Angewandte Chemie International Edition

Cover image for Vol. 50 Issue 25

June 14, 2011

Volume 50, Issue 25

Pages 5587–5771

  1. Cover Picture

    1. Top of page
    2. Cover Picture
    3. Inside Cover
    4. Back Cover
    5. Editorial
    6. Graphical Abstract
    7. News
    8. Author Profile
    9. Obituary
    10. Book Review
    11. Highlights
    12. Minireview
    13. Review
    14. Communications
    15. Preview
    1. Cover Picture: Redox-Controlled Magnetic {Mn13} Keggin Systems (Angew. Chem. Int. Ed. 25/2011) (page 5587)

      Dr. Graham N. Newton, Satoshi Yamashita, Koen Hasumi, Junzo Matsuno, Norifumi Yoshida, Dr. Masayuki Nihei, Dr. Takuya Shiga, Prof. Dr. Motohiro Nakano, Prof. Dr. Hiroyuki Nojiri, Dr. Wolfgang Wernsdorfer and Prof. Dr. Hiroki Oshio

      Version of Record online: 27 APR 2011 | DOI: 10.1002/anie.201102590

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      Manganese oxide nanoclusters with α-Keggin-type cores and redox-tunable magnetic behavior were synthesized by H. Oshio et al. In their Communication on page 5716 ff., they report that the clusters could be oxidized in one-electron steps, leading to increases in the single-molecule-magnetic properties. The image shows the transition from a {Mn13}4+ species through {Mn13}5+ to {Mn13}6+ and the changes in the resultant hysteretic responses.

  2. Inside Cover

    1. Top of page
    2. Cover Picture
    3. Inside Cover
    4. Back Cover
    5. Editorial
    6. Graphical Abstract
    7. News
    8. Author Profile
    9. Obituary
    10. Book Review
    11. Highlights
    12. Minireview
    13. Review
    14. Communications
    15. Preview
    1. Inside Cover: Electron Transport through Single Molecules Comprising Aromatic Stacks Enclosed in Self-Assembled Cages (Angew. Chem. Int. Ed. 25/2011) (page 5588)

      Dr. Manabu Kiguchi, Takuya Takahashi, Yuta Takahashi, Dr. Yoshihiro Yamauchi, Dr. Takashi Murase, Prof. Dr. Makoto Fujita, Dr. Tomofumi Tada and Prof. Dr. Satoshi Watanabe

      Version of Record online: 23 MAY 2011 | DOI: 10.1002/anie.201102746

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      Electron transport in π-stacked systems plays a vital role in biological systems, organic electronics, and materials science. In their Communication on page 5708 ff., M. Kiguchi, M. Fujita et al. report the successful formation of, and single-molecule conductance in, molecular junctions comprising discrete assemblies of π-stacked aromatic molecules enclosed within self-assembled coordination cages. The single-molecule π-stacks exhibit good conductance and show only a moderate loss with increasing transport length.

  3. Back Cover

    1. Top of page
    2. Cover Picture
    3. Inside Cover
    4. Back Cover
    5. Editorial
    6. Graphical Abstract
    7. News
    8. Author Profile
    9. Obituary
    10. Book Review
    11. Highlights
    12. Minireview
    13. Review
    14. Communications
    15. Preview
    1. Back Cover: Base-Driven Assembly of Large Uranium Oxo/Hydroxo Clusters (Angew. Chem. Int. Ed. 25/2011) (page 5588)

      Dr. Biplab Biswas, Victor Mougel, Dr. Jacques Pécaut and Dr. Marinella Mazzanti

      Version of Record online: 25 MAY 2011 | DOI: 10.1002/anie.201103371

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      Low-valent uranium clusters provide good models to understand the formation and behavior of UO2 nanoparticles. In their Communication on page 5745 ff., M. Mazzanti et al. present a reproducible method for the synthesis of such clusters. Benzoic acid is used to promote the formation of large oxo–hydroxo clusters, and cluster size can be tuned by the choice of solvent and base, thus leading to a U16 compound that is the largest UIV cluster reported to date.

