Two-Photon-Triggered Drug Delivery in Cancer Cells Using Nanoimpellers (pages 13813–13817)
Jonas Croissant, Dr. Marie Maynadier, Audrey Gallud, Dr. Harmel Peindy N'Dongo, Dr. Jeff L. Nyalosaso, Dr. Gaëlle Derrien, Dr. Clarence Charnay, Dr. Jean-Olivier Durand, Dr. Laurence Raehm, Prof. Françoise Serein-Spirau, Dr. Nathalie Cheminet, Dr. Thibaut Jarrosson, Dr. Olivier Mongin, Dr. Mireille Blanchard-Desce, Dr. Magali Gary-Bobo, Dr. Marcel Garcia, Dr. Jie Lu, Prof. Fuyuhiko Tamanoi, Dr. Derrick Tarn, Tania M. Guardado-Alvarez and Prof. Jeffrey I. Zink
Version of Record online: 7 NOV 2013 | DOI: 10.1002/anie.201308647
A therapy of cancer cells: Two-photon-triggered camptothecin delivery (see picture) with nanoimpellers was studied in MCF-7 breast cancer cells. A fluorophore with a high two-photon absorption cross-section was first incorporated in the nanoimpellers. Fluorescence resonance energy transfer (FRET) from the fluorophore to the azobenzene moiety was demonstrated.