Ceria Nanoparticles that can Protect against Ischemic Stroke (pages 11039–11043)
Dr. Chi Kyung Kim, Taeho Kim, In-Young Choi, Min Soh, Dr. Dohoung Kim, Young-Ju Kim, Dr. Hyunduk Jang, Hye-Sung Yang, Dr. Jun Yup Kim, Dr. Hong-Kyun Park, Dr. Seung Pyo Park, Sangseung Park, Dr. Taekyung Yu, Prof. Byung-Woo Yoon, Prof. Seung-Hoon Lee and Prof. Taeghwan Hyeon
Version of Record online: 11 SEP 2012 | DOI: 10.1002/anie.201203780
Uniform 3 nm-sized ceria nanoparticles can protect against ischemic stroke by scavenging reactive oxygen species (ROS) and reducing apoptosis. PEGylated ceria nanoparticles showed protective effects against ROS-induced cell death in vitro. Optimal doses of ceria nanoparticles reduced infarct volumes and the rate of ischemic cell death in vivo.