Opsin, a Structural Model for Olfactory Receptors? (pages 11021–11024)
Prof. Dr. Jung Hee Park, Dr. Takefumi Morizumi, Yafang Li, Joo Eun Hong, Prof. Dr. Emil F. Pai, Prof. Dr. Klaus Peter Hofmann, Prof. Dr. Hui-Woog Choe and Prof. Dr. Oliver P. Ernst
Article first published online: 26 AUG 2013 | DOI: 10.1002/anie.201302374
Receptor–ligand interaction: Olfactory receptors (ORs) are G-protein-coupled receptors (GPCRs), which detect signaling molecules such as hormones and odorants. The structure of opsin, the GPCR employed in vision, with a detergent molecule bound deep in its orthosteric ligand-binding pocket provides a template for OR homology modeling, thus enabling investigation of the structural basis of the mechanism of odorant–receptor recognition.