Angewandte Chemie International Edition

Cover image for Vol. 51 Issue 12

March 19, 2012

Volume 51, Issue 12

Pages 2785–3026

  1. Cover Picture

    1. Top of page
    2. Cover Picture
    3. Inside Cover
    4. Inside Back Cover
    5. Back Cover
    6. Graphical Abstract
    7. News
    8. Author Profile
    9. News
    10. Book Review
    11. Highlights
    12. Minireview
    13. Review
    14. Communications
    15. And Finally
    16. Preview
    1. Cover Picture: In Vitro Developmental Acceleration of Hippocampal Neurons on Nanostructures of Self-Assembled Silica Beads in Filopodium-Size Ranges (Angew. Chem. Int. Ed. 12/2012) (page 2785)

      Kyungtae Kang, Sung-Eun Choi, Hee Su Jang, Dr. Woo Kyung Cho, Prof. Dr. Yoonkey Nam, Prof. Dr. Insung S. Choi and Prof. Dr. Jin Seok Lee

      Version of Record online: 30 DEC 2011 | DOI: 10.1002/anie.201108840

      Thumbnail image of graphical abstract

      Topographical cues play an important role in in vitro neuronal development. In their Communication on page 2855 ff., Y. Nam, I. S. Choi, J. S. Lee, and co-workers show that neuritogenetic acceleration occurs on silica-bead monolayers made up of beads with a diameter of more than 200 nm, but not on monolayers of beads with smaller diameters. The biochemical study indicates neurons sense topographical differences in nanostructures and alter their behavior accordingly.

  2. Inside Cover

    1. Top of page
    2. Cover Picture
    3. Inside Cover
    4. Inside Back Cover
    5. Back Cover
    6. Graphical Abstract
    7. News
    8. Author Profile
    9. News
    10. Book Review
    11. Highlights
    12. Minireview
    13. Review
    14. Communications
    15. And Finally
    16. Preview
    1. Inside Cover: Catalytic Polymerization of Anthracene in a Recyclable SBA-15 Reactor with High Iron Content by a Friedel–Crafts Alkylation (Angew. Chem. Int. Ed. 12/2012) (page 2786)

      Jeonghun Kim, Dr. Chokkalingam Anand, Siddulu N. Talapaneni, Dr. Jungmok You, Prof. Salem S. Aldeyab, Prof. Eunkyoung Kim and Prof. Ajayan Vinu

      Version of Record online: 20 JAN 2012 | DOI: 10.1002/anie.201200229

      Thumbnail image of graphical abstract

      Well-ordered mesoporous iron silicates that have an ultralarge pore diameter and high Fe content are stable, active, and reusable catalysts for the synthesis of poly(methyleneanthracene) (PMAn) by polymerization of anthracene inside the nanopores. In their Communication on page 2859 ff., E. Kim, A. Vinu, and co-workers report that the physical and optical properties of PMAn can be controlled by tuning the pore diameter and the iron content of the mesoporous catalysts.

  3. Inside Back Cover

    1. Top of page
    2. Cover Picture
    3. Inside Cover
    4. Inside Back Cover
    5. Back Cover
    6. Graphical Abstract
    7. News
    8. Author Profile
    9. News
    10. Book Review
    11. Highlights
    12. Minireview
    13. Review
    14. Communications
    15. And Finally
    16. Preview
    1. Inside Back Cover: Well-Defined, Reversible Boronate Crosslinked Nanocarriers for Targeted Drug Delivery in Response to Acidic pH Values and cis-Diols (Angew. Chem. Int. Ed. 12/2012) (page 3027)

      Dr. Yuanpei Li, Dr. Wenwu Xiao, Dr. Kai Xiao, Dr. Lorenzo Berti, Prof. Juntao Luo, Harry P. Tseng, Gabriel Fung and Prof. Kit S. Lam

      Version of Record online: 20 JAN 2012 | DOI: 10.1002/anie.201109103

      Thumbnail image of graphical abstract

      A cross-linked micellar nanocarrier system for on-demand drug delivery is described by J. Luo, K. S. Lam, and co-workers in their Communication on page 2864 ff. The reversible catechol boronate cross-link increases the stability of the nanocarriers against severe conditions in the blood stream. After the ball-like nanocarriers reach the tumor target, the cross-links are cleaved by the acidic tumor environment or by exogenous cis-diols (e.g. mannitol), causing the ball to burst and releasing the drug.

  4. Back Cover

    1. Top of page
    2. Cover Picture
    3. Inside Cover
    4. Inside Back Cover
    5. Back Cover
    6. Graphical Abstract
    7. News
    8. Author Profile
    9. News
    10. Book Review
    11. Highlights
    12. Minireview
    13. Review
    14. Communications
    15. And Finally
    16. Preview
    1. Back Cover: Enantioselective Alkynylbenzaldehyde Cyclizations Catalyzed by Chiral Gold(I) Acyclic Diaminocarbene Complexes Containing Weak Au–Arene Interactions (Angew. Chem. Int. Ed. 12/2012) (page 3028)

      Sachin Handa and Prof. LeGrande M. Slaughter

      Version of Record online: 20 JAN 2012 | DOI: 10.1002/anie.201109229

      Thumbnail image of graphical abstract

      Creating an asymmetric environment at AuI is a challenge because of the linear coordination geometry of the ion. In their Communication on page 2912 ff., S. Handa and L. M. Slaughter report the highly enantioselective catalysis of a tandem addition/cycloisomerization reaction of alkynylbenzaldehydes by chiral gold carbene complexes containing weak metal–π interactions. These secondary interactions help to create an asymmetric pocket around the gold atom that is analogous to a baseball glove gripping a ball. (Picture by L. M. Slaughter and S. Ball.)

