Solid-Phase Synthesis of Sequence-Defined T-, i-, and U-Shape Polymers for pDNA and siRNA Delivery (pages 8986–8989)
Dr. David Schaffert, Christina Troiber, Eveline E. Salcher, Thomas Fröhlich, Irene Martin, Dr. Naresh Badgujar, Christian Dohmen, Daniel Edinger, Raphaela Kläger, Dr. Gelja Maiwald, Katarina Farkasova, Dr. Silke Seeber, Dr. Kerstin Jahn-Hofmann, Dr. Philipp Hadwiger and Prof. Ernst Wagner
Article first published online: 11 AUG 2011 | DOI: 10.1002/anie.201102165
Artificial oligo(ethylene amino) acids, together with selected natural amino acids and fatty acid modifications, have been used for the solid-phase-assisted synthesis of polymers with precise sequence, topology, and modifications (see picture). First proof-of-concept studies demonstrate the high potential of such polymers in pDNA and siRNA delivery. K=lysine, A=alanine.