Angewandte Chemie International Edition

Cover image for Vol. 50 Issue 21

May 16, 2011

Volume 50, Issue 21

Pages 4715–4989

  1. Cover Picture

    1. Top of page
    2. Cover Picture
    3. Inside Cover
    4. Back Cover
    5. Editorial
    6. Graphical Abstract
    7. News
    8. Author Profiles
    9. Book Review
    10. Highlights
    11. Essay
    12. Minireview
    13. Reviews
    14. Communications
    15. Preview
    1. Cover Picture: Integrated Synthetic Strategy for Higher Catechin Oligomers (Angew. Chem. Int. Ed. 21/2011) (page 4715)

      Dr. Ken Ohmori, Dr. Tomohiro Shono, Yuki Hatakoshi, Takahisa Yano and Prof. Dr. Keisuke Suzuki

      Article first published online: 18 MAR 2011 | DOI: 10.1002/anie.201101348

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      The widespread occurrence of oligocatechins in plants has captured the interest of chemists because of their biological activities. In their Communication on page 4862 ff. K. Suzuki and co-workers describe the block synthesis of oligocatechins, an approach that enables extention of the oligomers through equimolar couplings of higher oligomeric units. (Cover picture by K. Ohmori.)

  2. Inside Cover

    1. Top of page
    2. Cover Picture
    3. Inside Cover
    4. Back Cover
    5. Editorial
    6. Graphical Abstract
    7. News
    8. Author Profiles
    9. Book Review
    10. Highlights
    11. Essay
    12. Minireview
    13. Reviews
    14. Communications
    15. Preview
    1. Inside Cover: Cooperative Assembly of Binary Molecular Components into Tubular Structures for Multiple Photonic Applications (Angew. Chem. Int. Ed. 21/2011) (page 4716)

      Dr. Qing Liao, Prof. Hongbing Fu, Chen Wang and Prof. Jiannian Yao

      Article first published online: 3 MAY 2011 | DOI: 10.1002/anie.201102497

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      Cooperative self-assembly by hydrogen bonding between two luminescent molecular components generates binary microtubes with precisely controlled lengths. As H. B. Fu, J. N. Yao, and co-workers report in their Communication on page 4942 ff., the microtubes behave as annular microcavities that are capable of propagating photoluminescence along the length of the tube.

  3. Back Cover

    1. Top of page
    2. Cover Picture
    3. Inside Cover
    4. Back Cover
    5. Editorial
    6. Graphical Abstract
    7. News
    8. Author Profiles
    9. Book Review
    10. Highlights
    11. Essay
    12. Minireview
    13. Reviews
    14. Communications
    15. Preview
    1. Back Cover: Diatomic [CuO]+ and Its Role in the Spin-Selective Hydrogen- and Oxygen-Atom Transfers in the Thermal Activation of Methane (Angew. Chem. Int. Ed. 21/2011) (page 4716)

      Dipl.-Chem. Nicolas Dietl, Dipl.-Chem. Christian van der Linde, Dr. Maria Schlangen, Prof. Dr. Martin K. Beyer and Prof. Dr. Helmut Schwarz

      Article first published online: 27 APR 2011 | DOI: 10.1002/anie.201102192

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      The final puzzle piece of the first-row transition-metal oxides has been found. In their Communication on page 4966 ff., H. Schwarz et al. describe how more than ten years after its theoretical prediction to serve as a powerful methane[RIGHTWARDS ARROW]methanol converter, the bare [CuO]+ cation has been successfully generated in the gas phase. The crucial role of two-state reactivity and the importance of oxygen-centered radicals for selectivity in the oxidation of methane have been revealed by a combination of mass spectrometry and DFT calculations.

  4. Editorial

    1. Top of page
    2. Cover Picture
    3. Inside Cover
    4. Back Cover
    5. Editorial
    6. Graphical Abstract
    7. News
    8. Author Profiles
    9. Book Review
    10. Highlights
    11. Essay
    12. Minireview
    13. Reviews
    14. Communications
    15. Preview
    1. You have free access to this content
      Angewandte Chemie International Edition Celebrates Its 50th Birthday (pages 4718–4719)

      Prof. Dr. Michael Dröscher

      Article first published online: 21 APR 2011 | DOI: 10.1002/anie.201102322

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      Angewandte Chemie International Edition Celebrates Its 50th Birthday

  5. Graphical Abstract

    1. Top of page
    2. Cover Picture
    3. Inside Cover
    4. Back Cover
    5. Editorial
    6. Graphical Abstract
    7. News
    8. Author Profiles
    9. Book Review
    10. Highlights
    11. Essay
    12. Minireview
    13. Reviews
    14. Communications
    15. Preview
    1. Graphical Abstract: Angew. Chem. Int. Ed. 21/2011 (pages 4721–4733)