  5. Graphical Abstract

    1. Top of page
    2. Cover Picture
    3. Inside Cover
    4. Inside Back Cover
    5. Back Cover
    6. Graphical Abstract
    7. News
    8. Author Profile
    9. News
    10. Book Review
    11. Highlights
    12. Minireview
    13. Review
    14. Communications
    15. And Finally
    16. Preview
  6. News

    1. Top of page
    2. Cover Picture
    3. Inside Cover
    4. Inside Back Cover
    5. Back Cover
    6. Graphical Abstract
    7. News
    8. Author Profile
    9. News
    10. Book Review
    11. Highlights
    12. Minireview
    13. Review
    14. Communications
    15. And Finally
    16. Preview
  7. Author Profile

    1. Top of page
    2. Cover Picture
    3. Inside Cover
    4. Inside Back Cover
    5. Back Cover
    6. Graphical Abstract
    7. News
    8. Author Profile
    9. News
    10. Book Review
    11. Highlights
    12. Minireview
    13. Review
    14. Communications
    15. And Finally
    16. Preview
    1. Masahiro Murakami (page 2808)

      Version of Record online: 29 FEB 2012 | DOI: 10.1002/anie.201108679

      Thumbnail image of graphical abstract

      “When I was eighteen I wanted to be a rice farmer. The biggest challenge facing scientists is solar energy capture …” This and more about Masahiro Murakami can be found on page 2808.

  8. News

    1. Top of page
    2. Cover Picture
    3. Inside Cover
    4. Inside Back Cover
    5. Back Cover
    6. Graphical Abstract
    7. News
    8. Author Profile
    9. News
    10. Book Review
    11. Highlights
    12. Minireview
    13. Review
    14. Communications
    15. And Finally
    16. Preview
  9. Book Review

    1. Top of page
    2. Cover Picture
    3. Inside Cover
    4. Inside Back Cover
    5. Back Cover
    6. Graphical Abstract
    7. News
    8. Author Profile
    9. News
    10. Book Review
    11. Highlights
    12. Minireview
    13. Review
    14. Communications
    15. And Finally
    16. Preview
    1. Nanostructured Catalysts. Selective Oxidations. Edited by Christian Hess and Robert Schlögl. (page 2810)

      Andreas Martin

      Version of Record online: 24 FEB 2012 | DOI: 10.1002/anie.201200132

      Thumbnail image of graphical abstract

      RSC Publishing, Cambridge, 2011. 452 pp., hardcover, £ 144.99.—ISBN 978-1854041862

  10. Highlights

    1. Top of page
    2. Cover Picture
    3. Inside Cover
    4. Inside Back Cover
    5. Back Cover
    6. Graphical Abstract
    7. News
    8. Author Profile
    9. News
    10. Book Review
    11. Highlights
    12. Minireview
    13. Review
    14. Communications
    15. And Finally
    16. Preview
    1. Supramolecular Chemistry

      Soluble and Tubular Higher Fullerenes that Encapsulate Metals (pages 2812–2814)

      Prof. Dr. Xing Lu, Prof. Dr. Takeshi Akasaka and Prof. Dr. Shigeru Nagase

      Version of Record online: 6 FEB 2012 | DOI: 10.1002/anie.201108401

      Thumbnail image of graphical abstract

      Tubular! The detection of a series of very large, soluble endofullerenes extending from La2C90 to La2C138 proves that endohedral metal doping is an effective strategy for stabilizing these giant molecules. The X-ray structure of the most abundant isomer, La2@D5(450)-C100 (see image), shows a tubular structure featuring a long La–La distance and maximal separation of pentagons within the cage framework.

    2. Total Synthesis

      Total Synthesis and Structural Revision of the Piperarborenines: When Photochemistry Meets C[BOND]H Activation (pages 2815–2817)

      Dr. Frédéric Frébault and Dr. Nuno Maulide

      Version of Record online: 13 FEB 2012 | DOI: 10.1002/anie.201108592

      Thumbnail image of graphical abstract

      Activate and reiterate: The activation of C(sp3)[BOND]H bonds is a highly desirable transformation because molecular complexity can be increased at the expense of the most simple and readily available organic linkage. In recent contributions this approach was used for coupling reactions with small all-carbon rings, as exemplified by the sequential C[BOND]H activation steps in an elegant total synthesis of the piperarborenines (see scheme; DG=directing group).

  11. Minireview

    1. Top of page
    2. Cover Picture
    3. Inside Cover
    4. Inside Back Cover
    5. Back Cover
    6. Graphical Abstract
    7. News
    8. Author Profile
    9. News
    10. Book Review
    11. Highlights
    12. Minireview
    13. Review
    14. Communications
    15. And Finally
    16. Preview
    1. Molecular Materials

      Allenes in Molecular Materials (pages 2818–2828)

      M. Sc. Pablo Rivera-Fuentes and Prof. Dr. François Diederich

      Version of Record online: 3 FEB 2012 | DOI: 10.1002/anie.201108001

      Thumbnail image of graphical abstract

      Property development: A critical account of the development of allene-based molecular materials is presented in this Minireview. Shape-persistent macrocycles, foldamers, polymers, and other allene-containing functional materials are discussed, with a focus on their synthesis and chiroptical properties.

