Development of Multinuclear Polymeric Nanoparticles as Robust Protein Nanocarriers (pages 8975–8979)
Dr. Jun Wu, Dr. Nazila Kamaly, Dr. Jinjun Shi, Lili Zhao, Dr. Zeyu Xiao, Geoffrey Hollett, Rohit John, Shaunak Ray, Dr. Xiaoyang Xu, Dr. Xueqing Zhang, Prof. Philip W. Kantoff and Prof. Omid C. Farokhzad
Article first published online: 2 JUL 2014 | DOI: 10.1002/anie.201404766
Polymer–polycation nanoparticles have been used as nuclei to readily adsorb large amounts of protein (>20 % of the nanoparticles by weight) to form new hybrid nanospheres with diameters <200 nm in aqueous solutions without organic solvents through electrostatic interactions. This model system was used to demonstrate the relationships between nanosphere size, surface charge, polymer–polycation composition, and protein loading.