torsten Gutmann, Prof. Dr. Leticia González, Dr. Oliver Ohlenschläger, Dr. Hergen Breitzke, Dr. Matthias Görlach and Prof. Dr. Gerd Buntkowsky

      Version of Record online: 25 FEB 2011 | DOI: 10.1002/anie.201005027

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      Water in site: The structure of a stable adduct of a peptide-based nickel superoxide dismutase model (NiSOD) with cyanide as substrate analogue is determined by NMR spectroscopy and optimized by DFT methods. A functional water molecule is found in the active site (see picture; Ni brown, O red/pink, C green, N blue). The role of this water molecule in the catalytic degradation of O2.− is discussed.

    3. Enzymatic Halogenation

      Changing the Regioselectivity of the Tryptophan 7-Halogenase PrnA by Site-Directed Mutagenesis (pages 2951–2953)

      Dr. Alexander Lang, Stefan Polnick, Tristan Nicke, Peter William, Dr. Eugenio P. Patallo, Prof. James H. Naismith and Prof. Karl-Heinz van Pée

      Version of Record online: 25 FEB 2011 | DOI: 10.1002/anie.201007896

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      Creating more space in the active site of the tryptophan 7-halogenase PrnA by exchanging the large amino acid phenylalanine for the smaller alanine makes it possible for the substrate to bind in different orientations (see picture; yellow PrnA, blue PrnAF103A variant). This results in halogenation of the differently bound substrate in the 5-position of the indole ring.

    4. Diterpenes

      Enantioselective Total Synthesis of the Diterpenes Kempene-2, Kempene-1, and 3-epi-Kempene-1 from the Defense Secretion of Higher Termites (pages 2954–2956)

      Melanie Schubert and Prof. Dr. Peter Metz

      Version of Record online: 25 FEB 2011 | DOI: 10.1002/anie.201007551

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      Two rings in one sweep: A domino metathesis of the bicyclic dienyne 4 (TBS=tert-butyldimethylsilyl) obtained from a catalytic enantioselective Diels–Alder reaction as the key process enabled the efficient preparation of the tetracyclic diterpenes kempene-2 (1), kempene-1 (2), and 3-epi-kempene-1 (3).

    5. Alkynylzinc Addition

      Asymmetric Autocatalysis Enables an Improved Synthesis of Efavirenz (pages 2957–2961)

      Dr. Nicka Chinkov, Dr. Aleksander Warm and Prof. Dr. Erick M. Carreira

      Version of Record online: 1 MAR 2011 | DOI: 10.1002/anie.201006689

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      Priming the pump: An asymmetric autocatalytic zinc acetylide addition employs catalytic amounts of the enantiomerically pure product as part of a chiral cocktail. This new strategy enables an improved synthesis of a key precursor to efavirenz (see scheme).

    6. Cyclohexyne in Total Synthesis

      Total Syntheses of Guanacastepenes N and O (pages 2962–2965)

      Christian M. Gampe and Prof. Dr. Erick M. Carreira

      Version of Record online: 2 MAR 2011 | DOI: 10.1002/anie.201007644

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      The cycloinsertion of cyclohexyne into a pentalene has provided access to the carbon scaffold of the guanacastepenes in nine steps. A late-stage diversifying oxidation of the core structure enabled the synthesis of guanacastepene N and the first total synthesis of guanacastepene O.

    7. Heterocycle Synthesis

      Three-Component Synthesis of Ynediones by a Glyoxylation/Stephens–Castro Coupling Sequence (pages 2966–2969)

      Dipl.-Chem. Eugen Merkul, Janis Dohe, MSc Charlotte Gers, Dr. Frank Rominger and Prof. Dr. Thomas J. J. Müller

      Version of Record online: 23 FEB 2011 | DOI: 10.1002/anie.201007194

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      One step back, two steps forward! Starting from diverse heterocycles, the title reaction furnishes ynediones under very mild conditions in a direct and preparatively simple one-pot process. The key to avoiding decarbonylation is the CuI-catalyzed Stephens–Castro alkynylation rather than the usually more efficient Sonogashira coupling. In addition, novel highly atom-economical four-component syntheses of various heterocycles can be achieved.