  12. Review

    1. Top of page
    2. Cover Picture
    3. Inside Cover
    4. Inside Back Cover
    5. Back Cover
    6. Graphical Abstract
    7. News
    8. Author Profile
    9. News
    10. Book Review
    11. Highlights
    12. Minireview
    13. Review
    14. Communications
    15. And Finally
    16. Preview
    1. Synthetic Methods

      A Fascinating Journey into History: Exploration of the World of Isonitriles En Route to Complex Amides (pages 2834–2848)

      Rebecca M. Wilson, Dr. Jennifer L. Stockdill, Dr. Xiangyang Wu, Dr. Xuechen Li, Dr. Paul A. Vadola, Dr. Peter K. Park, Dr. Ping Wang and Prof. Samuel J. Danishefsky

      Version of Record online: 24 FEB 2012 | DOI: 10.1002/anie.201106628

      Thumbnail image of graphical abstract

      New take on an old classic: Recent explorations in the field of isonitrile chemistry led to the development of an array of broadly useful coupling methods for the formation of peptidyl and glycopeptidyl amide bonds. The methods were applied to the syntheses of complex systems, including the cyclic peptide cyclosporine A, constrained peptide systems, and heterocycles (see scheme; FCMA=formimidate carboxylate mixed anhydride).

  13. Communications

    1. Top of page
    2. Cover Picture
    3. Inside Cover
    4. Inside Back Cover
    5. Back Cover
    6. Graphical Abstract
    7. News
    8. Author Profile
    9. News
    10. Book Review
    11. Highlights
    12. Minireview
    13. Review
    14. Communications
    15. And Finally
    16. Preview
    1. G-Quadruplex DNA Channels

      Free-Energy Landscapes of Ion Movement through a G-Quadruplex DNA Channel (pages 2850–2854)

      Parisa Akhshi, Prof. Dr. Nicholas J. Mosey and Prof. Dr. Gang Wu

      Version of Record online: 13 JAN 2012 | DOI: 10.1002/anie.201107700

      Thumbnail image of graphical abstract

      How easily can ions move in DNA channels? Three-dimensional free-energy landscapes for the movement of Na+, K+, and NH4+ ions through G-quadruplex DNA channels have been obtained by molecular dynamics simulations. The computed results are in qualitative agreement with the limited experimental data: large K+ and NH4+ ions squeeze through the G-quartets with some difficulty, while Na+ ions pass through with less impedance.

    2. Neurite Outgrowth

      In Vitro Developmental Acceleration of Hippocampal Neurons on Nanostructures of Self-Assembled Silica Beads in Filopodium-Size Ranges (pages 2855–2858)

      Kyungtae Kang, Sung-Eun Choi, Hee Su Jang, Dr. Woo Kyung Cho, Prof. Dr. Yoonkey Nam, Prof. Dr. Insung S. Choi and Prof. Dr. Jin Seok Lee

      Version of Record online: 25 NOV 2011 | DOI: 10.1002/anie.201106271

      Thumbnail image of graphical abstract

      Something to sprout about: The developmental acceleration of hippocampal neurons occurred on well-packed structures of silica beads with diameters over 200 nm (see picture; scale bar: 5 μm, inset scale bar: 1 μm). The neurons sensed the size differences of the nanostructures and altered their behaviors, thus implying that nanotopographical stimuli are one of the important features for guiding neurites during neural developments in vivo.

    3. Heterogeneous Catalysis

      Catalytic Polymerization of Anthracene in a Recyclable SBA-15 Reactor with High Iron Content by a Friedel–Crafts Alkylation (pages 2859–2863)

      Jeonghun Kim, Dr. Chokkalingam Anand, Siddulu N. Talapaneni, Dr. Jungmok You, Prof. Salem S. Aldeyab, Prof. Eunkyoung Kim and Prof. Ajayan Vinu

      Version of Record online: 2 JAN 2012 | DOI: 10.1002/anie.201107145

      Thumbnail image of graphical abstract

      Ironing it out: A FeSBA-15 catalyst with a high iron content as well as a large pore diameter has been synthesized and used for the production of soluble poly(methylene anthracene) (PMAn, see scheme). The catalyst is stable, active, reusable, and affords a high yield of high-molecular-weight PMAn. The properties of the PMAns obtained can be controlled by tuning the specific surface area, pore diameter, pore volume, and Fe content of the catalysts.

    4. Drug Delivery

      Well-Defined, Reversible Boronate Crosslinked Nanocarriers for Targeted Drug Delivery in Response to Acidic pH Values and cis-Diols (pages 2864–2869)

      Dr. Yuanpei Li, Dr. Wenwu Xiao, Dr. Kai Xiao, Dr. Lorenzo Berti, Prof. Juntao Luo, Harry P. Tseng, Gabriel Fung and Prof. Kit S. Lam

      Version of Record online: 17 JAN 2012 | DOI: 10.1002/anie.201107144

      Thumbnail image of graphical abstract

      Demand and deliver: Micelles reversibly crosslinked by boronate esters (see scheme) show in vitro and in vivo stability, and thus minimize premature drug release under physiological conditions. After reaching the tumor sites, drug (stars in scheme) release is activated by cleavage of the boronate esters by the acidic conditions around the tumor or in the target cells, or by the administration of mannitol.

    5. Heterocycles

      Synthesis of 3-Fluoro-3-aryl Oxindoles: Direct Enantioselective α Arylation of Amides (pages 2870–2873)

      Linglin Wu, Laura Falivene, Dr. Emma Drinkel, Sharday Grant, Priv.-Doz. Dr. Anthony Linden, Prof. Dr. Luigi Cavallo and Prof. Dr. Reto Dorta

      Version of Record online: 6 FEB 2012 | DOI: 10.1002/anie.201200206

      Thumbnail image of graphical abstract

      Modus operandi: Catalytic access to the title compounds through a new asymmetric α-arylation protocol is reported (see scheme). These products are formed in good yields and excellent enantioselectivities by using a new and easily synthesized chiral N-heterocyclic carbene (NHC) ligand. Advanced DFT calculations reveal the properties of the NHC ligand and the mode of operation of the catalyst.

