Porphyrins for Probing Electrical Potential Across Lipid Bilayer Membranes by Second Harmonic Generation (pages 9044–9048)
Dr. James E. Reeve, Dr. Alex D. Corbett, Igor Boczarow, Wojciech Kaluza, Dr. William Barford, Prof. Hagan Bayley, Prof. Tony Wilson and Prof. Harry L. Anderson
Version of Record online: 16 JUL 2013 | DOI: 10.1002/anie.201304515
Feeling the field! The intensity of second harmonic generation (SHG) from a porphyrin in a lipid bilayer is exceptionally sensitive to electric field, thus indicating that these dyes may be useful probes for electrical signals in excitable cells such as neurons. The porphyrin-based membrane probe (see picture, not to scale) gives a fast electro-optic response which is about 5–10 times greater than those of conventional styryl dyes.