      Article first published online: 6 MAY 2011 | DOI: 10.1002/anie.201190041

  6. News

    1. Top of page
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    3. Inside Cover
    4. Back Cover
    5. Editorial
    6. Graphical Abstract
    7. News
    8. Author Profiles
    9. Book Review
    10. Highlights
    11. Essay
    12. Minireview
    13. Reviews
    14. Communications
    15. Preview
  7. Author Profiles

    1. Top of page
    2. Cover Picture
    3. Inside Cover
    4. Back Cover
    5. Editorial
    6. Graphical Abstract
    7. News
    8. Author Profiles
    9. Book Review
    10. Highlights
    11. Essay
    12. Minireview
    13. Reviews
    14. Communications
    15. Preview
    1. Takashi Kato (page 4740)

      Article first published online: 26 APR 2011 | DOI: 10.1002/anie.201007361

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      “My favorite subjects at school were the sciences and geography. When I was eighteen I wanted to be an engineer or a scientist. …” This and more about Takashi Kato can be found on page 4740.

    2. Buxing Han (page 4741)

      Article first published online: 4 MAY 2011 | DOI: 10.1002/anie.201102147

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      “If I were not scientist, I would be an architect. When I wake up I have a big breakfast and think about what I will be doing during the day …” This and more about Buxing Han can be found on page 4741.

  8. Book Review

    1. Top of page
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    3. Inside Cover
    4. Back Cover
    5. Editorial
    6. Graphical Abstract
    7. News
    8. Author Profiles
    9. Book Review
    10. Highlights
    11. Essay
    12. Minireview
    13. Reviews
    14. Communications
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    1. Chemical Synthesis of Hormones, Pheromones and Other Bioregulators. By Kenji Mori. (page 4742)

      Stefan Schulz

      Article first published online: 28 APR 2011 | DOI: 10.1002/anie.201101284

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      John Wiley & Sons, Hoboken 2010. 314 pp., softcover, € 48.90.—ISBN 978-0470697238

  9. Highlights

    1. Top of page
    2. Cover Picture
    3. Inside Cover
    4. Back Cover
    5. Editorial
    6. Graphical Abstract
    7. News
    8. Author Profiles
    9. Book Review
    10. Highlights
    11. Essay
    12. Minireview
    13. Reviews
    14. Communications
    15. Preview
    1. Nanotechnology

      Carbon Nanotube Rubber Stays Rubbery in Extreme Temperatures (pages 4744–4746)

      Prof. Dr. Liming Dai

      Article first published online: 19 APR 2011 | DOI: 10.1002/anie.201100414

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      Extreme elastic: A new viscoelastic material has recently been developed from carbon nanotubes (CNT rubber; see picture). This material is similar to silicone rubber but maintains its viscoelasticity from −196 to 1000 °C in an oxygen-free environment. CNT rubber is promising for a wide range of applications, including use in high-vacuum furnaces and even aerospace vehicles that travel to the cold interstellar space.

    2. Inorganic Double Helices

      Inorganic Materials with Double-Helix Structures (pages 4747–4750)

      Dr. Dang Sheng Su

      Article first published online: 14 APR 2011 | DOI: 10.1002/anie.201007147

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      Two different methods recently yielded inorganic materials with double-helix structures: Silicon microtubes (see picture) formed when high inner pressure forced NaSi melt through an opening in the surface of a disc, and carbon nanotubes were prepared when plates of layered double hydroxide coated with active catalyst particles were used as substrate. These reports open the door for the application of double-helical inorganic materials in chemistry and biology.

  10. Essay

    1. Top of page
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    3. Inside Cover
    4. Back Cover
    5. Editorial
    6. Graphical Abstract
    7. News
    8. Author Profiles
    9. Book Review
    10. Highlights
    11. Essay
    12. Minireview
    13. Reviews
    14. Communications
    15. Preview
    1. History of Chemistry

      Marie Curie: Recipient of the 1911 Nobel Prize in Chemistry and Discoverer of the Chemical Elements Polonium and Radium (pages 4752–4758)

      Prof. Dr. Christoph Friedrich and Prof. Dr. Horst Remane

      Article first published online: 29 MAR 2011 | DOI: 10.1002/anie.201008063

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      Déjà vu all over again: When the Polish-born scientist Marie Skłodowska-Curie traveled from Paris to Stockholm in December 1911 to receive the Nobel Prize in Chemistry, it was the second time that she had been recognized with the sciences' top honor; she had already received the Nobel Prize in Physics in 1903. Madame Curie's contributions included her pioneering investigations of radioactivity and the discovery of the radioactive elements radium and polonium.

