Visualization and Isolation of Langerhans Islets by a Fluorescent Probe PiY (pages 8557–8560)
Dr. Nam-Young Kang, Dr. Sung-Chan Lee, Dr. Sung-Jin Park, Prof. Hyung-Ho Ha, Dr. Seong-Wook Yun, Dr. Elena Kostromina, Dr. Natalia Gustavsson, Dr. Yusuf Ali, Yogeswari Chandran, Dr. Hang-Suk Chun, Dr. MyungAe Bae, Dr. Jin Hee Ahn, Dr. Weiping Han, Dr. George K. Radda and Prof. Young-Tae Chang
Article first published online: 28 MAY 2013 | DOI: 10.1002/anie.201302149
Lighting up the pancreas: A pancreatic beta cell selective probe PiY (red, see picture) was developed which stains Langerhans islets in live animals without toxicity or side effects. Through tail-vein injection, PiY allowed for a comparison of the islets between healthy and diabetic mice. PiY also facilitated the isolation of healthy Langerhans islets by using a fluorescence-guided surgical procedure.