Reaction Discovery by Using a Sandwich Immunoassay (pages 6144–6148)
Dr. Julia Quinton, Sergii Kolodych, Dr. Manon Chaumonet, Valentina Bevilacqua, Marie-Claire Nevers, Dr. Hervé Volland, Sandra Gabillet, Dr. Pierre Thuéry, Dr. Christophe Créminon and Dr. Frédéric Taran
Article first published online: 4 MAY 2012 | DOI: 10.1002/anie.201201451
Mmm, a reaction sandwich… Using an immunoassay-based technique able to monitor any kind of cross-coupling reaction, a systematic and rapid evaluation of a large panel of random reactions was carried out. This approach led to the discovery of two new copper-promoted reactions: a desulfurization reaction of thioureas leading to isoureas and a cyclization reaction leading to thiazole derivatives from alkynes and N-hydroxy thioureas.