  4. Editorial

    1. Top of page
    2. Cover Picture
    3. Inside Cover
    4. Back Cover
    5. Editorial
    6. Graphical Abstract
    7. News
    8. Author Profile
    9. Obituary
    10. Book Review
    11. Highlights
    12. Minireview
    13. Review
    14. Communications
    15. Preview
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      Editorial: Science in a Changing World (pages 5590–5591)

      Prof. Gautam R. Desiraju

      Version of Record online: 17 MAY 2011 | DOI: 10.1002/anie.201102495

  5. Graphical Abstract

    1. Top of page
    2. Cover Picture
    3. Inside Cover
    4. Back Cover
    5. Editorial
    6. Graphical Abstract
    7. News
    8. Author Profile
    9. Obituary
    10. Book Review
    11. Highlights
    12. Minireview
    13. Review
    14. Communications
    15. Preview
  6. News

    1. Top of page
    2. Cover Picture
    3. Inside Cover
    4. Back Cover
    5. Editorial
    6. Graphical Abstract
    7. News
    8. Author Profile
    9. Obituary
    10. Book Review
    11. Highlights
    12. Minireview
    13. Review
    14. Communications
    15. Preview
  7. Author Profile

    1. Top of page
    2. Cover Picture
    3. Inside Cover
    4. Back Cover
    5. Editorial
    6. Graphical Abstract
    7. News
    8. Author Profile
    9. Obituary
    10. Book Review
    11. Highlights
    12. Minireview
    13. Review
    14. Communications
    15. Preview
    1. Patrik Schmuki (page 5608)

      Version of Record online: 1 JUN 2011 | DOI: 10.1002/anie.201102412

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      “If I could be anyone for a day, I would be Neil Armstrong on the moon. In a spare hour I watch stand-up comedy (Bill Hicks is my all time favorite) …” This and more about Patrik Schmuki can be found on page 5608.

  8. Obituary

    1. Top of page
    2. Cover Picture
    3. Inside Cover
    4. Back Cover
    5. Editorial
    6. Graphical Abstract
    7. News
    8. Author Profile
    9. Obituary
    10. Book Review
    11. Highlights
    12. Minireview
    13. Review
    14. Communications
    15. Preview
    1. Bernhard Witkop (1917–2010) (pages 5609–5610)

      Rolf Huisgen

      Version of Record online: 12 MAY 2011 | DOI: 10.1002/anie.201102615

  9. Book Review

    1. Top of page
    2. Cover Picture
    3. Inside Cover
    4. Back Cover
    5. Editorial
    6. Graphical Abstract
    7. News
    8. Author Profile
    9. Obituary
    10. Book Review
    11. Highlights
    12. Minireview
    13. Review
    14. Communications
    15. Preview
    1. Computational Spectroscopy. Methods, Experiments and Applications. Edited by Jörg Grunenberg. (pages 5611–5612)

      Petr Bouř

      Version of Record online: 18 MAY 2011 | DOI: 10.1002/anie.201101367

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      Wiley-VCH, Weinheim 2010. 416 pp., hardcover, € 149.00.—ISBN 978-3527326495

  10. Highlights

    1. Top of page
    2. Cover Picture
    3. Inside Cover
    4. Back Cover
    5. Editorial
    6. Graphical Abstract
    7. News
    8. Author Profile
    9. Obituary
    10. Book Review
    11. Highlights
    12. Minireview
    13. Review
    14. Communications
    15. Preview
    1. Main-Group Chemistry

      Parent Heavy Methylenes: Chemical Tricks to Access Isolable Complexes of Elusive H2E: Species (E=Ge and Sn) (pages 5614–5615)

      Prof. Dr. Shigeyoshi Inoue and Prof. Dr. Matthias Driess

      Version of Record online: 4 MAY 2011 | DOI: 10.1002/anie.201101812

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      A milestone in main-group chemistry: Elusive heavy methylene analogues :EH2 (E=Ge and Sn) were tamed to give isolable species. This feat was achieved by applying the concept of donor–acceptor stabilization: concomitant coordination of a transition metal or monoborane as a Lewis acid and of an N-heterocyclic carbene as a Lewis base (see scheme).

    2. Crystal Structure Prediction

      Crystal Structure Prediction—Dawn of a New Era (pages 5616–5617)

      Prof. Christian W. Lehmann

      Version of Record online: 5 MAY 2011 | DOI: 10.1002/anie.201101530

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      No longer mere speculation? Improved methodology has led to recent progress in predicting crystal structures of organic molecules. The combination of tailor-made force fields and most importantly dispersion-corrected density functional theory calculations are key factors for successful structure predictions.

