Total Synthesis of Pactamycin (pages 3497–3500)
Prof. Dr. Stephen Hanessian, Dr. Ramkrishna Reddy Vakiti, Stéphane Dorich, Dr. Shyamapada Banerjee, Dr. Fabien Lecomte, Dr. Juan R. DelValle, Jianbin Zhang and Benoît Deschênes-Simard
Article first published online: 2 MAR 2011 | DOI: 10.1002/anie.201008079
Lest we forget: 50 years after pactamycin was first isolated from a fermentation broth of Streptomyces pactum var pactum, this highly functionalized aminocyclopentitol natural product has finally succumbed to total synthesis. The modular and stereocontrolled introduction of functional groups should lead to the synthesis of less toxic congeners that maintain the antibacterial and cytotoxic activities.