OsO4⋅Streptavidin: A Tunable Hybrid Catalyst for the Enantioselective cis-Dihydroxylation of Olefins (pages 10863–10866)
Dr. Valentin Köhler, Dr. Jincheng Mao, Tillmann Heinisch, Dr. Anca Pordea, Dr. Alessia Sardo, Dr. Yvonne M. Wilson, Livia Knörr, Dr. Marc Creus, Jean-Christophe Prost, Prof. Dr. Tilman Schirmer and Prof. Dr. Thomas R. Ward
Article first published online: 21 SEP 2011 | DOI: 10.1002/anie.201103632
Taking control: Selective catalysts for olefin dihydroxylation have been generated by the combination of apo-streptavidin and OsO4. Site-directed mutagenesis allows improvement of enantioselectivity and even inversion of enantiopreference in certain cases. Notably allyl phenyl sulfide and cis-β-methylstyrene were converted with unprecedented enantiomeric excess.