  11. Minireview

    1. Top of page
    2. Cover Picture
    3. Inside Cover
    4. Back Cover
    5. Editorial
    6. Graphical Abstract
    7. News
    8. Author Profile
    9. Obituary
    10. Book Review
    11. Highlights
    12. Minireview
    13. Review
    14. Communications
    15. Preview
    1. Analytical Methods

      In Vivo Solid-Phase Microextraction in Metabolomics: Opportunities for the Direct Investigation of Biological Systems (pages 5618–5628)

      Dr. Dajana Vuckovic, Sanja Risticevic and Prof. Janusz Pawliszyn

      Version of Record online: 23 MAY 2011 | DOI: 10.1002/anie.201006896

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      How well does the metabolome at the time of analysis represent the true metabolome at the time of sampling? In vivo solid-phase microextraction is a relatively new sample preparation technique used to study cell, plant, animal, and human metabolomics. This technique is particularly suited for capturing unstable and/or short-lived metabolites not observed by traditional methods.

  12. Review

    1. Top of page
    2. Cover Picture
    3. Inside Cover
    4. Back Cover
    5. Editorial
    6. Graphical Abstract
    7. News
    8. Author Profile
    9. Obituary
    10. Book Review
    11. Highlights
    12. Minireview
    13. Review
    14. Communications
    15. Preview
    1. Hetero-Diels–Alder Reactions

      The Nitrosocarbonyl Hetero-Diels–Alder Reaction as a Useful Tool for Organic Syntheses (pages 5630–5647)

      Dr. Brian S. Bodnar and Prof. Dr. Marvin J. Miller

      Version of Record online: 21 APR 2011 | DOI: 10.1002/anie.201005764

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      Utility like N-O other! Nitrosocarbonyl hetero-Diels–Alder (HDA) reactions allow for the simultaneous stereospecific introduction of carbon–nitrogen and carbon–oxygen bonds in one synthetic step and provide direct access to 3,6-dihydro-1,2-oxazines. This Review describes the development of the nitrosocarbonyl HDA reaction and the utility of the resulting oxazine ring in the synthesis of a variety of important, biologically active molecules.

  13. Communications

    1. Top of page
    2. Cover Picture
    3. Inside Cover
    4. Back Cover
    5. Editorial
    6. Graphical Abstract
    7. News
    8. Author Profile
    9. Obituary
    10. Book Review
    11. Highlights
    12. Minireview
    13. Review
    14. Communications
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    1. C[BOND]H Activation

      Evidence for a Precursor Complex in C[BOND]H Hydrogen Atom Transfer Reactions Mediated by a Manganese(IV) Oxo Complex (pages 5648–5653)

      Isaac Garcia-Bosch, Dr. Anna Company, Dr. Clyde W. Cady, Dr. Stenbjörn Styring, Dr. Wesley R. Browne, Dr. Xavi Ribas and Dr. Miquel Costas

      Version of Record online: 14 APR 2011 | DOI: 10.1002/anie.201100907

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      HAT trick: [MnIV(OH)2(H,MePytacn)]2+ (A) and [MnIV(O)(OH)(H,MePytacn)]+ (B) differ in their reactions with C[BOND]H bonds: compound A engages in typical single-step hydrogen atom transfer (HAT) reactions, whereas B first forms a substrate–B encounter complex (C; see scheme). This equilibrium alters the relative C[BOND]H reactivity from that expected from C[BOND]H bond dissociation energies.

    2. Electrostatic Interactions

      The Absence of Redox Reactions for Palladium(II) and Copper(II) on Electrostatically Charged Teflon: Relevance to the Concept of “Cryptoelectrons” (pages 5654–5657)

      Dr. Silvia Piperno, Dr. Hagai Cohen, Dr. Tatyana Bendikov, Prof. Meir Lahav and Prof. Igor Lubomirsky

      Version of Record online: 9 MAY 2011 | DOI: 10.1002/anie.201101203

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      Rub-a-dub-dub: The hypothesis of contact electrification through the transfer of cryptoelectrons was tested by scrutinizing the evidence for the reduction of Pd2+ and Cu2+ by static charges on rubbed Teflon. X-ray photoelectron spectroscopy studies indicated that neither of these ions is reduced (see picture; black: Pd2+ adsorbed, red: Pd0 adsorbed and then reduced by formadehyde, green: mixture of Pd2+ and Pd0 arising from partial reduction after 2 h under the XPS probe) by the static charge. The presented alternative interpretation challenges the role of cryptoelectrons.

    3. Cyclase Enzyme Mimics

      Terminating Platinum-Initiated Cation-Olefin Reactions with Simple Alkenes (pages 5658–5661)

      Joseph G. Sokol, Dr. Chandra Sekhar Korapala, Dr. Peter S. White, Dr. Jennifer J. Becker and Prof. Dr. Michel R. Gagné

      Version of Record online: 13 MAY 2011 | DOI: 10.1002/anie.201100463

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      All for one: Phosphine-ligated platinum(II) electrophiles can activate polyalkenes for cyclase enzyme mimicking cascade cyclizations without the need for special terminating groups (see scheme). Like the cyclase enzymes, terminal alkenes that generate tertiary cations are good substrates, although the details of the cation termination depend on the alkene arrangement.