  11. Minireview

    1. Top of page
    2. Cover Picture
    3. Inside Cover
    4. Back Cover
    5. Editorial
    6. Graphical Abstract
    7. News
    8. Author Profiles
    9. Book Review
    10. Highlights
    11. Essay
    12. Minireview
    13. Reviews
    14. Communications
    15. Preview
    1. Cooperative Catalysis

      Recent Advances in Direct Catalytic Asymmetric Transformations under Proton-Transfer Conditions (pages 4760–4772)

      Dr. Naoya Kumagai and Prof. Dr. Masakatsu Shibasaki

      Article first published online: 21 APR 2011 | DOI: 10.1002/anie.201100918

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      Give me an H: The sophisticated synergism of the two concepts of asymmetric catalysis and atom economy offers a truly efficient synthetic strategy for the production of requisite chemical entities with high enantiomeric purity. Recent advances in this field are highlighted, with a particular emphasis on catalytic asymmetric reactions that proceeds under proton-transfer conditions.

  12. Reviews

    1. Top of page
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    4. Back Cover
    5. Editorial
    6. Graphical Abstract
    7. News
    8. Author Profiles
    9. Book Review
    10. Highlights
    11. Essay
    12. Minireview
    13. Reviews
    14. Communications
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    1. Chemical Biology

      Chemistry and the Worm: Caenorhabditis elegans as a Platform for Integrating Chemical and Biological Research (pages 4774–4807)

      Dr. S. Elizabeth Hulme and Prof. George M. Whitesides

      Article first published online: 15 APR 2011 | DOI: 10.1002/anie.201005461

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      What makes a living thing alive?Caenorhabditis elegans is a popular model organism for genetic research. Although the worm (see picture) is a simple organism, it still exhibits many of the complex phenomena found in higher organisms, including aging, behavior, cognition, and susceptibility to disease. This review provides an introduction to worm biology and argues that C. elegans is a useful system for the examination of complex biological phenomena from a chemical perspective.

    2. Aromatic Rings

      Aromatic Rings in Chemical and Biological Recognition: Energetics and Structures (pages 4808–4842)

      M. Sc. Laura M. Salonen, Dr. Manuel Ellermann and Prof. Dr. François Diederich

      Article first published online: 28 APR 2011 | DOI: 10.1002/anie.201007560

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      The role of aromatic rings in chemical and biological recognition is explored with a multidimensional approach, which includes synthetic host–guest studies, small-molecule crystallography, investigations with biological receptors and biostructural analysis, and database mining in the Cambridge Structural Database (CSD) and the Protein Data Bank (PDB). Topics covered are arene–arene, perfluoroarene–arene, S⋅⋅⋅aromatic, cation–π, and anion–π interactions, as well as hydrogen bonding to π surfaces. Shown here is the complexation of a cationic 7-methylguanosine ring in the human nuclear cap-binding complex.

  13. Communications

    1. Top of page
    2. Cover Picture
    3. Inside Cover
    4. Back Cover
    5. Editorial
    6. Graphical Abstract
    7. News
    8. Author Profiles
    9. Book Review
    10. Highlights
    11. Essay
    12. Minireview
    13. Reviews
    14. Communications
    15. Preview
    1. Self-Assembly

      Mapping the Sequential Self-Assembly of Heterometallic Clusters: From a Helix to a Grid (pages 4844–4848)

      Dr. Graham N. Newton, Tatsuya Onuki, Dr. Takuya Shiga, Mao Noguchi, Takuto Matsumoto, Jennifer S. Mathieson, Dr. Masayuki Nihei, Prof. Dr. Motohiro Nakano, Prof. Dr. Leroy Cronin and Prof. Dr. Hiroki Oshio

      Article first published online: 25 FEB 2011 | DOI: 10.1002/anie.201007388

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      Two iron/cobalt mixed-valence clusters were synthesized using multidentate polypyridyl ligands (see picture: FeII orange, FeIII yellow, CoII blue, O red). A heptanuclear helix and a [3×3] grid complex form depending on the metal ion stoichiometry. ESI-MS measurements suggest that the helical cluster is an intermediate to the grid complex.

    2. Protein Engineering

      Post-Crystal Engineering of Zinc-Substituted Myoglobin to Construct a Long-Lived Photoinduced Charge-Separation System (pages 4849–4852)

      Dr. Tomomi Koshiyama, Dr. Masanobu Shirai, Tatsuo Hikage, Hiroyasu Tabe, Prof. Dr. Koichiro Tanaka, Prof. Dr. Susumu Kitagawa and Prof. Dr. Takafumi Ueno

      Article first published online: 14 APR 2011 | DOI: 10.1002/anie.201008004

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      An artificial photoinduced electron-transfer system has been constructed by accumulating redox cofactors in a myoglobin crystal. The crystal space allowed the construction of a site-specific dense array, and the different redox cofactors had low reorganization energies, as observed in native photosynthesis. A charge-separated state with a half-life 2800 times longer than that of one previously reported in organic solution was achieved.