    6. Drug Development

      Duocarmycin Analogues Target Aldehyde Dehydrogenase 1 in Lung Cancer Cells (pages 2874–2877)

      M. Sc. Tanja Wirth, Dr. Kianga Schmuck, Prof. Dr. Lutz F. Tietze and Prof. Dr. Stephan A. Sieber

      Version of Record online: 14 FEB 2012 | DOI: 10.1002/anie.201106334

      Thumbnail image of graphical abstract

      Reacquiring the target: A proteomic profiling approach has been used to show that aldehyde dehydrogenase 1 may be an additional or alternative target of duocarmycin. Selective inhibition of this enzyme in lung cancer cells explains the antitumor activity of duocarmycin analogues (see scheme).

    7. Photoswitchable Compounds

      High-Contrast Reversible Fluorescence Photoswitching of Dye-Crosslinked Dendritic Nanoclusters in Living Vertebrates (pages 2878–2882)

      Dr. Yoonkyung Kim, Hye-youn Jung, Yun Hui Choe, Chaewoon Lee, Sung-Kyun Ko, Soonil Koun, Yohan Choi, Dr. Bong Hyun Chung, Dr. Byoung Chul Park, Prof. Dr. Tae-Lin Huh, Prof. Dr. Injae Shin and Prof. Dr. Eunkyoung Kim

      Version of Record online: 3 FEB 2012 | DOI: 10.1002/anie.201107086

      Thumbnail image of graphical abstract

      Dendrimers crosslinked with a photochromic diarylethene (blue in picture) were labeled with the fluorescent dye Cy3 (red) for reversible fluorescence photoswitching. If the obtained nanoclusters are irradiated with UV light, the Cy3 fluorescence is quenched by the diarylethene in its ring-closed form, whereas upon irradiation with visible light, the nanoclusters show fluorescence. High-contrast fluorescence imaging was achieved inside a living zebrafish.

    8. DNA Nanotechnology

      A Molecular Cryptosystem for Images by DNA Computing (pages 2883–2887)

      Sivan Shoshani, Dr. Ron Piran, Prof. Yoav Arava and Prof. Ehud Keinan

      Version of Record online: 3 FEB 2012 | DOI: 10.1002/anie.201107156

      Thumbnail image of graphical abstract

      Cracking the encryption: Parallel computing with molecular finite-state automata and fluorescently labeled DNA molecules has been used to decipher two different images encrypted onto a single DNA chip (see picture). The images were deciphered by a mixture of input molecules that were processed by biomolecular automata, a strategy that potentially offers a huge diversity of encrypted images.

    9. Mesoporous Salts

      A Topotactic Synthetic Methodology for Highly Fluorine-Doped Mesoporous Metal Oxides (pages 2888–2893)

      Dr. Zhen-an Qiao, Dr. Suree S. Brown, Dr. Jamie Adcock, Dr. Gabriel M. Veith, Dr. J. Chris Bauer, Dr. E. Andrew Payzant, Dr. Raymond R. Unocic and Dr. Sheng Dai

      Version of Record online: 6 FEB 2012 | DOI: 10.1002/anie.201107812

      Thumbnail image of graphical abstract

      F tactic: Highly fluorine-doped mesoporous metal oxides (up to 40 atom %) were synthesized by topotactic fluorination synthesis with mesoporous metal oxides as starting materials and fluorine as the fluorination agent. The surface areas, pore sizes, pore volumes, and F atomic concentrations of these materials could be adjusted over a wide range by varying the fluorination time and temperature.

    10. Porphyrin Chemistry

      Oxidative Annulation of β-Aminoporphyrins into Pyrazine-Fused Diporphyrins (pages 2894–2897)

      Masanari Akita, Dr. Satoru Hiroto and Prof. Dr. Hiroshi Shinokubo

      Version of Record online: 8 FEB 2012 | DOI: 10.1002/anie.201108037

      Thumbnail image of graphical abstract

      Dimers are a girl's best friend: The oxidative fusion reaction of β-aminoporphyrins with 2,3-dichloro-5,6-dicyano-1,4-benzoquinone (DDQ) under high-dilution conditions furnishes pyrazine-fused diporphyrins 1 in high yields. In a further application of the reaction, the oxidation of a 5,10,15,20-tetraphenylporphyrin derivative provides a singly linked diaminodiporphyrin 2 along with the pyrazine-fused diporphyrin (see scheme; only core structures are shown).

    11. Enzyme Structure/Mechanism

      Insights into the Mechanistic Pathway of the Pantoea agglomerans Phenylalanine Aminomutase (pages 2898–2902)

      Susan Strom, Udayanga Wanninayake, Nishanka Dilini Ratnayake, Prof. Kevin D. Walker and Prof. James H. Geiger

      Version of Record online: 8 FEB 2012 | DOI: 10.1002/anie.201108525

      Thumbnail image of graphical abstract

      The structure of the title aminomutase has been solved. The steric bulk of Phe 455 (green CPK structure) twists the phenylpropanoate ligand (green stick) by approximately 15° about the Cβ axis, which precludes a stronger bidentate salt bridge with Arg 323 (magenta structure). Instead, a weaker monodentate bridge may partially explain the different configuration of the product, relative to that obtained with an isoenzyme that forms a bidentate intermediate.