    4. Bioinorganic Chemistry

      A Fully Delocalized Mixed-Valence Bis-μ(Thiolato) Dicopper Complex: A Structural and Functional Model of the Biological CuA Center (pages 5662–5666)

      Dr. Marcello Gennari, Dr. Jacques Pécaut, Dr. Serena DeBeer, Prof. Frank Neese, Dr. Marie-Noëlle Collomb and Dr. Carole Duboc

      Version of Record online: 9 MAY 2011 | DOI: 10.1002/anie.201100605

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      A {Cu2S2} diamond core has been stabilized thanks to the synthesis of a novel dinucleating ligand. The resulting dicopper complex has been isolated in the two formal oxidation states (see picture) that mimic most of the essential structural, spectroscopic, and functional properties of the CuA center.

    5. Caged Proteins

      Light-Triggered Myosin Activation for Probing Dynamic Cellular Processes (pages 5667–5670)

      Brenda N. Goguen, Dr. Brenton D. Hoffman, Dr. James R. Sellers, Prof. Martin A. Schwartz and Prof. Barbara Imperiali

      Version of Record online: 3 MAY 2011 | DOI: 10.1002/anie.201100674

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      Shining light on myosin: The incorporation of a caging group onto the essential phosphoserine residue of myosin by protein semisynthesis enables light-triggered activation of the protein (see picture). Caging eliminates the myosin activity, but exposure to 365 nm light restores its function to native levels. The caged protein can also be introduced into cells to facilitate studies of myosin with precise spatial and temporal resolution.

    6. Hydrogenase

      A Five-Coordinate Iron Center in the Active Site of [Fe]-Hydrogenase: Hints from a Model Study (pages 5671–5673)

      Dr. Dafa Chen, Dr. Rosario Scopelliti and Prof. Dr. Xile Hu

      Version of Record online: 5 MAY 2011 | DOI: 10.1002/anie.201100201

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      What's your number? The synthesis, structure, and reactivity of a five-coordinate model complex of [Fe]-hydrogenase are described. The work suggests that the iron center in [Fe]-hydrogenases could be five-coordinate in the resting state.

    7. Synthetic Methods

      ortho-Selective Nucleophilic Addition of Primary Amines to Silylbenzynes: Synthesis of 2-Silylanilines (pages 5674–5677)

      Dr. Takashi Ikawa, Tsuyoshi Nishiyama, Takashi Shigeta, Shinya Mohri, Shinsuke Morita, Dr. Sho-ichi Takayanagi, Yuki Terauchi, Yuki Morikawa, Akira Takagi, Dr. Yoshinobu Ishikawa, Prof. Dr. Satoshi Fujii, Prof. Dr. Yasuyuki Kita and Prof. Dr. Shuji Akai

      Version of Record online: 9 MAY 2011 | DOI: 10.1002/anie.201100360

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      Cause and effect: The first ortho-selective nucleophilic addition reaction of amines to 3-substituted benzynes has been achieved. Despite a large trimethylsilyl substituent, primary amines attack the C2 position of 3-silylbenzynes to produce 2-silylanilines (see scheme). This outcome is likely to result from the inductive electron-donating effect of the silyl group, which overrides its steric repulsion with the approaching amines.

    8. Oxygen Activation

      Copper-Catalyzed Intramolecular Dehydrogenative Aminooxygenation: Direct Access to Formyl-Substituted Aromatic N-Heterocycles (pages 5678–5681)

      Honggen Wang, Yong Wang, Dongdong Liang, Lanying Liu, Prof. Dr. Jiancun Zhang and Prof. Dr. Qiang Zhu

      Version of Record online: 4 MAY 2011 | DOI: 10.1002/anie.201100362

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      A direct synthesis of carbaldehydes through intramolecular dehydrogenative aminooxygenation has been developed. The process uses a catalytic amount of copper(II) in DMF or DMA under oxygen and does not require additional oxidants (see scheme). Mechanistic studies suggest that the carbonyl oxygen atom of the aldehyde is derived from oxygen through a copper-mediated oxygen activation process via a peroxy–copper(III) intermediate.

