Ultrasensitive Near-Infrared Raman Reporters for SERS-Based In Vivo Cancer Detection (pages 6089–6092)
Animesh Samanta, Dr. Kaustabh Kumar Maiti, Kiat-Seng Soh, Xiaojun Liao, Dr. Marc Vendrell, Dr. U. S. Dinish, Dr. Seong-Wook Yun, Ramaswamy Bhuvaneswari, Hyori Kim, Shashi Rautela, Prof. Junho Chung, Prof. Malini Olivo and Prof. Young-Tae Chang
Article first published online: 17 MAY 2011 | DOI: 10.1002/anie.201007841
Of good report: Synthesis and screening of an 80-member tricarbocyanine library identified CyNAMLA-381 as a near-IR surface-enhanced Raman spectroscopy (SERS) reporter with good signal stability and higher sensitivity than the standard. Encapsulation of CyNAMLA-381 on gold nanoparticles and conjugation to an antibody afforded SERS nanotags with excellent sensitivity, stability, and tumor specificity in xenograft models (see picture).