    3. Carbon Nanotubes

      Coaxially Stacked Coronene Columns inside Single-Walled Carbon Nanotubes (pages 4853–4857)

      Prof. Toshiya Okazaki, Yoko Iizumi, Dr. Shingo Okubo, Dr. Hiromichi Kataura, Dr. Zheng Liu, Dr. Kazu Suenaga, Yoshio Tahara, Dr. Masako Yudasaka, Prof. Susumu Okada and Prof. Sumio Iijima

      Article first published online: 23 MAR 2011 | DOI: 10.1002/anie.201007832

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      Pancakes in tubes: Coronenes, a class of planar π-conjugated molecules, organize in 1D structures when using single-walled carbon nanotubes (SWCNTs) as templates (see picture). Coronene columns with coaxial stacking in SWCNTs exhibit characteristic fluorescence spectra that significantly differ from those of isolated coronene molecules and three-dimensional crystals and that are related to their well-ordered 1D structure.

    4. Core–Shell Nanoparticles

      The Precise Synthesis and Growth of Core–Shell Nanoparticles within a Self-Assembled Spherical Template (pages 4858–4861)

      Dr. Kosuke Suzuki, Kiyotaka Takao, Dr. Sota Sato and Prof. Dr. Makoto Fujita

      Article first published online: 4 MAR 2011 | DOI: 10.1002/anie.201006965

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      The synthesis within: Highly monodisperse core–shell nanoparticles (SiO2/TiO2, SiO2/ZrO2) with a polydispersity index of <1.01 and a diameter of 3 nm were synthesized within structurally exact self-assembled spherical Pd complexes that act as three-dimensional templates (see picture; gray spheres: TiO2 or ZrO2, purple spheres: SiO2, yellow spheres: Pd).

    5. Oligocatechins

      Integrated Synthetic Strategy for Higher Catechin Oligomers (pages 4862–4867)

      Dr. Ken Ohmori, Dr. Tomohiro Shono, Yuki Hatakoshi, Takahisa Yano and Prof. Dr. Keisuke Suzuki

      Article first published online: 25 FEB 2011 | DOI: 10.1002/anie.201007473

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      Chain linked: An integrated strategy for the rapid assembly of catechin oligomers has been developed, thus enabling access to higher oligomers ranging from 6- to 24-mers. The method exploits an orthogonal, block-type coupling strategy (see scheme).

    6. Polycarbonate Synthesis

      Stereocomplex of Poly(propylene carbonate): Synthesis of Stereogradient Poly(propylene carbonate) by Regio- and Enantioselective Copolymerization of Propylene Oxide with Carbon Dioxide (pages 4868–4871)

      Dr. Koji Nakano, Shinichi Hashimoto, Mitsuru Nakamura, Toshihiro Kamada and Prof. Kyoko Nozaki

      Article first published online: 4 MAR 2011 | DOI: 10.1002/anie.201007958

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      Cobalt(III)–salen complexes with ammonium arm(s) have been used to catalyze the title transformation. Higher thermal decomposition temperatures than those of typical poly(propylene carbonate)s (PPCs) were observed for the stereogradient and the stereoblock PPCs obtained by this method.

    7. Supramolecular Gels

      Size-Complementary Rotaxane Cross-Linking for the Stabilization and Degradation of a Supramolecular Network (pages 4872–4875)

      Dr. Yasuhiro Kohsaka, Dr. Kazuko Nakazono, Dr. Yasuhito Koyama, Prof. Dr. Shigeo Asai and Prof. Dr. Toshikazu Takata

      Article first published online: 27 APR 2011 | DOI: 10.1002/anie.201008020

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      Break it down: Gels formed from rotaxane cross-linkers with end groups that are size-complementary to the macrocyclic cavity of wheel components (see picture) were prepared. The network structure was maintained in polar organic solvents or in the presence of a base to prevent hydrogen bonding. Anion exchange enabled the selective and efficient de-cross-linking of the gels.

    8. Vesicular Catalyst

      Molecular-Architecture-Based Administration of Catalysis in Water: Self-Assembly of an Amphiphilic Palladium Pincer Complex (pages 4876–4878)

      Dr. Go Hamasaka, Tsubasa Muto and Prof. Dr. Yasuhiro Uozumi

      Article first published online: 31 MAR 2011 | DOI: 10.1002/anie.201100827

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      Testing the waters: An architecture-based system for transition-metal catalysis consisting of a self-assembled amphiphilic pincer palladium complex bearing hydrophilic and hydrophobic chains has been developed. Self-assembly of the bilayer vesicles of the complex, concentration of the organic substrates within the hydrophobic region of the bilayer membrane, and catalytic transformation of the substrate all occur sequentially in water (see scheme).

