Abyssomicins from the South China Sea Deep-Sea Sediment Verrucosispora sp.: Natural Thioether Michael Addition Adducts as Antitubercular Prodrugs (pages 1231–1234)
Qian Wang, Assoc. Prof. Fuhang Song, Dr. Xue Xiao, Pei Huang, Assoc. Prof. Li Li, Prof. Aaron Monte, Dr. Wael M. Abdel-Mageed, Dr. Jian Wang, Hui Guo, Dr. Wenni He, Feng Xie, Dr. Huanqin Dai, Miaomiao Liu, Dr. Caixia Chen, Hao Xu, Assoc. Prof. Mei Liu, Dr. Andrew M. Piggott, Assoc. Prof. Xueting Liu, Prof. Robert J. Capon and Prof. Lixin Zhang
Article first published online: 6 DEC 2012 | DOI: 10.1002/anie.201208801
From the deep: The title actinomycete yielded three new abyssomicins J–L. The dimeric thioether J (see scheme) represents a unique example of a masked Michael acceptor with anti-TB properties. Mechanistic insights into the biosynthesis, biomimetic synthesis, stability, and biological mechanism of action of abyssomicins aid our understanding of, and prospects for the development of Michael-acceptor-based drugs.