    12. Polar–π Interactions

      Basicity of (2,6-Pyridino)paracyclophanes: Lone Pair–π, Cation–π, and Solvation Effects (pages 2903–2906)

      Prof. Kim K. Baldridge, Prof. Franco Cozzi and Prof. Jay S. Siegel

      Version of Record online: 15 FEB 2012 | DOI: 10.1002/anie.201108545

      Thumbnail image of graphical abstract

      Lost in solvation: A study of the basicity of (2,6-pyridino)paracyclophanes (see picture; C light blue, N blue, S orange, F yellow, H green) reveals the importance of bulk solvation compared to cation–π effects in determining the relative stability of cations.

    13. Synthetic Methods

      An Approach to the Site-Selective Deoxygenation of Hydroxy Groups Based on Catalytic Phosphoramidite Transfer (pages 2907–2911)

      Peter A. Jordan and Prof. Dr. Scott J. Miller

      Version of Record online: 8 FEB 2012 | DOI: 10.1002/anie.201109033

      Thumbnail image of graphical abstract

      Selective: The deoxygenation of simple and complex natural products employing a readily synthesized phosphoramidite and tetrazole catalysts can be executed as a two-step process, without the need to isolate intermediate deoxygenation precursors. Furthermore, a peptide-based tetrazole catalyst controls the site selectivity of deoxyerythromycin synthesis (see scheme), thus overcoming the notorious challenges with unprotected erythromycin A.

    14. Enantioselective Gold Catalysis

      Enantioselective Alkynylbenzaldehyde Cyclizations Catalyzed by Chiral Gold(I) Acyclic Diaminocarbene Complexes Containing Weak Au–Arene Interactions (pages 2912–2915)

      Sachin Handa and Prof. LeGrande M. Slaughter

      Version of Record online: 4 JAN 2012 | DOI: 10.1002/anie.201107789

      Thumbnail image of graphical abstract

      Hold me close: Highly enantioselective catalysis of tandem acetalization/cycloisomerization reactions of o-alkynylbenzaldehydes has been achieved using gold complexes of chiral acyclic diaminocarbene ligands that have electron-deficient aryl substituents. X-ray crystallography and DFT calculations implicate weak gold-arene interactions—absent in the case of simple phenyl substituents—that define the chirality of the substrate binding site.

    15. Carbon Nanotubes

      Multifunctional Ferromagnetic Carbon-Nanotube Arrays Prepared by Pulse-Injection Chemical Vapor Deposition (pages 2916–2919)

      Dr. Vinay Gupta and Dr. Ravinder Kumar Kotnala

      Version of Record online: 8 FEB 2012 | DOI: 10.1002/anie.201106566

      Thumbnail image of graphical abstract

      Particles in tubes: Multiwalled carbon nanotubes containing Fe3C particles (see SEM image) have been prepared by pulse-injection chemical vapor deposition. The Fe3C particles provide the nanotubes with magnetic properties. The use of the nanotubes was also investigated in in vitro drug-release studies.

    16. Heterogeneous Catalysis

      Design of a Highly Active Ir/Fe(OH)x Catalyst: Versatile Application of Pt-Group Metals for the Preferential Oxidation of Carbon Monoxide (pages 2920–2924)

      Dr. Jian Lin, Dr. Botao Qiao, Prof. Dr. Jingyue Liu, Dr. Yanqiang Huang, Prof. Dr. Aiqin Wang, Dr. Lin Li, Dr. Wansheng Zhang, Dr. Lawrence F. Allard, Prof. Dr. Xiaodong Wang and Prof. Dr. Tao Zhang

      Version of Record online: 3 FEB 2012 | DOI: 10.1002/anie.201106702

      Thumbnail image of graphical abstract

      With the right support: A Ir/Fe(OH)x catalyst was designed. The Fe(OH)x support stabilizes the metal catalyst used for the oxidation of carbon monoxide. The catalyst was highly active for the oxidation of carbon monoxide in the presence of excess hydrogen at room temperature and showed a wide temperature range for the total conversion of CO (see picture).

    17. Domino C[BOND]O/C[BOND]N Bond Formation

      Copper-Catalyzed Cross-Coupling Interrupted by an Opportunistic Smiles Rearrangement: An Efficient Domino Approach to Dibenzoxazepinones (pages 2925–2929)

      Dr. Matthew O. Kitching, Dr. Timothy E. Hurst and Prof.Dr. Victor Snieckus

      Version of Record online: 6 FEB 2012 | DOI: 10.1002/anie.201106786

      Thumbnail image of graphical abstract

      Unexpected Smiles! An unusual and highly regioselective synthesis of dibenzoxazepinones by a domino sequence assisted by an unexpected Smiles rearrangement is reported. The process is effective on electronically differentiated phenols and shows a high tolerance to variation in the benzamide substituents. A plausible path for the reaction, supported by preliminary mechanistic data, is offered.

    18. Multiple Bonds

      Formation of a Germylyne Complex: Dehydrogenation of a Hydrido(hydrogermylene)tungsten Complex with Mesityl Isocyanate (pages 2930–2933)

      Dr. Hisako Hashimoto, Tetsuya Fukuda, Prof. Hiromi Tobita, Dr. Mausumi Ray and Prof. Shigeyoshi Sakaki

      Version of Record online: 6 FEB 2012 | DOI: 10.1002/anie.201107501

      Thumbnail image of graphical abstract

      The germylyne complex 2 was obtained by dehydrogenation of a hydrido (hydrogermylene) complex 1 with mesityl isocyanate on heating. A reaction intermediate 3 was also isolated by a room temperature reaction, which was converted into 2 by heating, with elimination of MesNHCHO. A possible mechanism for the formation of 2 was elucidated by kinetic studies and DFT calculations.

