Organotin(IV)-Loaded Mesoporous Silica as a Biocompatible Strategy in Cancer Treatment (pages 5982–5987)
Mirna Z. Bulatović, Dr. Danijela Maksimović-Ivanić, Christian Bensing, Prof. Santiago Gómez-Ruiz, Prof. Dirk Steinborn, Dr. Harry Schmidt, Dr. Marija Mojić, Prof. Aleksandra Korać, Igor Golić, Dr. Damian Pérez-Quintanilla, Dr. Miljana Momčilović, Dr. Sanja Mijatović and Prof. Goran N. Kaluđerović
Version of Record online: 14 MAY 2014 | DOI: 10.1002/anie.201400763
More than packaging: When a nanostructured material is loaded with an organotin(IV) compound, the efficacy of the anticancer drug is amplified dramatically. The loaded nanomaterial almost completely abolished tumor growth in syngeneic C57BL/6 mice. The reversion of the cancer cells to the normal phenotype is highly compatible with the surrounding tissue and presents a very safe mechanism for fighting cancer.