Total Synthesis of Pectenotoxin-2 (pages 780–784)
Prof. Dr. Kenshu Fujiwara, Yuki Suzuki, Nao Koseki, Yu-ichi Aki, Yuta Kikuchi, Shun-ichi Murata, Fuyuki Yamamoto, Mariko Kawamura, Prof. Dr. Toshio Norikura, Prof. Dr. Hajime Matsue, Prof. Dr. Akio Murai, Prof. Dr. Ryo Katoono, Prof. Dr. Hidetoshi Kawai and Prof. Dr. Takanori Suzuki
Article first published online: 29 NOV 2013 | DOI: 10.1002/anie.201308502
A shellfish toxin: Non-anomeric spiroacetal pectenotoxin-2 was synthesized by the acidic isomerization of anomeric spiroacetal pectenotoxin-2b. In the isomerization step, [6,6]-spiroacetal pectenotoxin-2c was the major product at equilibrium. However, the early termination of a dynamic transition process to equilibrium in the step produced pectenotoxin-2 selectively.