Selective Imaging of the Angiogenic Relevant Integrins α5β1 and αvβ3 (pages 11656–11659)
Dr. Stefanie Neubauer, Dr. Florian Rechenmacher, Dr. Ambros J. Beer, Dr. Flavio Curnis, Karolin Pohle, Dr. Calogero D'Alessandria, Prof. Dr. Hans-Jürgen Wester, Prof. Dr. Ute Reuning, Prof. Dr. Angelo Corti, Prof. Dr. Markus Schwaiger and Prof. Dr. Horst Kessler
Version of Record online: 20 SEP 2013 | DOI: 10.1002/anie.201306376
Pattern seekers: For the two angiogenic relevant integrins α5β1 and αvβ3, functionalized derivatives of the selective antagonists 1 and 2 could target and discriminate between tumor cells in vivo based on their different integrin patterns and also delay tumor growth in vivo. In addition, the first α5β1-selective integrin antagonist that enables specific molecular imaging by positron emission tomography was developed.