    8. Carbocations

      A Strain-Releasing Trap for Highly Reactive Electrophiles: Structural Characterization of Bowl-Shaped Arenium Carbocations (pages 2971–2974)

      Dr. Alexander V. Zabula, Sarah N. Spisak, Dr. Alexander S. Filatov, Dr. Andrey Yu. Rogachev and Prof. Dr. Marina A. Petrukhina

      Version of Record online: 17 FEB 2011 | DOI: 10.1002/anie.201007762

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      Trap for electrophiles: The reaction of corannulene with halogenated hydrocarbons in the presence of AlCl3 gave the products of an electrophilic attack on the hub carbon atom of the curved aromatic surface (see picture). The X-ray diffraction characterization of a series of bowl-shaped cations illustrates structural deformations caused by the site-directed interior surface functionalization.

    9. Synthetic Methods

      An Efficient and General Iron-Catalyzed C[BOND]C Bond Activation with 1,3-Dicarbonyl Units as a Leaving Groups (pages 2975–2978)

      Dr. Huanrong Li, Wenjuan Li, Weiping Liu, Zhiheng He and Prof. Dr. Zhiping Li

      Version of Record online: 23 FEB 2011 | DOI: 10.1002/anie.201006779

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      With our compliments: The 1,3-dicarbonyl unit has been shown to be a new and useful leaving group for iron-catalyzed bond cleavage (see scheme). This new strategy can complement the traditional Friedel–Crafts reaction and was applied in the synthesis of indene derivatives.

    10. Crystal-Structure Prediction

      Molecule VI, a Benchmark Crystal-Structure-Prediction Sulfonimide: Are Its Polymorphs Predictable? (pages 2979–2981)

      H. C. Stephen Chan, Dr. John Kendrick and Dr. Frank J. J. Leusen

      Version of Record online: 24 FEB 2011 | DOI: 10.1002/anie.201007488

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      The tale of Molecule VI: Past failures to predict the polymorphs of a sulfonimide using molecular mechanics have led to speculation that crystal-structure prediction may be of limited use owing to the kinetic nature of crystallization. An approach based on quantum mechanics now successfully predicts the three known polymorphs of this compound (molecule VI, see structure). Accurate lattice energy calculations are thus sufficient to predict the polymorphs of small organic molecules.

    11. Olefin Separation

      Surface Energy-Level Tuning of Silver Nanoparticles for Facilitated Olefin Transport (pages 2982–2985)

      Il Seok Chae, Prof. Sang Wook Kang, Ji Yun Park, Yong-Gun Lee, Jung Hyun Lee, Prof. Jongok Won and Prof. Yong Soo Kang

      Version of Record online: 25 FEB 2011 | DOI: 10.1002/anie.201007557

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      Calling the tune: High positive surface charges induced by tetracyanoquinodimethane (TCNQ) allow tuning of the energy levels of silver nanoparticles (AgNPs) through an interface dipole (see picture). Facilitated transport membranes containing AgNPs with TCNQ dispersed in poly(vinylpyrrolidone) show high mixed-gas selectivity for the separation of olefin/paraffin mixtures.

    12. Heterogeneous Catalysis

      Selective Deoxygenation of Epoxides to Alkenes with Molecular Hydrogen Using a Hydrotalcite-Supported Gold Catalyst: A Concerted Effect between Gold Nanoparticles and Basic Sites on a Support (pages 2986–2989)

      Akifumi Noujima, Dr. Takato Mitsudome, Dr. Tomoo Mizugaki, Prof. Dr. Koichiro Jitsukawa and Prof. Dr. Kiyotomi Kaneda

      Version of Record online: 24 FEB 2011 | DOI: 10.1002/anie.201007679

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      A picky catalyst: Hydrotalcite-supported gold nanoparticles (Au/HT) efficiently catalyze the deoxygenation of epoxides to alkenes using molecular hydrogen as an ideal reductant. Various epoxides have been deoxygenated to the corresponding alkenes (see picture) with over 99 % selectivity. The high selectivity is based on the concerted effect between basic sites of HT and the gold nanoparticles.

