Synthetic Polymers for Simultaneous Bacterial Sequestration and Quorum Sense Interference (pages 9852–9856)
Xuan Xue, Dr. George Pasparakis, Dr. Nigel Halliday, Dr. Klaus Winzer, Prof. Steven M. Howdle, Dr. Christopher J. Cramphorn, Prof. Neil R. Cameron, Dr. Paul M. Gardner, Prof. Benjamin G. Davis, Dr. Francisco Fernández-Trillo and Prof. Cameron Alexander
Article first published online: 16 SEP 2011 | DOI: 10.1002/anie.201103130
Double agents: Dual-action polymers are able to sequester rapidly the marine organism Vibrio harveyi from suspension, while at the same time quenching bacterial quorum sense (QS) signals (see picture). The potency of the polymers is assessed by cell aggregation experiments and competitive binding assays against a QS signal precursor, and their effect on bacterial behavior is shown by means of bioluminescence.