Chemical Interrogation of Drug/RNA Complexes: From Chemical Reactivity to Drug Design (pages 3148–3151)
Ester Jiménez-Moreno, Irene Gómez-Pinto, Dr. Francisco Corzana, Dr. Andrés G. Santana, Dr. Julia Revuelta, Dr. Agatha Bastida, Dr. Jesus Jiménez-Barbero, Dr. Carlos González and Dr. Juan Luis Asensio
Article first published online: 7 FEB 2013 | DOI: 10.1002/anie.201209434
When you're in a (RNA) bind: An NMR-based method to explore the reactivity of ligand/RNA complexes can be used as source of valuable information for drug design. By combining NMR spectroscopy and a simple isotopic labeling strategy (see picture), positional chemical reactivity information can be readily extracted from complex aminoglycoside mixtures. C green, N blue, O red, Me purple.