    13. C[BOND]H Functionalization

      Stereospecific Copper-Catalyzed C[BOND]H Allylation of Electron-Deficient Arenes with Allyl Phosphates (pages 2990–2994)

      Tomoyuki Yao, Dr. Koji Hirano, Prof. Dr. Tetsuya Satoh and Prof. Dr. Masahiro Miura

      Version of Record online: 25 FEB 2011 | DOI: 10.1002/anie.201007733

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      Rapid and concise: The title reaction proceeds via copper complexes in a highly stereospecific manner (see scheme; acac=acetylacetonate, phen=1,10-phenanthroline, TBS=tBuMe2Si). The catalysis provides a rapid and concise route to allylarenes that contain fluorinated aromatic cores of an electron-deficient nature.

    14. Solar Cells

      Development of Fluorinated Benzothiadiazole as a Structural Unit for a Polymer Solar Cell of 7 % Efficiency (pages 2995–2998)

      Huaxing Zhou, Liqiang Yang, Andrew C. Stuart, Samuel C. Price, Dr. Shubin Liu and Prof. Dr. Wei You

      Version of Record online: 2 MAR 2011 | DOI: 10.1002/anie.201005451

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      High-powered polymer: Fluorinated benzothiadiazole was incorporated into a polymer that was used in a high-performance solar cell. The model polymer 2 has decreased HOMO and LUMO energy levels and a similar band gap when compared with its nonfluorinated analogue 1. A bulk heterojunction device derived from 1 demonstrated a high power conversion efficiency of 7.2 % (5.0 % for 1).

    15. Electrochemical Cells

      Investigation of the O2 Electrochemistry in a Polymer Electrolyte Solid-State Cell (pages 2999–3002)

      Dr. Jusef Hassoun, Prof. Fausto Croce, Prof. Michel Armand and Prof. Bruno Scrosati

      Version of Record online: 1 MAR 2011 | DOI: 10.1002/anie.201006264

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      A polymer makes it possible: Use of an advanced polymer electrolyte allowed clarification of the oxygen reaction mechanism in lithium–air solid-state batteries. The related reversible processes are identified to occur at potential values that are the lowest ever reported in the absence of catalyst.

    16. Zeolite Analogues

      A Gallogermanate Zeolite Constructed Exclusively by Three-Ring Building Units (pages 3003–3005)

      Yide Han, Dr. Yi Li, Prof. Jihong Yu and Prof. Ruren Xu

      Version of Record online: 23 FEB 2011 | DOI: 10.1002/anie.201006500

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      A new zeotype structure with 3D intersecting 10-ring channels is found in [Ni(en)3][Ga2Ge4O12] (denoted GaGeO-CJ63, en=ethylenediamine). Its framework (see picture) is constructed exclusively by 3-rings, and the framework density is the second lowest among all known zeolite structures. One of the two kinds of cages in GaGeO-CJ63 is chiral and its chirality comes from the Δ and Λ enantiomers of occluded [Ni(en)3]2+.

    17. N-alkylation

      Iron/Amino Acid Catalyzed Direct N-Alkylation of Amines with Alcohols (pages 3006–3009)

      Dr. Yingsheng Zhao, Siong Wan Foo and Dr. Susumu Saito

      Version of Record online: 25 FEB 2011 | DOI: 10.1002/anie.201006660

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      Ironing it out: The straightforward N-alkylation using alcohols and iron/amino acid catalysis is described (see scheme). The reaction does not proceed by the conventional “borrowing hydrogen” mechanism, but appears to involve a substitution pathway (SN) at the sp3 carbon atom bearing the hydroxy group of the alcohol. Developing a catalyst that is effective at a near neutral pH was key to the successful N-alkylation.

    18. Carbene Ligands

      A Fischer Carbene within an Arduengo Carbene (pages 3010–3012)

      Dr. Javier Ruiz, Lucía García, Dr. Bernabé F. Perandones and Dr. Marilín Vivanco

      Version of Record online: 24 FEB 2011 | DOI: 10.1002/anie.201007937

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      A Fischer carbene complex within the N-heterocyclic carbene skeleton is present in MnI/AuI heterometallic compounds that were synthesized from an acyclic diaminocarbene complex, through a translocation process of metallic ions under basic conditions and subsequent alkylation with methyl triflate (see scheme; bipy=bipyridyl, [Mn]=[Mn(CO)2(bipy)]).