    9. Natural Products

      Functional Analysis of Synthetic Substructures of Polytheonamide B: A Transmembrane Channel-Forming Peptide (pages 4879–4883)

      Dr. Shigeru Matsuoka, Dr. Naoki Shinohara, Tomoaki Takahashi, Maiko Iida and Prof. Dr. Masayuki Inoue

      Article first published online: 21 APR 2011 | DOI: 10.1002/anie.201101533

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      Longer is better: Polytheonamide B, the largest nonribosomal linear peptide identified to date, is a transmembrane channel-forming peptide. Nine of its substructures have now been chemically synthesized. The membrane-disrupting and ion-channel-forming sequences as well as the cytotoxicity-enhancing sequence have been identified.

    10. Natural Products Synthesis

      Total Synthesis of (−)-Conophylline and (−)-Conophyllidine (pages 4884–4887)

      Dr. Yuki Han-ya, Prof. Dr. Hidetoshi Tokuyama and Prof. Dr. Tohru Fukuyama

      Article first published online: 15 APR 2011 | DOI: 10.1002/anie.201100981

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      Double take: The total syntheses of the title compounds were accomplished in a highly convergent manner. The approach features the regio- and diastereoselective Polonovski–Potier-type reaction for the coupling of two aspidosperma skeletons and the formation of the dihydrofuran ring. Troc=2,2,2-trichloroethoxycarbonyl.

    11. Chemoselective Catalysis

      Organocatalytic Chemoselective Monoacylation of 1,n-Linear Diols (pages 4888–4892)

      Keisuke Yoshida, Dr. Takumi Furuta and Prof. Dr. Takeo Kawabata

      Article first published online: 4 MAY 2011 | DOI: 10.1002/anie.201100700

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      Matters of length: Exclusive or predominant monoacylation of 1,n-linear diols took place in the presence of 1 when the chain length of linear diols was equal to or shorter than five carbon atoms. The chemoselectivity of acylation between 1,5-pentanediol (n=5) and 1,6-hexanediol (n=6) was 5.2, and that between 1,5-pentanediol and its monoacylate was 113.

    12. Asymmetric Catalysis

      Chiral Silver Amide Catalyst for the [3+2] Cycloaddition of α-Amino Esters to Olefins (pages 4893–4896)

      Dr. Yasuhiro Yamashita, Takaki Imaizumi and Prof. Dr. Shū Kobayashi

      Article first published online: 6 APR 2011 | DOI: 10.1002/anie.201008272

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      Silver lining: Highly exo-selective asymmetric [3+2] cycloaddition of α-amino ester Schiff bases with activated olefins proceeds in the presence of AgHMDS/1. The α-amino ester Schiff bases including those derived from aliphatic imines successfully reacted to afford the corresponding pyrrolidine derivatives in high yield with high exo- and enantioselectivities. EWG=electron-withdrawing group, HMDS=hexamethyldisilazide.

    13. Copper Catalysis

      An exo- and Enantioselective 1,3-Dipolar Cycloaddition of Azomethine Ylides with Alkylidene Malonates Catalyzed by a N,O-Ligand/Cu(OAc)2-Derived Chiral Complex (pages 4897–4900)

      Ming Wang, Zheng Wang, Yu-Hua Shi, Prof. Xiao-Xin Shi, Dr. John S. Fossey and Prof. Wei-Ping Deng

      Article first published online: 29 APR 2011 | DOI: 10.1002/anie.201007960

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      Anexo-lent catalyst: An N,O-ligand/Cu(OAc)2 derived chiral complex is an excellent catalyst for inducing asymmetry in the catalytic enantioselective 1,3-dipolar cycloadditions of azomethine ylides with various alkylidene malonates. A series of highly functionalized exo-pyrrolidines were obtained in excellent yields (80–99 %) and enantioselectivities (91–99 % ee; see scheme; M.S.: molecular sieve).

    14. C[BOND]N Activation

      Nickel-Catalyzed Cross-Coupling of Aryltrimethylammonium Iodides with Organozinc Reagents (pages 4901–4904)

      Lan-Gui Xie and Prof. Dr. Zhong-Xia Wang

      Article first published online: 27 APR 2011 | DOI: 10.1002/anie.201100683

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      Broad scope and good tolerance: An efficient cross-coupling of aryltrimethylammonium iodide salts with aryl-, methyl-, and benzylzinc chlorides catalyzed by [Ni(PCy3)2Cl2] has been achieved (see scheme). The reaction involves cleavage of the C[BOND]N bond and displays broad substrate scope and good functional group tolerance. NMP=N-methylpyrrolidine.

