End-to-End Continuous Manufacturing of Pharmaceuticals: Integrated Synthesis, Purification, and Final Dosage Formation (pages 12359–12363)
Salvatore Mascia, Patrick L. Heider, Haitao Zhang, Richard Lakerveld, Brahim Benyahia, Paul I. Barton, Richard D. Braatz, Charles L. Cooney, James M. B. Evans, Timothy F. Jamison, Klavs F. Jensen, Allan S. Myerson and Bernhardt L. Trout
Article first published online: 2 OCT 2013 | DOI: 10.1002/anie.201305429
A series of tubes: The continuous manufacture of a finished drug product starting from chemical intermediates is reported. The continuous pilot-scale plant used a novel route that incorporated many advantages of continuous-flow processes to produce active pharmaceutical ingredients and the drug product in one integrated system.