    19. Natural Products

      Formal Asymmetric Synthesis of Echinopine A and B (pages 3013–3016)

      Dr. Philippe A. Peixoto, Dr. Rene Severin, Dr. Chih-Chung Tseng and Prof. Dr. David Y.-K. Chen

      Version of Record online: 18 FEB 2011 | DOI: 10.1002/anie.201008000

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      Enticing structures: The formal syntheses of 1 and 2 were accomplished by using a cascade strategy involving an enyne cycloisomerization reaction and an intramolecular Diels–Alder reaction starting from 3. The resulting 4 underwent a late-stage ring contraction to enable the preparation of a reported advanced intermediate, thereby constituting a formal synthesis of the structurally intriguing title compounds.

      Corrected by:

      Corrigendum: Corrigendum: Formal Asymmetric Synthesis of Echinopine A and B

      Vol. 51, Issue 42, 10436, Version of Record online: 10 OCT 2012

    20. Theranostic Agents

      Gold-Nanoshelled Microcapsules: A Theranostic Agent for Ultrasound Contrast Imaging and Photothermal Therapy (pages 3017–3021)

      Hengte Ke, Prof. Jinrui Wang, Prof. Zhifei Dai, Yushen Jin, Enze Qu, Dr. Zhanwen Xing, Dr. Caixin Guo, Prof. Xiuli Yue and Prof. Jibin Liu

      Version of Record online: 25 FEB 2011 | DOI: 10.1002/anie.201008286

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      A valuable shell: The combination of electrostatic deposition of gold nanoparticles onto microcapsules and a surface seeding method results in the formation of gold nanoshells (see picture). This nano/microcomposite is able to operate as a theranostic agent for both contrast-enhanced ultrasonic imaging (diagnostic) and photohyperthermia (therapeutic), and thus holds a great potential for photothermal therapy in cancer treatment.

    21. Aromatic Cations

      On the Benzylium/Tropylium Ion Dichotomy: Electronic Absorption Spectra in Neon Matrices (pages 3022–3025)

      Adam Nagy, Dr. hab. Jan Fulara, Iryna Garkusha and Prof. John P. Maier

      Version of Record online: 23 FEB 2011 | DOI: 10.1002/anie.201008036

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      Benzyl and tropyl in charge: Electronic spectra of mass-selected benzylium (Bz+) and tropylium (Tr+) cations embedded in solid neon are reported for the first time. They reveal a weak (1)1B1[LEFTWARDS ARROW]equation image1A1 visible (see picture) and a much stronger (1)1A1[LEFTWARDS ARROW]equation image1A1 ultraviolet transition for Bz+ (C2v symmetry). The lowest dipole-allowed 1A′′2[LEFTWARDS ARROW]equation image1A′1 absorption in the ultraviolet region for Tr+ (D7h) is also observed.

    22. Artificial Metalloenzyme

      Artificial Transfer Hydrogenases for the Enantioselective Reduction of Cyclic Imines (pages 3026–3029)

      Marc Dürrenberger, Tillmann Heinisch, Yvonne M. Wilson, Thibaud Rossel, Elisa Nogueira, Livia Knörr, Annette Mutschler, Karoline Kersten, Malcolm Jeremy Zimbron, Julien Pierron, Tilman Schirmer and Prof. Dr. Thomas R. Ward

      Version of Record online: 24 FEB 2011 | DOI: 10.1002/anie.201007820

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      Man-made activity: Introduction of a biotinylated iridium piano stool complex within streptavidin affords an artificial imine reductase (see scheme). Saturation mutagenesis allowed optimization of the activity and the enantioselectivity of this metalloenzyme, and its X-ray structure suggests that a nearby lysine residue acts as a proton source during the transfer hydrogenation.

