Creation of Pure Nanodrugs and Their Anticancer Properties (pages 10315–10318)
Dr. Hitoshi Kasai, Dr. Tatsuya Murakami, Yoshikazu Ikuta, Yoshitaka Koseki, Dr. Koichi Baba, Prof. Hidetoshi Oikawa, Prof. Hachiro Nakanishi, Dr. Masahiro Okada, Mitsuru Shoji, Prof. Minoru Ueda, Prof. Hiroshi Imahori and Prof. Mitsuru Hashida
Article first published online: 11 SEP 2012 | DOI: 10.1002/anie.201204596
A method for preparing nanoparticles of a water-insoluble drug that are suitable for administration to the human body has been established. A reprecipitation method was used to fabricate 50 nm nanoparticles of dimerized SN-38, an anticancer camptothecin derivative, that form stable aqueous dispersions and can penetrate into cancer cells to inhibit cell proliferation more potently than irinotecan.