Multiphase Intrafibrillar Mineralization of Collagen (pages 5762–5766)
Dr. Li-na Niu, Dr. Kai Jiao, Dr. Heonjune Ryou, Dr. Cynthia K. Y. Yiu, Dr. Ji-hua Chen, Dr. Lorenzo Breschi, Dr. Dwayne D. Arola, Dr. David H. Pashley and Dr. Franklin R. Tay
Article first published online: 18 APR 2013 | DOI: 10.1002/anie.201210259
Why waste space? In the first stage of the multiphase biomineralization of collagen, silicic acid precursors (purple) infiltrated the collagen fibril (yellow) and condensed into amorphous silica to give a hierarchical composite. Amorphous calcium phosphate precursors (red) then filled the intrafibrillar spaces of the silicified collagen, where the precipitation and maturation of apatite crystallites (blue) occurred to complete the process.