    23. Macrocycles

      Empty Helical Nanochannels with Adjustable Order from Low-Symmetry Macrocycles (pages 3030–3033)

      Dr. Martin Fritzsche, Dr. Anne Bohle, Dr. Dmytro Dudenko, Dr. Ute Baumeister, Dr. Daniel Sebastiani, Dr. Gabriele Richardt, Prof. Dr. Hans Wolfgang Spiess, Dr. Michael Ryan Hansen and Prof. Dr. Sigurd Höger

      Version of Record online: 15 FEB 2011 | DOI: 10.1002/anie.201007437

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      Take the tube: Self-organization of shape-persistent macrocycles in the liquid-crystalline phase by π–π stacking leads to empty nanochannels that have an inner diameter above one nanometer and either tight or more permeable walls (see picture). Solid-state NMR spectroscopy was used to confirm that the channels do not contain solvent molecules or alkyl chains.

    24. Supramolecular Chemistry

      Molecular Networks Based on Dative Boron–Nitrogen Bonds (pages 3034–3037)

      Erin Sheepwash, Vincent Krampl, Dr. Rosario Scopelliti, Olha Sereda, Antonia Neels and Prof. Kay Severin

      Version of Record online: 23 FEB 2011 | DOI: 10.1002/anie.201007225

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      The BN connection: Crystalline and soft molecular networks can be constructed using dative B[BOND]N bonds (see picture). The networks are obtained in a one-step, three-component reaction involving a triboronic acid, a catechol, and a bipyridyl linker.

    25. Dendritic Micelles

      Photoregulated Release of Noncovalent Guests from Dendritic Amphiphilic Nanocontainers (pages 3038–3042)

      Volkan Yesilyurt, Rajasekharreddy Ramireddy and Prof. S. Thayumanavan

      Version of Record online: 25 FEB 2011 | DOI: 10.1002/anie.201006193

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      Supramolecular disassembly: Phototriggered release of noncovalently sequestered lipophilic guest molecules from dendritic supramolecular assemblies has been demonstrated. Facially amphiphilic dendrimers have been shown to provide a unique opportunity to fine-tune the release kinetics of the guest molecules in response to light (see picture).

    26. Liquid Crystals

      Graphene Oxide Liquid Crystals (pages 3043–3047)

      Ji Eun Kim, Dr. Tae Hee Han, Dr. Sun Hwa Lee, Ju Young Kim, Dr. Chi Won Ahn, Dr. Je Moon Yun and Prof. Sang Ouk Kim

      Version of Record online: 23 FEB 2011 | DOI: 10.1002/anie.201004692

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      Crystal clear: The liquid crystallinity of graphene oxide platelets in aqueous dispersion is demonstrated. Graphene oxide sheets are arranged around liquid-crystal disclinations (see picture). The orientation of the liquid crystals can be manipulated by a magnetic field or mechanical deformation.

    27. Microreactors

      Chaotically Accelerated Polymerase Chain Reaction by Microscale Rayleigh–Bénard Convection (pages 3048–3052)

      Radha Muddu, Prof. Yassin A. Hassan and Prof. Victor M. Ugaz

      Version of Record online: 25 FEB 2011 | DOI: 10.1002/anie.201004217

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      Going with the flow: DNA replication by the polymerase chain reaction (PCR) can proceed at a greatly accelerated rate when performed in the presence of a chaotic flow induced by microscale thermal convection (see picture). The consequences of these effects sharply contradict established design rules for chemistry involving coupled flow and reaction.

    28. Electron Microscopy

      Oxygen-Vacancy Ordering at Surfaces of Lithium Manganese(III,IV) Oxide Spinel Nanoparticles (pages 3053–3057)

      Dr. Rong Huang, Dr. Yumi H. Ikuhara, Dr. Teruyasu Mizoguchi, Dr. Scott D. Findlay, Dr. Akihide Kuwabara, Dr. Craig A. J. Fisher, Dr. Hiroki Moriwake, Dr. Hideki Oki, Dr. Tsukasa Hirayama and Prof. Yuichi Ikuhara

      Version of Record online: 23 FEB 2011 | DOI: 10.1002/anie.201004638

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      Direct observation of light elements (Li and O) in oxygen-deficient lithium manganese spinel by spherical aberration-corrected scanning transmission electron microscopy is reported. A previously unknown ordered structure was revealed by annular dark-field (ADF) imaging of oxygen columns, while Li ions are visualized successfully by annular bright-field (ABF) imaging (see picture).