    9. Asymmetric Catalysis

      Enantioselective N–H Functionalization of Indoles with α,β-Unsaturated γ-Lactams Catalyzed by Chiral Brønsted Acids (pages 5682–5686)

      Yinjun Xie, Yingwei Zhao, Bo Qian, Dr. Lei Yang, Prof. Dr. Chungu Xia and Prof. Dr. Hanmin Huang

      Version of Record online: 17 MAY 2011 | DOI: 10.1002/anie.201102046

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      Nitrogen revives: Cyclic N-acyliminium ions were generated from α,β-unsaturated γ-lactams (1) and underwent intermolecular addition by indole nucleophiles (2) under the catalysis of a chiral Brønsted acid (3). A variety of N-functionalized indole derivatives containing a pyrrolidinone moiety (4) were assembled with high enantioselectivity. Bn=benzyl.

    10. Homogeneous Catalysis

      Divergent Regioselectivity in the Synthesis of Trisubstituted Allylic Alcohols by Nickel- and Ruthenium-Catalyzed Alkyne Hydrohydroxymethylation with Formaldehyde (pages 5687–5690)

      Dr. Cory C. Bausch, Ryan L. Patman, Prof. Bernhard Breit and Prof. Michael J. Krische

      Version of Record online: 9 MAY 2011 | DOI: 10.1002/anie.201101496

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      Stoichiometric metals banned: Nonsymmetrically disubstituted alkynes were converted into primary trisubstituted allylic alcohols upon exposure to paraformaldehyde in the presence of nickel or ruthenium catalysts, which exhibit complementary regioselectivity and complete stereoselectivity in the absence of exogenous reducing agents (see scheme).

    11. Porphyrins

      Synthesis of Carbazole-Containing Porphyrinoids by a Multiple Annulation Strategy: A Core-Modified and π-Expanded Porphyrin (pages 5691–5694)

      Dr. Chihiro Maeda, Tomoki Yoneda, Dr. Naoki Aratani, Dr. Min-Chul Yoon, Jong Min Lim, Prof. Dr. Dongho Kim, Prof. Dr. Naoki Yoshioka and Prof. Dr. Atsuhiro Osuka

      Version of Record online: 12 MAY 2011 | DOI: 10.1002/anie.201101864

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      Going around in circles: The copper(I)-mediated annulation of a doubly 1,3-butadiyne-bridged carbazole dimer with amines or Na2S provides isophlorins containing carbazole or thiophene-carbazole moieties, respectively (see scheme). Oxidization of the thiophene-containing isophlorin with MnO2 gives the corresponding porphyrin, which displays distinct aromaticity and remarkably intensified and red-shifted absorption bands in the near IR region.

    12. Near-Infrared Bioimaging

      Water-Dispersed Near-Infrared-Emitting Quantum Dots of Ultrasmall Sizes for In Vitro and In Vivo Imaging (pages 5695–5698)

      Prof. Yao He, Yiling Zhong, Dr. Yuanyuan Su, Yimei Lu, Ziyun Jiang, Fei Peng, Tingting Xu, Dr. Shao Su, Prof. Qing Huang, Prof. Chunhai Fan and Prof. Shuit-Tong Lee

      Version of Record online: 9 MAY 2011 | DOI: 10.1002/anie.201004398

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      Small but powerful: NIR-emitting CdTe quantum dots (QDs) are directly prepared in aqueous phase through a one-step microwave synthesis. The QDs display excellent aqueous dispersibility, strong luminescence, and high stability. In vitro and in vivo imaging applications show high spectral and spatial resolution. The QDs are efficiently accumulated in tumors of live mice (see picture).

    13. Multipyrrolic Macrocycles

      Cyclo[8]isoindoles: Ring-Expanded and Annelated Porphyrinoids (pages 5699–5703)

      Prof. Dr. Tetsuo Okujima, Dr. Guangnan Jin, Naoki Matsumoto, Dr. John Mack, Dr. Shigeki Mori, Prof. Dr. Keishi Ohara, Daiki Kuzuhara, Chie Ando, Prof. Dr. Noboru Ono, Prof. Dr. Hiroko Yamada, Prof. Dr. Hidemitsu Uno and Prof. Dr. Nagao Kobayashi

      Version of Record online: 9 MAY 2011 | DOI: 10.1002/anie.201007510

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      Retro: Cyclo[8]isoindole, which has a saddle-shaped geometry (see picture, 2), was synthesized by oxidative coupling of a bicyclo[2.2.2]octadiene(BCOD)-fused 2,2′-bipyrrole followed by a retro-Diels–Alder reaction of BCOD-fused cyclo[8]pyrrole (1). Key trends in the optical spectra of ring-annelated cyclo[8]pyrroles are identified based on magnetic circular dichroism spectra and theorectical calculations.

