Mechanism of UV-Induced Formation of Dewar Lesions in DNA (pages 408–411)
Karin Haiser, Dr. Benjamin P. Fingerhut, Korbinian Heil, Dr. Andreas Glas, Teja T. Herzog, Bert M. Pilles, Dr. Wolfgang J. Schreier, Prof. Dr. Wolfgang Zinth, Prof. Dr. Regina de Vivie-Riedle and Prof. Dr. Thomas Carell
Article first published online: 23 NOV 2011 | DOI: 10.1002/anie.201106231
The importance of a backbone: The mechanism of formation of Dewar lesions (see scheme) has been investigated by using femtosecond IR spectroscopy and ab initio calculations of the exited state. The 4π electrocyclization is rather slow, occurs with an unusual high quantum yield, and—surprisingly—is controlled by the phosphate backbone.