Ultrasmall Rigid Particles as Multimodal Probes for Medical Applications (pages 12299–12303)
Dr. François Lux, Dr. Anna Mignot, Dr. Pierre Mowat, Dr. Cédric Louis, Dr. Sandrine Dufort, Dr. Claire Bernhard, Prof. Franck Denat, Dr. Frédéric Boschetti, Dr. Claire Brunet, Prof. Rodolphe Antoine, Prof. Philippe Dugourd, Dr. Sophie Laurent, Prof. Luce Vander Elst, Prof. Robert Muller, Dr. Lucie Sancey, Dr. Véronique Josserand, Prof. Jean-Luc Coll, Dr. Vasile Stupar, Dr. Emmanuel Barbier, Dr. Chantal Rémy, Dr. Alexis Broisat, Prof. Catherine Ghezzi, Dr. Géraldine Le Duc, Prof. Stéphane Roux, Prof. Pascal Perriat and Prof. Olivier Tillement
Article first published online: 4 NOV 2011 | DOI: 10.1002/anie.201104104
Ultrasmall but multifunctional: Rigid imaging particles that are smaller than 5 nm in size can be obtained in a top-down process starting from a core–shell structure (core=gadolinium oxide; shell=polysiloxane). They represent the first multifunctional silica-based particles that are sufficiently small to escape hepatic clearance and enable animal imaging by four complementary techniques.