    14. Biosensors

      Multivalent Nanoparticle Networks as Ultrasensitive Enzyme Sensors (pages 5704–5707)

      Dr. Roberto de laRica, Dr. Raluca M. Fratila, Dr. Anna Szarpak, Prof. Dr. Ir. Jurriaan Huskens and Dr. Aldrik H. Velders

      Version of Record online: 17 MAY 2011 | DOI: 10.1002/anie.201008189

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      As few as 23 enzyme molecules could be detected on the basis of the dispersion of Au nanoparticles in a model bioassay whose sensitivity was boosted by the interplay between multivalent and monovalent supramolecular interactions: a diferrocenyl ligand (red) caused the assembly of nanoparticle clusters; upon its oxidation, a competing monovalent guest molecule (blue) favored the formation of monovalent interactions for more efficient disassembly.

    15. Single-Molecule Conductance

      Electron Transport through Single Molecules Comprising Aromatic Stacks Enclosed in Self-Assembled Cages (pages 5708–5711)

      Dr. Manabu Kiguchi, Takuya Takahashi, Yuta Takahashi, Dr. Yoshihiro Yamauchi, Dr. Takashi Murase, Prof. Dr. Makoto Fujita, Dr. Tomofumi Tada and Prof. Dr. Satoshi Watanabe

      Version of Record online: 17 MAY 2011 | DOI: 10.1002/anie.201100431

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      Face-to-face communication: Electron transport through single-molecule π stacks was directly measured between gold nanogap electrodes by using STM (see scheme). Self-assembled coordination cages containing π-stacked aromatic molecules are conductive (right), whereas the empty cage is not (left).

    16. Photonic Films

      Transfer of Preformed Three-Dimensional Photonic Crystals onto Dye-Sensitized Solar Cells (pages 5712–5715)

      Dr. Agustín Mihi, Chunjie Zhang and Prof. Paul V. Braun

      Version of Record online: 9 MAY 2011 | DOI: 10.1002/anie.201100446

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      Film star: Preformed self-assembled 3D photonic crystals (see picture) can be infilled with a polycarbonate matrix for mechanical stability and transferred onto rough and porous optoelectronic and photovoltaic devices. This technique allows the incorporation of photonic crystals onto independently processed devices, in which the transferred films have high optical quality.

    17. High-Spin Keggin Systems

      Redox-Controlled Magnetic {Mn13} Keggin Systems (pages 5716–5720)

      Dr. Graham N. Newton, Satoshi Yamashita, Koen Hasumi, Junzo Matsuno, Norifumi Yoshida, Dr. Masayuki Nihei, Dr. Takuya Shiga, Prof. Dr. Motohiro Nakano, Prof. Dr. Hiroyuki Nojiri, Dr. Wolfgang Wernsdorfer and Prof. Dr. Hiroki Oshio

      Version of Record online: 15 APR 2011 | DOI: 10.1002/anie.201100515

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      Stronger magnetic moment with fewer electrons: An α-Keggin-type {Mn13} single-molecule magnet (SMM) was synthesized and subsequently oxidized (see picture); its one- and two-electron-oxidized derivatives could be isolated. The spin ground states of the more oxidized species are higher despite the electron loss, resulting in amplification of the SMM properties.

    18. Self-Assembly

      A Triple Anion Helicate Assembled from a Bis(biurea) Ligand and Phosphate Ions (pages 5721–5724)

      Shaoguang Li, Chuandong Jia, Prof. Biao Wu, Qiong Luo, Xiaojuan Huang, Zaiwen Yang, Prof. Qian-Shu Li and Prof. Xiao-Juan Yang

      Version of Record online: 10 MAY 2011 | DOI: 10.1002/anie.201180593

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      A word in urea: A strategy of mimicking the scaffold and metal coordination behavior of oligo-2,2′-bipyridine ligands was used to obtain a triple anion helicate from a bis(biurea) receptor and phosphate ions. The successful assembly of the triple helical structure provides guidelines for the design of new anion ligands by taking advantage of the similarities of metal and anion coordination.