    29. Protein Delivery

      Delivery of Intact Transcription Factor by Using Self-Assembled Supramolecular Nanoparticles (pages 3058–3062)

      Yang Liu, Dr. Hao Wang, Dr. Ken-ichiro Kamei, Dr. Ming Yan, Kuan-Ju Chen, Qinghua Yuan, Prof. Linqi Shi, Prof. Yunfeng Lu and Prof. Hsian-Rong Tseng

      Version of Record online: 2 MAR 2011 | DOI: 10.1002/anie.201005740

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      Special delivery: A supramolecular nanoparticle provides a facile and modular protein delivery system (see picture, TAT enables cell membrane penetration, RGD targeting, and PEG passivation) for highly efficient transduction of intact (unmodified) transcription factors (TF). Such a TF delivery approach provides a powerful method for manipulating cellular behavior.

    30. Imaging Agents

      Coupling of Luminescent Terbium Complexes to Fe3O4 Nanoparticles for Imaging Applications (pages 3063–3066)

      Baodui Wang, Jun Hai, Qin Wang, Tianrong Li and Zhengyin Yang

      Version of Record online: 1 MAR 2011 | DOI: 10.1002/anie.201006195

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      Dual imaging agent: A fluorescent TbIII complex coupled to Fe3O4 nanoparticles and bearing a folic acid residue (see picture) shows superparamagnetism, low cytotoxicity, and high cell uptake, and thus can be used for in vitro fluorescence and magnetic resonance imaging of cells that overexpress the folate receptor, such as HeLa cells.

    31. Metal–Organic Frameworks

      Thermal Amorphization of Zeolitic Imidazolate Frameworks (pages 3067–3071)

      Thomas D. Bennett, Prof. David A. Keen, Dr. Jin-Chong Tan, Dr. Emma R. Barney, Dr. Andrew L. Goodwin and Prof. Anthony K. Cheetham

      Version of Record online: 25 FEB 2011 | DOI: 10.1002/anie.201007303

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      Each the same: A stable, recoverable, amorphous phase (see topology model) was produced by heating each of four different zeolitic imidazolate frameworks ZIF-1, -3, -4, and Co-ZIF-4. By comparing nanoindentation results, density measurements, and X-ray total scattering results, it is concluded that the structure of the amorphous phase is equivalent in each case. Amorphization was only observed in ZIFs encompassing unsubstituted imidazolate ligands.

    32. Asymmetric Catalysis

      Enantioselective Ficini Reaction: Ruthenium/PNNP-Catalyzed [2+2] Cycloaddition of Ynamides with Cyclic Enones (pages 3072–3074)

      MSc Christoph Schotes and Prof. Dr. Antonio Mezzetti

      Version of Record online: 25 FEB 2011 | DOI: 10.1002/anie.201007753

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      Chiral cyclobuteneamides made easy: Double chloride abstraction from the ruthenium/PNNP complex 1 in the presence of unsaturated β-keto esters 2 gives the dicationic adducts [Ru(2)(PNNP)]2+ (3) that catalyze the [2+2] cycloaddition of a variety of ynamides 4 to produce cyclobuteneamides 5 with high yield and enantioselectivity (see scheme).

    33. Atropisomerism

      Atropisomerism in the Vaptan Class of Vasopressin Receptor Ligands: The Active Conformation Recognized by the Receptor (pages 3075–3079)

      Hidetsugu Tabata, Jun Nakagomi, Daisuke Morizono, Dr. Tetsuta Oshitari, Prof. Dr. Hideyo Takahashi and Prof. Dr. Hideaki Natsugari

      Version of Record online: 24 FEB 2011 | DOI: 10.1002/anie.201007772

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      Latent chirality: Atropisomerism in the vaptan class of vasopressin receptor ligands with N-benzoyl benzo-fused seven-membered-ring nitrogen heterocycles was investigated by freezing the axis by ortho substitution. The aS/aR atropisomers caused by the Ar[BOND]N([DOUBLE BOND]CO) axis were separated to reveal that the vasopressin receptor recognizes the cis,aS conformation (see picture; R=CH3, X=[BOND]CO[BOND], Y=H) when it binds to the ligand.