    15. Fuel-Cell Catalysts

      A Methanol-Tolerant Pt/CoSe2 Nanobelt Cathode Catalyst for Direct Methanol Fuel Cells (pages 4905–4908)

      Dr. Min-Rui Gao, Qiang Gao, Jun Jiang, Chun-Hua Cui, Wei-Tang Yao and Prof. Dr. Shu-Hong Yu

      Article first published online: 24 MAR 2011 | DOI: 10.1002/anie.201007036

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      High alcohol tolerance: A Pt/CoSe2 nanobelt cathode catalyst for direct methanol fuel cells was prepared by in situ loading of Pt nanoparticles on CoSe2/diethylenetriamine nanobelts through a polyol reduction approach. The resulting functionalized nanobelts (see picture) exhibit high activity in the four-electron oxygen reduction reaction and are highly methanol tolerant.

    16. Chirality

      Helix-Sense-Selective Polymerization of Achiral Substituted Acetylenes in Chiral Micelles (pages 4909–4912)

      Xiaofeng Luo, Prof. Jianping Deng and Prof. Wantai Yang

      Article first published online: 2 MAR 2011 | DOI: 10.1002/anie.201006658

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      Hold that shape: An achiral acetylene underwent helix-sense-selective polymerization in chiral micelles consisting of [{(nbd)RhCl}2] (nbd=2,5-norbornadiene) and dodecylphenylalanine as a chiral emulsifier to produce optically active helical polymers and polymeric emulsions.

    17. Asymmetric Hydrogenation

      Enhancement of the Performance of a Platinum Nanocatalyst Confined within Carbon Nanotubes for Asymmetric Hydrogenation (pages 4913–4917)

      Dr. Zhijian Chen, Zaihong Guan, Prof. Mingrun Li, Prof. Qihua Yang and Prof. Can Li

      Article first published online: 2 MAR 2011 | DOI: 10.1002/anie.201006870

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      Going through the proper channels: A highly active and enantioselective heterogeneous asymmetric catalyst was fabricated by confining Pt nanoparticles that are modified with cinchonidine within the channels of carbon nanotubes. A high turnover frequency (TOF) and enantioselectivity are achieved when using this catalyst for the asymmetric hydrogenation of α-ketoesters.

    18. Carbon Capture

      Tuning the Basicity of Ionic Liquids for Equimolar CO2 Capture (pages 4918–4922)

      Dr. Congmin Wang, Xiaoyan Luo, Dr. Huimin Luo, Dr. De-en Jiang, Prof. Haoran Li and Dr. Sheng Dai

      Article first published online: 2 MAR 2011 | DOI: 10.1002/anie.201008151

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      What a catch! Basic ionic liquids (ILs) based on a phosphonium hydroxide derivative can be tuned for CO2 capture by varying the weak proton donors, which have different pKa values. The stability, absorption capacity, and absorption enthalpy of the ILs could be easily tuned: the best IL for CO2 capture has good stability (>300 °C), energy saving (ca. 56 kJ mol−1), and equimolar absorption capability.

    19. Tunable Vesicles

      CO2-Responsive Polymeric Vesicles that Breathe (pages 4923–4927)

      Qiang Yan, Rong Zhou, Changkui Fu, Dr. Huijuan Zhang, Prof. Yingwu Yin and Prof. Jinying Yuan

      Article first published online: 28 APR 2011 | DOI: 10.1002/anie.201100708

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      Vesicles breathe CO2! A new type of vesicle that self-assembles from amidine-containing diblock copolymer displays “breathing” features. Treating the vesicles with CO2 or Ar can reversibly tune the expansion and contraction of the vesicular volume, as if a bubble is breathing (see picture, PAD=poly((N-amidino)dodecyl acrylamide), PEO=poly(ethylene oxide), Rh=hydrodynamic radius).

    20. Asymmetric Synthesis

      Highly Enantioselective Michael Addition of Pyrazolin-5-ones Catalyzed by Chiral Metal/N,N′-Dioxide Complexes: Metal-Directed Switch in Enantioselectivity (pages 4928–4932)

      Zhen Wang, Zhigang Yang, Donghui Chen, Dr. Xiaohua Liu, Dr. Lili Lin and Prof. Dr. Xiaoming Feng

      Article first published online: 14 APR 2011 | DOI: 10.1002/anie.201008256

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      Make the switch: The first example of a switch in enantioselectivity in the asymmetric Michael addition of pyrazolin-5-ones to 4-oxo-4-arylbutenoates that is controlled by the metal center of the catalyst is reported. By using the same N,N′-dioxide ligand L with different metals the respective enantiomers of various 4-substituted 5-pyrazolone derivatives were obtained. Tf=trifluoromethanesulfonyl.