    19. Dynamic Nanoreceptors

      Proton-Driven Switching Between Receptors for C60 and C70 (pages 5725–5728)

      Dr. Artur R. Stefankiewicz, Dr. Emiliano Tamanini, Dr. G. Dan Pantoş and Prof. Jeremy K. M. Sanders

      Version of Record online: 9 MAY 2011 | DOI: 10.1002/anie.201100806

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      Buckybinding: The selective binding of either C60 and C70 in a mixture of the two fullerenes occurs by proton-induced, reversible, and controllable morphological switching between receptors for different fullerenes (see picture). Using hydrogen bonding as the exchange reaction, the response of the naphthalenediimide (NDI) building blocks to the presence of fullerene guests depends on the concentration of protons as a third component.

    20. Metal–Organic Frameworks

      Nanoscale Light-Harvesting Metal–Organic Frameworks (pages 5729–5733)

      Dr. Xuanjun Zhang, Mohamed Ali Ballem, Zhang-Jun Hu, Prof. Dr. Peder Bergman and Prof. Dr. Kajsa Uvdal

      Version of Record online: 9 MAY 2011 | DOI: 10.1002/anie.201007277

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      Highly crystalline nanoparticles of metal–organic frameworks with efficient light-harvesting properties were prepared by coordination-directed assembly (see picture). Functionalization of the ligands with long alkyl chains effectively stabilizes the nanoparticles and increases crystallinity. Different metal ions and ligands are organized into single nanoparticles and both organic acceptors and lanthanide ions can be co-sensitized within the frameworks.

    21. Reprogramming

      Pan-Src Family Kinase Inhibitors Replace Sox2 during the Direct Reprogramming of Somatic Cells (pages 5734–5736)

      Dr. Judith Staerk, Dr. Costas A. Lyssiotis, Lea A. Medeiro, Michael Bollong, Dr. Ruth K. Foreman, Dr. Shoutian Zhu, Michael Garcia, Qing Gao, Dr. Laure C. Bouchez, Dr. Luke L. Lairson, Bradley D. Charette, Dr. Lubica Supekova, Dr. Jeffrey Janes, Dr. Achim Brinker, Dr. Charles Y. Cho, Prof. Rudolf Jaenisch and Prof. Peter G. Schultz

      Version of Record online: 5 MAY 2011 | DOI: 10.1002/anie.201101042

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      Small molecules do the job: Somatic cells are reprogrammed into iPS cells upon ectopic expression of Oct4, Sox2, Klf4 and c-Myc. Application of a cell-based, high-throughput chemical screen led to the identification of Src family kinase (SFK) inhibitors as chemical replacements for retroviral Sox2 delivery. These compounds are used to study the mechanisms underlying direct reprogramming and may ultimately help to bring iPS cell technology one step closer to clinical application.

    22. Liquid Crystals

      Complementary Hydrogen Bonding Between a Clicked C3-Symmetric Triazole Derivative and Carboxylic Acids for Columnar Liquid-Crystalline Assemblies (pages 5737–5740)

      Mi-Hee Ryu, Jin-Woo Choi, Dr. Ho-Joong Kim, Prof. Noejung Park and Prof. Byoung-Ki Cho

      Version of Record online: 9 MAY 2011 | DOI: 10.1002/anie.201101013

      Thumbnail image of graphical abstract

      Two's complement: A series of discotic hydrogen-bonded complexes was prepared from a “clicked” triazole derivative with C3 symmetry and carboxylic acids (see picture; R1, R2=alkyl groups). Owing to the extended rigid core structure, the supramolecular discs could be stacked on top of each other, leading to hexagonal columnar liquid-crystalline phases.

    23. Maya Pigments

      From Maya Blue to “Maya Yellow”: A Connection between Ancient Nanostructured Materials from the Voltammetry of Microparticles (pages 5741–5744)

      Prof. Antonio Doménech, Prof. María Teresa Doménech-Carbó and Dr. María Luisa Vázquez de Agredos-Pascual

      Version of Record online: 9 MAY 2011 | DOI: 10.1002/anie.201100921

      Thumbnail image of graphical abstract

      The yellow hue of a series of samples from wall paintings in several Mayan archaeological sites can be attributed to the presence of indigoid compounds, including isatin and dehydroindigo, attached to palygorskite, a local phyllosilicate clay. SEM/EDX, TEM, UV/Vis spectroscopy, and voltammetry of microparticles show that the ancient Mayas could prepare indigo, Maya Blue, and “Maya Yellow” during successive stages.

