Helical Oligomers of Thiazole-Based γ-Amino Acids: Synthesis and Structural Studies (pages 6006–6010)
Loïc Mathieu, Dr. Baptiste Legrand, Cheng Deng, Dr. Lubomir Vezenkov, Emmanuel Wenger, Dr. Claude Didierjean, Dr. Muriel Amblard, Dr. Marie-Christine Averlant-Petit, Dr. Nicolas Masurier, Prof. Vincent Lisowski, Prof. Jean Martinez and Dr. Ludovic T. Maillard
Version of Record online: 25 APR 2013 | DOI: 10.1002/anie.201302106
9-Helix: 4-Amino(methyl)-1,3-thiazole-5-carboxylic acids (ATCs) were synthesized as new γ-amino acid building blocks. The structures of various ATC oligomers were analyzed in solution by CD and NMR spectroscopy and in the solid state by X-ray crystallography. The ATC sequences adopted a well-defined 9-helix structure in the solid state and in aprotic and protic organic solvents as well as in aqueous solution.