    19. Metal Nanoparticles

      Anti-Galvanic Reduction of Thiolate-Protected Gold and Silver Nanoparticles (pages 2934–2938)

      Prof. Dr. Zhikun Wu

      Version of Record online: 1 FEB 2012 | DOI: 10.1002/anie.201107822

      Thumbnail image of graphical abstract

      Unexpected: Anti-galvanic reduction (AGR), that is, metal ions are reduced by more-noble metals, was found in small thiolated gold (see figure) and silver nanoparticles! These findings are not only unexpected considering the classic galvanic theory, but also provide a facile and mild method to make alloys on the nanoscale or tune the compositions, structures, and properties of nanostructures that are otherwise difficult to obtain.

    20. C[BOND]H Insertion

      Gold-Catalyzed Oxidative Cyclizations of cis-3-En-1-ynes To Form Cyclopentenone Derivatives (pages 2939–2942)

      Dr. Sabyasachi Bhunia, Satish Ghorpade, Deepak B. Huple and Prof. Dr. Rai-Shung Liu

      Version of Record online: 1 FEB 2012 | DOI: 10.1002/anie.201108027

      Thumbnail image of graphical abstract

      Golden tendencies: The title reaction for synthesizing cyclopentenone derivatives utilizes a gold complex and 8-methylquinoline oxide as the catalyst system (see scheme; IPr=1,3-bis(diisopropylphenyl)imidazol-2-ylidene). Such products are not attainable using diazocarbonyl reagents, as the gold carbenoids tend to react with C[BOND]H bonds.

    21. Metal-Free Borylation

      Transition-Metal-Free Synthesis of Pinacol Alkylboronates from Tosylhydrazones (pages 2943–2946)

      Huan Li, Long Wang, Dr. Yan Zhang and Prof. Dr. Jianbo Wang

      Version of Record online: 10 FEB 2012 | DOI: 10.1002/anie.201108139

      Thumbnail image of graphical abstract

      Highly efficient: Pinacol alkylboronates were synthesized by the reaction of tosylhydrazones with bis(pinacolato)diboron or pinacolborane under transition-metal-free conditions. This reaction represents an expeditious conversion of carbonyl functionality into a boronate group.

    22. Trifluoromethylation

      Iron(II)-Catalyzed Trifluoromethylation of Potassium Vinyltrifluoroborates (pages 2947–2950)

      Dr. Andrew T. Parsons, Todd D. Senecal and Prof. Dr. Stephen L. Buchwald

      Version of Record online: 10 FEB 2012 | DOI: 10.1002/anie.201108267

      Thumbnail image of graphical abstract

      Exchanging BF3 by CF3: The title reaction proceeds under exceedingly mild reaction conditions and provides 2-arylvinyl- and 2-heteroarylvinyl-substituted substrates with E/Z selectivities of more than 95:5. Experimental observations suggest that the reaction does not proceed through a transmetalation of the RBF3K species to the iron catalyst.

    23. Asymmetric Synthesis

      Kinetic Resolution of Planar-Chiral (η6-Arene)Chromium Complexes by Molybdenum-Catalyzed Asymmetric Ring-Closing Metathesis (pages 2951–2955)

      Prof. Masamichi Ogasawara, Dr. Wei-Yi Wu, Sachie Arae, Dr. Susumu Watanabe, Tomotaka Morita, Prof. Tamotsu Takahashi and Prof. Ken Kamikawa

      Version of Record online: 3 FEB 2012 | DOI: 10.1002/anie.201108292

      Thumbnail image of graphical abstract

      Molybdenum-catalyzed asymmetric ring-closing metathesis has been used for the kinetic resolution of racemic planar-chiral (η6-arene)chromium complexes with excellent enantioselectivity. The products are excellent precursors for the synthesis of various planar-chiral (η6-arene)chromium derivatives and can also be applied as chiral ligands in rhodium-catalyzed asymmetric reactions.

    24. Surface Chemistry

      A Statically Oleophilic but Dynamically Oleophobic Smooth Nonperfluorinated Surface (pages 2956–2959)

      Dr. Dalton F. Cheng, Dr. Chihiro Urata, Dr. Makoto Yagihashi and Dr. Atsushi Hozumi

      Version of Record online: 14 FEB 2012 | DOI: 10.1002/anie.201108800

      Thumbnail image of graphical abstract

      Nonstick: Dynamically oleophobic surfaces have been produced from low-molecular-weight poly(dimethylsiloxane) (PDMS) brush films. Despite the statically oleophilic nature of these nonroughened, nonperfluorinated surfaces, ultralow tilt angles (TAs) that set drops of various nonpolar liquids in motion were achieved. Heating the surfaces enhances droplet mobility by significantly reducing the TAs (see scheme; CA=contact angle).

    25. Radical Chemistry

      Carbon-Centered Radicals Can Transfer Hydrogen Atoms between Amino Acid Side Chains (pages 2960–2963)

      Dr. Quentin Raffy, David-Alexandre Buisson, Dr. Jean-Christophe Cintrat, Dr. Bernard Rousseau, Dr. Serge Pin and Dr. Jean Philippe Renault

      Version of Record online: 6 FEB 2012 | DOI: 10.1002/anie.201108856

      Thumbnail image of graphical abstract

      Radical migration between aliphatic amino acid side chains can occur in solution and intramolecularly in peptides. The kinetic constant of the hydrogen transfer reaction was measured by using competition kinetics, and the half-life as well as the distance that a radical can move within a protein was calculated.