    24. Uranium Clusters

      Base-Driven Assembly of Large Uranium Oxo/Hydroxo Clusters (pages 5745–5748)

      Dr. Biplab Biswas, Victor Mougel, Dr. Jacques Pécaut and Dr. Marinella Mazzanti

      Version of Record online: 12 MAY 2011 | DOI: 10.1002/anie.201101327

      Thumbnail image of graphical abstract

      Uranium building blocks: Two new uranium cluster topologies are obtained from the stoichiometric hydrolysis of low-valent uranium in non-aqueous media (see picture). The organic base TMEDA directs the self-assembly process towards the formation of a nanosized oxo-hydroxo U16 cluster.

    25. Protein Structures

      A Conformational Switch Underlies ClpP Protease Function (pages 5749–5752)

      Dr. Sebastian R. Geiger, Dr. Thomas Böttcher, Prof. Dr. Stephan A. Sieber and Prof. Dr. Patrick Cramer

      Version of Record online: 4 MAY 2011 | DOI: 10.1002/anie.201100666

      Thumbnail image of graphical abstract

      A “breathing” protein: The first structure of the virulence regulator and heat shock protein ClpP from Staphylococcus aureus reveals a previously unobserved compressed state of the ClpP barrel. A conformational switch in the active center “handle region” results in closure of the active sites and opening of equatorial pores. These results confirm proposed modes of processive substrate degradation and product release for the ClpP protease family.

    26. Organocalcium Chemistry

      The Allylcalcium Monocation: A Bridging Allyl Ligand with a Non-Bent Coordination Geometry (pages 5753–5756)

      Crispin Lichtenberg, Phillip Jochmann, Dr. Thomas P. Spaniol and Prof. Dr. Jun Okuda

      Version of Record online: 12 MAY 2011 | DOI: 10.1002/anie.201100073

      Thumbnail image of graphical abstract

      Zigzag bridge: The allylcalcium monocation was found in the solid-state structure of [Ca(μ211-C3H5)([18]crown-6)]+[Zn(η1-C3H5)3]. This allyl ligand exhibits an unusual bridging mode within a hexagonal-bipyramidal non-bent coordination geometry (see picture: Ca green, Zn blue, O red, C gray).

    27. Indole Synthesis

      Zirconium-Catalyzed Multistep Reaction of Hydrazines with Alkynes: A Non-Fischer-Type Pathway to Indoles (pages 5757–5761)

      Thorsten Gehrmann, Dr. Julio Lloret Fillol, Solveig A. Scholl, Prof. Dr. Hubert Wadepohl and Prof. Dr. Lutz H. Gade

      Version of Record online: 12 MAY 2011 | DOI: 10.1002/anie.201101070

      Thumbnail image of graphical abstract

      Dominos at zirconium: A cascade of N–N and C–H scissions and C–C and C–N coupling steps in the coordination sphere of zirconium directly converts alkynes and hydrazines into indoles. The reaction pathway differs fundamentally from that of the Fischer indole synthesis.

    28. Gold Catalysis

      Gold(I)-Catalyzed Formation of Benzo[b]furans from 3-Silyloxy-1,5-enynes (pages 5762–5765)

      Prof. Dr. A. Stephen K. Hashmi, M. Sc. Weibo Yang and Dr. Frank Rominger

      Version of Record online: 9 MAY 2011 | DOI: 10.1002/anie.201100989

      Thumbnail image of graphical abstract

      Sport of kings: A new gold(I)-catalyzed transformation has been developed that occurs under mild conditions and proceeds by an expected substituent “castling” (see red and blue circles in scheme) to give efficient access to benzo[b]furans from the easy to obtain 3-silyloxy-1,5-enynes (IPr=N,N′-bis(2,6-diisopropylphenyl)imidazol-2-ylidene, NTf2=bis(trifluoromethylsulfonylimide).

    29. Tin Coordination Chemistry

      1,1,1-Tris(distanna-closo-dodecaborate)stannate: A Tripodal Tin Ligand (pages 5766–5769)

      Claudia Nickl, Dr. Klaus Eichele, Dr. Dominik Joosten, Thorsten Langer, Dr. Falko M. Schappacher, Prof. Dr. Rainer Pöttgen, Prof. Dr. Ulli Englert and Prof. Dr. Lars Wesemann

      Version of Record online: 12 MAY 2011 | DOI: 10.1002/anie.201100936

      Thumbnail image of graphical abstract

      Tin tripod: Starting from 1,2-distanna-closo-dodecaborate and tin(II) chloride, the first tripodal tin ligand was prepared. It is made up of three clusters and one central tin atom that build a frame of seven tin atoms. The coordination ability is illustrated by reaction with [Cu(CH3CN)4]PF6: a binuclear copper complex is formed surrounded by two Sn7 ligands (see picture).

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