    34. Fluorescent Probes

      Highly Luminescent Water-Dispersible Silicon Nanowires for Long-Term Immunofluorescent Cellular Imaging (pages 3080–3083)

      Dr. Yao He, Yiling Zhong, Fei Peng, Xinpan Wei, Yuanyuan Su, Shao Su, Wei Gu, Prof. Liangsheng Liao and Prof. Shuit-Tong Lee

      Version of Record online: 7 MAR 2011 | DOI: 10.1002/anie.201100482

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      All aglow: Multicolored fluorescent quantum-dot (QD)-decorated silicon nanowires (SiNWs) are easily prepared by a one-pot microwave-assisted synthesis. The as-prepared SiNWs are highly luminescent (see picture, left) and are well-suited to long-term immunofluorescent cellular imaging (see stability comparison, right).

    35. Cell Capture

      Highly Efficient Capture of Circulating Tumor Cells by Using Nanostructured Silicon Substrates with Integrated Chaotic Micromixers (pages 3084–3088)

      Dr. Shutao Wang, Dr. Kan Liu, Dr. Jian Liu, Dr. Zeta T.-F. Yu, Xiaowen Xu, Libo Zhao, Tom Lee, Dr. Eun Kyung Lee, Jean Reiss, Prof. Yi-Kuen Lee, Prof. Leland W. K. Chung, Prof. Jiaoti Huang, Prof. Matthew Rettig, Prof. David Seligson, Dr. Kumaran N. Duraiswamy, Prof. Clifton K.-F. Shen and Prof. Hsian-Rong Tseng

      Version of Record online: 4 MAR 2011 | DOI: 10.1002/anie.201005853

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      Finding a needle in a haystack: A new technology is demonstrated to enrich circulating tumor cells (CTCs) with high efficiency by integrating an antibody-coated silicon nanopillar (SiNP, see picture; gray) substrate with an overlaid polydimethylsiloxane (PDMS) microfluidic chaotic mixer (turquoise). It shows significantly improved sensitivity in detecting rare CTCs from whole blood, thus providing an alternative for monitoring cancer progression.

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    1. Top of page
    2. Cover Picture
    3. Inside Cover
    4. Graphical Abstract
    5. News
    6. Author Profile
    7. News
    8. Obituary
    9. Book Reviews
    10. Highlight
    11. Correspondence
    12. Minireview
    13. Review
    14. Communications
    15. Preview
    16. Back Cover
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  15. Back Cover

    1. Top of page
    2. Cover Picture
    3. Inside Cover
    4. Graphical Abstract
    5. News
    6. Author Profile
    7. News
    8. Obituary
    9. Book Reviews
    10. Highlight
    11. Correspondence
    12. Minireview
    13. Review
    14. Communications
    15. Preview
    16. Back Cover
    1. Back Cover: Highly Luminescent Water-Dispersible Silicon Nanowires for Long-Term Immunofluorescent Cellular Imaging (Angew. Chem. Int. Ed. 13/2011) (page 3090)

      Dr. Yao He, Yiling Zhong, Fei Peng, Xinpan Wei, Yuanyuan Su, Shao Su, Wei Gu, Prof. Liangsheng Liao and Prof. Shuit-Tong Lee

      Version of Record online: 4 MAR 2011 | DOI: 10.1002/anie.201101112

      Thumbnail image of graphical abstract

      Multicolored highly fluorescent silicon nanowires (SiNWs) are described by Y. He, S. T. Lee, and co-workers in their Communication on page 3080 ff. The SiNWs show potential in optoelectronic and biological applications because of their excellent aqueous dispersibility, strong photoluminescence, and high photostability. The picture shows SiNWs used as fluorescent probes in long-term cellular imaging.

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