    26. Cationic Phosphorus

      Ligand-Stabilized [P4]2+ Cations (pages 2964–2967)

      Maximilian Donath, Eamonn Conrad, Paul Jerabek, Prof. Gernot Frenking, Roland Fröhlich, Prof. Neil Burford and Dr. Jan J. Weigand

      Version of Record online: 6 FEB 2012 | DOI: 10.1002/anie.201109010

      Thumbnail image of graphical abstract

      The bis(triphenylarsane) complex of the [P4]2+ dication has been formed in a high-yielding one-pot synthesis. X-ray crystallography reveals a butterfly structure of the bicyclo[1.1.0]-tetraphosphane-1,4-diium core, with two triphenylarsane ligands in an exo,exo configuration (see picture). The reaction of [(Ph3As)2P4]2+ with Ph3P results in the quantitative formation of [(Ph3P)2P4]2+ and Ph3As.

    27. Cross-Coupling

      Regioselective and Stereospecific Cross-Coupling of Primary Allylic Amines with Boronic Acids and Boronates through Palladium-Catalyzed C[BOND]N Bond Cleavage (pages 2968–2971)

      Man-Bo Li, Yong Wang and Prof. Dr. Shi-Kai Tian

      Version of Record online: 14 FEB 2012 | DOI: 10.1002/anie.201109171

      Thumbnail image of graphical abstract

      The NH2 group serves as an effective leaving group in the palladium-catalyzed regioselective and stereospecific title reaction (see scheme). The reaction works well with aryl- and alkenylboronic acids and aryl-, alkenyl-, allyl-, and benzylboronates, and complete transfer of chirality has been achieved when using α-chiral primary allylic amines as the allylic electrophiles.

    28. Enantioselective Propargylation

      Diastereo- and Enantioselective Iridium-Catalyzed Carbonyl Propargylation from the Alcohol or Aldehyde Oxidation Level: 1,3-Enynes as Allenylmetal Equivalents (pages 2972–2976)

      Dr. Laina M. Geary, Dr. Sang Kook Woo, Joyce C. Leung and Prof. Michael J. Krische

      Version of Record online: 15 FEB 2012 | DOI: 10.1002/anie.201200239

      Thumbnail image of graphical abstract

      Axial to axial to point chirality transfer: Exposure of conjugated enynes to alcohols in the presence of an iridium catalyst modified by a segphos ligand results in the generation of aldehyde–allenyliridium pairs and formation of enantiomerically enriched products of carbonyl anti-(α-methyl)propargylation (see scheme). An identical set of products are obtained from aldehydes under related transfer hydrogenation conditions by employing formic acid as a reductant.

    29. Boron Radicals

      An Isolable Radical Anion Based on the Borole Framework (pages 2977–2980)

      Prof. Dr. Holger Braunschweig, Dr. Vladimir Dyakonov, Dr. J. Oscar C. Jimenez-Halla, Dr. Katharina Kraft, Dr. Ivo Krummenacher, Dr. Krzysztof Radacki, Andreas Sperlich and Johannes Wahler

      Version of Record online: 14 FEB 2012 | DOI: 10.1002/anie.201108632

      Thumbnail image of graphical abstract

      Give me five! A new boron-centered radical anion based on the borole framework is an example of a cyclic, planar, and conjugated π system hosting five electrons. Single-crystal X-ray analysis, EPR spectroscopy, and DFT methods indicate that the unpaired spin is delocalized within the borole ring. Despite steric shielding by the mesityl group, the boron atom is still available for radical-type reactions.

    30. CO2 Reduction

      Silyl Cation Mediated Conversion of CO2 into Benzoic Acid, Formic Acid, and Methanol (pages 2981–2984)

      Dipl.-Chem. André Schäfer, Dipl.-Chem. Wolfgang Saak, Detlev Haase and Prof. Dr. Thomas Müller

      Version of Record online: 6 FEB 2012 | DOI: 10.1002/anie.201107958

      Thumbnail image of graphical abstract

      As you like it: The choice of solvents and substituents at the silicon atom determine what product is formed from carbon dioxide after electrophilic activation by silyl cations (see scheme). Benzoic acid as well as the C-1 building blocks formic acid and methanol are on the product tableau.

    31. Tropos Ligands

      Effects of the Stationary Phase and the Solvent on the Stereodynamics of biphep Ligands Quantified by Dynamic Three-Column HPLC (pages 2985–2988)

      Dipl.-Chem. Frank Maier and Prof. Dr. Oliver Trapp

      Version of Record online: 9 FEB 2012 | DOI: 10.1002/anie.201107907

      Thumbnail image of graphical abstract

      Dynamics and kinetics in a single stroke: The stereodynamics of the tropos-chiral diphosphine biphep and its 3,3′-dialkoxy analogues were investigated by enantioselective dynamic HPLC (DHPLC) and a novel three-column approach, in with the dynamics and kinetics of the interconversion were examined in a single experimental setup (see scheme).

    32. Iron Oxide Nanorods

      Rod-Shaped Fe2O3 as an Efficient Catalyst for the Selective Reduction of Nitrogen Oxide by Ammonia (pages 2989–2993)

      Xiaoling Mou, Dr. Bingsen Zhang, Dr. Yong Li, Dr. Lide Yao, Xuejiao Wei, Dr. Dang Sheng Su and Dr. Wenjie Shen

      Version of Record online: 6 FEB 2012 | DOI: 10.1002/anie.201107113

      Thumbnail image of graphical abstract

      Nanorust: Fe2O3 nanomaterials with controllable crystal phase and morphology have been successfully fabricated. The γ-Fe2O3 nanorods that are enclosed by the reactive {110} and {100} facets are highly active and distinctively stable for selective catalytic reduction of NO with NH3. The picture shows the shape and surfaces and the surface atomic configurations of the preferentially exposed {110} and {001} planes.