    21. Nucleoside Synthesis

      An Efficient Approach to the Synthesis of Nucleosides: Gold(I)-Catalyzed N-Glycosylation of Pyrimidines and Purines with Glycosyl ortho-Alkynyl Benzoates (pages 4933–4936)

      Qingju Zhang, Dr. Jiansong Sun, Yugen Zhu, Dr. Fuyi Zhang and Prof. Biao Yu

      Article first published online: 15 APR 2011 | DOI: 10.1002/anie.201100514

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      Persuaded with gold: The title reaction in the presence of [Ph3PAuNTf2] (Tf=trifluoromethanesulfonyl) led conveniently to the corresponding nucleosides with excellent regioselectivity (see scheme). Even purine derivatives underwent this transformation owing to the mild conditions, which enabled the use of protecting groups that would not usually be compatible with N-glycosylation conditions.

    22. Gold Catalysis

      Efficient Gold(I)-Catalyzed Direct Intramolecular Hydroalkylation of Unactivated Alkenes with α-Ketones (pages 4937–4941)

      Dr. Ya-Ping Xiao, Dr. Xin-Yuan Liu and Prof. Dr. Chi-Ming Che

      Article first published online: 28 APR 2011 | DOI: 10.1002/anie.201100044

      Thumbnail image of graphical abstract

      Easy access by gold: The AuI-catalyzed title reaction provides simple and efficient access to highly substituted cyclic compounds with excellent yields and good diastereoselectivity. This transformation constitutes the first example of transition-metal-catalyzed direct hydroalkylation of unactivated alkenes with simple α-ketone groups in the absence of additive reagents. Bn=benzyl, Ts=tosyl.

    23. Self-Assembly

      Cooperative Assembly of Binary Molecular Components into Tubular Structures for Multiple Photonic Applications (pages 4942–4946)

      Dr. Qing Liao, Prof. Hongbing Fu, Chen Wang and Prof. Jiannian Yao

      Article first published online: 6 MAY 2011 | DOI: 10.1002/anie.201006681

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      Take the tube: Tubular structures can be fabricated by the cooperative self-assembly of the binary molecular components TPI and APO (see picture). This method can also be used to make a single binary tube capable of performing multiple photonic functions, such as an annular microcavity waveguide, waveguide modulation, and a controllable waveguide switch.

    24. Polymer Capsules

      Facile Fabrication of Stimuli-Responsive Polymer Capsules with Gated Pores and Tunable Shell Thickness and Composite (pages 4947–4951)

      Changxu Lin, Wei Zhu, Haowei Yang, Qi An, Cheng-an Tao, Weina Li, Jiecheng Cui, Zilu Li and Prof. Dr. Guangtao Li

      Article first published online: 6 MAY 2011 | DOI: 10.1002/anie.201007747

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      A hollow victory: A multifunctional polymerizable ionic liquid (IL)-based surfactant is used in the synthesis of silica spheres with tunable size. Hollow capsules with a mesoporous polymer-network shell and pendant IL moieties are then fabricated by template synthesis (see picture). The pore size of the shell is reversibly adjustable by exchange of counteranions (blue and red circles) of the pendant IL units.

    25. Self-Assembly

      Superamphiphiles Based on Directional Charge-Transfer Interactions: From Supramolecular Engineering to Well-Defined Nanostructures (pages 4952–4956)

      Kai Liu, Chao Wang, Prof. Zhibo Li and Prof. Xi Zhang

      Article first published online: 29 MAR 2011 | DOI: 10.1002/anie.201007167

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      Give and take: X- or H-shape superamphiphiles form on the basis of directional charge-transfer complexes and lead to the formation of one-dimensional nanorods and two-dimensional nanosheets, respectively (see picture, blue: pyridinium ion, red: naphthalene derivatives, green: naphthalene diimide). The superstructures form after elaborate tuning of the building block structures.

    26. Inhibitor Design

      Structure-Guided Development of Selective RabGGTase Inhibitors (pages 4957–4961)

      Dr. Robin S. Bon, Dr. Zhong Guo, E. Anouk Stigter, Dr. Stefan Wetzel, Dr. Sascha Menninger, Dr. Alexander Wolf, Dr. Axel Choidas, Prof. Dr. Kirill Alexandrov, Dr. Wulf Blankenfeldt, Prof. Dr. Roger S. Goody and Prof. Dr. Herbert Waldmann

      Article first published online: 21 APR 2011 | DOI: 10.1002/anie.201101210

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      Designing for selectivity: A combination of protein crystal-structure analysis, virtual screening, and synthetic chemistry has been used to develop noncytotoxic inhibitors of RabGGTase (IC50: 42 nM for the example shown; red O, blue N, yellow S) that are selective over FTase and GGTase I. Furthermore, the inhibitors display cellular activity and inhibit cancer cell proliferation.

