A Protein-Based Pentavalent Inhibitor of the Cholera Toxin B-Subunit (pages 8323–8327)
Dr. Thomas R. Branson, Dr. Tom E. McAllister, Jaime Garcia-Hartjes, Dr. Martin A. Fascione, Dr. James F. Ross, Dr. Stuart L. Warriner, Dr. Tom Wennekes, Prof. Han Zuilhof and Dr. W. Bruce Turnbull
Article first published online: 2 JUL 2014 | DOI: 10.1002/anie.201404397
Cholera versus cholera: The inhibition of multivalent protein/carbohydrate interactions between toxins and glycolipids in cell membranes can prevent the toxins from entering cells. The site-specific modification of a protein scaffold, matched in both size and valency to the target toxin, led to a multivalent inhibitor with an IC50 value of 104 pM for the cholera toxin B-subunit.