Broad-Spectrum Antimicrobial and Biofilm-Disrupting Hydrogels: Stereocomplex-Driven Supramolecular Assemblies (pages 674–678)
Yan Li, Dr. Kazuki Fukushima, Dr. Daniel J. Coady, Dr. Amanda C. Engler, Dr. Shaoqiong Liu, Yuan Huang, Dr. John S. Cho, Dr. Yi Guo, Dr. Lloyd S. Miller, Dr. Jeremy P. K. Tan, Dr. Pui Lai Rachel Ee, Dr. Weimin Fan, Prof. Yi Yan Yang and Dr. James L. Hedrick
Version of Record online: 19 NOV 2012 | DOI: 10.1002/anie.201206053
Fighting the resistance: Biodegradable and injectable/moldable hydrogels with hierarchical nanostructures (see picture) were made with broad-spectrum antimicrobial activities and biofilm-disruption capability. They demonstrate no cytotoxicity in vitro, and show excellent skin biocompatibility in animals. These hydrogels have great potential for clinical use in prevention and treatment of various multidrug-resistant infections.