    27. Dendronized Anions

      Synthesis of Nanometer-Sized, Rigid, and Hydrophobic Anions (pages 4962–4965)

      David Türp, Dr. Manfred Wagner, Dr. Volker Enkelmann and Prof. Dr. Klaus Müllen

      Article first published online: 23 FEB 2011 | DOI: 10.1002/anie.201007070

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      Size matters: The strategy of divergent dendronization allows for the synthesis of unprecedented large, rigid, and bulky anions (see picture). Their size, density, and chemical nature of surface can be tailored to obtain more hydrophobic, less nucleophilic, and more weakly coordinating anions.

    28. Methane Activation

      Diatomic [CuO]+ and Its Role in the Spin-Selective Hydrogen- and Oxygen-Atom Transfers in the Thermal Activation of Methane (pages 4966–4969)

      Dipl.-Chem. Nicolas Dietl, Dipl.-Chem. Christian van der Linde, Dr. Maria Schlangen, Prof. Dr. Martin K. Beyer and Prof. Dr. Helmut Schwarz

      Article first published online: 21 APR 2011 | DOI: 10.1002/anie.201100606

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      The final piece in an intriguing puzzle: More than ten years after its theoretical prediction to serve as a powerful converter of methane to methanol, the bare [CuO]+ cation has been successfully generated in the gas phase. A combination of mass spectrometry and DFT calculations revealed the crucial role of two-state reactivity and oxygen-centered radicals in the selectivity in the oxidation of methane.

    29. Polybromides

      [C4MPyr]2[Br20]: Ionic-Liquid-Based Synthesis of a Three-Dimensional Polybromide Network (pages 4970–4973)

      Michael Wolff, Jens Meyer and Prof. Dr. Claus Feldmann

      Article first published online: 24 FEB 2011 | DOI: 10.1002/anie.201004804

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      A Br stunt: The first three-dimensional polybromide network is found in [C4MPyr]2[Br20] (see structure of the [Br20]2− network). The compound was obtained in an ionic-liquid-based synthesis—and with 18:2 contains the highest Br0:Br ratio ever observed.

    30. Coordination Chemistry

      A Stable Molecular Entity Derived from Rare Iron(II) Minerals: The Square-Planar High-Spin-d6 FeIIO4 Chromophore (pages 4974–4978)

      Xaver Wurzenberger, Dr. Holger Piotrowski and Prof. Dr. Peter Klüfers

      Article first published online: 30 MAR 2011 | DOI: 10.1002/anie.201006898

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      The odd couple: The red chromophore of both the rare silicate mineral gillespite (BaFeSi4O10; see picture, left, on sanbornite, BaSi2O5) and the bis(meso-oxolanediolato)ferrate(II) anion in its lithium salt (right) is the square-planar, high-spin-d6 ferrous center. The unusual combination of structure and spin state for the FeO4 moiety is not forced by a rigid environment of the central metal, but rather results from an intrinsically stable entity.

    31. Selective Membranes

      Covalent Post-Functionalization of Zeolitic Imidazolate Framework ZIF-90 Membrane for Enhanced Hydrogen Selectivity (pages 4979–4982)

      Dr. Aisheng Huang and Prof. Dr. Jürgen Caro

      Article first published online: 29 MAR 2011 | DOI: 10.1002/anie.201007861

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      MOF constrictor: Covalent modification of a ZIF-90 membrane was achieved by imine condensation of the aldehyde groups of the metal–organic framework (MOF) linker by ethanolamine (see picture). The modification leads to constriction of the pore apertures and prevents unselective permeation through defect pores, thus improving gas separation performance. For a H2/CO2 mixture, selectivity can be increased from 7.3 to 62.5.

    32. Asymmetric Organocatalysis

      Highly Asymmetric NHC-Catalyzed Hydroacylation of Unactivated Alkenes (pages 4983–4987)

      Isabel Piel, Marc Steinmetz, Dr. Keiichi Hirano, Dr. Roland Fröhlich, Prof. Dr. Stefan Grimme and Prof. Dr. Frank Glorius

      Article first published online: 14 APR 2011 | DOI: 10.1002/anie.201008081

      Thumbnail image of graphical abstract

      NHC-catalysis proto(n)type: The title reaction produces 21 different chroman-4-one-type products in good yields and excellent enantioselectivities, in each case building up a new all-carbon quaternary stereocenter (see scheme). Based on DFT calculations a mechanistic scenario involving proton transfer, possible transition states, and a mode of enantioinduction is presented.

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      Article first published online: 6 MAY 2011 | DOI: 10.1002/anie.201190042

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