    33. Metastable Phases

      Synthesis and Identification of Metastable Compounds: Black Arsenic—Science or Fiction? (pages 2994–2997)

      Oliver Osters, Prof. Dr. Tom Nilges, Frederik Bachhuber, Florian Pielnhofer, Dr. Richard Weihrich, Michael Schöneich and Prof. Dr. Peer Schmidt

      Version of Record online: 9 FEB 2012 | DOI: 10.1002/anie.201106479

      Thumbnail image of graphical abstract

      Back in black: All metastable and stable phases can be identified for the solid solution arsenic/phosphorus by a combination of quantum-chemical calculations and investigations of the phase formation. Reaction paths for phase formations and transitions in situ were also evaluated. The results show that orthorhombic black arsenic (o-As) is metastable in pure form and has only been previously obtained by stabilizing impurities.

    34. NMR Spectroscopy

      Solid-State NMR Spectroscopy on Cellular Preparations Enhanced by Dynamic Nuclear Polarization (pages 2998–3001)

      Dr. Marie Renault, Dr. Shane Pawsey, Dr. Martine P. Bos, Eline J. Koers, Dr. Deepak Nand, Ria Tommassen-van Boxtel, Dr. Melanie Rosay, Prof. Jan Tommassen, Dr. Werner E. Maas and Prof. Marc Baldus

      Version of Record online: 1 FEB 2012 | DOI: 10.1002/anie.201105984

      Thumbnail image of graphical abstract

      A peek inside: Dynamic nuclear polarization (DNP) enhances the spectroscopic sensitivity of solid-state NMR measurements of uniformly (13C,15N)-labeled preparations of Escherichia coli cells by more than an order of magnitude (see picture; MW=microwaves, ε=enhancement factor). The major molecular components in the cells can be characterized in this way.

    35. Methanol Steam Reforming

      You have full text access to this OnlineOpen article
      Hydrogen Production by Methanol Steam Reforming on Copper Boosted by Zinc-Assisted Water Activation (pages 3002–3006)

      Dr. Christoph Rameshan, Mag. Werner Stadlmayr, Dr. Simon Penner, Mag. Harald Lorenz, Prof. Norbert Memmel, Dr. Michael Hävecker, Dr. Raoul Blume, Dr. Detre Teschner, Dr. Tulio Rocha, Dr. Dmitry Zemlyanov, Dr. Axel Knop-Gericke, Prof. Robert Schlögl and Prof. Bernhard Klötzer

      Version of Record online: 15 FEB 2012 | DOI: 10.1002/anie.201106591

      Thumbnail image of graphical abstract

      A Zn-in-Cu near-surface alloy covered by a thin wetting layer of interfacial Zn(ox) is the most active state of an inverse CuZn catalyst. The bifunctional action of the mixed Cu(Zn)0/Zn(ox) surface allows for selective dehydrogenation of methanol to formaldehyde and for optimized water activation, thus providing the required source of oxygen for the total oxidation of HCHO to CO2.

    36. Supramolecular Chemistry

      Influencing the Symmetry of High-Nuclearity and High-Spin Manganese Oxo Clusters: Supramolecular Approaches to Manganese-Based Keplerates and Chiral Solids (pages 3007–3011)

      Dr. Lei Zhang, Dr. Rodolphe Clérac, Pierre Heijboer and Dr. Wolfgang Schmitt

      Version of Record online: 6 FEB 2012 | DOI: 10.1002/anie.201107358

      Thumbnail image of graphical abstract

      Meet me at the symmetry gates: A supramolecular approach using chlorides as structure-directing ligands gives high-nuclearity, mixed-valent Mn coordination clusters with {MnIIMnIII12}, {MnII3MnIII10}, and {MnII3MnIII11} core structures that have supramolecular chirality. The {MnIIMnIII12} complex (see structure: Mn blue, Cl green, O red) is the first structurally characterized Mn-based Keplerate and has one of the highest symmetries reported for a high-nuclearity Mn coordination cluster.

  14. And Finally

    1. Top of page
    2. Cover Picture
    3. Inside Cover
    4. Inside Back Cover
    5. Back Cover
    6. Graphical Abstract
    7. News
    8. Author Profile
    9. News
    10. Book Review
    11. Highlights
    12. Minireview
    13. Review
    14. Communications
    15. And Finally
    16. Preview
    1. Gilbert Stork

      Gilbert Stork: In His Own Words and in the Musings of His Friends (pages 3012–3023)

      Dr. Jeffrey I. Seeman

      Version of Record online: 1 MAR 2012 | DOI: 10.1002/anie.201200033

      Thumbnail image of graphical abstract

      Storkisms: In honor of the 90th birthday of Professor Gilbert Stork, a collection of poignant quotes and anecdotes have been gathered which illustrate his philosophies of life and his unique qualities of intensity, humor, and gentleness. These stories are both entertaining and didactic, while revealing aspects of the academic life of a chemist from 1940 to 2011.

  15. Preview

    1. Top of page
    2. Cover Picture
    3. Inside Cover
    4. Inside Back Cover
    5. Back Cover
    6. Graphical Abstract
    7. News
    8. Author Profile
    9. News
    10. Book Review
    11. Highlights
    12. Minireview
    13. Review
    14. Communications
    15. And Finally
    16. Preview
    1. You have free access to this content

SEARCH

SEARCH BY CITATION